全國中小學科展

三等獎

Fig Preservation

Figs have become an expanding industry here in New Zealand and are a current export fruit which could potentially provide a large amount of profit to both growers and the New Zealand market as a whole. Nicola’s family has about 10 acres of fig trees. They sell the figs locally and as an export. They generally sell for about $13 per kilogram here in New Zealand and $26 in the USA. However, figs only have a shelf life of about 7 days. This is because at present there is no proven pre or post-harvest treatment or method of storage that helps to decrease the rate of decay of the fig fruit. After researching post-harvest treatments for figs, Nicola found a report which claimed to have developed treatments that increased the shelf life of figs by about 5 weeks. With this kind of increase, it would be possible to transport, store and export figs over longer periods of time without running the risk of losing large amounts of produce, or delivering unsatisfactory fruit to customers. Nicola developed 7 different post-harvest treatments based on the ones that had shown promise in earlier research. These were hot-water baths of different temperatures, both with and without different bleach concentrations. To test these on the fruit she set up four experiments – a dry matter test, a firmness test (using a penetrometer), a colour test and observation of detrimental features of the fig. She tested these treatments at 0, 7, 14, 21 and 28 days from harvest. Nicola found that after 7 days, the firmness of all of the figs that had been treated had decreased to a large degree. The only figs that did not have a massive decrease were the untreated fruit. However after about 14 days, the firmness of all of the fruit became about the same and after this 14 day mark, she would not have considered any of the figs to be edible. However, in the appearance tests, it seemed that the treated figs that had the least amount of mould and rot were the ones that had been treated with higher levels of bleach such as the 55 degree Celsius water bath with 0.003L of bleach to every litre of water, and the 35 degree Celsius water bath with the same concentration of bleach. Overall, Nicola’s results showed that the hot water bath, and hot water bath and bleach post-harvest treatments did not slow the decay of the fruit in the earlier weeks after picking. In effect, Nicola’s research showed that the information she had relied on to help plan her study had claimed too much and that the treatments were less effective than had been stated. More research will be needed to find a more reliable way to improve the shelf life of figs.

A New Generation Colorimetric Method for Lead Analysis: APTAMER MODIFIED GOLD NANOPARTICLES

Lead is a toxic element which is used in the production of chemicals, dyes, accumulators and various industrial areas. It may cause complications even extended to death when it is taken consistently in high amounts. Lead poisoning is in the first place among the occupational diseases. It is gaining importance to develop new and sensitive methods for lead analysis. Because lead poisoning can progress without any symptoms and poisoning level (10µg/dL) is low. Disadvantages of the systems used for lead analysis are such as longer detection time, being expensive and difficult to implement. The aim of this project is to develop a new generation method in order to detect lead in blood, based on aptamer modified gold nanoparticles. We detected the lead in terms of color change obtained in gold nanoparticle solutions, with composite biochemosensor that is prepared with 20 & 80 nm sized gold nanoparticles and TBA(Thrombin Binding Aptamer). While immobilizing TBA to the gold nanoparticles, we benefitted from the magnificent surface affinity of the –SH (Thiol) groups that modified to the TBA. Gold nanoparticles that are used in development of our biotechnological method do not stimulate the immune system. The preparation of aptamers in completely sterile medium provides us to use our system in the lead detection of blood. Our method can also be used in the lead detection of mediums such as waste water, food and soil. We have developed a biochemosensor that can be used to detect the presence and absence of Pb2+ by taking into consideration the toxic effect in the human body. Also we detected the presence of lead colorimetrically, in low concentration levels and wide interval values of 4.4 – 11 µg/dL. The developed system is first that; it provides TBA to be used with its complimentary sequence detects the presence of lead colorimetrically and can be used in physiological media such as blood. Also our system can detect lead in amounts that are lower than the poisoning threshold.

Antiviral Therapy for Hepatitis C Virus (HCV): Black Mustard Seeds

Hepatitis C Virus (HCV) is an RNA virus, which is considered the main cause of progressive chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) worldwide. The number of the patients who are infected with this sleeping virus is increasing rapidly every year, as the unsuitability of the current therapy – interferon α and ribavirin – for most of the genotypes is the main cause of these high rates. Hence, the recent researches are focusing on finding out a new immunotherapy to affect this virus. In this research work, Black Mustard (Brassica nigra) has been used as powdered spice samples to prepare aqueous extracts; One of the included phytochemicals in the black mustard; glucosinolates and their hydrolysis products, was proposed to be used for the HCV patients to prevent the virus progression. Also, the Isothiocyanates are shown with chemotherapeutic and anti-tumor properties. Moreover, some of the structure-related isothiocyanates have the ability to induce the enzyme paraoxonase-1 (PON-1) that is considered hepato-protective agent against liver impairment, inflammation, fibrosis and liver disease mediated by monocyte chemoattractant protein-1 (MCP-1), and is thought to affect the entry of the virus into the hepatocytes. The effect of the black mustard and the produced myrosinase enzyme on the HCV RNA replication is still unknown. In conclusion, the black mustard is thought to affect the progression and the fluidity of the HCV envelope resulting in impairment of viral binding and fusion.

乾坤大挪移

會議室圓桌上有n個座位,順時針依序放有編號①、②、③、 、n,共n張名牌。將參與這場會議的人也編碼,依序為1、2、3、 、 ,假設編號1的人一定會先抵達並坐到了名牌②的位置,剩下的人則依亂序到來,先找到自己名牌的座位,如果位置是空的就坐下,如果位置被佔了就往順時針方向找到下一個空位坐下(例如3到達時,若③、④均被坐了,而⑤位置是空的,則3就坐到名牌⑤的位置)。等到一個人坐定後,另一個人再進入會議室,依此規則,最後此n人到底會有幾種不同的坐法? 我們以遞迴手法以外的方法解決了這個的問題,並深入探討: 1.能否從入座的順序立刻得知最後坐定的位置? 2. 能否從最後坐定的位置,找出進入會議室的順序?同時得知有幾種不同進入會議室的順序會符合同一種坐法? 3. 每個人坐錯位置的機率為何?恰k人坐錯位置的機率為何?坐錯位置人數的期望值為何?

以蛋白質體學方法鑑定人類肝癌細胞經蕾莎瓦治療之預後的潛力生物標記 Identification of Potential Prognostic Biomarkers in Hepatocellular Carcinoma Cells Treated with Sorafenib

肝癌是死亡率極高的癌症。目前並無非侵入性方法判斷標靶藥物治療效果。蕾莎瓦(Sorafenib)是一種使用於肝癌晚期治療的標靶藥物,但有些病患在治療過程中會出現抗藥性,因此可預測蕾莎瓦治療效果的生物標記相當重要。 血液中的生物標記可及時追蹤疾病進展與預後之評估。本實驗利用質譜法鑑定分析在肝癌細胞(HuH7)中加入蕾莎瓦模擬治療後肝癌的分子機轉,並透過生物資訊軟體了解蛋白質在HuH7細胞中所扮演的角色。我們發現Galectin-3 和HMGB1可能參與腫瘤細胞的增生和遷移,以西方墨點法觀察其表現量,發現Galectin-3 和HMGB1在受到藥物處理後,表現量皆有下降的情形。 蕾莎瓦可抑制B-RAF激酶進而阻斷MAPK pathway。MAPK pathway又可分成ERKs、JNKs和p38/SAPKs三類。為確認Galectin-3之訊息傳遞路徑,將蕾莎瓦和ERK抑制劑處理細胞,發現Galectin-3的表現量隨著時間而下降,證實Galectin-3的表現會受到ERK路徑調控。 Galectin-3與 HMGB1是極具潛力的生物標記可應用於蕾莎瓦的治療,希望這些生物標記可以應用在臨床上。

對弈機器人運用於預防及延緩失智症之研究

本研究目標在於改良對弈機械人及分析長期對弈資訊,運用於早期老人失智症之預防。 據文獻及詢問專家後得知對弈遊戲具有預防失智症狀的功效,而研究中的對弈機器人以大腦功能狀態評估(JOMAC)為研究方向,研究資料分析如「玩家思考時間、對弈棄局次數、下錯頻率」等資訊並設計檢測橋段等機制以符合評估項目達到預防提醒之目的。對弈人工智慧,針對玩家棋力會自動調整機器人的棋力。採用 UCT 演算法,透過搜尋模擬能計算出各點落子勝率,藉由選擇較高或較低勝率的落子點,使人工智慧棋力與使用者旗鼓相當,保持使用者遊戲體驗及強化思考使失智症狀得以延緩。此外運用類神經網路改良影像自動校正,利用學習的方式解決不穩定環境光下誤判過多的問題,且提高校正速度,使對弈過程更加穩定。

The Polar Equation from Butterfly Sprinkler Heads

This project aims to create the polar equations from the relation of the points on the centre line of the water twisted from Butterfly sprinkler heads. The water path includes inner rim, outer rim and centre line laying in the middle of the water path is used Rhombus’s property. The diagonals are perpendicular bisectors of each other to create the centre line. Then we create the polar equation of the centre line of water that twists from 4 types of the Butterfly sprinkler heads: edge frame, curve frame, STL and STL rotary. The polar equation of outer rim and inner rim is created by adding and removing the “ f ” value ( ; is the distance between the outer rim and the centre line, and is the geometric sequence that is ) of the coefficient (a) of the polar equation respectively. The results show that the formal equation of the centre line is which can explain the different properties of Butterfly sprinkler heads. If “ f ” value is increasing the water path and the blade will be wider that affects droplets distributing thoroughtly. Furthermore the relationship between the volume of water and the radius of water distribution can be processed to find the least time that can increase the appropriate moisture level of soil.

VERMICOMPOSTING-EFFICIENT DAIRY SLUDGE MANAGEMENT

The continued growth of dairy farming in NZ and the move toward keeping cows on stand-off pads has seen a major increase in two significant waste streams, the wood fibre that is scrapped off the surface of the standing pads and the effluent that is now concentrated at the site of these pads. In combination these waste streams offer the farmer an opportunity to recycle valuable nutrients back into the soil as an up-valued soil conditioner. This investigation explores vermicomposting as a tool to efficiently manage these two significant waste streams. Sludge was removed from a settling pond and mixed with a range of carbon products that are recommended by Dairy NZ for use in stand-off pads: wood chips, post peeling, sawdust and also wood shavings (used in calf sheds). The wood fibre/sludge mixtures were assessed on their acceptability to tiger worms (Eisenia fetida) by measuring the pH of the mixture and seeing if they corresponded with the preferred pH for tiger worms. The vertical spatial distribution of tiger worms was measured over a period of 15 days and the rate at which the worms moved into the different mixtures was assessed. The worm mass before and after this 15 day period was also measured to ascertain the mixtures’ ability to support worm growth. Finally, different ratios of sludge and post peelings removed from a calf shed were used in a choice chamber experiment to establish the worms’ preference. Tiger worms were used throughout the investigation as they represent the worm species most widely used in vermicomposting in New Zealand. Tiger worms feed on decomposing organic matter, bacteria and fungi in the upper organic horizon of soil. All of the unused wood fibre and dairy sludge tested lay within the acceptable pH range for tiger worms. Wood fibre exposed to large amounts of urine ie calf shed post peelings, that lie outside the acceptable range can be favourably adjusted with the addition of dairy sludge. All the particle sizes of the wood fibre tested were found to be acceptable to tiger worms and capable of supporting increase in their body mass beyond that of the compost. Due to the observation that the worms did not integrate themselves as fully in sawdust as the other fibres tested it is recommended that further investigation should be carried out before sawdust is used for vermicomposting. While a comparison of the average worm density in each mixture may indicate a preference for post peelings this cannot be statistically proven and more trials are recommended. The preferred ratio within the limits that were tested is 1:3 calf shed post peelings to sludge (41% dry weight). Vermicomposting can therefore be recommended as a possible onsite technology to process the twin waste streams of wood fibre and effluent generated by dairy farms. The next step would be to implement medium scale field trials with a continuous windrow system, testing resulting compost for its nutrient content and then comparing this output to that of current practises

故態復「蒙」,「日」新月異-Monge's theorem的性質探討與推廣

本研究以蒙日定理「平面上三圓彼此的外公切線交點共線」及其對偶定理「平面上三圓彼此的內公切線交點與另一圓的圓心的連線共點」出發,探討三圓更多由內、外公切線所產生的共點共線性質,進而探討四圓以上的情形,以及正多邊形、圓錐曲線等位似圖形,並推廣至空間中的球體。正如本研究作品名稱,我們將鮮少人研究的蒙日定理萌發出新枝,在日夜中茁壯,甚至最後有驚人的發現「在空間中n個外離的球,任意1個球的球心與另n-1個球的蒙日點連線會共交一點,此點稱之為n球的蒙日點」,此「點」發現,讓人不禁對宇宙中星體之間的關係產生更多無限的想像。

A Novel Selection Process for the Conversion of Conventional Bacteria into Electrotrophs

The redox reactions of bacteria metabolism have been extrinsically studied. These mechanisms allow certain types of bacteria to be able to synthesize extremely valuable extracellular byproducts. Other types of bacteria are able to extract toxic metals from water by donating electrons directly to those aqueous metal ions, thus turning them into solid precipitates. However, the problem of these microorganisms is that their efficiency rates and production speeds are exceptionally low. This study focuses on the properties of electrotrophs, which are bacteria that can feed on pure electrons directly from an electrode (Rabaey et al 2010). Compared to normal organic-feeding bacteria, electrotrophs direct the majority of the electrons obtained to the production of metabolic byproducts (Nevin et al 2010). Therefore, when electrotrophs are employed in bioelectrochemical systems (BESs) their metabolic redox reaction efficiency rates are dramatically increased. This makes it possible to produce large quantities of valuable compounds such as hydrocarbons, plastics and medicine or efficiently remediating the environment (He et al 2016). Moreover, the usage of electricity as an energy source compared to conventional organic substrates is immensely cheaper (Rabaey et al 2010). However, not all bacteria are electrotrophs nor do all electrotrophs have favourable metabolic traits. Thus, there is a need for a novel procedure to turn conventional bacteria into electrotrophs which is a crucial step to making the BES an aggressive competitor in the sustainable energy industry.