果蠅緯度相關晝夜節律特徵:穩定性、活動量分佈與演化意義
Latitude-Dependent Circadian Traits in Drosophila: Stability, Activity Peaks, and Evolutionary Implications
生物時鐘可對生物體的行為與生理造成影響,在探討晝夜節律特徵的差異時,過去研究常侷限於北美大陸的品系,缺少赤道及南半球品系的晝夜節律特徵探討。有鑒於黑腹果蠅在全球各大洲的廣泛分佈,因此我們以黑腹果蠅(近赤道與中高緯度品系)為材料,研究果蠅是否因緯度而有相異的晝夜節律特徵?結果顯示不同緯度的果蠅品系展現出相異的晝夜節律特徵。赤報品系在全暗狀態下仍維持原本光暗12小時的穩定節律,而南北半球的中高緯度品系則具有相似節律特徵,即在全暗狀態下的節律不對齊原本正常光源的穩定節律,其他如活動量、週期、及節律強度等皆有著品系間的差異。更進一步比對實驗中各個品系基因序列,研究發現per和tim在調控區段有許多SNP變異,顯示其與晝夜節律特徵的關係,有助於後續尋找更多造成晝夜節律特徵差異的可能遺傳變異並探討。
ChordSeqAI: Generating Chord Sequences Using Deep Learning
This report presents a novel AI-driven tool for aiding musical composition through the generation of chord progressions. Data acquisition and analysis are discussed, uncovering intriguing patterns in chord progressions across diverse musical genres and periods. We developed a range of deep learning models, from basic recurrent networks to sophisticated Transformer architectures, including conditional and style-based Transformers for improved controllability. Human evaluation indicates that, within the context of our specific data processing methods, the chord sequences generated by the more advanced models are practically indistinguishable from real sequences. The models are then integrated into a userfriendly open-source web application, making advanced music composition tools accessible to a broader audience.