全國中小學科展

2023年

以深度學習進行心音及高血壓關聯性之研究

2019年衛生福利部死因統計資料顯示和高血壓有高度相關的心臟疾病、腦血管疾病和高血壓性疾病皆在十大死因之列[15]。本研究提出以深度學習對心跳聲的時序頻譜圖進行訓練與分析的研究方法,應用此方法我們能以Convolution Neural Network(CNN)模型從受測者心跳聲預測出其血壓層級。CNN一般用於圖像分類,但在此研究中我們以此來分析心跳聲。本研究發現利用僅萃取第二心音的資料庫訓練效果較佳,並透過熱圖分析注意到模型對特定頻率域較為重視,在後續實驗中更進一步發現0~200 Hz和400~600 Hz在判斷高血壓時扮演重要角色。同時,我們也成功應用此方法,區分出長期高血壓和運動高血壓,證明心血管的結構改變在時序頻譜圖上有對應特徵。若應用於穿戴型裝置持續監控心跳聲,就能隨時追蹤使用者的血壓層級的變化,有異常便能盡早就醫,避免憾事發生。

全無機 CsPbBr3鈣鈦礦量⼦點與其⼆價陽離⼦摻雜之光學特性、穩定性與噴墨列印應⽤之研究

本研究提出一款新型硫化氫偵測之螢光探針,我們選用BTIC作為探針螢光主結構並藉由修飾上疊氮達成偵測硫化氫之目的。帶入設計上,利用PPH3形成與粒線體的電位差使其將探針帶進粒線體,最終進行粒線體內硫化氫之偵測與顯影。 目前本實驗已合成出螢光探針基本結構與側鍊結構,並初步檢測探針對於硫化氫的偵測能力,確認其能夠與之反應並有顯著螢光變化。另外,目前已成功接上側鍊,待純化出目標產物後將進行進一步的性質檢測,包括選擇性、靈敏性、及持久性。 最後,我們預計將探針實際進行生物顯影,做多個結構顯影的比對,確認本研究之成效。此外,我們希望此款螢光探針除硫化氫偵測外,還能夠進行生物機制探討或疾病細胞篩選的應用。

Optimization of honey production by monitoring the behavior of bees based on studying their sounds

This is a first approach in the development of beekeeping and the preserving of bees, a crucial and important species in the balance of ecology on our planet. This project consists in designing and building a small affordable device that will help beekeepers keep an eye on their hives and prevent theft whenever and wherever they are by providing them with instant and continuous data and information about their beehive status through a mobile application. This IOT approach will rely on many physical variables especially the sound frequency of the bee buzz, which appears to be a way for the bees to communicate with each other in special circumstances. That is why; we aimed to analyze the sound frequencies of the bee buzz to detect beehive behavioral changes. Many other factors are also important for the keeping of a healthy beehive such us temperature, humidity, weight and fly activity. And as for security measures we are going to add a GPS tracker to the system to keep track of the hives and alert the beekeeper if there is any kind of danger. The development of this real time beehive monitoring system will not only help the beekeeper keep track of his hive and collect useful data but also increase the honey production and avoid many colony losses and thus preserve the bees and ensure their well-being.

自製模型模擬地震對地球自轉速率變化之探討

為了解地震對地球自轉速率變化之影響,本研究使用自製地球模型、模擬板塊裝置,並運用 Tracker 等程式,模擬地震後地球自轉變化情形。 自製地球轉動時角速度有週期變化,可當作模擬地震發生的背景資料。研究結果顯示,加重板塊負重,角速度無明顯變化趨勢,但自轉一圈所需時間皆增加。改變板塊位置,北緯 22.5 度組角速度圖形高峰值及振幅顯著增加,赤道、北緯 45 度組變化則不明顯。 板塊移動與球體旋轉同向時,角速度變化振幅明顯加大,反向則不明顯。在角速度相對小時移動板塊,角速度趨勢往下,平均角速度減少;反之,在角速度相對大時移動板塊,角速度趨勢往上,平均角速度增加。 本模型模擬之地震所引發之日長改變量,經由換算相當於自轉週期 24 小時的地球改變了 36 分鐘。

液滴爆炸

本研究探討乙醇水溶液液滴於疏水流體表面之分裂現象。此現象可利用揮發造成乙醇之濃度梯度所驅動的表面張力梯度來解釋,此現象又稱為馬倫哥尼效應(Marangoni Effect)。液體為達到最低表面能而改變表面積的普托瑞立不穩定現象(Plateau Rayleigh Instability)也可以做為液滴分裂的解釋之一。 在研究中,研究團隊發現溶液在油面上會隨時間分裂出子液滴,並對於最終子液滴的半徑與分裂現象分別進行定量與定性之探討。本研究於先遣實驗中發現乙醇水溶液濃度之臨界下限為65%~67%重量百分濃度,並以大於(含)此濃度之溶液進行關於乙醇濃度、溶液體積與油層厚度、油層黏度四項參數對於最終子液滴半徑、分裂時間、液滴最大擴散半徑與擴散半徑演變之影響,也針對與參考文獻所選用液體不同深入探討異丙醇與乙醇的蒸發速率的差異如何影響實驗結果。

Adversarial Attacks Against Detecting Bot Generated Text

With the introduction of the transformer architecture by Vaswani et al. (2017), contemporary Text Generation Models (TGMs) have shown incredible capabilities in generating neural text that, for humans, is nearly indistinguishable from human text (Radford et al., 2019; Zellers et al., 2019; Keskar et al., 2019). Although TGMs have many potential positive uses in writing, entertainment and software development (Solaiman et al., 2019), there is also a significant threat of these models being misused by malicious actors to generate fake news (Uchendu et al., 2020; Zellers et al., 2019), fake product reviews (Adelani et al., 2020), or extremist content (McGuffie & Newhouse, 2020). TGMs like GPT-2 generate text based on a given prompt, which limits the degree of control over the topic and sentiment of the neural text (Radford et al., 2019). However, other TGMs like GROVER and CTRL allow for greater control of the content and style of generated text, which increases its potential for misuse by malicious actors (Zellers et al., 2019; Keskar et al., 2019). Additionally, many state-of-the-art pre-trained TGMs are available freely online and can be deployed by low-skilled individuals with minimal resources (Solaiman et al., 2019). There is therefore an immediate and substantial need to develop methods that can detect misuse of TGMs on vulnerable platforms like social media or e-commerce websites. Several methods have been explored in detecting neural text. Gehrmann et al. (2019) developed the GLTR tool which highlights distributional differences in GPT-2 generated text and human text, and assists humans in identifying a piece of neural text. The other approach is to formulate the problem as a classification task to distinguish between neural text and human text and train a classifier model (henceforth a ‘detector’). Simple linear classifiers on TF-IDF vectors or topology of attention maps have also achieved moderate performance (Solaiman et al., 2019; Kushnareva et al., 2021). Zellers et al. (2019) propose a detector of GROVER generated text based on a linear classifier on top of the GROVER model and argue that the best TGMs are also the best detectors. However, later results by Uchendu et al. (2020) and Solaiman et al. (2019) show that this claim does not hold true for all TGMs. Consistent through most research thus far is that fine-tuning the BERT or RoBERTa language model for the detection task achieves state-of-the-art performance (Radford et al., 2019; Uchendu et al., 2020; Adelani et al., 2020; Fagni et al., 2021). I will therefore be focussing on attacks against a fine-tuned RoBERTa model. Although extensive research has been conducted on detecting generated text, there is a significant lack of research in adversarial attacks against such detectors (Jawahar et al., 2020). However, the present research that does exist preliminarily suggests that neural text detectors are not robust, meaning that the output can change drastically even for small changes in the text input and thus that these detectors are vulnerable to adversarial attacks (Wolff, 2020). In this paper, I extend on Wolff’s (2020) work on adversarial attacks on neural text detectors by proposing a series of attacks designed to counter detectors as well as an algorithm to optimally select for these attacks without compromising on the fluency of generated text. I do this with reference to a fine-tuned RoBERTa detector and on two datasets: (1) the GPT-2 WebText dataset (Radford et al., 2019) and (2) the Tweepfake dataset (Fagni et al., 2021). Additionally, I experiment with possible defences against these attacks, including (1) using count-based features, (2) stylometric features and (3) adversarial training.

Designing a LiDAR topographic navigation system: A novel approach to aid the visually impaired

The WHO reports 2.2 billion people internationally have a form of visual impairment, with Perkins School of Blind adding that 4 to 8 percent (8.8 - 17.6 million people) solely rely on a white cane for navigation. In an interview by Stephen Yin for NPR, visually impaired interviewees claimed that a white cane was ineffective as it failed to detect moving obstacles (ex. bikes), aerial obstacles (ex. falling objects), and it became physically demanding after a prolonged period. This problem can be solved with a headset that integrates LiDAR technology and haptic feedback to provide a real-time assessment of their environment. Theoretically, the device will determine how far an object is from the user and place it into one of three conditionals based on distance (0- 290mm, 310-500mm, 510-1200mm). As the user gets closer to the object, the haptic will vibrate more frequently. The device has 11 LIDAR sensors, beetle processors, and ERM motors so that when the LiDAR detects an object, the device will send a haptic signal in that area. It not only identifies the existence of an object but it tells the user its relative position with a latency period of approximately 2 milliseconds. When testing the device, a simulated walking environment was made. Ten obstacles were included: five below the waist (72”, 28”, 35” and 8.5” tall sticks) and five above the waist (paper suspended 6”, 10”, 48” and 28” from the ceiling). The white cane detected 4.1 obstacles, whereas the device detected 7.3 on average. The LiDAR navigation system is 178% more effective at detecting objects comparatively. Visually impaired individuals no longer must rely on the white cane; rather, using this device, they can detect small, moving, and aerial objects at a much faster, and more accurate speed.

原薯蕷皂苷對腎臟癌細胞的影響

癌症治療多半會傷害到人體的健康,所以國民大多較偏好以較養生的方法來治療癌症,例如中藥。本實驗以山藥萃取物原薯蕷皂苷抑制腎癌細胞 A498 及 786-O ,期望能達抑制腎臟癌細胞增生之目的。 實驗方法包括以 MTT 試驗、細胞菌落試驗來觀測腎癌細胞受原薯蕷皂苷作用後的活性及存活量,再透過西方墨點法及流式細胞儀來了解腎臟癌細胞死亡途徑。實驗結果顯示將原薯蕷皂苷抑制人類腎癌細胞株786-O及A498的增生能力具有抑制的能力。再透過流式細胞儀的分析,顯示原屬蕷皂苷可誘發兩種腎臟癌細胞的凋亡作用,並且透過西方墨點法觀察出是抑制Bcl-2蛋白、增加Bax蛋白和caspase-9/PARP蛋白的表現,進而導致腎臟癌細胞株產生細胞凋亡。 本研究是在實驗室中進行,且只是利用細胞株來觀測此項研究結果。或許未來可以透動物實驗以及臨床實驗,確認原薯蕷皂苷抗癌之功效,並推廣至全球以造福全人類之健康。

朽木生花-初探以中藥萃取液對木材染色之防蟲抑菌效果

In our experiment, we used traditional Chinese medicine to dye on cheap wood, in addition to avoiding the impact of chemical paint on human body; After dyeing, the color and texture quality of the wood are improved, which makes cheap wood have higher price and improves the value of wood; At the same time, it can reduce the felling of slow growing precious wood, which has the functions of environmental protection, earth love and carbon saving. The test material was pretreated with hydrogen peroxide and surfactant, and the bleaching effect was obvious. After dyed with different Chinese medicinal, soak in strong acid and alkali solution for 15 minutes, which shows that strong acid and acid treatment is not allowed. On the other hand, after 15 minutes of immersion in detergent, the color difference value is less than 2, and the rubbing fastness is above grade 4. In the bacteriostasis experiment, no fungus grew in the first 3 days, and it did not grow in the 12th day. In the anti-termite experiment, the mortality rate on the fifth day was 65% for Lithospermum and 83.8% for Wolfberry, and the other groups had a good effect of total elimination. While plastic products have a great impact on the environment, wood that is dyed or modified with natural colored dye, its environmental value far exceeds the human visual perception.

白花蛇舌草免疫抗癌新機轉及活性物質分析

白花蛇舌草是中醫常使用的抗癌中藥,本研究主要探究白花蛇舌草治療大腸癌的可能效應、機轉及活性物質。本研究利用大腸癌動物實驗搭配次世代基因定序,期望發現白花蛇舌草的新穎免疫抗癌標靶,並利用氣相層析質譜儀搭配新穎免疫抗癌標靶分子對接,分析主要的活性物質。結果顯示,白花蛇舌草可以減少小鼠結直腸增生組織的數量及大小,將被影響的基因進行生物資訊程式分析,發現白花蛇舌草會干擾與免疫細胞趨化有關的基因群組以及與上皮細胞增生有關的白細胞介質IL-17訊息路徑,而且存在於白花蛇舌草的阿魏酸可以阻斷IL-17與IL-17受體的結合,減緩小鼠的大腸直腸癌。本研究將古老知識透過現代科學證實有用,呈現與發炎或與上皮細胞增生有關的細胞激素可以作為免疫抗癌標靶,也發現白花蛇舌草的免疫抗癌新機制,並由免疫抗癌新機轉成功求證白花蛇舌草的主要活性物質。