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化學

法拉第波輔助合成奈米鎳並應用於有機污染物的快速脫色 Nanostructured Nickel Synthesized through Faraday Waves and Its Application to Rapid Contaminants Decolorization

超音波已廣泛用於奈米粒子的製備,然可聽聞音對奈米粒子製備的影響卻少有研究。本研究以簡易喇叭裝置產生可聽聞音並在溶液表面產生法拉第波及內部流動,來輔助製備奈米鎳。法拉第波是一種表面非線性駐波,透過調整容器形狀、振動頻率等,可產生不同波形。本研究嘗試在法拉第波輔助下,以化學還原法及電沉積法製備出不同性質的奈米粒子。SEM量測並比較無輔助、法拉第波輔助、超音波輔助製備出的奈米鎳的形貌、分布的差異。並將其應用於有機物(即剛果紅、亞甲藍、4-硝基苯酚、2-硝基苯酚)之催化還原。而由SEM量測、催化還原結果及理論模擬反應熱可知,法拉第波確實能夠改善奈米鎳的粒徑大小、分散性、對氫的吸附能力及催化還原能力。

Detection of Calcium Oxalate in Nephrolithiasis Using Ca-D

Nephrolithiasis isacommondiseasewherestoneisfoundinthe kidney. Kidney stones areharddepositsmadeofmineralsandsalts that form inside your kidneys. Urine has various wastes dissolved in it. When there is too much waste in too little liquid, crystals begin to form. Sometimes, tiny stones move out ofthebodyinthe urine without causingtoomuchpainanditcontainscalciumoxide. But stones that don't move may cause a back-up of urine in the kidney, ureter, the bladder, or the urethra. Therefore, Ca-d is used as an effective and affordable alternative device to check kidney stones. A new detector we can operate as an indicator for people who have high calcium oxalate levels in their urine. Which will help us to check calcium oxalate levels easily and practically with the use of tds (PPM as its unit). It can check whether people have high PPM levels that can cause issues like nephrolithiasis. It can also be used regularly so that people can avoid the disease by consistently checking their urine with Ca-d.

理論設計與高效率合成三吲哚衍生物應用於癌症標靶藥物 Theoretical Design and Highly Efficient Synthesis of Triindole Derivatives for Targeted Cancer Therapeutics

抗癌藥物的研究一直受到重視,吲哚(indole)衍生物可助抵擋自由基,而二吲哚(Di-indole)衍生物已成為抗癌劑。鈣離子/鈣調蛋白依賴性蛋白激酶 (Ca2+/calmodulin-dependent protein kinase II,CaMKII)之抑制劑為癌症標靶藥物重要研究方向之一,抑制CaMKII可降低各種癌細胞增殖和存活,但目前尚無CaMKII抑制劑藥物。本研究以三吲哚為主架構,發展衍生物作為CaMKII抑制劑,期望可應用於抗癌劑。電腦軟體Discovery Studio2016模擬各種三吲哚衍生物分子模型與CaMKII α(PDB: 2VZ6)之結合能,選出結合能較大之化合物3,並延伸結構/活性(SAR)最佳化,進行一系列高效率藥物合成純化工作。經由送測生物細胞活性,其中先導化合物(lead compound) 3-1對癌細胞之毒性高且對CaMKIIα的抑制效果佳,符合癌症治療上的需求,將繼續最佳化此結構,並進行細胞訊號傳送途徑及動物實驗。

可同時用於霧水收集與風力發電的石墨烯仿生陣列魔毯

受到地區限制,偏遠地區一直面臨著缺水和缺電的問題。有許多解決方案,其中一個被視為在乾燥地區收集水的有效方法是薄膜霧氣收集技術。這項研究受到自然界沙漠甲蟲的啟發。我們在不吸水的石墨烯/PVDF基底上使用仿生的幾丁聚醣陣列,幫助水滴在霧氣中凝結和滾動脫落,使水收集效率達到0.63LMH。此外,我們使用石墨烯和離子液體一起誘導PVDF晶型自組裝成具壓電性的β相,獲得最適化薄膜的電壓輸出可達到13V(±6.5V)。我們還對於薄膜進行同時取水和取電的可行性評估,結果顯示,在4m/s的霧氣風速下,水收集效率為0.74LMH,發電功率為99.2mW/m2。基於上述研究結果,我們證實了使用單一薄膜利用霧和風作為驅動力,可實現同時產生水和電,這對解決偏遠地區的缺水與缺電問題提供了新的解決方案。

Application of Carbon Aerogels in Lithium-Air Batteries

One of the main challenges with today’s batteries is their relatively low volumetric and specific capacities. The highest specific capacity can be achieved with lithium-air batteries, which use metallic lithium as the anode and typically some form of porous carbon as the cathode. To enhance performance, aerogels—among the world’s lightest solid materials—are ideal candidates for cathodes. Resorcinol-formaldehyde (RF)-based carbon aerogels, for example, serve this purpose well. In my work, I utilized two types of carbon aerogels as cathode materials: one derived from pyrolyzed resorcinol-formaldehyde polymer and the other a graphene-oxide-modified version of this carbon gel. I integrated the carbon aerogels I had pyrolyzed into lithium-air batteries to improve the cell’s performance, energy density, and capacity compared to cells using activated carbon. In my research, I examined the pore structure and surface properties of these materials in aqueous media using NMR (nuclear magnetic resonance) relaxometry and cryoporometry, exploring their impact on battery efficiency. I found that the graphene-oxide-containing sample's pores filled with water in a layered manner, indicating a more hydrophilic surface, which suggests a denser arrangement of oxygen-containing functional groups compared to the unmodified carbon aerogel. The pore sizes were reduced after adding graphene oxide, resulting in an increased specific surface area for the sample. Incorporating the reduced graphene-oxide-containing carbon aerogel enabled the creation of a more efficient, higher-capacity battery than with the RF carbon aerogel. This improved performance is likely due to the aerogel’s higher oxygen content and altered morphology. The increased oxygen content provides more active sites for oxygen reduction, meaning that a greater specific power output can be obtained from the battery.

理論設計與高效率合成三吲哚衍生物應用於癌症標靶藥物 Theoretical Design and Highly Efficient Synthesis of Triindole Derivatives for Targeted Cancer Therapeutics

抗癌藥物的研究一直受到重視,吲哚(indole)衍生物可助抵擋自由基,而二吲哚(Di-indole)衍生物已成為抗癌劑。鈣離子/鈣調蛋白依賴性蛋白激酶 (Ca2+/calmodulin-dependent protein kinase II,CaMKII)之抑制劑為癌症標靶藥物重要研究方向之一,抑制CaMKII可降低各種癌細胞增殖和存活,但目前尚無CaMKII抑制劑藥物。本研究以三吲哚為主架構,發展衍生物作為CaMKII抑制劑,期望可應用於抗癌劑。電腦軟體Discovery Studio2016模擬各種三吲哚衍生物分子模型與CaMKII α(PDB: 2VZ6)之結合能,選出結合能較大之化合物3,並延伸結構/活性(SAR)最佳化,進行一系列高效率藥物合成純化工作。經由送測生物細胞活性,其中先導化合物(lead compound) 3-1對癌細胞之毒性高且對CaMKIIα的抑制效果佳,符合癌症治療上的需求,將繼續最佳化此結構,並進行細胞訊號傳送途徑及動物實驗。

探討鐵鎳合金催化劑對電解產氫之影響

目前大部分電解產氫反應(HER)均使用貴金屬,如鉑和鈀,作為催化劑。而我們提出了更便宜的 FexNiyP 金屬磷化物用於經濟製氫。在催化劑的製備中採用不同的化學成分(x/y 比例)和合成條件(氧化溫度)。並將合成樣品通過掃描式電子顯微鏡(SEM)、能量色散 X射線光譜(EDS)和 X光繞射儀(XRD)進行了鑑定,以確認其形態、成分和晶體結構。再通過線性掃描伏安法(LSV)測試了它們的 HER催化效率。實驗結果發現,磷化程度強烈影響催化性能,且可以通過合成條件來適當調整,而 250° C是最佳氧化溫度。此外,電化學測試顯示,FeP 啟動反應所需之能量最低,具有最低的過電位(overpotential);而 NiP 反應路徑最佳,具有最低的塔菲爾斜率(Tafel slope)。我們的結果解決了 HER的反應機構,並對氫燃料生產的發展提供了有用信息。

利用水凝膠進行亞硝酸鹽的檢測

亞硝酸鹽與對胺基苯甲酸 (4-Aminobenzoicacid, PABA)反應生成重氮化合物,並與 N-(1- 萘基) 乙二胺二鹽酸鹽 (N-(1-Naphthyl)-1,2-ethanediamine dihydrochloride, NED) 進行偶聯反應,進一步生成紫色、褐色的化合物,使水凝膠的表面從無色轉變成化合物的顏色。隨著亞硝酸鹽濃度的改變,水凝膠成色的效果也會有所不同,這也導致了其表面灰階的變化。重氮化偶聯反應可用於亞硝酸鹽的比色測定,亦被證明可用於實際水樣本中的亞硝酸鹽檢測。

Application of Carbon Aerogels in Lithium-Air Batteries

One of the main challenges with today’s batteries is their relatively low volumetric and specific capacities. The highest specific capacity can be achieved with lithium-air batteries, which use metallic lithium as the anode and typically some form of porous carbon as the cathode. To enhance performance, aerogels—among the world’s lightest solid materials—are ideal candidates for cathodes. Resorcinol-formaldehyde (RF)-based carbon aerogels, for example, serve this purpose well. In my work, I utilized two types of carbon aerogels as cathode materials: one derived from pyrolyzed resorcinol-formaldehyde polymer and the other a graphene-oxide-modified version of this carbon gel. I integrated the carbon aerogels I had pyrolyzed into lithium-air batteries to improve the cell’s performance, energy density, and capacity compared to cells using activated carbon. In my research, I examined the pore structure and surface properties of these materials in aqueous media using NMR (nuclear magnetic resonance) relaxometry and cryoporometry, exploring their impact on battery efficiency. I found that the graphene-oxide-containing sample's pores filled with water in a layered manner, indicating a more hydrophilic surface, which suggests a denser arrangement of oxygen-containing functional groups compared to the unmodified carbon aerogel. The pore sizes were reduced after adding graphene oxide, resulting in an increased specific surface area for the sample. Incorporating the reduced graphene-oxide-containing carbon aerogel enabled the creation of a more efficient, higher-capacity battery than with the RF carbon aerogel. This improved performance is likely due to the aerogel’s higher oxygen content and altered morphology. The increased oxygen content provides more active sites for oxygen reduction, meaning that a greater specific power output can be obtained from the battery.

探討電漿沉積六甲基二矽氮烷與四氟化碳對材料疏水性與抗腐蝕性之影響

生醫材料的開發與應用,現今佔有極重要的地位,但以金屬製的生醫材料而言,仍有植入人體內,被體液腐蝕或氧化的問題。本研究希望藉由高分子薄膜沉積與基材表面處理兩種方式,使金屬醫材能夠抵抗腐蝕,以延長使用年限。 本研究比較以真空電漿系統分別沉積六甲基二矽氮烷 (HMDSZ) 薄膜與使用四氟化碳 (CF4) 處理基材後,對不鏽鋼基材表面之抗腐蝕性和疏水性的影響;並找出使基材表面具較佳抗腐蝕性的工作條件。實驗結果中發現:(1) 在單體壓力為 60mtorr、功率為 30W的電漿參數下,沉積 HMDSZ薄膜 30分鐘,具較佳抗腐蝕效果與疏水性;(2)在沉積後 21天內,HMDSZ薄膜置於室溫時間越長,其抗腐蝕效果越佳;(3)CF4表面處理可能造成蝕刻或沉積,實驗中尚未找到可增加疏水性與抗腐蝕性之參數。