臺灣

本研究工作自2001 年7 月至2002 年6 月止，在臺北市內湖區金面山進行地衣實地探勘採集調查，以位於臺北市內湖區之麗山高級中學之校園為中心點，範圍由校園金面山至學校前門所面對的港墘路與環山路口。應用「外部型態比較」，「切片觀察(徒手切片技術)」與「化學分析(薄層色層分析Thin Layer Chromatography, TLC)」等三種方法，鑑定所採集之地衣所屬種類，並探討空氣污染程度對金面山地衣類分佈狀況的影響。調查至2002年6月為止，本研究已發現生長於金面山區之數種地衣，其中殼狀地衣包含有：癩屑衣屬(Lepraria)、球粉衣屬(Spheophorus)、大孢衣屬(Megalospora)等三屬；屬於莖狀地衣的僅有石蕊屬(Cladonia)；為葉狀地衣的則有：黃梅衣屬(Xanthoparmelia)、裸緣梅衣屬(Parmotrema)、梅衣屬(Parmelia)等三屬，合計共七個屬。本研究針對臺北市金面山區及麗山高級中學之校園附近市區道路地衣類分佈的情形做調查，結果發現行道樹上之附生地衣在較靠近山區的地方，於樹幹上的生長覆蓋面積才會有明顯增加的情形，又其中在市區道路上只發現殼狀地衣生長，而莖狀及葉狀地衣則出現於金面山頂附近，所以就此情況而言，除了金面山區外，市區已呈現地衣沙漠化之狀況，間接顯示，市區的空氣污染是相當嚴重的。本研究將所調查結果之各屬地衣類進行特徵描述與分佈地區之標定，以便於日後臺北市內湖區金面山地衣之鑑識及後續相關研究之進行。This research was carried out between July 2001 and June 2002 on the Jinmian Mountain in Neihu,\r Taipei City and consisted of an on-the-spot exploration and collection of lichen. The Taipei Municipal\r Lishan High School was the center of this research, and the researched territory consisted of the areas\r between the mountain at the back of the school (Jinmian Mountain) and the intersection between\r Gangcian Rd. and Huanshan Rd. in front of the school’s main gate. Comparison of external appearance,\r dissectional observation (manual breaking technique), and chemical analysis (Thin Layer\r Chromatography, TLC) were the research methods applied to determine the genus of the lichen and the\r influence of the degree of air pollution on the distribution of the lichen.\r By the end of the research in June 2002 the presence of three types of lichen on the Jinmian\r Mountain was observed: crustose lichen: Lepraria, Spheophorus, Megalospora; fruticose lichen: Cladonia;\r foliose lichen: Xanthoparmelia, Parmotrema, Parmelia. Seven different genus of lichen have been found.\r The research has been done on the distribution of these different genus of lichen in the area of the\r Jinmian Mountain and The Taipei Municipal Lishan High School: By observation the sidewalk trees\r near the mountain’s area, we found the covering area of the lichen on the sterns apparently increases,\r while on the trees in the city district, only crustose lichen grow. The fruticose and foliose lichen only\r grow near the top of the Jinmian Mountain. This impoverishment of the diversity of lichen in the city\r district might (indirectly) be an indicator of the considerable decline of air quality in the city. The\r outcomes of this research regarding the description and distribution of the lichens contribute to the\r knowledge on lichens in the Jingmian Mountain area in the Neihu District, and may raise the similar\r research in the future as well.

動脈硬化是個致病率和致死率相當高的慢性發炎疾病。HMG-CoA 還原酵素抑制劑 纇藥物，簡稱statin, 是一類強效的降血脂藥物，而且在臨床上對於心血管疾病有廣泛的 治療效果。然而近年來的研究報導指出，statin 會有如此廣效治療效果，其原因不僅僅 是因為它的降血脂能力，而是statin 也具有抑制發炎作用的效果。雖然臨床上已經證實 statin 可以減緩動脈硬化的病程，但是statin 對於誘發型一氧化氮合成酵素(iNOS)表現的 調控機制還不明確。有文獻指出NOS 代謝產物nitric oxide (NO)可以改善血流，而可能 在動脈硬化上扮演保護角色。值得一提的是雖然適量 NO 有維持血管恆定的功能，過 量時則會造成血壓過低休克的現象，這就是細菌感染後因內毒素 lipopolysaccharide (LPS) 作用引發敗血性休克的主要原因之一。在本實驗中，我們使用fluvastatin、lovastatin、 pravastatin 和 atorvastatin 這四種statins 來探討它們對於血管平滑肌細胞由LPS 及IL-1β 誘導iNOS 基因表現的影響。我們發現，statin 可以抑制LPS 所誘發的NO 和iNOS 表現， 但卻會促進IL-1β所誘發的反應。NF-κB 在iNOS 的基因調控上扮演重要的角色，而在 探討NF-κB 被LPS 和IL-1β活化的情形中，statin 同樣會促進IL-1β活化NF-κB，但抑制 LPS 活化NF-κB。我們也發現fluvastatin 對於IL-1β所引發NO 的產生、iNOS 的表現、 NF-κB 的活化，以及p65 向細胞核移動的促進作用，在ROCK 抑制劑Y-27632 的處理後 可以看到相同的現象。IKK kinase assay 顯示Y-27632 對於LPS 所促進的IKK 活性影響 很小，但是會促進IL-1β的活化作用。接著，在ROCK 的活性方面，LPS 會抑制原本已 表現的ROCK 活性， 而相反的，IL-1β會增加ROCK 的活性。總括來說，這些結果顯示 ROCK 在血管平滑肌細胞中扮演IKK/NF-κB 的負向訊息調控者角色，而這個機制在LPS 和IL-1β的訊息傳遞路徑中有不同的調控。即ROCK 以負向調控機制角色影響IL-1β的 訊息傳遞，卻不存在於LPS 的情況中。就是因為透過反轉這個負向調控的機制，statins 3 和ROCK 抑制劑對於LPS 及IL-1β引發血管平滑肌細胞的iNOS 表現，呈現相反的調控 結果。這些作用可能參與statin 預防血管再阻塞，抗發炎，抗動脈硬化的作用。此外Statin 抑制LPS 的iNOS 表現作用或許將來可運用於治療敗血性休克。利用基因微陣列分析也 偵測到一些受fluvastatin 正向或負向調控的基因，目前我們正朝鑑定基因的表現改變及 確認其功能，生理意義進行實驗中。 The 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, statins, are potent inhibitors of cholesterol synthesis and have wide therapeutic use in cardiovascular diseases. Recent evidence, however, suggests that the beneficial effects of statins may extend beyond their action on serum cholesterol levels. Although statins have been shown to reduce progression of atherosclerosis, little is known about mechanism by which statins affect iNOS expression. Optimal level of NOS product, NO, possesses the anti-inflammation and anti-proliferation effects in atherosclerosis, while large amount of NO contributes to the septic shock in response to bacterial endotoxin, lipopolysaccharide (LPS). In this study, we investigated the effects of fluvastatin, lovastatin, pravastatin and atorvastatin on IL-1β- and LPS-induced NO production in cultured rat vascular smooth muscle cells (VSMC). We found statins can inhibit LPS-induced iNOS expression and NO production, while they can potentiate IL-1β-elicited responses. In studying the activity of NF-κB, which plays an important role for iNOS gene induction, we found that fluvastatin can increase IL-1β-induced p65 nuclear translocation and NF-κB activity, while inhibit those induced by LPS. The potentiation effects of fluvastatin on IL-1β-induced NO production, iNOS expression, NF-κB activation and p65 nuclear translocation were all mimicked by a ROCK inhibitor, Y-27632. IKK kinase assay showed that Y-27632 itself has minimal effect on LPS-induced IKK activation, while enhances the response of IL-1β. Studies on examining ROCK activity showed LPS can downregulate constitutive ROCK activity, while IL-1β oppositely increases ROCK activity. Taken together these data suggest ROCK is a crucial negative regulator of IKK/NF-κB signaling pathway in VSMC, and this negative control is existing in the action IL-1β, but is absent in the action of LPS. Through abrogating the function of this negative regulator, statins and ROCK inhibitor thus differentially regulate iNOS expression induced by LPS and IL-1β in VSMC. These results suggest that stimulation of iNOS expression in the presence of IL-1β might contribute to the beneficial effects of statins in atherosclerotic process in terms of vasodilation, anti-inflammation and inhibition of smooth muscle cell proliferation. In contrast, the diminishing effect on LPS-induced NO response possibly may provide new therapeutic strategy in sepsis. Al these results strengthen the pleiotropic actions of statins in anti-inflammation and anti-atherosclerosis. Preliminary microarray analysis further revealed several genes either upregulated or downregulated by fluvastatin. The identification of these genes and studying their functional roles in atherosclerosis are currently in progress.

我們從日常生活中的酒瓶填塞問題，延伸出圓在相守條件下產生的衍生圖面\r 積極值及相守圓排法等問題，研究過程中我們發現以下的結果：\r 一、 我們可以利用較少個相守圓的排法，以繁殖或增加的方式排出較多個相守圓\r 的衍生圖。\r 二、 當相守圓數量為2個、4個及6個時，相守圓以對角線排列，且衍生圖為正方形\r 時，面積會產生最大值。而當相守圓數量為3 個及5 個時，衍生圖面積最大\r 值會出現在相守圓排成波浪形時，但其夾角並非特殊角。\r 三、當相守圓數量為2個至6個時，相守圓以直線排列，衍生圖面積會產生最小值。\r 四、透過不同層數、個數的研究得知：當相守圓的數量為11個或14個以上時，存\r 在正三角形排法小於直線排法的情形 。而相守圓個數在10個以下時，直線排\r 法面積都叫正三角形排法小。\r 五、我們可以用質單元分割的方式討論更多圓數時，相守圓間的排列方式，使得\r 生多元間的排列變為數字間的加法排列，可以大大降低討論情形的複雜度。\r 六、我們可以用密度的概念，搭配質單元分割的方式，得到不同圓數時，以不同\r 衍生多元搭配波浪形法形成之衍生圖密度最小值。\r 七、我們可以算幾及柯西不等式來驗證特定類型的衍生圖面積極值，也可以列出\r 面積函數來分析不同類型的衍生圖面積極值。

Feeding behavior is the action which animals depend on maintain livelihood. Snakes usually use the three following ways to catch their preys: winding, venom-releasing and pressing their game to death. However, previews study is rare about the feeding behavior of Ramphotyphlops braminus. This puzzles us, prompting us to do in-depth research on it. When performing an experiment, we will use the camera with infrared function to record entire experiment and the obtained data will transform the graph. Our result shows the feeding behavior of R.braminus is a new way to catch their game, and the minute process of this special way is also written down in our report. We hope that the result can let everyone be clear about Ramphotyphlops braminus of soil ecosystem status, and it is an essential contribution for building the archive of Family Typhlopidae. 攝食行為是動物賴以維生的行為。在蛇類中，常見的捕捉方式有：纏繞、 使用毒液、壓斃等三種類型。但，文獻中卻沒有任何有關於鉤盲蛇(Ramphotyphlops braminus)的捕食行為。這使我們感到疑惑，並想深入探討。在實驗進行當中，我們使用紅外線攝影機將實驗全程錄製下來，並將所得的數據轉化成圖表。而其結果顯示鉤盲蛇(Ramphotyphlops braminus)的捕食行為是一種全新的模式，這種模式的詳細過程也被我們全部收錄到報告中。我們希望做出來的結果能讓大家對鉤盲蛇(Ramphotyphlops braminus)在土壤生態系中的地位更加了解，而且對於建立盲蛇科(Typhlopidae)資料庫有實質的貢獻。

以隨手可得拍攝影像的工具（如智慧型手機、個人數位助理、網路攝影機等）及網際網路的便利性，讓使用者能隨時透過書籍條碼影像向遠端資料庫查詢書籍的相關訊息。本研究以「ISBN書籍條碼」為例，經過條碼影像的擷取、偵測並分割出影像中的條碼、歪斜校正以及辨識後，透過網際網路，從ISBN書籍資料庫中查詢出該書籍的相關資訊，讓我們體驗行動通訊科技所帶來的便利。在程式的實作上，除了使用現有影像處理技術中的霍夫轉換與邊緣偵測外，也搭配上自行設計的變化量分配圖，使得ISBN條碼的辨識能力大為提升。此外，為了將使用者查詢時等待回應的時間降至最低，採用了記憶體直接存取的方法來處理影像外，也針對程式執行時的瓶頸部分，以平行處理的機制來加速，經過在Intel i5 M560四核心處理器上的實際測試，一幅900×675像素的影像，平均只要花費1.08秒即可辨識出ISBN條碼，相當的迅速。

本研究的目的在於設計出一機械裝置，使振翅翼的升力比傳統的設計能更有效率的提升，並經由實驗證實此種機械裝置理論的正確性。在觀察有關鳥類飛行過程的錄影帶及尋找鳥類相關的資料且界定欲實驗的種類和現有的能力及資源後，本研究中設計出三種可行的振翅翼機械裝置，並進行在相同風速、相同振翅頻率(每分鐘振翅翼拍動144 下)的條件下，測試在不同振翅翼機械設計條件下的升力系數，在實驗中發現既有而廣泛的應用於玩具上的振翅翼設計與固定面振翅翼的設計，二者在拍打的過程中各有優缺點，而第三種的半活動面振翅翼設計，在拍打時能排除前者的缺失而同時擁有前兩種的優點。此種半活動面振翅翼機械裝置大大的提升了振翅翼的升力，且在設計上與現有的形式差異不大，若能更進一步的在機構上做更精密的改良設計，則將可大大提昇現有振翅機的性能。The study on the flapping wings with various angle of attack and different wing designs have been done. Three types of wing have been examined in a home-build wind tunnel . One is a membrane wing with fixed leading-edge support, the second is a membrane wing with both fixed leading-edge and fixed-web support , the third wing is a membrane wing with fixed leading-edge support and half-free-joint web support , with varions web length and web curvature under different angle of attacks , the wind tunnel testing results show that the half-free-joint web support membrane wing with fixed leading-edge can offer a much higher lift coefficient . It is suggested that the third type wing is the best choice for designing the future flapping wing vehicle.

我們使用陽極氧化鋁(AAO)模板來製備銅及其氧化物的奈米線。以硫酸銅和乳酸配製電鍍液，利用氫氧化鈉水溶液(NaOH)將其pH 值調整到12，供以不同電壓，可電鍍出銅及氧化亞銅奈米線。在較高電壓下可製備出銅奈米線，而在較低電壓下可製成氧化亞銅奈米線，若使用中間電壓則能製得銅及氧化亞銅的混合態。利用x 光繞射分析儀(XRD)來分析其結晶構造、使用場發射掃描式電子顯微鏡(SEM)以得知其表面形貌。電鍍出的奈米線直徑約60 nm。奈米線的長度可藉由調整電鍍時間或電壓來控制。在製作IC 內部導線方面，銅奈米線深具開發潛能；在提升太陽能電池的轉換效率、製作可見光光觸媒方面，氧化亞銅奈米線極具前瞻性。We electrodeposited copper and cuprous oxide (Cu2O) nanowires with anodic aluminum oxide (AAO) templates. Both Cu and Cu2O nanowires could be prepared with an alkaline cupric lactate solution, which was adjusted to pH 12 using a 6 M NaOH, when supplied with different electrolytic voltages. Cu nanowires could be prepared when a higher voltage was supplied, and Cu2O nanowires could be prepared with a lower voltage. A mixture of Cu and Cu2O nanowires could be prepared with a supply of a voltage in between. X-ray diffraction (XRD) is used to determine the phase composition, and scanning electron microscopy (SEM) is employed to characterize the morphology of the nanowires. The length of nanowires can be controlled by adjusting the time spent on electrodeposition and the voltage supplied. The resultant diameter of the nanowires was about 60 nm. Cu nanowires are promising materials for making the conductive wires in IC, and Cu2O nanowires hold great promise for improving the conversion efficiency of solar cells and manufacturing visible-light photocatalyst.

中文摘要：\r 本文利用溶膠－凝膠法（Sol－Gel method）製備二氧化鈦奈米粒子（Anatase\r 晶相），測定廷得耳效應判斷其是否為奈米粒子，並以二氧化鈦奈米粒子加入水\r 中，以紫外光照射測試其光催化分解水反應的活性，並測試其分解南崁溪河川廢\r 水的能力。結果顯示自製二氧化鈦奈米粒子具有明顯的廷得耳效應，光催化分解\r 水反應因紫外光源功率過低未能呈現，有待改進；分解河川廢水的能力仍在進行\r 中。\r Abstract\r This experiment produces Titanium dioxide nano-particles (Anatase crystal\r phase)by using Sol-Gel method. We prove the particles as nano-order by the Tyndall\r effect And adds Titanium Dioxide into water, illuminate it with special wavelength\r ultraviolet radiation. The activity of its light catalysis reaction to water was tested.\r The capability of the treatment of wastewater in Nancan River by nano-titanium\r particles was also studied. The results show that the powder prepared by this\r experiment has apparently Tyndall effect，the photo-catalysis reaction of water is\r failed due to the weak power of UV light sources. The test of wastewater treatment is\r still processed.

本研究以攝影紀錄的方式，透過電腦進行影像分析，記錄不同刺激下美洲蜚蠊(Periplaneta americana)的觸角擺動模式，計算出各項觸角運動的參數，以瞭解光線(光刺激或光適應)、震動刺激、喝水與進食對其觸角行為的影響。我們發現在不同因子的刺激下，觸角擺動的模式具有差異，若兩種不同的刺激同時發生，蜚蠊觸角的行為亦具整合性的反應。蜚蠊於不同狀態下(如喝水或進食)，對相同的刺激有不同的反應，證明蜚蠊觸角的行為模式，受環境因子與個體狀態調節。透過掃瞄式電子顯微鏡的觀察，也發現觸角具多種感覺毛，且雌雄的感覺毛的分佈與數量具有差異。綜合以上發現，證明觸角除了為敏感的受器，亦為能反映出生理與環境狀態的動器，同時也適合進行發展檢測器的仿生學應用，用來檢測環境中物理及化學因子。The aim of this study is to investigate the different swing motion modes of antennae of American cockroach (Periplaneta americana) by computer-aided Imaging Analysis. The parameters of each swing movement were calculated in order to analyze how light (including light stimulation or light adaptation), vibration, food and drinking water may affect the antennae behavior of American cockroach. It was found that the antennae swing motion modes were significantly different under different types of stimulus. If two different types of stimulus occurred at the same time, the reactions of antennae motion may become conformable. Under different environmental conditions (such as food or water), same stimulus may result in different reactions. The antennae behavior has shown to be significantly affected by environmental conditions and individual physiological status. Through the observation with scanning electron microscope (SEM), it was found that the antennae has many types of sensilla; and the distribution and quantity of these sensilla are significant different between sexes. In conclusion, not only the antennae are considered as the sensitive receptors, but also they are the important effectors to reflect physiological status and environmental conditions. The current model is suitable for the development of specific detectors in the applications of Bionics to detect the physical and chemical factors in certain environments.

本實驗利用喇叭、薄膜電極、波型產生器、鎖相放大器、及750 介面卡組合一套系統,此系統可使偵測精密度大幅提升(±4*10-5cm),使得水槽及地表模型尺度變小(40*22*35cm),因此可節省實驗的成本與時間我們在坡度實驗中,發現坡度在3 度左右,淺化係數都超過3. 對照台灣沿岸發生海嘯的歷史記載,確實在台灣東北角及西南沿岸等坡度為三度之地區都發生較明顯的海嘯危害. 反之,坡度在四度以上的東岸其海嘯波高都非常低.最後再藉著硬體系統及電腦2D 動畫模擬的整合,使我們可方便掌握波浪在不同坡度及位置,其波長及波高變化比,如此有助於預估及說明海嘯隨地形變化的狀況.By using the horn, membranous electrodes, function generator, phase-locked amplifier, and Science Workshop 750, we plan to assemble a tsunami simulation system in which the precision can be getting increased (±4*10-5cm) .Because of the improvement of its precision, the size of the tank and of the surface models will become smaller .As a result, the money and time spent on the experiment will be spare. When experimenting on the influence of inclination of the landforms, we observed that when the inclination reaches about 3 degrees, the shoaling coefficient exceeded 3 .The result of our experiment can provide an explanation to the tsunami on the northeast and southwest coast of Taiwan .According to the historical records, the disastrous tsunami happens frequently on the northeast and southwest coast of Taiwan where its inclination is also about 3 degrees as well .On the other hand, on the eastern coast, the wave height is lower and its inclination exceeds 4 degrees .Apparently, our experimenting result is correspond to the natural phenomena in Taiwan’s coast . Besides, with the help of hardware system and computer 2D animation simulation, we can easily measure the wavelength and wave height scale of the wave in different inclinations and positions. Therefore, this tsunami simulation system can provide a great help to estimate and explain the phenomena of tsunami which may change its condition in different landforms.