全國中小學科展

2019年

自轉易導致presupernova階段 ? 探討恆星自轉於演化過程及最終狀態扮演之角色

自轉是塑造恆星演化的關鍵物理因素(A. Maeder et al. 2012),然而,在一些研究當中,模擬恆星演化仍會選擇忽略旋轉的影響(Pietrinferni et al. 2004),這開啟了我探討自轉在恆星演化扮演的角色之興趣,於是展開以下研究。MESA(Modules for Experiments in Stellar Astrophysics)為一專業天文物理界中普遍使用之電腦程式,能模擬各種恆星演化場景,本研究藉由MESA模擬不自轉至具自轉程度差異之恆星演化模型,探討其演化過程之變化及最終狀態之差異。研究結果分析發現自轉混合導致不同殼層位置之元素有更好的對流性,因而產生較好之化學同質性質 (Chemical Homogeneous),而自轉效應在驅使恆星進入presupernova階段亦有一定程度的重要性。

水稻根表鐵膜對植體營養元素吸收的影響

鐵是植物生長的必要營養元素之一,土壤中的鐵含量雖然不低,但受限於含鐵礦物的溶解度使得鐵的有效性低,植物對鐵的吸收因此受限,進而影響人類的鐵攝取量並造成相關的健康問題。欲提高植物對鐵的利用效率,必須先了解植物對其吸收之相關機制,主要關鍵之一為植物根如何改變根圈環境以控制鐵吸收的有效性。 本研究以水稻為對象,探討水稻不同根部泌氧能力,對水稻根部鐵膜組成、鐵吸收效率,及其對其他營養元素吸收的影響。我們藉由遺傳篩選方法,選殖出較不易生成鐵膜之突變株(#878),透過比較野生型與突變株 (#878)水稻生理性狀之差異,發現通氣組織的生成為控制根系泌氧的影響因子;此泌氧能力會使根系周圍的鐵氧化,並於根表形成一層含有鐵氧化物的沉澱 (即鐵膜);而鐵膜的生成會影響水稻營養元素的吸收,其中鐵膜對陽離子型態的營養元素有較好吸持效果。

直接觀測表面修飾之氧化石墨烯對改善抗血栓性能之研究

臨床上,人工血管與心血管支架常因血栓導致其使用壽命減短,甚至造成病人生命危險,而血栓起因乃為血小板活化。氧化石墨烯為新穎二維材料,其於醫學方面的應用也極具潛力。本研究藉由微流道觀測系統,透過光學顯微鏡直接觀測氧化石墨烯表面與血小板間之交互作用,再進一步使用紫外光還原氧化石墨烯表面,並使用原子力顯微鏡(AFM)、X光光電子能譜儀(XPS)、凱爾文探測力顯微鏡(Kelvin Probe)等檢測氧化石墨烯表面性質。 經實驗證實,鍍有氧化石墨烯之表面在流動狀態下,可有效地減少血小板的活化與貼附,並推測因氧化石墨烯表面帶有負電荷,可排斥同帶負電荷之血小板,以達到減少血栓生成的目的,未來可進一步應用在人工心血管支架上,延長其使用壽命。此研究突顯了改善人工血管與支架表面性質與其臨床上應用的重要性,而材料表面修飾也為優化臨床應用提供一個可行方法。

藉由雙硫化物交聯製成的植物核酸奈米粒子可當作穀胱甘肽誘發的抗癌藥物載體

由於人工合成的化學材料在包覆藥物進行人體醫療測試時,不可分解性會帶來體內累積的毒性,搜尋各類化合物的結構後,發現核酸上的含氮鹼基具有一級胺結構,可和天然交聯劑京尼平或DTSSP進行反應,因此,本研究抽取水果的核酸進行實驗,利用界面活性劑乳化的過程中將阿黴素(DOX),包覆進入交聯後的核酸水膠,穿透式顯微鏡的結果顯示交聯後的水膠結構是球狀,平均粒徑大約是120奈米,核酸本身帶負電,水膠有包覆藥物的界面電位稍微減少負電,利用人類正常肺上皮細胞進行水膠共同培養,2毫克/毫升的水膠溶液在連續培養48小時後,並不會造成細胞死亡,奈米水膠在pH值5.5釋放DOX的量比pH值7.4還要高出27%,有奈米水膠包覆DOX的情況下,更能有效率進入癌細胞內與引起癌細胞毒性,本水果核酸製成的奈米水膠在生物體可分解的無毒包覆材料上,於未來可提供一個新的藥物載體參考。

(Alternating Rotational Conversion) Generator

ARC Generator is a acronym for Alternating Rotational Convertor. The purpose of the generator is to convert rotational motion into an alternating current. What makes this generator unique from other generators is that it uses a combination of aspects from rotational as well as linear generators. The A.R.C Generator is a experiment to generate electricity in new ways, potentially opening new doors in the area of electrical generation. The final goals for the ARC Generator project are to: 1. Make a electrical generator that is unique compared to other types of generators. 2. Make a hydro power based generator that is simple as well as affordable for private use. The generator itself is split into four distinct parts: • The channels • The inner chamber • The core • The coils

A 100% Solar Electric Vehicle: Applying high efficiency solar modules in sustainable transport

As our planet suffers the effects of climate change, it is only a matter of time before society will have to centre all aspects of development around sustainability. In the past, clean solutions for transportation have been dismissed due to the higher cost, and lower efficiency than fossil fuels. However, in the past few decades, there has been a steep decline in solar module cost, and and a steady climb towards higher efficiency. From my findings in this project, I have concluded that we are now at a point where we can embrace the clean, renewable potential which our sun offers. I have created and tested a proof-of concept electric vehicle (Solar EV), which can run indefinitely during daylight hours, provided sunny conditions. There are several mechanical features of my project which highlight the potential that renewable energy in transportation can have. Firstly the vehicle’s 500W motor is powered by 3 100W solar modules, and 3 50W modules, for a total of 450W or power generation. This means that when driving at anything less than 90% throttle, the Solar EV can run continuously without needing to stop to charge or refuel. Another design mechanism installed in the vehicle are three 12V lead acid batteries. These batteries allow the Solar EV to be powered for over 1.5 hours, which is useful during cloudy conditions, night, and most importantly, when driving through areas of shade. A unique efficiency component designed into my vehicle is the linear actuator I installed into the module racking system. This design element allows the tilt of the modules to be altered, to maximize the efficiency of the solar module array. At early or late hours of the day, it can be heavily tilted with the press toggle switch, or kept at a relatively flat level when the sun is the highest in the sky. I ran a series of trials to figure out whether or not the theoretical data matches up with the experimental results. After my series of trials, the bike was yet to run out of power. The solar vehicle reaches speeds up to 32 km/h, however comfortably glides at around 25 km/h. The linear actuator I installed allows the solar modules’ tilt to change . During different times of day or year, the sun is at different heights in the sky, however it is very important to maximize the solar potential. With the press of a switch, the module can be actuated to account for this. Lastly, regenerative braking captures the energy from braking. Using the reversible nature of a DC motor with a specialized motor controller responding to feedback from the brake actuators allows the vehicle to reuse energy that would otherwise be wasted as heat.

銅修飾二硫化錫應用於光催化二氧化碳還原產生太陽能燃料

本文研究轉換二氧化碳成為替代能源,介紹運用太陽能源,以SnS2及光觸媒進行CO2還原反應,以產生碳氫和碳氫氧化合物。我們以溶劑熱法配置SnS2,過程中藉由加入不同重量百分比例的銅(0, 0.5, 1, 5, 10 wt.%)探討銅的添加對於觸媒的影響:能隙縮短、底面為從六角形至四邊形晶體結構、吸收光範圍延伸至可見光之域。以活性測試探討其綜合性能,結果呈現1 wt.%銅修飾的SnS2光觸媒有最高CO2轉換效率,且產物單一為乙醛。未來希望藉由研究最佳銅修飾的比例,以改良二硫化錫光觸媒的吸光特性、減少電子電洞對復合,並進一步增加其量子轉換效率、增加產量。

應用仿生機器人於蜂鳥起飛行為之研究

本研究利用仿生機器人(Biomorphic robotics)來探討蜂鳥(hummingbird)在不同重量變化下的飛行機制。本實驗利用了使用多連桿結構組成的仿生蜂鳥機器人,並使用懸吊裝置來模擬不同重量的蜂鳥,再藉由慢動作高速攝影機來紀錄蜂鳥振翅飛行的過程。透過影像分析與紀錄重量變化來分析仿生蜂鳥拍翅時的動態行為後,我們可以得到與仿生蜂鳥重量相對應的上升力結果與不同蜂鳥重量下相對應的拍翅頻率數據。我們從這些關係分析作圖並推導出對應的公式,這些結果可以解釋為何大部分蜂鳥重量都介於10 - 20克以及拍翅頻率介於20-50Hz,目前尚未有文獻發現及探討這些相關現象的研究,此研究的結果可作為未來微型撲翼機(ornithopter) 的設計參考,有助於微型軍用探測機械與小型空中救援機械的發展。

上皮細胞黏著分子(EpCAM)促進大腸癌細胞中對於艾瑞莎(Gefitinib)之抗藥性研究 EpCAM enhances Gefitinib-induced drug resistance in colon cancer cells

上皮生長因子受體 (EGFR) 已被確認在人類上皮惡性腫瘤扮演重要角色,因此臨床上開發出許多針對EGFR之大腸癌、肺癌等的小分子標靶藥物,但治療期間所產生的抗藥性仍是一大瓶頸。 過去上皮細胞黏著分子(EpCAM)只被認為是胞間連接分子,現今則在癌幹細胞 (cancer stem cells,CSCs)等領域被研究。然而從文獻與先前實驗室的試驗,可以看見EpCAM促進癌症抗藥性的可能。 本研究發現在大腸癌中,艾瑞莎 (Gefitinib) 會透過轉錄因子FOXO3a促進細胞凋亡,而EpEX會經由抑制FOXO3a所促進的凋亡路徑,導致癌細胞產生Gefitinib抗藥性,且此抗藥性,也與EpICD下游之誘導性多能幹細胞相關基因 ( iPS-related genes )的表現有關,但其分子機制尚不清楚。 本研究以大腸癌與Gefitinib做為癌症與EGFR小分子藥物的模型,找出EpCAM可能造成的抗藥路徑,未來可應用在各類癌症之聯合治療 (Combination therapy) ,以克服癌症治療所產生的EGFR小分子藥物抗藥性。

Satellite Modeling of Wildfire Susceptibility in California Using Artificial Neural Networking

Wildfires have become increasingly frequent and severe due to global climatic change, demanding improved methodologies for wildfire modeling. Traditionally, wildfire severities are assessed through post-event, in-situ measurements. However, developing a reliable wildfire susceptibility model has been difficult due to failures in accounting for the dynamic components of wildfires (e.g. excessive winds). This study examined the feasibility of employing satellite observation technology in conjunction with artificial neural networking to devise a wildfire susceptibility modeling technique for two regions in California. Timeframes of investigation were July 16 to August 24, 2017, and June 25 to December 8, 2017, for the Detwiler and Salmon August Complex wildfires, respectively. NASA’s MODIS imagery was utilized to compute NDVI (Normalized Difference Vegetation Index), NDWI (Normalized Difference Water Index), land surface temperature, net evapotranspiration, and elevation values. Neural network and linear regression modeling were then conducted between these variables and ∆NBR (Normalized Burn Ratio), a measure of wildfire burn severity. The neural network model generated from the Detwiler wildfire region was subsequently applied to the Salmon August Complex wildfire. Results suggest that a significant degree of variability in ∆NBR can be attributed to variation in the tested environmental factors. Neural networking also proved to be significantly superior in modeling accuracy as compared to the linear regression. Furthermore, the neural network model generated from the Detwiler data predicted ∆NBR for the Salmon August Complex with high accuracy, suggesting that if fires share similar environmental conditions, one fire’s model can be applied to others without the need for localized training.