全國中小學科展

二等獎

SeaUVeed Succeed

In the first part of this project, distilled water and 95% ethanol were used to extract ultra-violet(UV)-absorbing and anti-oxidizing compounds from different types of algae including kelp, wakame, sea grape and nori. Activated charcoal was used in attempt to purify the extracts and removed excessive pigments. It was found that the charcoal was more effective in adsorbing pigments from ethanol extract in which up to 80 to 100% pigments could be removed. The UV-absorbing and anti-oxidizing properties of the algae extracts were also studied. All algae extracts showed significant UV-absorbing and anti-oxidizing properties. In particular, extract formed by using 3 g kelp powder in distilled water could significantly reduce 50% UV intensity and react 96.5% DPPH solution which acts as a source of free radicals. In the second part of the project, three applications of algae were explored in details. Firstly, it was found that kelp, wakame and nori extracts by using over 2 g of algae in 30 mL olive oil could absorb UVA and UVB by over 90%, which is comparable to the performance of zinc oxide, a common ingredient in commercial sunscreen products. Costs of preparing the sunscreens were also compared. Except for wakame extract, all other extracts were cheaper than using zinc oxide. Moreover, the kelp extract was found to maintain its UV- absorbing and anti-oxidizing abilities after at least 30 days of storage under room conditions. Lastly, sodium alginate was successfully extracted from kelp with a product yield up to 30%. The alginate solution was then used to form a calcium-alginate protective coating on plastic slides to reduce UV intensity by up to 50%. This aims to apply on nails or fingers during UV nail gel polish to protect against UVR.

Inclined Sedimentation of Suspensions: Theoretical and Experimental Investigation into the Boycott Effect

The Boycott Effect is a phenomenon where sedimentation rate can be increased by tilting the container which holds the suspension, making it a way to increase the efficiency of the process without additional energy input. This makes the Boycott Effect valuable in speeding up and optimising a multitude of industrial applications such as wastewater management and food processing, all of which employ sedimentation to separate particulate matter from the fluids in which they are suspended in. Thus, it is imperative to model the Boycott Effect accurately for a wide range of cases, including arbitrary shaped containers and suspensions of various concentrations without the need to run costly, computationally expensive numerical simulations. In this project I investigated the inclined sedimentation of suspensions both theoretically and experimentally. Experimentally, two image tracking programs were created and tested out on my own experimental videos. I demonstrated the use of a novel method for making use of the Beer-Lambert Law to optically keep track of local concentration of suspensions. This method allows more information to be gathered about the sedimentation process in a very low-cost, non-equipment intensive or invasive way. Theoretically, I expanded upon the well-known analytical 2D PNK theory by accounting for concentration-hindering and sediment build-up effects, as well as the geometrical theory for 3D cylindrical geometries. All parts of the theoretical model were verified with experimental data and shown to have good agreement. (233 words)

RBM4調控BDNF表達對發育的重要性

RBM4 是種 RNA 結合蛋白,以其在各種組織中作為剪接調節因子進而豐富了蛋白質多樣性而受到關注。在我的研究中,藉由 RNA 定序找到了可能由 RBM4 主導的選擇性剪接, 包含 Rbfox2、Prpf40b 和 Add3 等,並發現這些剪接事件在不同時間點和組織中存在差異。因為在不同的組織中看到了選擇性剪接的變化,更透過觀察組織切片比較了野生型與 Rbm4 基因剔除的小鼠中其腦部、心臟、骨骼肌、棕色脂肪組織和胰臟的表現型,進而發現這些差異與基因的關聯。 此外,我的研究揭示了 Rbm4 雙基因剔除小鼠在骨骼肌和胰臟中 Bdnf 和一些指標基因的 mRNA 表現量明顯下降。而令人驚訝的是,腹腔注射 TrkB 活化因子 DHF 能夠顯著地完全恢復 Rbm4 雙基因剔除小鼠中的 Bdnf 表現量。這些發現共同突顯了 RBM4 在調控 Bdnf 中的關鍵作用,並展示了 DHF 作為潛在治療方法的有效性。

Design of a new Hydrogen Fueled Hybrid Car Prototype

The proposed project involves a new water-fueled hybrid car prototype that integrates various technologies, including photovoltaic (PV) panels, electrolysis, a fuel cell, a metal hydride tank, and a battery. The car is equipped with PV panels on its surface, such as the roof or hood, which convert solar energy into electricity. This electricity powers a DC motor that propels the vehicle. Excess electricity can be stored in a battery or used in an electrolysis system to split water into hydrogen and oxygen. The hydrogen is stored in a metal hydride tank for later use. Metal hydrides are materials capable of absorbing and releasing hydrogen gas, providing a safe and compact storage solution. The fuel cell converts hydrogen into electricity to power the DC motor when sunlight is not available. This hybrid system allows for direct solar-powered operation while also storing excess energy as hydrogen. Experimental tests were conducted on a prototype of this water-fueled car, with the fuel cell serving as a backup power source to ensure continuous operation even without solar energy. This concept offers several advantages, including the use of renewable solar energy, zero emissions during fuel cell operation, and the ability to store and utilize excess energy.

由楊氏矩陣變形之三角楊氏陣列的探討

楊氏矩陣是由有限多個相鄰的方格排列而成的表格,各橫列的左邊對齊,格子數由下而上遞增,而標準楊氏矩陣中每列與每行的元素皆嚴格遞增。我們將楊氏矩陣的「方格」變形為「三角形」,制定與原先楊氏矩陣相似的規則,並命名之為三角楊氏陣列。 本篇研究中,我們首先求得了將某些特定形狀的兩列三角楊氏陣列的遞迴關係式、生成函數、一般項,其與組合學上著名的卡特蘭數亦有相關。後來更是一般化至任意的兩列三角楊氏陣列,得到能夠求其方法數的通式。研究中使用的推算邏輯與方法,也許對未來再研究更一般(或云更多列)的三角楊氏陣列會有所幫助,另外,此研究與偏序集合(Partially Ordered Set)有關,可能可以應用於資訊領域的排序問題。

On the Application of Inequalities Containing Sums of Minimum/Maximum of Numbers

Retail inventory management is a crucial part of many businesses due to the high profit associated with it as well as the uncertainty around it, especially for industries with short production cycles and a complex supply chain.Proper management ofretail inventories can lead to decreased inventory costs, prevent spoilage and obsoles- cence, and improve customer satisfaction, all of which lead to increased profits for the company.Inthispaper,wefirstproposeextendingawell-knowninequalityandtry to generalize it to other conditions and similar inequalities.The inequality involves multiple variables and how the maximum/minimum values of a subset of the numbers compare to the maximum/minimum values of the whole set of numbers.Our main contribution is applying such inequality in inventory management to help estimate the total cost of inventory management, which would allow us to determine the shutdown pointforaspecificcompanyusingthegeneralizationsoftheinequality.Lastly,weshow thatourestimatesarereasonableandproposesomefutureareaswheremoreworkcan be done.

利用Chain-of-thought Prompt優化ChatGPT邏輯推理方面的能力

ChatGPT 問世後,許多問題皆已能由其回答。然而在邏輯方面的問題,ChatGPT 免費版有著明顯的不足,時常出現似是而非的答案。為了解決此問題,本研究利用連線 ChatGPT API,使用四種 Chain-of-thought prompt 的方式,將問題分解成若干個子問題,利用子問題們提供原問題較多的資訊以降低在解題過程出現的錯誤。最後分析四種方法的優劣,四種方法各有優缺,並無一方法於所有題目皆正確率最高。

探討C1GALT1與IL-1受體醣基化在關節炎中的角色並尋找可能的治療藥物

C1GALT1為氧型醣基化的關鍵基因,若以 IL-1β與 TGF-β刺激 ATDC5細胞株模擬關節炎,C1GALT1 的mRNA 與蛋白質表現量增加,而這樣的趨勢在誘導關節炎的小鼠軟骨組織中也可以觀察到。抑制 C1GALT1 的mRNA 後,促炎基因-一氧化氮合酶(iNOS)與第二型膠原蛋白基因(Collagen II)的 mRNA 表現量下降,代表 C1GALT1 參與了促進發炎的調控路徑。透過以大數據為基礎的 NetOGlyc-4.0平台分析,我們發現小鼠和人類的 IL-1β受體上都含有可能的氧型醣基化位點,C1GALT1 可能透過醣基化 IL-1 受體以增加 iNOS 的表現,進而促進發炎。抑制 C1GALT1的mRNA會使 IL-1R1的蛋白質表現量下降,而抑制 C1GALT1的mRNA或是蛋白質皆可使 IL-1R1在核周內膜系統中的表現量減少,代表 C1GALT1所促進的醣基化修飾是調控 IL-1R1形成的關鍵,抑制 C1GALT1可能具有減緩關節炎的療效。伊曲康挫(Itraconazole)可抑制 C1GALT1 且對人體傷害極小,透過老藥新用,或許能夠應用於治療關節炎。

Look your eyes,know your life~A portable body detection device

本研究是基於去年的 PBC(Protect Brain Cylinder)作品[1],並根據評審指導將作品做了大幅度修改。相較於 PBC 需要一個額外的裝置,本研究僅須在手機相機前方,安裝光源處理模組,搭配本團隊開發的 App,即可清楚地拍攝出瞳孔影像。並經由 App 中的影像分析功能,即可在影像拍攝完成後的兩秒內完成分析, 並將結果繪圖呈現在手機螢幕上。偵測的時間相較 PBC,大幅縮短了 60%。 相較 PBC 僅能偵測患者瞳孔直徑對光刺激的反應速度。本研究除了大幅縮短偵測的時間外,在結果分析及應用上更有長足的進步,能判斷出以下的五種身體狀況: (1)瞳孔形狀 (2)虹膜脂質堆積環 (3)鞏膜血絲分布及比例 (4)水晶體混濁與白內障關係 (5)瞳孔直徑對光刺激的反應速度與酒測值的關係 本研究除了藉由偵測瞳孔來判定身體狀況外,更開發出了身體『傷口大小量化』功能。希望協助醫護人員一機在手,即可解決上列的臨床問題。

邁向淨零之低碳海水淡化整合技術

「2030 永續發展目標」,其中 SDG6 clean water 和 SDG13 的 climate action 讓我們開始思考怎麼樣可以讓人人能享有乾淨衛生的水以及面對氣候變遷的調適。我們建置一套液流式脫鹽電池實作海水淡化實驗,並將電極以碳布作修飾, 在 0.4 V 的操作條件下進行了 450 分鐘的海水淡化實驗。海水的導電度在淡室中從 45.36mS/cm 降至 0.29 mS/cm,並於濃室中提升至 76.17mS/cm。其 ASRR 為726.98μg/min/cm2,所需能耗為 55.29kJ/mol,電荷效率達 69.79%,成功的將海水淡化。分離後的鹵水再與二氧化碳及澎湖的玄武岩進行礦化反應實驗,在鹵水溶液礦化封存反應初期,二氧化碳與水溶液中大量的陽離子反應使得水溶液整體的濃度及 pH 值下降,使得整體反應趨向於玄武岩溶解反應;而隨著反應時間的增加玄武岩溶解量逐漸提高,水溶液中的陽離子濃度及 pH 值再度上升,使得整體反應自溶解狀態朝著礦化沉澱方向發展,在得到珍貴的水資源的同時還可將二氧化碳礦化,達到淨零的目標。