Phytochemical screening and evaluation of antiangiogenic properties of sapinit (Rubus fraxinifolius) fruit crude extracts
Plants are potential low-cost alternatives for cancer treatment. Rubus fraxinifolius or “sapinit” has been found to possess phytochemicals with anti-cancer potential. This project aimed to evaluate the antiangiogenic properties of methanolic R. fraxinifolius fruit crude extracts through the chick chorioallantoic membrane (CAM) assay. Through phytochemical screening, leucoanthocyanins, phenols, and tannins were detected. For the CAM assay, 10, 20, and 30 μg/μL extracts, distilled water, methanol, and retinoic acid were applied on 60 ten-day-old chicken eggs. The CAM photographs were analyzed using ImageJ Software. The mean percent inhibitions (MPI) of total length and vascular density from both analyses were subjected to One-Way Analysis of Variance (ANOVA). The ANOVA for the MPI of total length, followed by a Tukey post hoc test, show that only retinoic acid treatment has significantly higher MPI (p = 0.0010). Meanwhile, the results for the MPI of vascular density show no significant differences between all groups (p = 0.1630). It is possible that the concentrations used in the study may not be the concentrations needed to achieve optimal antiangiogenesis. The results may also be due to the absence of phytochemicals that exhibit significant antiangiogenic properties such as alkaloids. Lower concentrations and isolated phytochemicals may also be tested.
LENS WITH VARIABLE OPTICAL CHARACTERISTICS
Research work on creating a lens, the optical power can be changed depending on human needs. Most people have visual impairments that need to be corrected with surgery or optical devices (glasses and contact lenses). The optical characteristics of the human eye vary depending on age, health, intensity of visual load. We propose to give people the opportunity to smoothly adjust the optical power of the spectacle lens by changing the transparent tubes between the two windows of transparent films. Experimental studies have shown the possibility of adjusting the optical power of the proposed line in a wide range. Existing devices and materials for changing the optical power of the line are analyzed. The design of a lens with variable optical characteristics is proposed, which is created from two window films, the space between which is filled with liquid. Publicly available materials for the outer shell of the lens and liquid for its filling. The effect of the amount of liquid to be filled on the optical power of the lens was experimentally determined. The formula for experimental finding of focal length of a lens is entered. Novelty is impossible because you can use the lens in another field. For example, in the future it is planned to perform an experiment with a lens system to create, for example, a telescope.
Mentor Hunt App
The Information Technology (IT) area has shown great growth in recent years, even with the economic recession that 巴西 has been through and the impact of the coronavirus pandemic. It is estimated that by 2024 the area will have a deficit of more than 290 thousand professionals. However, companies still face other difficulties in hiring, especially people who are looking for their first job in the Information Technology area. Most part of these difficulties are lack of qualified manpower and high prerequisites to fill internship or junior positions. As a result, the objective of this project is: to develop a platform that connects people who seek guidance, improvement or professional relocation in the Information Technology area with professionals that already have the experience they are seeking. The first step was a research and analysis of similar platforms in the market, whose proposal involves mentoring or professional connections, and it concluded that there are no services that fully meet the project’s proposal. In the second step, a research was done about mobile development, highlighting Flutter and Firebase platform. The third step defined the application’s features, such as suggestion of users and mentors, search for users, become a mentor, private chat, video calls, Portuguese and English languages, light and dark themes and profile customization. The suggestion of users and mentors is done by a match with the registered users, relating their areas of work (where the user has experience) and the areas of interest of each one. For the coding of the project, Flutter and Firebase technologies were used. To design the app, it followed Material Design specifications. For testing and distribution, the app was published on Play Store, Google’s Android application platform. The tests were performed by both the researcher and a selected group of users to verify if the functionalities were in accordance to what was defined in the beginning of the project. Perceiving the correct functioning of the application, the project achieved the proposed objective. In addition, it expanded its reach area, because it is possible to find users and mentors from any other area of the market.