本研究以二氯化鐵和三氯化鐵所合成之磁性奈米粒子為基底，包覆上以蝦紅素為模板修飾的二氧化矽，製作出具有蝦紅素專一性的磁性奈米粒子，應用於萃取福壽螺卵中之蝦紅素。 利用干擾物證明磁性奈米萃取粒子具有蝦紅素的專一性，再探討奈米粒子合成及萃取條件的影響。福壽螺卵經過打碎離心後，依序加入0.2 M氫氧化鈉及1 mM十二烷基硫酸鈉，使蝦紅素水解並去脫去蛋白質轉換為游離態。當模板濃度為0.059 mg/mL、TEOS濃度為1.892 mg/mL和蝦紅素的濃度為0.07 mg/mL時，會有最佳的萃取率達60.7 %。此磁性奈米粒子在萃取步驟後，再以丙酮進行脫附，至少重複使用3次。此技術可減少福壽螺的農害，也極具經濟價值，很值得研究。

Currently, no method can completely eliminate the human immunodeficiency virus (HIV) in an infected person. HIV employs an accessory protein called Nef that forms a complex with cellular AP-1, preventing detection of HIV-infected cells. Lovastatin has been recently identified to inhibit the formation of said Nef-AP-1 complex, but its effective concentration is remarked to be far higher than other Nef inhibitors. This study aims to develop a modified lovastatin molecule exhibiting higher binding affinity to the HIV-1 Nef protein than lovastatin in silico. Modified lovastatin molecules based on the interaction map of lovastatin with Nef were modeled, and flexible ligand-flexible receptor docking to the Nef binding site was performed using AutoDock Vina. Residues within the Nef binding site identified by Liu et al. (2019) to be crucial (Glu-63, Val-66, Phe-68, Asp-108, Leu-112, Tyr-115) were set as flexible. Fragment-based drug design was utilized to append molecular fragments to lovastatin in order to maximize its interactions with said crucial residues. From the fragment-based approach, molecule F4 ((1S,3S)‐8‐{2‐[(2R,4R)‐4‐chloro‐6‐oxooxan‐2‐yl]ethyl}‐3‐(hydroxymethyl)‐7‐methyl‐1,2,3,4‐tetrahydronaphthalen‐1‐yl 4‐aminobenzoate) exhibited a binding affinity of -9.0 kcal/mole, and its estimated IC50 ranges between 0.25-0.51 μM which is at least 7.5 times lower than the reported IC50 of lovastatin from literature. This study presents insights on the key modifications to improve lovastatin as an HIV-1 Nef inhibitor and pertinent information about the Nef binding site for future drug development studies.

核塌縮超新星(Core-Collapse Supernova，CCSN)，又名II型超新星(type II supernova)，是宇宙中最重大的爆炸現象之一，在天文物理學上有許多探索與應用。核塌縮超新星被認為源自於大質量恆星的死亡，但是目前尚不清楚大規模恆星演化及有關核塌縮超新星的物理學，為獲取有關核塌縮超新星的知識與應用，我們使用一維程式碼Modules for Experiments in Stellar Astrophysics (MESA)執行大質量的恆星演化模型。對於此次研究中我們模擬大質量恆星從零齡主星序(zero age main sequence，ZAMS)演化為核塌縮超新星，並透過考慮不同質量祖星(progenitor)上的各種爆炸能量、金屬量(metallicity)、角動量(angular momentum)展示其演化狀態，討論這些恆星演化的物理參數如何影響超新星爆炸及呈現的光變曲線。我們的模擬結果與觀測數據相當符合，可解釋其祖星的起源及物理意義。

平常聽音樂時經常有種似曾相識的感覺。為了描述這種感覺，我們展開了複音音樂片段相似性度量的研究。因為曾經使用過最長公共子序列實作卻效果不如預期，我們將音樂片段正規化後，視為座標平面上的時間、音高點對的集合，使用點對應與二分圖匹配的方法，定義兩個複音音樂片段的相似度為最大權重匹配的平均邊權。我們計算了資料集(JKUPDD)中相同、相異的音樂片段的相似性，調整算法中的參數，找出最適合的參數組合，並且透過音符之間的權重，畫出自相似度矩陣，發現樂曲中的重複片段。

閩南語有句俗諺：「打斷手骨顛倒勇」，人能在受傷後成長，越挫越勇，那植物呢？本研究發現，綠豆葉片在預先接受戳洞的物理刺激後，對生長不僅不會造成負面影響，更反而能提升綠豆耐鹽能力！隨著戳洞數增加或是延長戳洞後放置時間，皆能增強綠豆的耐鹽能力。深入研究結果顯示，戳洞刺激可能藉由鈣離子作為訊號傳遞分子，最終提升綠豆體內抗氧化酵素活性，藉此降低植物在逆境下的氧化傷害，提升其耐鹽能力。未來期望能將研究成果推廣至農業應用上，使其在面對天災人禍時，可以減少農損。

According to CNN Indonesia 2020, the demand for e-Commerce in Indonesia has nearly doubled during this pandemic. This surge in demand calls for a time-efficient method for warehouse order-picking. One approach to achieve that goal is by incorporating automation in their warehouse systems. Globally, the market of warehouse robotics is expected to reach 12.6 billion USD by 2027 (Data Bridge Market Research, 2020). In this research, the warehouse system studied would utilize AMR (Autonomous Mobile Robots) to lift and deliver movable shelf units to the packing station where workers are at. This research designed a heuristic algorithm called A.N.T.s (Algorithm for Navigating Traffic System) to conduct task assigning and pathfinding for AMR in the automated warehouse. The warehouse layout was drawn as a two-dimensional map in grids. When an order is placed, A.N.T.s would assign the task to a robot that would require the least amount of time to reach the target shelf. A.N.T.s then conducted pathfinding heuristically using Manhattan Distance. A.N.T.s would help the robot to navigate its way to the target shelf unit, lift the shelf and bring it to the designated packing station. A.N.T.s algorithm was tested in various warehouse layouts and with a varying number of AMRs. Comparison against the commonly used Djikstra’s algorithm was also conducted (Shaikh and Dhale, 2013). Results show that the proposed A.N.T.s algorithm could execute 100 orders in a 27x23 layout with five robots 9.96 times faster than Dijkstra with no collisions. The algorithm is also shown to be able to help assign tasks to robots and help them find short paths to navigate their ways to the shelf units and packing stations. A.N.T.s could navigate traffic to avoid deadlocks and collisions in the warehouse with the aid of lanes and directions.

n個人圍成一圈，面向圓心，且逆時針編號1,2,……,n。一開始每人手中有一個糖果，由1號開始，逆時針分別給右邊的人一個、兩個、一個、兩個……糖果，手上沒有糖果的人必須退出。我們將此傳遞規則定義為T_1,2，同理T_(1,2⋯,p)。這個傳遞遊戲，最終會有兩種情形，第一種是由一人獨得所有糖果(成功狀態)，第二種是數人間傳遞糖果且形成循環(循環狀態)。 研究後得知，在傳遞規則T_(1,2⋯,p) (p≥2)下，若p=〖p_1〗^(α_1 ) 〖p_2〗^(α_2 )⋯〖p_i〗^(α_i )⋯〖p_j〗^(α_j ) ( 為p的相異質因數)，任意的n值(n≥p+1)均可唯一表示成n=(p)^t×(〖p_1〗^(s_1 ) 〖p_2〗^(s_2 )⋯〖p_i〗^(s_i )⋅m)+q (t,m∈N, p ∤〖p_1〗^(s_1 ) 〖p_2〗^(s_2 )⋯〖p_i〗^(s_i ), (m,p)=1, q=1,2,⋯,p)，令S=(p^t (p-q)+(pq-1))/(p-1)+R⋅p^t，則當m=1時，最終為成功狀態，且獨得糖果者的初始編號為S；當m≥2時，最終為循環狀態，且由m人循環傳遞糖果，而此m人的初始編號是S, S+p^t 〖p_1〗^(s_1 ) 〖p_2〗^(s_2 )⋯〖p_i〗^(s_i ), ⋯⋯ , S+(m-1)⋅p^t 〖p_1〗^(s_1 ) 〖p_2〗^(s_2 )⋯〖p_i〗^(s_i )。上述公式中的R值，可透過我們研究出來的「R值迭代法」求得。更進一步，我們也找出達到成功狀態或循環狀態的最小傳遞數。

As the world has become concerned about the global waste crisis and global warming, there has been a surge of research within materials science to find materials that would replace plastic, such as bioplastics or biodegradable materials, in order to reduce environmental pollution. Plastics generates the microplastics that allowed them to become cross contamination enter the ocean through land, sea and river. Science research found (Lusher et al. (2017)) over 220 species of marine animals ingested microplastic, half of them are considered relevant for commercial purpose and increasing the risk of human consumption as it can induce immune response, oxidative stress, cytotoxicity, alter membrane integrity and cause differential expression of genes. Thailand is also experiencing such a challenge, as seen by the overabundance of plastic waste that might take centuries to decompose. For example, around 1680 million personal hygiene products such as diapers, sanitary napkins, and tampons are used each year. This study highlights the use of naturally accessible absorbent fibers from malva nut (Scaphium scaphigerum) (G. Don) Guib & Planch.), which is widely available and biodegradable in nature and has a low carbon footprint. This study also aimed to develop natural absorbent pads using compostable spun, external layers, and biodegradable glue. A prototype sanitary napkin with biodegradable absorbent pads was developed and evaluated for absorption ability, absorption rate, pH, and biodegradability. The absorbent material absorbed up to 19 times its weight in 2 minutes and 33 times its weight in 2 hours, which is enough for an average of 80-150 mL of menstrual blood. The prototype napkin deteriorated within 99 days, based on naked eye observation. Some signs of degradation and microorganisms growing on the prototype were also observed from scanning electron microscopic images. According to the findings, natural absorbent pads made from malva nut have the potential to be converted into sanitary napkins. Furthermore, it is proposed that the components, which include superabsorbent renewable materials, spinning compostable layer, external compostable layer and biodegradable glue, may be used in a variety of goods, including adult diaper pants, incontinence pads, and laboratory bench mats.

As the world has become concerned about the global waste crisis and global warming, there has been a surge of research within materials science to find materials that would replace plastic, such as bioplastics or biodegradable materials, in order to reduce environmental pollution. Plastics generates the microplastics that allowed them to become cross contamination enter the ocean through land, sea and river. Science research found (Lusher et al. (2017)) over 220 species of marine animals ingested microplastic, half of them are considered relevant for commercial purpose and increasing the risk of human consumption as it can induce immune response, oxidative stress, cytotoxicity, alter membrane integrity and cause differential expression of genes. Thailand is also experiencing such a challenge, as seen by the overabundance of plastic waste that might take centuries to decompose. For example, around 1680 million personal hygiene products such as diapers, sanitary napkins, and tampons are used each year. This study highlights the use of naturally accessible absorbent fibers from malva nut (Scaphium scaphigerum) (G. Don) Guib & Planch.), which is widely available and biodegradable in nature and has a low carbon footprint. This study also aimed to develop natural absorbent pads using compostable spun, external layers, and biodegradable glue. A prototype sanitary napkin with biodegradable absorbent pads was developed and evaluated for absorption ability, absorption rate, pH, and biodegradability. The absorbent material absorbed up to 19 times its weight in 2 minutes and 33 times its weight in 2 hours, which is enough for an average of 80-150 mL of menstrual blood. The prototype napkin deteriorated within 99 days, based on naked eye observation. Some signs of degradation and microorganisms growing on the prototype were also observed from scanning electron microscopic images. According to the findings, natural absorbent pads made from malva nut have the potential to be converted into sanitary napkins. Furthermore, it is proposed that the components, which include superabsorbent renewable materials, spinning compostable layer, external compostable layer and biodegradable glue, may be used in a variety of goods, including adult diaper pants, incontinence pads, and laboratory bench mats.

本研究利用合成生物學技術開發的創新基因組篩檢平台PRISM(v2.0)，採用合成轉錄因子(crispr-TF)辨認DNA但不進行剪切，透過修改CRISPR/Cas的PAM-interacting (PI) domain序列打破其辨認限制，由原本NGG序列變成可以結合NAG的序列，提升crispr-TF在高通量基因組的篩選能力，期待未來可以做出辨認NNN序列，以此技術初步成功建構Chk2/Rad53所參與的基因網絡，讓失去Chk2/Rad53功能的酵母菌能在DNA損傷的情況生存。Chk2/Rad53蛋白磷酸酶在DNA修復的訊息傳遞中調控龐大的基因網絡，其中潛在大量不同調控路徑聯結的組合性，過去的研究都無法有效地分析且重建完整的DNA修復機制。未來將進一步探討Chk2/Rad53調控的下游基因組，並以此新技術和研究應用於複雜腫瘤與老化疾病的預防及治療。