全國中小學科展

四等獎

探討自我參照和社會訊息對不同年齡、性別連結記憶的影響

連結記憶(Associative Memory)為記憶兩物體之間關係的能力,會隨著年齡增加而衰退。先前研究顯示不同性別在記憶的老化程度存在差異,然而針對連結記憶在不同性別的老化未被討論。過去研究發現自我參照效應以及改變刺激材料的社會訊息程度可提升連結記憶的表現。然而缺乏同時使用兩種方法研究,兩者之間的交互作用尚不清楚。本實驗分別針對不同年齡與性別的群體進行連結記憶測驗。我們引導受試者使用自我參照記憶具有不同社會訊息程度的圖片,測量其連結記憶表現。結果顯示,女性有顯著的連結記憶衰退;而男性沒有顯著的連結記憶衰退,其記憶衰退可能與項目記憶有關。另外,我們也觀察到參照與社會訊息對連結記憶的影響具有交互作用,在未來實驗中有必要注意兩者之間的互相影響。

磁星短x射線爆發特徵分析:以1E2259+586為例

我們是探討磁星的短X射線爆發(Short X-ray burst)。利用RXTE太空望遠鏡觀測磁星1E2259+586的數據,經由Bayesian block方法對光變曲線篩選找出爆發,並配合「波松分佈」與「虛無假設」找出50筆爆發事件(爆發的正確性有5σ的信心水準)。再利用HDBSCAN非監督式學習演算法來對短X射線爆發進行分群,找出此磁星有「短暫且高能爆發、中等持續與能量爆發、較長持續且溫和爆發、快速且低能爆發」現象,暗示了磁星爆發的多樣性並有不同的爆發機制。此外我們也發現磁星可能有「週期性」的現象,也許是自轉週期、地殼受的應力或磁場變化經過同樣時間累積(有週期性)而爆發。我們也比對有快速電波爆發 (Fast radio burst, FRB)的磁星SGR 1935+2154,看是否1E2259+586有FRB現象,結果暗示1E2259+586可能沒有FRB現象。

腔體共振與開孔氣流的探討

本研究探討聲音共振引起腔體開口處氣流噴出的現象。實驗通過揚聲器播放聲音,使固定的錐形瓶產生共振,並改變聲音頻率、聲音強度及腔體參數(體積、瓶口截面積、瓶頸長度)分析氣流的形成原理與機制。腔體非共振情況下,腔體內外氣壓的振幅差較小,且存在相位差,此時開口處並未測得氣流;而在共振時,腔體內氣壓振幅顯著增加,導致開口處出現氣流且流速達到峰值。而流速峰值頻率與腔體幾何參數的關係符合修正後的亥姆霍茲共振公式,其中瓶頸有效長度應為L+1.45D。此外,氣流形態受衝程比L/D影響,當衝程比小於0.1時,氣體噴出後容易被重新吸回腔體,無法形成噴流;而衝程比大於0.4時,噴出氣流形成穩定的不連續渦流環,即合成噴流;在0.1至0.4之間時,氣流形態處於過渡狀態。本研究為聲能轉動能方面提供新的研究途徑,並有進階研究的可能性。

In Silico Carotenoid Compound with Protein in Durian (Durio zibethinus Murr.) Seed Waste and Hedonic Test Innovation in Making Healthy Cereal Organic (HCO) (Nutrient-rich Functional Food Alternative)

Durians’ seeds have potential as a food source due to their content and nutrients. Durians’ seeds contain fiber, minerals, vitamins A, B1, B2, C, carbohydrates, folate, potassium and copper. Nutrients are needed for the body's health and growth and development process. Durians’ seeds have the potential as a nutrient-rich food alternative. Researchers made an innovation in the form of cereal, Healthy Cereal Organic (HCO). Analysis of durians’ seed content through two stages. First, wet lab examination and second, in silico method. The wet lab examination shows the results that durians’ seeds contain 10.17 Kcal of fat energy, 4.09% ash content, 11.25% water content, 72.79% carbohydrates, 1.13% total fat and 10.74% protein and the in silico method shows the content of carotenoid compounds (vitamin A, quercetin, beta-carotene, zeaxanthin) as a drug delivery system which means that this compound is able to be absorbed by the body with the help of albumin as a carrier that maintains stability and increases its activity. Feasibility analysis based on toxicity tests, Durians’ seed compounds show inactive (non-toxic) results. Allergenicity test showed non-allergen durians’ seed content. Hedonic test was conducted on 20 panelists dominant to the HCO1 sample for aroma by 60%, texture 90%, taste 40%. It can be concluded that durians’seeds can be used as a basic ingredient for making nutrient-rich Healthy Cereal Organic (HCO).

修正未切換注音輸入法產生之字元

臺灣的許多人要使用電腦打字時皆會選擇「注音輸入法」作為輸入的方法。然而要使用注音輸入法輸入中文時若無切換輸入法則有可能會誤用到英文輸入法。如要輸入「今天天氣好」五字,使用英文輸入法輸入時會輸出「rup wu0 wu0 fu4cl3」。這種文字不易理解。本研究的目的即為研究將未切換到注音輸入法而打出的英數符號混和字元翻譯為漢字的方法。 本研究使用「PTT 中文語料」與「維基百科中文資料庫」訓練 GRU、BiGRU、LSTM 和 Transformer 以及計算維特比演算法,並與 Google 輸入工具的進行比較。整體來看以 PTT 中文語料計算的維特比演算法的 BLEU4 分數最高,在準確率以及 BLEU4 的評分皆高於Google 輸入工具,分數分別為 0.94 與 88.3 分。 本研究之成果在應用方面極廣,可應用於線上翻譯或聊天軟體的即時翻譯。本研究使用之程式碼開源於 GitHub 頁面,除了可讓使用者下載使用外,使用者也可訓練自己的模型。

探討可調式聲波梯度透鏡受高強度雷射光穿透後的熱效應

由於符合活體研究、解析度、穿透深度等需求,加上螢光技術,使光學方法成為追蹤單一腦神經工作情形較合適的方式。其中重要元件 TAGlens (可調式聲學梯度折射透鏡)的透鏡(目前 z 軸焦距變動最快的透鏡裝置),透過焦距快速變動達到快速掃描。不過 TAGlens 在高強度雷射穿透下,焦距變化範圍會產生改變,我們稱之 TAGlens 的熱效應。 本研究即研究 TAGlens 的熱效應,使用不同研究方法以量化並分析,其中利用體積影像中螢光球軌跡變化的方法,明顯呈現了 TAGlens 熱效應的變化,我們發現入射雷射功率越大,會使 TAGlens 的焦距平衡點越遠,焦距變化範圍越小。未來可望校正 TAGlens 因熱效應造成的數據誤差。

Non-Invasive Vagus Nerve Stimulation as a Novel Therapy for Alzheimer’s Disease by Enhancing the Brain Clearance System(非侵入性迷走神經刺激術作為阿茲海默症的新療法—透過增強大腦清除系統)

阿茲海默症(AD)是導致失智症的主因,影響全球數千萬人。然而,AD目前的藥物大多昂貴且療效有限。目前已知腦內β類澱粉蛋白(Aβ)斑塊為AD的病理特徵,且大腦清除系統被認為對AD的治療具有重要性。先前研究發現非侵入性迷走神經刺激術(nVNS)增加腦脊髓液循環,但在神經退化疾病中的機制和應用尚不明確。本研究旨在探討nVNS增強大腦清除系統來作為AD新療法之成效,使用Aβ誘導之AD小鼠模型,利用巨視顯微鏡和免疫組織化學染色評估其膠淋巴系統功能,並以新奇事物測試評估認知功能。本研究發現於AD小鼠中,給予nVNS使大腦清除系統之水通道蛋白-4顯著增加、促進膠淋巴系統,進而改善認知功能。本研究首次發現nVNS可通過增強大腦清除系統功能,進而改善AD病理引起的失智症狀,支持nVNS作為AD新療法的可行性。

理論設計與高效率合成三吲哚衍生物應用於癌症標靶藥物 Theoretical Design and Highly Efficient Synthesis of Triindole Derivatives for Targeted Cancer Therapeutics

抗癌藥物的研究一直受到重視,吲哚(indole)衍生物可助抵擋自由基,而二吲哚(Di-indole)衍生物已成為抗癌劑。鈣離子/鈣調蛋白依賴性蛋白激酶 (Ca2+/calmodulin-dependent protein kinase II,CaMKII)之抑制劑為癌症標靶藥物重要研究方向之一,抑制CaMKII可降低各種癌細胞增殖和存活,但目前尚無CaMKII抑制劑藥物。本研究以三吲哚為主架構,發展衍生物作為CaMKII抑制劑,期望可應用於抗癌劑。電腦軟體Discovery Studio2016模擬各種三吲哚衍生物分子模型與CaMKII α(PDB: 2VZ6)之結合能,選出結合能較大之化合物3,並延伸結構/活性(SAR)最佳化,進行一系列高效率藥物合成純化工作。經由送測生物細胞活性,其中先導化合物(lead compound) 3-1對癌細胞之毒性高且對CaMKIIα的抑制效果佳,符合癌症治療上的需求,將繼續最佳化此結構,並進行細胞訊號傳送途徑及動物實驗。

Application of Carbon Aerogels in Lithium-Air Batteries

One of the main challenges with today’s batteries is their relatively low volumetric and specific capacities. The highest specific capacity can be achieved with lithium-air batteries, which use metallic lithium as the anode and typically some form of porous carbon as the cathode. To enhance performance, aerogels—among the world’s lightest solid materials—are ideal candidates for cathodes. Resorcinol-formaldehyde (RF)-based carbon aerogels, for example, serve this purpose well. In my work, I utilized two types of carbon aerogels as cathode materials: one derived from pyrolyzed resorcinol-formaldehyde polymer and the other a graphene-oxide-modified version of this carbon gel. I integrated the carbon aerogels I had pyrolyzed into lithium-air batteries to improve the cell’s performance, energy density, and capacity compared to cells using activated carbon. In my research, I examined the pore structure and surface properties of these materials in aqueous media using NMR (nuclear magnetic resonance) relaxometry and cryoporometry, exploring their impact on battery efficiency. I found that the graphene-oxide-containing sample's pores filled with water in a layered manner, indicating a more hydrophilic surface, which suggests a denser arrangement of oxygen-containing functional groups compared to the unmodified carbon aerogel. The pore sizes were reduced after adding graphene oxide, resulting in an increased specific surface area for the sample. Incorporating the reduced graphene-oxide-containing carbon aerogel enabled the creation of a more efficient, higher-capacity battery than with the RF carbon aerogel. This improved performance is likely due to the aerogel’s higher oxygen content and altered morphology. The increased oxygen content provides more active sites for oxygen reduction, meaning that a greater specific power output can be obtained from the battery.

Application of Carbon Aerogels in Lithium-Air Batteries

One of the main challenges with today’s batteries is their relatively low volumetric and specific capacities. The highest specific capacity can be achieved with lithium-air batteries, which use metallic lithium as the anode and typically some form of porous carbon as the cathode. To enhance performance, aerogels—among the world’s lightest solid materials—are ideal candidates for cathodes. Resorcinol-formaldehyde (RF)-based carbon aerogels, for example, serve this purpose well. In my work, I utilized two types of carbon aerogels as cathode materials: one derived from pyrolyzed resorcinol-formaldehyde polymer and the other a graphene-oxide-modified version of this carbon gel. I integrated the carbon aerogels I had pyrolyzed into lithium-air batteries to improve the cell’s performance, energy density, and capacity compared to cells using activated carbon. In my research, I examined the pore structure and surface properties of these materials in aqueous media using NMR (nuclear magnetic resonance) relaxometry and cryoporometry, exploring their impact on battery efficiency. I found that the graphene-oxide-containing sample's pores filled with water in a layered manner, indicating a more hydrophilic surface, which suggests a denser arrangement of oxygen-containing functional groups compared to the unmodified carbon aerogel. The pore sizes were reduced after adding graphene oxide, resulting in an increased specific surface area for the sample. Incorporating the reduced graphene-oxide-containing carbon aerogel enabled the creation of a more efficient, higher-capacity battery than with the RF carbon aerogel. This improved performance is likely due to the aerogel’s higher oxygen content and altered morphology. The increased oxygen content provides more active sites for oxygen reduction, meaning that a greater specific power output can be obtained from the battery.