全國中小學科展

四等獎

Beyond Limits: An Intelligent Wheelchair for Inclusive Living

The aim of this project is to enhance the mobility of individuals with disabilities, particularly aiding them in navigating stairs and challenging terrains. Across the world, powered wheelchair employ various methods, primarily categorized into two: 1) tracked mechanisms and 2) robotic wheelchair utilizing intricate robotic systems. The design presented by our team belongs to the latter category, which is recognized for its lighter build when contrasted with the former. However, despite its lightweight structure, this wheelchair design incorporates equipment that renders it more cost-effective and practical than conventional designs within the same category. Our design integrates three distinct mechanisms to adjust the height and center of mass of the passenger during stair climbing and maintain balance and surface contact. Utilizing an array of sensors, it continuously monitors the position of the person on the wheelchair and the wheelchair on the surface. This data guides adjustments in the mechanisms, ensuring stability. This innovation harbors the potential for enhancing various functionalities, including: GPS integration for user navigation. Real-time monitoring of vital signs (e.g., heart rate, blood pressure, body temperature). In an emergency, this data can be transmitted to ambulance centers to pinpoint the individual's location and immediate assistance. A simplified ambulance request system, accessible via a single button press. Overall, this innovative wheelchair prototypes aims to revolutionize accessibility, granting enhanced mobility and independence to individuals with disabilities.

Production of Nano-Composite Artificial Bone Tissue Using Bioceramic Synthesis from Bio-Waste

Certain specially structured ceramics, which can be used as biomaterials to replace bone, have recently started being utilized in the medical field. The aim of this study is to produce high-bioactivity silica from corn cob waste, a widely available organic material in nature, and combine it with calcium oxide (CaO) obtained by grinding organic mussel shell waste with high bioactivity. This combination is intended to synthesize dicalcium silicate (2CaO.SiO₂) to develop an alternative tissue scaffold with high bioactivity, capable of replacing bone, for existing titanium alloys. The goal is to incorporate this scaffold into PEEK (polyether ether ketone), a novel tissue scaffold material, at varying percentages to create a next-generation innovative bone substitute material. An additional objective is to demonstrate through biocompatibility tests that the produced ceramic-polymer biocomposite exhibits antibacterial activity against Staphylococcus aureus.

雙酚 A 對白線斑蚊幼蟲生長發育的影響及病媒蚊防治策略探究

登革熱病媒蚊幼蟲主要孳生於人工積水容器中,幼蟲生長發育主要受到溫度與食物的影響。本研究至戶外調查人工積水容器,發現塑膠類人工容器為主要孳生類型。於實驗室以 11 種人工容器培養白線斑蚊幼蟲,結果發現塑膠底盆的幼蟲發育速度較快,蚊蟲平均翅長較長。以塑膠組成物質雙酚 A 進行試驗, 發現高濃度 (>50 mg/L) 雙酚 A 會導致幼蟲死亡, 活動力降低; 中濃度(12.5~1.56 mg/L) 會促進幼蟲生長速率,縮短發育時間;低濃度 (<0.78 mg/L) 則不顯著。以濃 6.25mg/L 雙酚A 處理蚊幼蟲,Q-PCR 顯示四個齡期的幼蟲蛻皮激素基因 (Ecr) 分別表現量都有增加,其中四齡幼蟲增加 9.68 倍,蛋白質分析顯示 34~72 kDa 之間的片段濃度增加。在蚊幼蟲防治上,4.0 %蛋胺酸和 1.0% 硼酸皆可 100%抑制孑孓活性,結合低濃度蛋胺酸(0.13%)和硼酸(< 0.5% )可以提升 30% 抑制孑孓活性的功效。

Non-Invasive Vagus Nerve Stimulation as a Novel Therapy for Alzheimer’s Disease by Enhancing the Brain Clearance System(非侵入性迷走神經刺激術作為阿茲海默症的新療法—透過增強大腦清除系統)

阿茲海默症(AD)是導致失智症的主因,影響全球數千萬人。然而,AD目前的藥物大多昂貴且療效有限。目前已知腦內β類澱粉蛋白(Aβ)斑塊為AD的病理特徵,且大腦清除系統被認為對AD的治療具有重要性。先前研究發現非侵入性迷走神經刺激術(nVNS)增加腦脊髓液循環,但在神經退化疾病中的機制和應用尚不明確。本研究旨在探討nVNS增強大腦清除系統來作為AD新療法之成效,使用Aβ誘導之AD小鼠模型,利用巨視顯微鏡和免疫組織化學染色評估其膠淋巴系統功能,並以新奇事物測試評估認知功能。本研究發現於AD小鼠中,給予nVNS使大腦清除系統之水通道蛋白-4顯著增加、促進膠淋巴系統,進而改善認知功能。本研究首次發現nVNS可通過增強大腦清除系統功能,進而改善AD病理引起的失智症狀,支持nVNS作為AD新療法的可行性。

分子結構語言與熔沸點性質的人工智慧預測

背景:預測分子性質如溶解度、毒性及熔沸點對於基礎科學至關重要。然而,實驗測量這些性質耗時且昂貴,因此本研究使用多種機器學習模型藉由調整變相來準確預測熔、沸點。 方法:本研究使用超過一萬筆數據及兩種類型的機器學習方法:淺度與深度學習。淺度學習由 PyCaret實現,並以Mordred作為分子描述器;深度學習使用圖神經網路,包括(CMPNN和GCN),並調整隱藏層參數。 結果:CMPNN在目前嘗試的模型中表現最佳。發現影響沸點預測的關鍵特徵是piPC1,與鍵級相關;熔點則是AATS0d,與σ電子的 Moreau-Broto自相關有關。 結論:CMPNN模型在沸點與熔點預測中均表現最佳。沸點中深度學習模型優於淺度學習模型(p<0.05)。此外,使用SHAP成功找出piPC1和AATS0d對最關鍵。本研究不僅得出了高準確性的模型,還發現了影響分子性質的關鍵特徵,且可擴展至其他預測。

短期睡眠剝奪對小鼠免疫系統的影響

現代社會中,睡眠剝奪已成為普遍問題,人們對其對免疫系統及整體健康的負面影響愈加關注。本研究使用特製的旋轉鼠籠讓小鼠連續72小時保持清醒,探討急性睡眠剝奪對小鼠免疫反應的影響。研究發現NK細胞與脾臟中的記憶CD8 T細胞比例明顯減少,顯示細胞毒性功能受損或記憶免疫反應下降。與此同時,抗炎細胞因子的表達增加,而促炎細胞因子和相關基因的表達則有顯著下調。此外,雖然觀察到B細胞比例有所增加,這可能是免疫系統在細胞免疫功能受損時,維持免疫穩態的反應。這些發現揭示了睡眠剝奪可能抑制免疫系統造成損害。本研究強調適量睡眠對維持免疫平衡的重要性,並指出睡眠不足可能促進慢性免疫問題的發展。在此基礎上,後續研究可探討短期睡眠剝奪與腫瘤及免疫系統的關聯,並延伸至長期剝奪的影響。

法拉第波輔助合成奈米鎳並應用於有機污染物的快速脫色 Nanostructured Nickel Synthesized through Faraday Waves and Its Application to Rapid Contaminants Decolorization

超音波已廣泛用於奈米粒子的製備,然可聽聞音對奈米粒子製備的影響卻少有研究。本研究以簡易喇叭裝置產生可聽聞音並在溶液表面產生法拉第波及內部流動,來輔助製備奈米鎳。法拉第波是一種表面非線性駐波,透過調整容器形狀、振動頻率等,可產生不同波形。本研究嘗試在法拉第波輔助下,以化學還原法及電沉積法製備出不同性質的奈米粒子。SEM量測並比較無輔助、法拉第波輔助、超音波輔助製備出的奈米鎳的形貌、分布的差異。並將其應用於有機物(即剛果紅、亞甲藍、4-硝基苯酚、2-硝基苯酚)之催化還原。而由SEM量測、催化還原結果及理論模擬反應熱可知,法拉第波確實能夠改善奈米鎳的粒徑大小、分散性、對氫的吸附能力及催化還原能力。

YKT6與癌纖維母細胞的「泌」密關係

本研究以人類肺癌A549細胞株和纖維母細胞模擬體內腫瘤微環境,挖掘纖維母細胞如何促進癌細胞的生長。從病人的正常和癌組織提取癌相關纖維母細胞(cancer-associated fibroblasts, CAFs) 和 正常纖維母細胞(Normal Fibroblasts, NFs),經過基因序列一對對作分析,開發新的治療策略和潛在的靶點。利用核糖核酸定序(RNA-Seq)分析發現CAFs會比NFs分泌更多SNARE 蛋白 YKT6,而更深入地探究獲悉YKT6會透過活化YKT6+CAFs途徑促進肺癌A549細胞惡化,此惡化過程包括誘導及提升癌細胞的生殖(proliferation),轉移(migration)和入侵(invasion)能力。 此外,在 CAFs 中敲除 YKT6基因,減弱CAFs 的外泌體(exosome)釋放,從而調節了其對肺癌細胞A549的腫瘤促進作用。本研究發現靶向YKT6並抑制外泌體分泌,從而降低CAFs對肺腺癌細胞的腫瘤支援功能可以為肺癌治療提供一種新的策略。

「稻」出「鋁」想「充」能力

本研究利用農業廢棄物再加工後的-炭化稻殼,經食用醋處理後搭配環保防水明膠配方製成碳紙電極,作為可充式鋁電池的正極材料;負極則是在鋁箔上塗一層較環保無毒的PVA;電解液使用2M氯化鋁/0.1M食鹽水/5g醋酸鈉,吸附在濾紙上,成功製作出可充式「炭化稻殼紙/鋁電池」,充放電循環3次後,放電的初始開路電壓最高可達1.296V,初始短路電流可達137.1mA,串聯兩個電池後,成功使LED燈發光持續至少72天,亦可推動風扇在約4mA的工作電流下維持215分鐘。本作品多使用食品級的環保材料,較以往作品具有低汙染、低成本、超輕薄、可充電、可彎曲等多項優勢,充電後的穩定性更優於市售石墨片電極,可連續充放電至少5次,在進行穿刺實驗後更證實其安全性較鋰電池高,期待能為大型儲能系統添加一股永續環保的新契機。

Automated Alternative Compression/Traction of Lower Extremities AACT as a Musculoskeletal Countermeasure to Mitigate Bone Loss and Muscle Atrophy in Microgravity

Space Medicine and relevant sciences are still considered a new era; the first humankind steps toward the space took place since less than 60 years. It has been noticed the adverse effects of microgravity on the human body in different aspects, our concern here is the musculoskeletal aspect. On the ground we didn’t notice how we can stand up, or how our muscles and bones of the lower limbs can keep us standing up right. This is by a complicated process including the bones, the equilibrium, and the anti-gravitational muscles of the lower limbs which occurred without thinking about it. The force of Earth gravity against our bones of the lower limbs makes them harder and makes the muscles stronger, because they are interfacing the earth gravitational force every moment we are standing up, as per Newton’s third law (for every action in nature there is an equal and opposite reaction), such forces are unavailable in space and its effect being obvious on arrival to earth after long stay space flights, so being unable to keep standing upright easily on their arrival. On return to earth the routine medical examinations revealed loss of astronaut muscle mass and bone density particularly of their lower extremities because they did not use them in space for a long time. Currently, astronauts on board of ISS (International Space Station) they accomplish daily tasks including resistive exercises ARED “Advanced Resistive Exercise Device” in form of treadmill, ergometer, and weightlifting machine, to decrease the loss of bone density and muscle mass of their lower limbs. Despite their discipline to those exercises they still lose 1-2% of the muscle mass and bone density that give importance to add some protective measures to keep their muscles and bones healthy. Through this article, the idea is to make a device such AACT (Automated Alternative Compression/Traction) to be applied daily to the astronauts lower limbs as part of their daily exercise during space flight to give push/traction forces to astronauts lower limbs to prevent or at least decrease such loss, by AACT we are mimicking the gravitational force of earth on astounds lower limbs during long space flights to let them be healthy till they come back.