全國中小學科展

四等獎

Development of new manufacturing method to generate hydrogen energy by using waste silicon ~ Reuse of waste of the semiconductor industry for hydrogen community ~

Because of the presence of an activated multiple carbon-carbon bond, α,β-unsaturated sulfones are high-reactive compounds which are widely used in organic synthesis. These compounds readily undergo the reactions of nucleophilic addition and pericyclic processes. At the current moment, a wide range of 1,3-dipolar cycloaddition reactions with α,β-unsaturated sulfones as dipolarophilic systems is known. However the interaction of α,β-unsaturated sulfones with azinium ylides is less studied and limited to only a few examples. In the present study, the interaction between a number of stable isoquinolinium and pyridinium ylides with aliphatic and aromatic vinylsulfones has been investigated. We considered the regioselectivity of these reactions. Mostly cycloadditions of isoquinolinium ylides to α,β-unsaturated sulfones led to the mixtures of isomeric sulfonyltetrahydroindolizines in different ratios. Also we found several examples of high-regioselective addition. The stereochemical result of the cycloaddition was examined by methods of 2D correlational 1H-NOESY NMR spectroscopy and X-ray crystallographic analysis. The process of formation of major regioisomer of cycloaddition N-phenacylisoqunolinium ylide to ethylvinylsulfone was highly stereoselective. The series of new sulfonyltetrahydroindolizines with potential bioactivity were obtained. The structure of all products was proved by IR and 1H NMR

簡易方法測量勞侖茲力

在一個壓克力製的長方形盒中放入兩層濃度不同的食鹽水,將一隻尖端磨平的針頭水平置放在盒中,針頭出水口恰沒入上層濃度較小的食鹽水中,針頭以橡皮管和滴定管相連,滴定管灌滿染料水溶液,打開活栓瞬間,染料在食鹽水中形成漩渦偶極子,由漩渦偶極子移動距離隨時間的變化,可求得染料作用於食鹽水的慣性力。等位線與電場實驗的電場形成盤放入兩層濃度不同的食鹽水,用兩片平行金屬板做電極,在食鹽水面上放一磁鐵,磁鐵下方滴入數滴染料,食鹽水中的離子受電力、勞侖茲力及黏滯力作用亦形成漩渦偶極子,由漩渦偶極子移動的距離隨時間的變化可求得勞侖茲力。

蒙地卡羅法模擬光跡與病變診斷驗證

此報告是利用蒙地卡羅法模擬光子在組織內的行徑軌跡,並且依照生物組織成分的光學特性,了解頻譜變化。以皮膚組織為例,可分為表皮與基質,依照其成分巨觀量測到的光學參數(如:折射率、吸收、散射及非均向係數),調整光子微觀的位置、方向和能量,藉此累加統計光子的反射、吸收及穿透狀況,解釋組織光學所觀察到光子走越深穿越遠的現象,與對應生理的巨觀的反射光譜變化。模擬數據中可看出波長越長對於病變組織反射率的變化越為敏感,與文獻中病變資料比較,可對應其提供的結果;並且我們延伸探討在紅外光的結果,此範圍的光為生物窗,其穿透深度較深,可以增加應用範圍。

草藥對癌症轉移之影響

癌症轉移是大部分癌症治療失敗的主因。癌症轉移涉及癌細胞不正常活化周圍蛋白水解酶並將胞外基底膜基質(ECM)降解,讓細胞得以轉移至其他器官。本研究聚焦於研發可以阻止癌細胞侵襲其他組織或轉移的藥物,並期望能以藥物控制蛋白水解酶的活性,進而達到降低癌症轉移的機會。我們發現兩種草藥萃取物(MSL-G和MSL-H)可有效地抑制肝、肺和攝護腺癌細胞的移動侵襲力。實驗結果顯示,此二草藥萃取物可有效抑制基質金屬蛋白酶(matrix metalloproteinase 2 and 9 (MMP2/9))的活性,並促進金屬蛋白酶抑制蛋白(TIMP1)的表現。因此這兩種草藥萃取物可能促使TIMP1的表現進而抑制MMP2/9的活性,或同時具抑制MMP2/9的蛋白酶活化機制,並指出此兩種萃取物具有開發為抗癌藥物之潛力,計畫將利用動物實驗進一步驗證此藥物對癌症轉移的效用。

使用機械手臂實現黑白棋之人機對弈

由工業4.0智慧生產的啟發,建構機械手臂進行人工智慧黑白棋之對弈系統,透過視訊分析棋面資料,輸入人工智慧黑白棋遊戲判斷。依據結果指揮機械手臂進行落子、取子的動作,人機對奕過程亦會判斷有無不合理的地方,以維持棋奕的規則公平。擷取雲端攝影機的盤面影像,使用霍夫找圓演算法取得棋目位置,透過彩度與明度分析黑子、白子或無子,黑白棋AI程式再透過遊戲樹演算決定落子、取子位置。透過畢氏定理及餘弦定理將棋子位置的立體座標轉成工具座標,再傳送至主控伺服器以指揮機械手臂進行正確的動作。透過減輕重量及使用彈力平衡力矩改善,機械手臂可改善硬體準確度,重現率測試達85%以上。黑白棋AI程式棋力可以與黑白棋app的3級力敵。視訊判斷棋局在調整適當彩度明度後可達100%正確率。透過演算法指揮機器手臂下棋,棋局中完成正確動作可達80%以上的成功率。

螂吞虎嚥-探討嗅覺及味覺刺激對蜚蠊口器、唾腺及砂囊的影響

本研究以不同濃度各種溶液作為嗅覺與味覺刺激,探討人體與蜚蠊的辨識率與口器反應,發現蜚蠊口器的嗅覺受器極為敏感,大致呈現劑量效應(dose response)趨勢,且可偵測人體無法辨識之揮發性極低的物質,且具熱量之營養物質可增強口器的反射行為。此外,利用記錄組織電位變化的方式,我們發現餵食蔗糖溶液時,蜚蠊唾腺放電反應減弱,推測蔗糖會抑制唾腺分泌水樣唾液,避免稀釋酵素濃度影響消化分解;餵食麩胺酸及醋酸溶液時,唾腺放電反應增強,推測其會引發唾腺分泌水樣唾液,稀釋過高濃度的溶液。而餵食蔗糖溶液時,蜚蠊砂囊放電反應減弱,推測蔗糖會抑制砂囊肌肉收縮;餵食麩胺酸溶液時,蜚蠊砂囊放電則增加,推測麩胺酸會增加砂囊肌肉收縮,以利磨碎食物。

以魚類耳石探討A.MAMORATA的生長和迴游特性

鱸鰻(Anguilla marmorata)曾經是台灣的保育類動物,雖然於2009年解除其保育類身分,但對於其生活史目前所知仍然非常有限,相關論文也很少。本研究欲藉由鱸鰻耳石上出現的年輪、日周輪以及微量元素之分析,來重建鰻魚的生長及洄游環境史。我們利用台灣大學漁業科學研究所採自菲律賓的野生鱸鰻和海南島的養殖鱸鰻進行分析,並且和已經發表的日本鰻(A. japonica) 文獻比對,以期歸納出鱸鰻的生活史以及棲地利用的特性。本研究的耳石測量在台灣大學漁業科學研究所進行,魚類耳石鍶鈣比則利用中央研究院地球科學研究所的電子微探儀(EPMA) 進行分析。結果發現鱸鰻自海中孵化後約莫經過130天會回到陸地的淡水環境成長,這與日本鰻回到陸地鹹淡水環境成長的特性有很大差別。這項發現對今後鱸鰻保育工作的環境管理措施,具有參考價值。

Sustainable Graphene Oxide Support for Ruthenium Catalysts to Improve the Efficiency of the Hydrodesulfurization of Thiophenes

沙烏地阿拉伯 is the largest oil exporter in the world. 64,000,000 tons of sulfur oxides are produced every year through the combustion of organic sulfur compounds in the oil industry. This leads to several environmentally serious problems, including air pollution. This research provides a novel strategy to utilize natural-based Graphene Oxide (GO) as a support for ruthenium (Ru/GO) to functionalize as a green catalyst for hydrodesulfurization. Physical activation of camel bone samples was carried out by carbonizing them at 500oC to produce camel bone charcoal. Modified hammer’s method was employed for GO production, followed by doping of ruthenium in a simple synthesis step. The prepared catalyst has been characterized by XRD, SEM and EDX techniques. Thiophene and 3-methylthiophene were used as model compounds in the hydrodesulfurization process. The catalytic reactions were carried out at atmospheric pressure in a continuous up-flow fixed-bed quartz reactor. The composition of the sulfur containing gaseous products was analyzed by gas chromatography. The product distribution achieved for thiophene was 3-6% butadiene and 76-77% butane. And for 3-methylthiophene, it was 32.3% of pentaned 1-pentene and 2-pentene and the selectivity percentage was 45%. Ru/GO has been found to be an excellent catalyst of thiophene and 3- methylthiophene hydrodesulfurization and is a considerable improvement when compared to the commercially available catalysts. The prepared catalyst shall potentially lead to the reduction of sulfur pollution in the future. The positive effect on the environment could be substantial.

FABRICATION AND CHARACTERIZATION OF CARBON NANOTUBE DOPED PHOTOVOLTAIC CELLS

Nowadays, the increase in population and the rapid depletion of nonrenewable energy sources brings the need for energy. In this case, scientists are forced to develop technologies by using renewable energy sources. Sun is the unlimited and renewable energy source. Organic solar cells absorb the light from the sun by the active polymer layer and transform it into electrical power. Organic solar cells are advantageous than inorganic ones because of being low-cost, easy-to-use and proper for large scale applications. In this project, it is aimed to produce organic solar cells by using specific amounts of carbon nanotube (CNT) doping. According to this aim, it is detected by using the fluorescence spectroscopy that CNTs can be used in organic solar cells. Later, the homogenous distribution of doping SWCNT into donor material was displayed by AFM, and correct proportion of SWCNTs are chosen by those images. In order to increase the efficiency of organic solar cell SWCNT doped P3HT was used as donor molecule. The acceptor molecule was PCBM in here. Surface characterization of prepared samples was made by Atomic Force Microscope (AFM), while electrical characterization of them is done with airless environment cabin (glove-box) system in nitrogen environment. As a result, devices prepared with addition of cyclohexanone in P3HT: SWCNT%:PCBM new load paths to carbon nanotubes were provided, as a result of the measurements short circuit current obtained was raised from the reference to 53%. The best yields were found as 2.24% in 0.2% SWCNT doped devices. This result shows efficiency is healed according to the reference rate as 64%. In this study, certain amounts of carbon nanotube doped organic solar cells were produced, which are highly efficient rather than traditional organic solar cells and low cost, easy-to-produce rather than inorganic solar cells, by using environmentally friendly materials.

The Effect of Hands Free - Cell Phone Conversation on Visual Fields

It is a known fact that using a cell phone while driving can lead to reckless driving. According to research done by the World Health Organisation (2011) thousands of car accidents occur worldwide, each day, due to cell phone use whilst driving. Many of these car accidents result in serious injury or death of drivers, passengers or pedestrians. According to the Automobile Association (2012), cell phones are the number one cause of traffic accidents in South Africa. The high rate of car accidents due to cell phone use has led to legislation being passed, in most countries, banning hand-held cell phone use while driving. Hands-free phone equipment is not prohibited as it is widely regarded as a safe means of making and taking a phone call while behind the wheel. The purpose of this study was to show that the act of talking on a cell phone and not the method of talking (hand-held versus hands-free) increases accident probability. This study used a Friedman Visual field analyser which measures subject’s visual fields with and without engaging in hands-free cellular conversation. The results showed a significant constriction of the visual fields when subjects were conversing on a cell phone. These results were and can be explained by the fact that the test subject experiences cognitive distraction. Cognitive distraction occurs because the driver has to divide his/her attention between the cell phone conversation and the tasks relating to driving. These results have significant ramifications for road safety in a driving environment.