全國中小學科展

二等獎

命中「助」定-間接互助模型的探討

每個人都有需要幫助的時候,當你遇到一個需要幫助的人,你會如何反應呢?有些人總是樂於助人,有些人選擇獨善其身,有些人則是會先觀察對方是什麼樣的人再做決定。這些不同的決定會交織成出什麼樣的故事呢? 我們假設社會上有三種人: 總是願意幫助別人的Cooperators、永遠不幫助別人的Defectors、依據人們過往的行為來決定是否幫助對方的Discriminators;由於cooperator和defector的行為是固定的,顯然discriminator的助人行為會有決定性的影響,因此我們從學者Berger的論文出發,修改discriminator決定是否幫助他人的判斷準則,架構了兩種間接互助模型並與Berger(2011)的工作做比較,觀察這些改變的影響,計算三種人的比例與彼此幫助率的關係。 Discriminator遇到不同的人會有不同的決定,隨著時間的推進,Berger在論文中已證明了他們的行為會趨於一致,並提出一種演化機制,探討三種族群之間的流動。那麼在我們提出的兩種模型中,discriminator的行為是不是也會趨於一致呢?因此我們證明了discriminator助人行為的收斂,也提出了一個新的演化機制,試圖用不同的觀點詮釋三種族群間的流動。 在我們的互助模型中,當使用Berger(2011)的演化機制時,演化行為只受discriminator佔全體比例的大小影響;然而若使用我們提出的演化機制,不論discriminator的比例為何,演化行為只會由 cooperator與defector 的比值決定。如此,我們便能刻劃出:可以使模型中所有的人至終演化成為 cooperators,理想中大同世界的範圍。

Effect of Air Resonance by Wind Speed Difference on Falling fruit

This study completes an air vibration equation expressed wind speed slope and wind speed. First, preliminary experiments identified air vibrations when wind speed differences occurred over distance. Several air fans were connected in series and the rotational speed of the air fan was adjusted to vary the wind speed with distance. At this time, only certain pendulum oscillates during a particular wind speed slope. It was expected that the pendulum would shake because the frequency of the air due to the slope of the wind speed was equal to the natural frequency of the pendulum. In addition, relatively short pendulum swings in large wind speed slope, long pendulum swings in short wind speed slope. After calculating the natural frequency of the seasonal growth of fruit using the physical factors model, we experiment how resonant frequency was related with cone length, angular width, wind speed, velocity and secondary derivative. the actual experiment analyzed the natural frequency of the fruit and resonance from the air vibration as the linear function of the wind speed, velocity, and secondary derivative. The experiment determined that the pendulum of a specified number of frequencies resonated with a particular wind speed pattern. It is judged that the vibration of air is related to first derivative of wind speed depending on speed and distance. However, it is very difficult to express the flow of nonlinear fluids as a function of simple function, particularly the effects of air vibrations caused by wind speed second derivative, which appeared to be associated with forces. This is a task that needs to be solved through further research.

圓周上跳躍回歸問題之研究

圓周上相異n個點,將圓周分割成n段弧,每次每個點沿逆時針方向變換成與下一點所成弧之中點,若某點經m次變換後回到初始點,則m的最小值以及m的所有可能值為何?我們發現,m的最小值為n+2。更進一步發現,m的充要條件為m≧n+2且m≠kn-1, kn, kn+1,其中k為正奇數。接著,我們將問題一般化,圓周上相異n個點,沿逆時針方向變換成與下一點所成弧之p:q處,若某點經m次變換後回到初始點,則m的最小值以及m的所有可能值為何?我們發現,若p, q∈N,(p,q)=1,當變換次數r足夠大時,此n個點的位置會收斂至圓周上n等分點,同時,此n個點會在變換T=n(p+q)/(n,p)次後再次收斂至相同的位置。在這篇研究中,我們推導出任意點Pi變換r次後的點之位置坐標Ai(r)的一般式,不失一般性,我們針對P0求出A0(r)的最小極端值Lr與最大極端值Ur,在變換次數r足夠大時,透過觀察Lr與Ur對應到圓周上的收斂位置所形成的區間是否涵蓋原點,可預期P0變換r次後可否回歸。此外,我們也針對n個點具特殊初始位置座標來研究其回歸性質。

當機立「斷」—— 浮萍自裂脫險的機制與生態意義

浮萍在逆境下葉狀體會有分離的現象,本研究證實:浮萍透過葉狀體分離,增加逃離逆境的機率,提升族群生存率。此分離機制受到過氧化物質(H2O2)的調控,逆境下,浮萍母葉節處(node)的H2O2含量上升並誘導細胞死亡,進而造成連接構造斷裂,另能透過乙烯途徑活化纖維素分解酶使葉狀體分離。我們也發現青萍及紫萍具不同生存策略:青萍對H2O2的高敏感度使其能在逆境下快速分離,進而降低其葉狀體間的內聚力,更容易藉由風吹或水流加速逃離逆境;紫萍則對H2O2較不敏感且內聚力大,以較大的單一個體及對逆境的高耐受性來渡過危機。蛋白質含量極高的浮萍是蛋白質補給品的好原料,期待分離機制的深入研究能應用在浮萍種植上,使其快速分離提升產量,應對將到來的糧食危機。

A Modular Construction 3D Printer

The 3D printer that we created is able to print objects out of concrete and is modular, so it can be assembled the way it is needed.

Multiple Time-step Predictive Models for Hurricanes in the North Atlantic Basin Based on Machine Learning Algorithms

The cost of damage caused by hurricanes in 2017 is estimated to be over 200 billion dollars. Quick and accurate prediction of the path of a hurricane and its strength would be very valuable in alleviating these losses. Machine learning based prediction models, in contrast to models based on physics, have been developed successfully in many problem domains. A machine learning system infers the modeling function from a training dataset. This project developed machine learning based prediction models to forecast the path and strength of hurricanes in the North Atlantic basin. Feature analysis was performed on the HURDAT2 dataset, which contains paths and strengths of past hurricanes. Artificial Neural Networks (ANNs) and Generalized Linear Model (GLM) approaches such as Tikhonov regularization were investigated to develop nine hurricane prediction models. Prediction accuracy of these models was compared using a testing dataset, disjoint from the training dataset. The coefficient of determination and the mean squared error were used as performance metrics. Post-processing metrics, such as geodesic error in path prediction and the mean wind speed error, were also used to compare different models. TLS linear regression model performed the best of out the nine models for one and two time steps, while the ANNs made more accurate predictions for longer periods. All models predicted location and strength with greater than .95 coefficient of determination for up to two days. My models predicted hurricane path in under a second with accuracy comparable to that of current models.

合成抗體徵召分子以提升免疫細胞對細菌辨識力之研究

自古以來,致病細菌便是人類免疫系統的強敵,加上近年來抗生素的濫用使細菌在具有抗藥性後更加棘手,相對的人體免疫系統愈顯衰弱。本研究成功合成了一個可以連結細菌和免疫細胞的複合分子,此複合分子是由萬古黴素、連接單元和生物素組成,稱之為複合分子VLB(Vancomycin-Linker-Biotin)。其中萬古黴素用來辨識並結合細菌細胞壁上的肽聚醣,生物素則可以與抗體結合並徵召免疫細胞。 我們以螢光基團及抗體等,實際測試複合分子VLB對細菌的辨識力,確認其能在萬古黴素端與革蘭氏陽性菌連結,並在生物素端與抗體結合。我們藉由複合分子VLB增加細菌及免疫系統之間的親和力,以提升免疫細胞辨識細菌的能力,使其更快更有效地對抗細菌,解決多重抗藥性細菌難以擊敗的問題。利用本研究合成抗體徵召分子的方法,大幅提升免疫細胞對致病細菌的辨識力,將來可望有效地應用在臨床醫學上。

切二連三--探索區塊數分布性質的奧秘

平面上n條直線的分割區塊數R的最大值顯然為(n2+n+2)/2,最小值顯然為n+1,在Oleg A. Ivanov教授的論文[3]裏探討了可能的分割區塊數R從某個定值開始到最大值(n2+n+2)/2之間呈連續整數分布。我們進一步研究R可能的值從n+1到(n2+n+2)/2之間在哪些區間產生不連續,我們稱這個不連續的區間為「跳躍」(jump)。以下是我們得到的結果: 當n≧8,平面上n條直線可能的分割區塊數R產生的「跳躍」區間為[(n2+n+2)/2+Ci2+1, (n2+n+2)/2-Ci-12-Cn-i+12-1] ,其中i=[(2n+3-√8n-15)/2], [(2n+3-√8n-15)/2]+1, ..., n 。

小花蔓澤蘭活性成分Dihydromilanolide誘導胃癌細胞凋亡與自噬性死亡

外來入侵種小花蔓澤蘭繁殖速度太快,使台灣本土生環境及多樣性受到破壞。我們研究發現,小花蔓澤蘭葉萃取物會誘導人類胃癌(AGS)細胞毒性;以HPLC分析及分離出小花蔓澤蘭葉萃取物的活性成分Dihydromilanolide (DHK),發現DHK會毒殺胞胃癌、卵巢癌、乳癌與血癌細胞,其中以胃癌(AGS)細胞毒殺性最強。此外,抗氧化劑N-acetylcysteine可減緩小花蔓澤蘭葉萃取物及DHK對胃癌細胞毒殺性,推測是透過活性氧化物(ROS)來毒殺胃癌細胞。我們亦發現,DHK可與抗癌藥物(Doxorubicin、Cisplatin或Paclitaxel)對胃癌細胞產生協同作用。DHK作用胃癌細胞會誘導Caspase-3增加、PARP蛋白裂解、促凋亡Bax增加及抑凋亡Bcl-2減少;產生酸性囊泡(AVOs)、促自噬LC3-II及Beclin-1蛋白增加,且加入自噬抑制劑 3-MA可保護DHK誘導胃癌細胞死亡。推論 DHK可誘發胃癌細胞凋亡(Apoptosis)及自噬性死亡(Autophagy)。總結,小花蔓澤蘭與活性成分Dihydromilanolide (DHK) 具抗胃癌功效且與抗癌藥物產生協同作用,可開發成抗癌的藥品或保健食品。

Co-evolution of transcription factors and their binding sites in DNA

The synthesis of RNA using DNA (transcription) can be regulated by special proteins - transcription factors (TF) by binding to specific DNA regions - binding sites (BSTF). The purpose of the project is building a phylogenetic tree of orthologous groups of the each studying TF subfamilies, compare it with the tree of the corresponding BSTF motifs belonging to one orthologous group, find some common parts.