Two Klatovy copies of Šimon Brixi's Domine ad Ad juvandum me festina and his time
The main goal of this paper was a creation of musical score for the composition from the 18th century Domine ad Ad juvandum in A minor and C major composed by Šimon Brixi. Another goal was finding as much information as possible related to this composition and summarize everything possible that was written previously. Separate parts were transcribed into one partiture. Nevertheless there were difficulties like mistakes in sheet music (corrected according to harmony of other voices), missing beats (replaced by identical parts of score), differences in period station. Hard times also bring on differences of period notation. The resulting musical scores can be directly used for music production, which is schemed for the next year. The second part was researching new or never-published information related to these compositions. Here I describe Š. Brixi´s life. I managed to read out the cause of Šimon Brixi death in a chronicle, which was not in the publication I found. Brixi died of tuberculosis like his son. Transcriptors, J.V.Flaška and J.J.Hoffman, are also mentioned. Lastly the information about sheet music itself and its historical context were described. Another discovery was an identification of watermark on sheet music paper. Assuming the sheet music is truly transcribed in 1742 the Kolinec paper mill watermark on the sheet music paper is the oldest evidence of its use. In this paper I summarized the historical context of the baroque era including social life, art and culture.I mentioned the most important events that were crucial for historical development in Bohemia and especially in the Klatovy region. This context can be useful for today’s musicians who want to understand the historical background and express the composition with full respect to the time of its creation.
朽木生花-初探以中藥萃取液對木材染色之防蟲抑菌效果
In our experiment, we used traditional Chinese medicine to dye on cheap wood, in addition to avoiding the impact of chemical paint on human body; After dyeing, the color and texture quality of the wood are improved, which makes cheap wood have higher price and improves the value of wood; At the same time, it can reduce the felling of slow growing precious wood, which has the functions of environmental protection, earth love and carbon saving. The test material was pretreated with hydrogen peroxide and surfactant, and the bleaching effect was obvious. After dyed with different Chinese medicinal, soak in strong acid and alkali solution for 15 minutes, which shows that strong acid and acid treatment is not allowed. On the other hand, after 15 minutes of immersion in detergent, the color difference value is less than 2, and the rubbing fastness is above grade 4. In the bacteriostasis experiment, no fungus grew in the first 3 days, and it did not grow in the 12th day. In the anti-termite experiment, the mortality rate on the fifth day was 65% for Lithospermum and 83.8% for Wolfberry, and the other groups had a good effect of total elimination. While plastic products have a great impact on the environment, wood that is dyed or modified with natural colored dye, its environmental value far exceeds the human visual perception.
Analysis of lncRNA, miRNA , mRNA-associated ceRNA networks include in promoting glioma cancer
The ceRNAs as a class of RNAs act by competitively binding to miRNAs and limiting their regulatory effect on the target genes. Increasing evidences point to the role of ceRNAs in glioma cancer. So far, limited studies have been reported on the role of ceRNA in the development in glioma cancer. In this study, we have analyzed online RNA sequencing data in order to predict the ceRNAs which are putative regulators of in glioma cancer.
Synthesis of Substituted Pyrrolidin-2-ones and Isoindolines from Donor-Acceptor Cyclopropanes and Anilines/Benzylamines
The development of rapid and efficient synthetic approaches to the bioactive cyclic and polycyclic azaheterocycles is one of the most important challenges in organic synthesis. In this work effective and simple synthetic approaches to polysubstituted pyrrolidin-2-ones 2 and isoindolines 3 from donor-acceptor cyclopropanes 1, bearing the ester group as the one of acceptor substituents, and amines were developed. The γ- pyrrolidone based skeletons and isoindoline ring system is a constituent of many biologically active molecules, both natural and synthetic, and a key component of clinically relevant entities (Fig.1,2) [1,2]. The synthesis of pyrrolidin-2-ones 2 includes Lewis acid-catalyzed opening of the donor-acceptor cyclopropane with primary amines (anilines, benzylamines, etc.) to γ-amino esters, followed by in situ lactamization and dealkoxycarbonylation. The reaction has a broad scope of applicability; a variety of substituted anilines, benzylamines, and other primary amines as well as a wide diversity of donor-acceptor cyclopropanes bearing (hetero)aromatic or alkenyl donor groups and various acceptor substituents, can be involved in this transformation. In this process, donor-acceptor cyclopropanes react as 1,4-C,C-dielectrophiles, and amines as 1,1- dinucleophiles. The resulting di- and trisubstituted pyrrolidin-2-ones can be also used in subsequent chemistry to obtain various nitrogen-containing polycyclic compounds of interest to medicinal chemistry and pharmacology, such as benz[g]indolizidine derivatives. The synthesis of the substituted isoindolines 3 is based on the domino-reaction between donor-acceptor cyclopropanes, bearing in ortho-position of aromatic substituent a bromomethyl group, and different primary amines (e.g., anilines, benzylamines, cycloalkylamines) was developed. The reaction involves the generation of secondary amine followed by nucleophilic ring opening of cyclopropane with amino group. Moreover, this process provided a new practical method for the rapid synthesis of benzo[b]pyrrolizidinone 4 from readily available starting materials.