Interaction of the unsaturated sulfones with azinium ylides
1. Introduction In Japan the energy self-efficiency is very low: only 6%. Hydrogen (H2) has been expected as a new and alternative energy source to imported one, such as petroleum resources. Now hydrogen energy comes into the practical use in the field of the fuel cell. Hydrogen must be extracted from other sources, for example, water, fossil fuel, and so on. Hydrogen is obtained from water by using electronic or thermal or photo energy in most cases, whereas it is well-known that hydrogen is given by the oxidation reaction of silicon in alkaline aqueous solution: Si + 2OH- + H2O → SiO32- + 2H2 Free silicon (Si) is not only used in the steel refining, aluminum-casting in the field of fine chemical industries but also is used as a material in semiconductor electronics. However, a lot of used silicon is thrown away as a waste, being not reused and recycled. In this study we try to apply a waste silicon to obtain hydrogen based on the above reaction. The purpose of the study is to develop a safe and convenient manufacturing method to generate hydrogen for an energy source of the fuel cell.
BA-ADA based ROS-responsive nanoparticles for selective drug delivery in cancer cells
Current medical intervention in cancer therapeutic methods has shown risks and side effects with normal tissues. This includes incomplete cancer eradication. In reference to numerous studies and literature reviews, a stimuli-responsive drug delivery system is selected as an innovative, safe and more assured treatment due to its site-specific release ability. This allows specific intervention upon the given stimulus which response to the presenting disease symptoms. Hence, we designed a ROS(Reactive Oxygen Species)-responsive BA-ADA(4-Hydroxyphenylboronic acid pinacol ester and 1-Adamantanecarboxylic acid bonded molecule) nanoparticle delivery system. In our study, ROS-responsive nanoparticle was designed and prepared based on a synthetic molecule from BA and ADA. A therapeutic payload, Doxorubicin, can be loaded into the nanoparticles and it can be selectively released within cancerous tissues whereby ROS level is over-expressed. This will enhance both therapeutic efficiency and reduce side effects. The stability and ROS-responsiveness of the particle were proven in a series of evidence-based experiments. The results showed a significant difference in cell viability during the experiments with healthy and cancerous cell samples. Further research will be required to extend the experiment in vivo.
An optimal-route algorithm for an intermodal Metro Manila trip planners using multiple parameters
Parameters of traffic, road availability, and fare were integrated into a web-based application for determining the best public transport routes within Metro Manila in order to assist commuters in their travel planning, whether for business or for pleasure. A user-friendly interface was developed to obtain a user’s place of origin and destination, as well as preferences in travel time, mode of transportation, and cost of journey. By accessing the traffic roadway network of the metropolis, a real-time situation of road availability was obtained, and used in a modified Dijkstra’s shortest-path algorithm to produce a model of a real-time adaptive transport network of Metro Manila. From the model, an optimal route that considers the user’s preferences can be determined. This project will be immensely useful in helping both businessmen and tourists in planning their routes that will save on time and money.
Prototyping a Compact Multi-Format Optical Transmitter for Next Generation Regional and Long Haul Terabit Networks
The last two decades have seen 60% annual growth rate (AGR) in the global IP traffic and it is expected that the AGR will keep the exponential growth in the next five years. Recent advances in digital signal processing enabled the implementation of the dual polarization (DP) optical coherent digital receivers, which substantially improved their performance. The goal of this research is to develop a prototype of a compact superchannel flexible DP M-ary quadrature amplitude modulation (MQAM) optical transmitter and demonstrate its reconfigurability to accommodate baud rates ranging from 8-32 Gbaud∕s to achieve 1 Tb/s and beyond using the same hardware. The research work consists of three phases; Phase I is the study of transmitter electrical and optical parts; Phase II investigates the potential configurations for frequency comb generator circuit; Phase III deals with the superchannel experimental prototype. The results obtained so far are pertaining to phase I and phase II with some preliminary experimental validation pertaining to phase III. The experimental results show that the measured component characteristics are matched with the components specifications data sheets. Additionally, the designed frequency comb generator was able to create up to 9 optical subcarriers with flat gain of 0.5 dB amplitude. Transmission over optical subcarriers has been attempted using standard optical transmitter. These results show promise towards the generation of a variable data rate up to 1Tb∕s. IEEE and ITU-T standardization effort considered these data rates to appear around 2017, and are intended for Next Generation Regional/Long-haul Networks.