全國中小學科展

2016年

攜手共解圓-扭結理論之探討

此篇研究發現在任何一個結中,都可以利用「牽手順序」和「交錯點編碼」兩種結的資訊直接看出一結化簡後的圖形。利用從「Reidemeister moves」所衍伸出的四種化簡方法{α, β, γ, δ}能更有效率的簡化結,並證明只需{α, β, γ, δ}就可化簡任何結,也利用{α, β, γ, δ}來驗證HOMFLY多項式是結不變量。由圖形及結的資訊我們發現,可使用「牽手順序」和「交錯點編碼」,搭配所討論出{α, β, γ, δ}的通式,依照步驟及通式簡化任何結。 本篇最重要的成果為:只需利用{α, β, γ, δ}即可化簡所有的結,而且比Reidemeister moves更有效率,因此可用{α, β, γ, δ}取代Reidemeister moves。 不管是一個封閉曲線或是兩個以上封閉曲線,都會遵守前述的規則,可利用{α, β, γ, δ}簡化圖形。文中也討論了較特別並具有規律的結──「星星結」,發現星星結只需使用「牽手順序」即可簡化,最後利用星星結的結論,發展出牽手遊戲中特殊的牽手遊戲情形。

Development of new manufacturing method to generate hydrogen energy by using waste silicon ~ Reuse of waste of the semiconductor industry for hydrogen community ~

Because of the presence of an activated multiple carbon-carbon bond, α,β-unsaturated sulfones are high-reactive compounds which are widely used in organic synthesis. These compounds readily undergo the reactions of nucleophilic addition and pericyclic processes. At the current moment, a wide range of 1,3-dipolar cycloaddition reactions with α,β-unsaturated sulfones as dipolarophilic systems is known. However the interaction of α,β-unsaturated sulfones with azinium ylides is less studied and limited to only a few examples. In the present study, the interaction between a number of stable isoquinolinium and pyridinium ylides with aliphatic and aromatic vinylsulfones has been investigated. We considered the regioselectivity of these reactions. Mostly cycloadditions of isoquinolinium ylides to α,β-unsaturated sulfones led to the mixtures of isomeric sulfonyltetrahydroindolizines in different ratios. Also we found several examples of high-regioselective addition. The stereochemical result of the cycloaddition was examined by methods of 2D correlational 1H-NOESY NMR spectroscopy and X-ray crystallographic analysis. The process of formation of major regioisomer of cycloaddition N-phenacylisoqunolinium ylide to ethylvinylsulfone was highly stereoselective. The series of new sulfonyltetrahydroindolizines with potential bioactivity were obtained. The structure of all products was proved by IR and 1H NMR

Biodegrable Roof

It became necessary to implement a project for the use of vegetable waste generated in the process of handling plantain cultivation, harvest and postharvest, since in Mexico at harvest large quantities of vegetable waste is produced, since only the fruit is used wasting the Pseudostem with leaves and spine. Based on this information, you can take advantage of banana fiber as raw materials in the manufacture of biodegradable sheets and support options that are feasible and possible to make alternative. This is an inexpensive process, also friendly with the environment, so that thousands of banana plants that bear fruit after they become sterile and are discarded without realizing their Pseudostem.

An optimal-route algorithm for an intermodal Metro Manila trip planners using multiple parameters

Parameters of traffic, road availability, and fare were integrated into a web-based application for determining the best public transport routes within Metro Manila in order to assist commuters in their travel planning, whether for business or for pleasure. A user-friendly interface was developed to obtain a user’s place of origin and destination, as well as preferences in travel time, mode of transportation, and cost of journey. By accessing the traffic roadway network of the metropolis, a real-time situation of road availability was obtained, and used in a modified Dijkstra’s shortest-path algorithm to produce a model of a real-time adaptive transport network of Metro Manila. From the model, an optimal route that considers the user’s preferences can be determined. This project will be immensely useful in helping both businessmen and tourists in planning their routes that will save on time and money.

IMPACT OF FIRE WOOD COLLECTION ON WEATHER AND CLIMATE OF JIRDIN VILLAGE

Climate is the average weather in a place over a long period. The changes in climate may be due to natural forces or from human activities. There is growing concern among the scientific community regarding climate change. Biodiversity, forest, monsoons, weather are now at risk due to climate change. Today climate change is happening at an increasing rapid rate. One of the causes is deforestation. Firewood collection in one of the major means the felling of trees. Excessive emission of CO2 by burning, which is a green house gas, responsible for increasing the temperature and causing drastic climate change. Hence, to know the impact of firewood collection in drastic climate change we have undertaken a project entitled, “Impact of firewood collection on weather and climate of Jirdin village.”

建立細菌系統的雙分子螢光互補試驗做為α-突觸核蛋白聚集抑制物篩檢平台

帕金森氏症(PD)是一種慢性中樞神經系統退化性疾病,患者臨床症狀包括靜止時震顫、動作遲緩、僵直及黑質緻密部多巴胺神經元的漸進性退化等。PD的主要病理特徵為多巴胺神經元中出現包含α-突觸核蛋白(SNCA)錯誤摺疊、聚集的路易小體。雖然PD的治療方法包括給予左旋多巴或其他藥物、物理治療、手術等,至今尚未有根治的方法。本研究建立雙分子螢光互補試驗與蛋白質摺疊報告者試驗兩種原核細胞平台,作為篩檢可幫助α-突觸核蛋白摺疊的化學伴隨蛋白平台。雙分子螢光互補試驗是將Venus黃螢光蛋白改進版切開成N端(VN1-211)及C端(VC212-239)二段,分別接在SNCA的N端(VN-SNCA)或C端(SNCA-VC),原本沒有螢光的片段可藉融合的SNCA聚集的再組裝而出現螢光。當構築的VN-SNCA and SNCA-VC質體共表現於大腸桿菌後,蛋白質染色及免疫轉漬可偵測到表現的VN-SNCA、SNCA-VC蛋白,並出現伴隨著SNCA聚集所導致的互補螢光。我們以可干擾SNCA聚集的海藻糖來測試此聚集抑制物篩選平台,發現在不影響大腸桿菌生長的狀況下,海藻糖的濃度與螢光下降程度呈正相關,推測因其能減少SNCA聚集,導致螢光分子互補的機率下降。蛋白質報告者試驗是將野生型(WT)與突變型(35/46/61 E-to-K)的α-突觸核蛋白與綠螢光蛋白的融合蛋白(SNCA-GFP)分別表現於大腸桿菌,突變型的α-突觸核蛋白的傾向錯誤摺疊,會影響融合的綠螢光蛋白摺疊,而導致綠螢光下降,而海藻糖的化學伴隨蛋白活性可幫助突變型的α-突觸核蛋白摺疊,因而改善融合的綠螢光蛋白的摺疊,導致綠螢光上升。未來我們用此兩種原核細胞平台,來篩檢可幫助α-突觸核蛋白摺疊的新穎化學伴隨蛋白。

Automated Illustration of Text to Improve Semantic Comprehension

Millions of people worldwide suffer from aphasia, a disorder that severely inhibits language comprehension. Medical professionals suggest that individuals with aphasia have a noticeably greater understanding of pictures than of the written or spoken word. Accordingly, we design a text-to-image converter that augments lingual communication, overcoming the highly constrained input strings and predefined output templates of previous work. This project offers four primary contributions. First, we develop an image processing algorithm that finds a simple graphical representation for each noun in the input text by analyzing Hu mo-ments of contours in images from The Noun Project and Bing Images. Next, we construct a da-taset of 700 human-centric action verbs annotated with corresponding body positions. We train support vector machines to match verbs outside the dataset with appropriate body positions. Our system illustrates body positions and emotions with a generic human representation created using iOS’s Core Animation framework. Third, we design an algorithm that maps abstract nouns to concrete ones that can be illustrated easily. To accomplish this, we use spectral clustering to iden-tify 175 abstract noun classes and annotate these classes with representative concrete nouns. Fi-nally, our system parses two datasets of pre-segmented and pre-captioned real-world images (Im-ageClef and Microsoft COCO) to identify graphical patterns that accurately represent semantic relationships between the words in a sentence. Our tests on human subjects establish the system’s effectiveness in communicating text using im-ages. Beyond people with aphasia, our system can assist individuals with Alzheimer’s or Parkin-son’s, travelers located in foreign countries, and children learning how to read.

小兵立大功-發現日常生活中可抑制腦癌細胞之植物萃取物

本實驗藉由「篩檢抑制癌細胞增長的藥物」來尋找可以抑制癌細胞生長的植物萃取物。我們希望從日常生活中唾手可得的蔬果類植物中尋得抗癌藥物。曾經在生物課聽老師提過,紫衫中的紫衫醇可抑制乳癌;由此我們產生一個想法:是否從日常生活中的植物中也能找出有效抑制癌症的成份?因此便著手進行。先從尋找相關論文、蒐集植物,經由萃取、篩檢四種蔬果類的不同部位之水粗萃物或酒粗萃物,我們得到三種蔬果類可有效抑制腦癌細胞的增長。之後選出實驗效果較為顯著兩種水粗萃物進行西方墨點法,初步確認影響腦癌細胞生長的可能機轉:Akt以及Erk;實驗過後發現以上有兩種水粗萃物能透過這兩種訊息傳遞分子影響細胞生長。最後再進行高效液相層析法,期望能夠找出抑制腦癌細胞生長的物質。日後希望這部份的實驗能完整,以期最後的成果。

利用硫醇分子合成之金銅奈米團簇偵測過氧化氫及葡萄糖

本研究的方向是利用聚苯乙烯磺酸鈣(PSS)、硫醇小分子(PA)、銅離子(Cu2+)和金離子(Au3+)於最佳比例下合成的穩定金銅奈米團簇,分析此穩定、具有響應性之金銅奈米團簇並探討此系統用於過氧化氫以及葡萄糖偵測的效果,確認最佳合成比例(也就是改變PA、Cu2+、Au3+的比例)、分析特性(螢光強度、奈米團簇大小、團簇溶液分散性、有無加入PSS之影響)後,探討偵測待分析物的效果。以葡萄糖為例,加入葡萄糖氧化酶後,製造出葡萄糖酸及過氧化氫,就能藉由過氧化氫改變團簇表面特性,使螢光強度減弱來進行間接偵測葡萄糖濃度。最後藉由此金銅奈米團簇做為偵測試劑於真實樣品中進行過氧化氫與葡萄糖之偵測並探討其效果。

What would you do?——以捷運實地實驗探討旁觀者的助人行為

本研究透過實地實驗的方式,旨在針對旁觀者表現的助人行為作探討。研究者於台北捷運站分別扮演強勢者、弱勢者以及普通人的角色,並且讓強勢者表現違反社會常規的行為(欺凌弱勢者),從旁紀錄當以上三者分別需要幫助時,旁觀者表現的幫助比率,進一步分析其中的差異。實驗結果主要顯示以下三點: (一) 幫助率普遍皆低於50% (二) 對照組的普通人獲得的幫助率明顯高於另外兩者 (三) 強勢者獲得的幫助率高於弱勢者 由此推知在類似情況下,弱勢的形像反而會降低旁觀者的幫助意願。因此我們分別從事件本身、旁觀者本身、社會因素、服從權威現象等面向分析此結果,並佐以過去的相關實驗及文本資料,以期獲得現今大眾普遍表現的助人行為及背後的影響因素。