全國中小學科展

二等獎

Bioplastic - The Future is Degradable Plastics. Investigating Biodegradation of Polyhydroxybutyrate Bioplastic by 紐西蘭 Soil Microorganisms

The rate and production of conventional petroleum based plastics is unsustainable and not eco-friendly. Plastics often end up in marine environments and can take hundreds of years to decompose in landfills. According to Statistica, in 2015 alone, global plastic production was approximately 322 million metric tonnes and is projected to increase in the future. PHB bioplastic or Polyhydroxybutyrate is both biologically produced and biodegradable and can serve as a viable alternative to conventional plastics. But can it be broken down by soil microbes within a reasonable time frame? I have set out to answer this question. My aim was to isolate and analyse microorganisms from the Rotorua area that are capable of degrading Polyhydroxybutyrate (PHB) bioplastic . I isolated PHB degrading microorganisms from Rotorua soils by culturing on an agar based mineral salt media supplemented with PHB powder (MSM PHB agar). Samples were taken from Mount Ngongotaha and Te Puia geothermal soils as well as Okareka, termite frass and termite guts. One isolate from the Te Puia sample (labelled G2) was found to successfully degrade PHB powder. After isolation and purification of the G2 isolate, it was cultured on a range of media types to examine properties exhibited under differing nutrient conditions. Multiple organisms were found to be involved in the degradation of PHB bioplastic and work together symbiotically, this included bacteria and fungi which was identified as penicillium. The sample isolated from Te Puia soils (site 2 – G2Clear) in the Rotorua environment was found capable of competently degrading PHB, clearing 8% of PHB after 26 days. The G2Clear isolate is a mixture of bacteria and fungi working in an endosymbiotic relationship to degrade PHB and are unable to successfully degrade PHB individually. It is through the secretion of an extracellular PHB depolymerase enzyme that PHB is degraded, conforming with my hypothesis. This proves that PHB bioplastic is a viable alternative to conventional petroleum based plastics as PHB can be relatively quickly broken down by soil microorganisms.

探討胃幽門螺旋桿菌毒性因子GroES之重要胺基酸組成及其致發炎機制

胃癌為全球癌症致死率第二高的癌症。胃幽門螺旋桿菌(Helicobacter Pylori)為其致癌最重要的因子之一,世界衛生組織更將其歸類於第一群確定性的致癌因子。幽門螺旋桿菌分泌毒性因子GroES蛋白,感染胃上皮細胞後能引起發炎反應;且發炎反應中,以介白素-8(Interleukin 8, IL-8)的釋放量最為顯著。GroES蛋白(全長1-118)在羧基端有28個延伸的胺基酸片段,刪去則GroES蛋白失去誘導細胞釋放IL-8之能力。因此我們希望進一步找出此延伸片段上最關鍵的致發炎片段及機制。 我們每次刪去6個胺基酸,探討GroES蛋白上與致成胃部發炎最為相關的胺基酸片段;接著以加入還原劑、加入螯合劑以及點突變的方式深入分析此致成胃發炎毒性因子的結構,探討可能的致發炎機轉。由實驗結果來看,GroES蛋白羧基端半胱胺酸(cysteine)之間雙硫鍵形成的環狀結構能夠誘導胃上皮細胞釋放IL-8,可能與致胃發炎有關;亦可能是組胺酸(histidine)與鎳離子之間的配位鍵引起細胞的發炎反應。Point mutation結果則顯示cysteine之間雙硫鍵形成的環狀結構。 未來我們將更進一步探討此環狀結構存在的條件,也探討histidine與鎳離子之間的配位鍵對於致發炎的影響。我們希望能將研究成果發展成生物標記分子、疫苗以及單株抗體,進而建立一個應用平台,以儘早發現並治療胃部發炎等胃部疾病。

論平行電板間肥皂泡之變形現象

觀察肥皂泡置於平行電板中時產生變形,本研究探討此現象並提出相關解釋。經由實驗發現肥皂泡在電場下的形狀是橢球的一部份;肥皂泡在施加電場前後的高度比與寬度比是兩電極板間電壓的二次曲線,且離心率與電壓成正比關係。透過觀察肥皂膜的光學性質、分析皂膜受力以推測其電學特性,確定系統之電荷與電位分布,進而提出理論模型計算系統能量,解釋平行電板間肥皂泡之變形現象。

流體動能應用系統-Stanley Generator製作及模組化應用

我們對於所發明的SG (StanleyGenerator同軸發電機)是應用法拉第電磁感應定律ε=NBAωsinωt,打破轉子不動的常規,以定子與轉子同時反向旋轉以提高角速度,即提高單位時間磁場變化量,進而創造了StanleyGenerator同軸發電機發電裝置,以超過傳統1.96倍(平均值)發電量,達到大幅提高發電的效率。同時設計了各種SG應用模組,包括一級應用的三層流體動能擷取系統,二級應用的雙軸單增速系統,三級應用的雙增速HV系統。都能發出比一般發電機高的電量(1.48~1.96倍),也比一般發電機更快(較低流速)達到發電機最大(額定)發電量。

建立細菌系統的雙分子螢光互補試驗做為α-突觸核蛋白聚集抑制物篩檢平台

帕金森氏症(PD)是一種慢性中樞神經系統退化性疾病,患者臨床症狀包括靜止時震顫、動作遲緩、僵直及黑質緻密部多巴胺神經元的漸進性退化等。PD的主要病理特徵為多巴胺神經元中出現包含α-突觸核蛋白(SNCA)錯誤摺疊、聚集的路易小體。雖然PD的治療方法包括給予左旋多巴或其他藥物、物理治療、手術等,至今尚未有根治的方法。本研究建立雙分子螢光互補試驗與蛋白質摺疊報告者試驗兩種原核細胞平台,作為篩檢可幫助α-突觸核蛋白摺疊的化學伴隨蛋白平台。雙分子螢光互補試驗是將Venus黃螢光蛋白改進版切開成N端(VN1-211)及C端(VC212-239)二段,分別接在SNCA的N端(VN-SNCA)或C端(SNCA-VC),原本沒有螢光的片段可藉融合的SNCA聚集的再組裝而出現螢光。當構築的VN-SNCA and SNCA-VC質體共表現於大腸桿菌後,蛋白質染色及免疫轉漬可偵測到表現的VN-SNCA、SNCA-VC蛋白,並出現伴隨著SNCA聚集所導致的互補螢光。我們以可干擾SNCA聚集的海藻糖來測試此聚集抑制物篩選平台,發現在不影響大腸桿菌生長的狀況下,海藻糖的濃度與螢光下降程度呈正相關,推測因其能減少SNCA聚集,導致螢光分子互補的機率下降。蛋白質報告者試驗是將野生型(WT)與突變型(35/46/61 E-to-K)的α-突觸核蛋白與綠螢光蛋白的融合蛋白(SNCA-GFP)分別表現於大腸桿菌,突變型的α-突觸核蛋白的傾向錯誤摺疊,會影響融合的綠螢光蛋白摺疊,而導致綠螢光下降,而海藻糖的化學伴隨蛋白活性可幫助突變型的α-突觸核蛋白摺疊,因而改善融合的綠螢光蛋白的摺疊,導致綠螢光上升。未來我們用此兩種原核細胞平台,來篩檢可幫助α-突觸核蛋白摺疊的新穎化學伴隨蛋白。

仙「鋁」奇「圓」-探討鉻鋼球碰撞的力與能量

本實驗主要在探討鉻剛球碰撞產生的情況與能量的傳遞,我們改變的變因有: (1)球落下高度、 (2)鉻剛球大小(兩種規格)、 (3)兩球撞擊的中間物材質(鋁箔、白紙、銅片)、 (4)中間物材質的厚度。 發現球自愈高的高度落下後產生碰撞,中間物(置於底下鉻剛球的上方,如:鋁箔)所產生的同心圓面積愈大;而大球相撞產生的同心圓也比小球相撞所產生的大。就碰撞後反彈高度而言,大球碰撞後反彈高度比小球碰撞後反彈高度來的高。與銅片有相同厚度的6層鋁箔,其碰撞產生的面積與銅片的卻不相同,可見不同材質的硬度及彈性,亦是影響面積大小的因素之一。

淘氣精靈與IOD關聯性之探討

前人研究發現聖嬰南方震盪(El Niño–Southern Oscillation, ENSO)和淘氣精靈(Elves)兩者間有顯著關係,顯示淘氣精靈的變化受太平洋上ENSO影響,因此我們想探討淘氣精靈與印度洋震盪(Indian Ocean Dipole, IOD)間是否也存在相似的關聯性。一般以DMI(Dipole Mode Index)代表IOD的發生情形,研究中我們挑出2005年6月2015年11月IOD正負事件時的海溫、雨量、閃電及淘氣精靈進行比較。研究結果顯示淘氣精靈在印度洋上也有震盪的現象,且其趨勢與海溫相同,再將其與雨量變化做比較後,我們推論IOD造成的海溫變化影響了大氣,進一步影響淘氣精靈的發生。

翻轉塗色驚嘆號

本作品『翻轉塗色驚嘆號』為2016年國際科展『翻轉塗色』的一般化延伸改進作品。在過去文獻中討論的問題是一列已上色的格子中,估計會有多少個『等間隔而且同色格子」的可能。而本研究所探討的問兩個顏色(以1及0表示,1跟0互為補色),並以Thue-Morse遞迴著色(若B已著色,則接下來的|B|個格子就著上B的補色,其中|B|表示B的格子數),其中每次遞迴時精確的『三個間隔相同而且同色的格子』(本作品稱為3-AP)的精確總數。為了表示方便,我們將著好顏色的格視為一雙色字串。在之前的作品中,我以中心排列手法算出了起始字串為1時每次遞迴的3-AP精確數目。而本作品的突破在我們推廣到對於任意起始字串B,所遞迴產生的Mp(B)字串都能精確算出3-AP總數,其困難點在於歸納不同B之間的共同性。令人驚嘆的是,在遞迴兩次之後,其3-AP增加的數目與B的內容無關,只與B的格子數有關。此為本作之重要定理。除此之外,我也給出依序刪去每次遞迴後所剩下的Mp,q(B)中3-AP總數的公式。其困難點在刪去之後失去了對稱性。在本作品中突破方式是改變中心排列以偏心排列找出基底,並以未定係數法將其3-AP總數找到。而令人驚嘆的地方在於,若同時增加後續字串並同時刪去前方字串,其3-AP增加的數目也與B的內容無關,只與|B|有關。

A Modular Construction 3D Printer

The 3D printer that we created is able to print objects out of concrete and is modular, so it can be assembled the way it is needed.

Effect of Air Resonance by Wind Speed Difference on Falling fruit

This study completes an air vibration equation expressed wind speed slope and wind speed. First, preliminary experiments identified air vibrations when wind speed differences occurred over distance. Several air fans were connected in series and the rotational speed of the air fan was adjusted to vary the wind speed with distance. At this time, only certain pendulum oscillates during a particular wind speed slope. It was expected that the pendulum would shake because the frequency of the air due to the slope of the wind speed was equal to the natural frequency of the pendulum. In addition, relatively short pendulum swings in large wind speed slope, long pendulum swings in short wind speed slope. After calculating the natural frequency of the seasonal growth of fruit using the physical factors model, we experiment how resonant frequency was related with cone length, angular width, wind speed, velocity and secondary derivative. the actual experiment analyzed the natural frequency of the fruit and resonance from the air vibration as the linear function of the wind speed, velocity, and secondary derivative. The experiment determined that the pendulum of a specified number of frequencies resonated with a particular wind speed pattern. It is judged that the vibration of air is related to first derivative of wind speed depending on speed and distance. However, it is very difficult to express the flow of nonlinear fluids as a function of simple function, particularly the effects of air vibrations caused by wind speed second derivative, which appeared to be associated with forces. This is a task that needs to be solved through further research.