全國中小學科展

四等獎

樂器研究—雙音箱柳琴

雙音箱柳琴和單音箱柳琴的不同處在於雙音箱柳琴比單音箱柳琴多加裝了一個共鳴板。我們想要了解單音箱和雙音箱柳琴的結構、發聲原理的不同。首先測量單音箱柳琴的頻率。之後把面板取下,並沿琴緣加高五公分。再次測量加高後柳琴的頻譜,又分別測量有加裝直徑十公分和直徑十八公分的圓形共鳴板的頻譜。本實驗測量三種柳琴,單音箱柳琴、加高音箱的柳琴、雙音箱柳琴。整理過測量到的頻譜圖後,發現雙音箱柳琴比單音箱柳琴更容易產生高頻,在單音箱柳琴、加高音箱的柳琴、雙音箱柳琴這三種類型的柳琴中,只有雙音箱柳琴的高頻最為顯著。另外,十八公分的共鳴版比十公分的共鳴版更能在高頻達到共鳴效果,四條弦中一弦(最細弦)可以產生最高頻率、最大響度。透過此雙音箱柳琴的實驗,希望可以將其原理應用在其他弦樂器上。

What is the relationship between angular velocity and power efficiency of a twin blanded single rotor helicopter system, in hover?

A traditional helicopter requires 60 - 80% more power to hover than when in forward or lateral flight, making the manoeuvre extremely power inefficient. To maximise efficiency, industrially many properties of the helicopter and rotor have been changed and tested, for example: optimising blade shape, fuselage shape and changing weights of different helicopter components. This report in particular aims to find a relationship between power efficiency and angular velocity for a twin bladed hovering helicopter with a single rotor. The angular velocity of a blade measures the frequency of its revolution about a fixed point. A theoretical approach was first taken and then justified with empirical data. Firstly, a model for power efficiency was derived with William Froude’s momentum and blade element theory. The efficiency equations incorporated the thrust and power coefficients. Therefore, the research focused on determining values for these coefficients by manipulating equations, using industrial specifications and simulations from the XFOIL software. In order to validate the accuracy for such theoretically generated data, an experiment was conducted for a comparison. The theoretical and empirical data were concurrent, as they followed a similar trend and the empirical values overlapped within the theoretical error bars. The power efficiency for different angular velocities were then found by substituting values for the coefficients. The results demonstrated a positive relationship; where, as angular velocity increases, power efficiency increases too, then plateaus and repeats the same trend once again. The research raises many questions and could be extended by determining if a similar relationship exists for tri-copters and quadcopters.

Utilizing Computer Vision And Machine Learning Algorithms To Control Smart Systems Helping Physically Disabled People.

About 15% of the world's population lives with some form of disability, of whom 2-4% experience significant difficulties in functioning. The global disability prevalence is higher than previous WHO estimates, which date from the 1970s and suggested a figure of around 10%. This global estimate for disability is on the rise due to population ageing and the rapid spread of chronic diseases, as well as improvements in the methodologies used to measure disability. This research deals specifically with the physically disabled and often people with physical disabilities feel frustrated because they cannot do activities such as: playing sports and doing exercise. Having a physical disability also changes the way a person lives their life. They may find their life changes and activities they had previously included as part of their daily routine such as brushing their teeth, washing and doing household chores suddenly become a huge effort and many people require another person's help to carry out these activities. Also, they suffer from three basic challenges like; education, economic and, communication. Firstly, Education: The results of the investigation revealed that the physically handicapped. They face a lot of problems while studying they can't learn as the normal ones and they needs someone to help in learning. Secondly, Economic: they can't work and achieve income to help in his practical life. And finally Communication: they can't communicate with others because of his disability.

Development of a neurointerface glove with tactile feedback

Research Question or Engineering Problem A stroke continues to be the most important medical and social problem of the modern world. Stroke is a type of acute cerebrovascular accident (ACVA) and is characterised by a sudden (within minutes, less often - hours) appearance of focal neurological symptoms (motor, speech, sensory, coordinating, visual and other disorders) and / or general brain disorders (depression of consciousness, headache, vomiting, etc.) that persist for more than 24 hours or lead to death of the patient in a short period of time due to a cause of cerebrovascular origin. There are two clinical and pathogenetic forms of stroke: ishemic stroke (cerebral infarction) is caused by acute focal cerebral ischemia, leading to infarction (zone of ischemic necrosis) of the brain; hemorrhagic stroke (non-traumatic intracerebral hemorrhage) is caused by rupture of an intracerebral vessel and blood penetration into the brain parenchyma or rupture of an arterial aneurysm with subarachnoid hemorrhage (SAH). ACVA also includes transient disorders of cerebral circulation, characterised by the sudden occurrence of focal neurological symptoms that develop in a patient with cardiovascular disease (arterial hypertension, atherosclerosis, atrial fibrillation, vasculitis, etc.), last for several minutes, less often hours, but no more than 24 hours, and ends with a full restoration of the impaired brain functions. Transient disorders of cerebral circulation include: transient ischemic attack (TIA), which develops as a result of short-term local cerebral ischemia and is characterised by sudden transient neurological disorders with focal symptoms; hypertensive cerebral emergency, which is a condition associated with an acute (usually significant) rise in blood pressure (BP) and accompanied by the appearance of general cerebral (less often focal) neurological symptoms secondary to hypertension. The most severe form of hypertensive crisis is acute hypertensive encephalopathy, the basis of pathogenesis of which is cerebral edema. Cerebral infarction generally is the result of the interaction of many etiopathogenetic factors, which can be subdivided into local and systemic ones. Local factors include: morphological changes in the brachiocephalic or intracerebral arteries (pathological tortuosity, etc.), atherosclerotic lesions of the vessels of the aortic arch and cerebral arteries, cardiac lesions as a source of thromboembolic cerebral infarctions, fibromuscular dysplasias of the walls of the brachiocephalic and cerebral arteries, brachiocephalic artery dissection, vasculitis (arteritis), changes in the cervical spine with the formation of extravasal compression of the vertebral arteries, anomalies in the structure of the vessels of the neck and brain (hypoplasia of the vertebral artery, trifurcation of the internal carotid artery), etc. Systemic factors include: disorders of central and cerebral hemodynamics (a sharp change in BP or a decrease in cardiac output, etc.), hereditary and acquired coagulopathies, polycythemia, certain forms of leukemia, hypovolemia, psychoemotional stress / distress, etc., hypercoagulative / hyperaggregatory side effects of a number of medications (oral contraceptives, etc.). In the 俄羅斯n Federation, more than 500 thousand people have a stroke every year. About 25,000 new cases of stroke occur in St. Petersburg every year. The incidence of stroke in the 俄羅斯n Federation is 3.48 ± 0.21 cases per 1000 people. The incidence of various types of ACVA varies widely, in particular, cerebral infarctions account for 65–75%, hemorrhages (including subarachnoid hemorrhages) – 15–20%, transient cerebral circulation disorders account for 10–15%. The frequency of cerebral strokes in the population over 50–55 years old increases by 1.8–2 times in each subsequent decade of life. Medical and socio-economic consequences of ACVA are very significant, in particular, death in the acute period of stroke occurs in 34.6% cases, during the first year after the end of the acute period in 13.4% cases; severe disability with the need for constant care is present in 20.0% of stroke patients; 56.0% have limited working capacity and only 8.0% return to their previous work activity. Disability due to stroke (the national average is 56–81%) in our country ranks first among all causes of primary disability, amounting to 3.2 per 10 thousand people. Stroke mortality among working-age population has increased in the 俄羅斯n Federation by more than 30% over the past 10 years. The annual death rate from stroke in our country is 175 per 100 thousand people. Stroke annually becomes the main cause of disability: 85% of victims experience a decrease in strength or a complete lack of ability to control the muscles of half of the body and only half of them recover limb functions partially or completely; the rest of those who have suffered a stroke remain paralysed and require care, since they are not able to completely independent existence. In this regard, recently, in the process of rehabilitation, the technology of brain-computer interfaces (BCI) has begun to be actively used. on the basis of this technology exercise machines are created. These exercise machines are controlled directly by the patient himself. This feature of the technology increases the effect of the procedure by providing a direct connection between the patient's desire and effort with the work of the simulator. The greatest development of this technology is observed in the field of medicine, where BCIs are used as a means of communication or as one of the tools of neurorehabilitation. In this regard, it seems very promising to develop the most optimal brain-computer interfaces. The goal of our project was to create an automated training complex in the form of a neuro-controlled glove with tactile feedback, designed to simplify access to rehabilitation means.

熱休克蛋白Hspb7基因表現調控之探討

小分子熱休克蛋白 B7 (HSPB7,Heat shock protein B7),又稱心血管熱休克蛋白 (cvHsp)。HSPB7表現於心肌細胞當中也表現在骨骼肌當中。我們可以從再生的肌肉細胞中看到熱休克蛋白B7大量的表現,可見其對於損傷的肌肉細胞至關重要。此外,Mef2a (Myocyte-specific enhancer factor 2A) 被發現對於Hspb7基因表現有所影響且、屬於AP-1 (Activated Protein 1) 家族的c-Jun (Jun proto-oncogene) 和Fra-2 (Fos-related antigen 2) 被發現影響了肌肉發育和參與了骨骼肌衛星細胞群的調控。 本實驗在HEK-293T細胞當中將克隆出的Mef2a、c-Jun、Fra-2與Hspb7上游不同長度且帶有螢火蟲螢光素基因之啟動子進行轉染實驗,並藉由螢光素酶檢測法觀察彼此調控關係。本研究發現,c-Jun、Fra-2對於Hspb7基因表現有抑制的成效而Mef2a有增加基因表現的成效。

Cellular Effects of DNA Demethylation Enzyme TET2 Knockdown

近年來許多研究指出TET家族應是抑癌基因,然其許多抑癌機制卻尚未明瞭。根據本實驗室未發表的實驗結果,TET2表現量在大多乳癌檢體內較低,且TET2表現量低之病患存活率較差。本研究以Western Blot發現H3k4甲基化量在TET2 knockdown後減少。實驗室microarray結果更發現重要乳癌抑癌基因DKK1在TET2 knockdown後表現量下降。本研究以real-time PCR進一步證實DKK1表現量下降;Western Blot與ELISA結果也顯示DKK1蛋白質在細胞內及培養液中減少。細胞實驗更發現TET2 knockdown及DKK1 knockdown皆導致細胞有更顯著的移行(migration)與增生(proliferation)特性,因此推測DKK1可能為受TET2調控的下游基因。已知DKK1轉譯出之蛋白質能拮抗抑制Wnt/β-catenin傳遞路徑,因此本研究正在探討TET2是否也調控此Wnt路徑。如證實此假設,將可提出TET2操控DKK1,DKK1調控Wnt路徑,終而影響EMT、癌症轉移的路徑。

以二階段電壓/電流步進陽極處理法探討TiO2奈米管製備及應用

本實驗以二階段電壓/電流步進陽極處理法生長二氧化鈦奈米管,並找出最佳生長參數並能有效降解有機物。在實驗過程中,我們發現以氟化銨及有機醇類在形成二氧化鈦奈米管,有著較長管徑的效果。本驗以20 x 20 mm2大小的鈦片,透過鈦片的前處理,不同程序的氧化步驟及不同的醇類來探討二氧化鈦奈米管進行降解亞甲藍的效果,以及二氧化鈦奈米管其生長情形。結果發現以化學處理及陽極氧化處理過的鈦片,在0.6w%的氟化銨2ml的水及98%的乙二醇當作溶劑,以每分鐘調整1V直至50V在恆壓一小時的電壓步進法進行陽極處理,最後以450度進行退火,最後可得其二氧化鈦奈米管有最佳的降解效果。

MafF對LRH-1調控代謝機制之探討

已知 liver receptor homolog-1(LRH-1)掌控著多種生理功能,在肝臟代謝中扮演著相當重要的角色,我們利用酵母菌雙雜交技術(Yeast two-hybrid)找出數種可能跟LRH-1產生交互作用的蛋白質,並從其中選擇v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F (MafF)作為主要研究對象,探討其與LRH-1之間的作用對代謝造成的影響。本研究中,我們利用免疫沉澱法證實MafF可與LRH-1形成複合體,而MafF並不影響LRH-1蛋白的表現量。隨後以啟動子活性檢測MafF-LRH-1複合體在細胞內之功能,發現MafF能促進由LRH-1所調控的small heterodimer partner (SHP)、glucokinase IV (Gck)及side chain cleavage enzyme (SCC)等代謝相關啟動子之活性。此外我們以GST-pull down發現MafF與LRH-1結合區域位於LRH-1的DNA 鍵結位(DBD)。LRH-1則是僅與具有完整basic region (BR)以及leucine zipper (LZ) 兩個domain的MafF產生交互作用,單獨的BR以及LZ無法與LRH-1結合。另外,在肝臟細胞株HepG2中過度表現Myc-MafF,Western blot結果發現GCK有減少的趨勢,SHP則是有增加的現象,而LRH-1亦呈現增多的趨勢。Real-time PCR結果,比對Myc以及Myc-MafF,發現MafF存在時會使LRH-1以及GCK mRNA含量較控制組Myc有減少的趨勢,對SHP mRNA 則是沒有顯著影響。此外,我們在肝臟細胞株HepG2中加入胰島素,發現二者表現量皆有明顯的增加,說明胰島素刺激之下,MafF以及LRH-1蛋白質增加能夠增強肝臟能量代謝。

Schaubcylindrichnus生痕化石化學分析與生成環境探討

根據在北海岸地質考察所觀察到生痕化石種類分布,大部分生痕化石生成於濱海帶,可以推測大寮層及南港層在尚未抬升時,沉積於濱海帶的砂層沉積。另外,石底層雖然同為海相,但屬於海退時期,生物活動區域相對於海進時期較為深,因此生痕化石數量較少。將地質考察採集到Schaubcylindrichnus進行初步的外形觀察,推測其為S.coronus型態以及S.formosus型態,並將Schaubcylindrichnus與Ophiomorpha製成薄片進行比較,發現Schaubcylindrichnus與Ophiomorpha都是由石英與有機物組成,但Schaubcylindrichnus的顆粒比Ophiomorpha小且較為密集,而在Schaubcylindrichnus與Ophiomorpha中,管壁中與管壁內外的有機物含量有明顯差異,Schaubcylindrichnus管壁中的有機物較管壁內外少,而Ophiomorpha管壁中比較多,且可以發現大塊有機物包裹數塊石英的壁襯結構。

太陽軌跡在車輛儲能之創新研究

本研究探討太陽軌跡在車輛儲能之創新應用,使得太陽電池以簡單的方法得到最大的吸收能量。首先,利用Stellarium免費天文軟體,完成一個太陽電池最佳方位角與仰角的計算公式,基於光學與鏡面反射原理之瞭解,提出全新的鏡面最佳轉角定理,使鏡面反射之轉角得以迅速精確計算。本文引入GPS衛星定位功能,將這個太陽電池能量追蹤方法,由靜態的的地面應用,推展到動態的車輛應用。最後,由本實驗結果顯示,利用本文提出的創新研究,與單純平放太陽電池之儲能作法比較,若將反射鏡或者太陽電池隨時對準最佳方位角與仰角,可以獲得多出20 %〜52 % 的免費能量!