動脈硬化是個致病率和致死率相當高的慢性發炎疾病，為台灣十大死因之一。在病理過程中血中濃度過高的膽固醇為動脈硬化的一大危險因子，其會誘發一連串的發炎反應驅使血管壁內皮細胞功能喪失，血壓上升，平滑肌細胞增生等。Statin 是臨床上十分有效的降血脂藥物，雖然其作用機制已知在於抑制膽固醇合成酵素 HMG-CoA reductase 而有降血脂功效，但近年來探討 statin 在抗發炎方面的作用也漸受重視。nitric oxide synthase (NOS) 代謝產物如 nitric oxide (NO)，cyclooxygenase (COX) 代謝產物如 prostaglandin (PGE?、PGI?)，及 heme oxygenase-1 (HO-1) 代謝產物如 carbon monoxide (CO)，均有文獻指出可以改善血流，而可能在動脈硬化上扮演保護角色。相反的，matrix metalloproteinase (MMP) 的表現會誘使更多的免疫細胞浸潤到血管壁，並增加動脈硬化斑破裂，引起栓塞和中風的發生。在此實驗中，我們利用培養的大鼠主動脈血管平滑肌細胞作為研究材料，發現了 statin (lovastatin 、pravastatin、atorvastatin 、fluvastatin) 具有一些和降血脂無關的直接保護血管壁能力。包括會增加 interleukin-1β (IL-1β) 所誘導 iNOS 蛋白的表現及NO 的產生; statin 本身會增加 COX-2 和 HO-1 蛋白的表現及 PGE? 和PGI? 的產生，及抑制 MMP-2 和 MMP-9 蛋白活性的表現。此外分析調控 iNOS 基因轉錄最為關鍵的基因轉錄因子 NF-κB，發現適量的 statin 會增加 IL-1β 活化NF-κB 的作用。值得一提的是雖然適量 NO 有維持血管恆定的功能，過量時則會造成血壓過低休克的現象，這就是細菌感染後因內毒素 lipopolysaccharide (LPS) 作用引發敗血性休克的主要原因之一。為更進一步釐清 statin 是否會影響受細菌感染病人的生命危險，我們也探討 statin 對LPS 作用的影響。結果發現 statin 反而會抑制 LPS 誘導大量 iNOS 蛋白的表現，NO 的產生及 NF-κB 的活化。這些新的實驗結果提供更多證據支持 statin 可以藉由維持血管舒張，減緩血管壁的發炎反應，穩定動脈硬化斑的作用，以有效控制動脈硬化各個病程的進展。這發現能讓我們更透徹明白 statin 的作用，且對將來研發 statin 在心血管疾病方面新的臨床治療用途是有所助益的。 ;The 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, statins, are potent inhibitors of cholesterol synthesis and have wide therapeutic use in cardiovascular diseases. Recent evidence, however, suggests that the beneficial effects of statins may extend beyond their action on serum cholesterol levels. In this study, we investigated the effects of lovastatin, pravastatin, atorvastatin, and fluvastatin on cultured rat vascular smooth muscle cells. We found statins can inhibit LPS-induced iNOS expression and NO production, while they can potentiate IL-1β-elicited responses. Moreover, statins themselves can stimulate COX-2 expression, PGE?, PGI? formation, and HO-1 induction. In contrast, statins can inhibit basal and IL-1β-induced enzyme activities of MMP-9 and MMP-2. In studying the activity of NF-κB, which plays an important role for iNOS gene induction, we found that statin can increase IL-1β-induced NF-κB activity, while inhibit that induced by LPS. All these results suggest that stimulation of iNOS expression in the presence of IL-1β, togeth1er with the increased COX-2 and HO-1 expression might contribute to the beneficial effects of statins in atherosclerotic process in terms of vasodilation and inhibition of smooth muscle cell proliferation. The inhibition of MMP activity might enhance plaque stability and reduce the development of atherosclerosis. All these results strengthen the pleiotropic actions of statins in anti-inflammation and anti-atherosclerosis.

Now Artificial Neural Networks using on the basic math is fewer. This paper is to suggest the Linear equation of the basic math using the BP Artificial Neural Networks. The BP Neural Networks have power ability for learning and can approximate any function, and regularity can be found to solve the linear equation. A good sample is one of the important elements for learning of Artificial Neural Networks. Generally, the samples are a lot of amount for the resolution of Linear equation. This paper is to use the principle of two points decide one line for the samples. The experiment shows that this method curtails many samples. Furthermore we also use Artificial Neural Networks to solve the problem of point-slope form. The experiment result is very satisfactory, and it offers some idea for the basic math using Artificial Neural Networks.目前人工神經網路較少用於基礎數學方面的求解，本文針對基礎數學直線方程式提出BP 人工神經網路應用於求解直線方程式，運用其很強的學習能力、(輸入向量和其對應的目標向量來訓練網路、逼近函數)，尋求規律來求解直線方程式；而良好的樣本是人工神經網路學習的重要條件之一，一般解決直線方程式需要大量樣本，本文利用二點決定一直線的原理來解決樣本問題，實驗結果顯示，這一方法成功的縮短了可觀的學習樣本，此外我們也運用BP 人工神經網路來求解點斜式的直線方程式問題，實驗結果是可行的，並且為人工神經網路用於基礎數學提供了一些思考方向。

打開水龍頭，水鉛直落到正下方的水平板時形成圓形水躍。我們實驗研究20＜Nr＜150 的低雷諾數圓形水躍的變因，探討圓形水躍半徑和流量、出水口高度、以及液體黏滯係數間的關係。改用高黏滯係數的液體（4：1 的乙二醇水溶液），鉛直落入板上方深h 的相同液體時，先形成圓形，h 漸大時形成環形圓紋曲面，再加大h，形成多邊形水躍，內外圍同方向旋轉，轉速ω；液中加水，黏滯係數高於及低於某定值，多邊形都消失，側面觀察，外圍液體作鉛直面旋轉。將水平板改置於旋轉盤上方，使高黏滯係數（4：1）的乙二醇水溶液鉛直落入板上方形成多邊水躍，逐漸加快旋轉盤的轉速至 ω 時，多邊形都消失；逐漸減少乙二醇的濃度，至完全用水實驗，亦有多邊形出現，我們認為；平板上方的液體的轉動是非圓形水躍的成因。When a jet of water falls vertically on to a horizontal plate, it spreads out rapidly in a thin layer until it reaches a critical radius at which the layer depth increases abruptly. This phenomenon commonly called the circular hydraulic jump. We study the variations of the circular hydraulic jump radius, as a function of volume flow rate of the jet, the drop height, and the viscosity of the fluid at low Reynold numbers (20＜Nr＜150). When a jet of ethylene-glycol mixed with water (the kinetic viscosity is 10 times of water) falls on to a horizontal plate which is immersed in the same liquid with height h. We find the circular state frequently undergoes spontaneous breaking at its axial symmetry into a stationary polygonal shape. Rather than displaying the weak angular deformation generally seen in fluids, the jump forms clear corners and edges that are often straight. Several of these polygon formations show consistency in height h. And we find the polygon structure rotates in a horizontal motion. When a jet of water falls on to a horizontal plate, and the plate is rotated by a motor ,we find the axial symmetry of the free surface of circular hydraulic jump is spontaneously broken a various number of cornered polygonal shapes. We study the number of corners as a result of the volume flow rate of the jet, the drop height and the viscosity of the fluid in the experiment. And the frequency of rotation of the plate is taking into consideration.

Based on environmental protection and new energy development, the energy containing low pollution and having high efficiency becomes more popular. The fuel cell is an emerging technology, which is the reason why it is considered as Green energy. However, high-price membrane electrode assembly (MEA) inhabits the development of fuel cell. Among these components in MEA, platinum-based electrode leads the most cost. We select the multi-walled carbon nanotubes (MWNTs) as catalyst support to improve electrode material performance and reduce Pt utilization. But the particle size and dispersion of platinum as well as character of catalyst support may significantly affect the efficiency of electrode.燃料電池因為具備低排放污染、低噪音及高轉換效率等環保特性，故被稱為綠色能源，可取代內燃機作為發電之能源系統。然而燃料電池中觸媒粒徑大小、分散情形以及使用不同的觸媒載體，均有可能會影響其電觸媒的催化效能，所以我們以「觸媒粒徑大小」、「觸媒分散情形」為主軸，著手以下的研究。本實驗在不同的酸鹼值下製備燃料電池的電極材料，並以電子顯微鏡等器材，觀察已披覆在電極上白金觸媒的特性，探討不同酸鹼環境對白金觸媒粒徑大小的影響，並探究白金觸媒粒徑大小與其發電效率的關係。

六種自行合成出來的聯吡啶釕錯合物Ru(bpy)₃、Ru(bpy)₂(phen) 、 Ru(bpy)₂dcbpy、Ru(phen)₃、Ru(phen)₂(bpy)、Ru(phen)₂dcbpy 及商用染料N3-dye，被成功的做成光敏性太陽能電池。光電流的產生率可由IPCE (incident photon-to-current conversion efficiency) 的測量可知。此類釕錯合物可以物理吸附或化學鍵結於TiO₂奈米粒子上。IPCE 的大小可以用來探討不同吸附方式的釕錯合物轉換光電流的效率。在物理吸附上Ru(phen)₂(bpy)的效率最好。化學鍵結的以N3 Dye 最好，我們合成的錯合物以Ru(bpy)₂dcbpy 較佳。此種以TiO₂奈米結構為承載基材的太陽能光電池(Dye-Sensitized Solar Cell)，染料仍以商用染料 N3-dye 最佳。本研究發現物理吸附的Ru complexes 也可產生光電流，若能最佳化，將可簡化染料錯合物之合成。 Six ruthenium complexes, Ru(bpy)₃, Ru(bpy)₂(phen), Ru(bpy)₂dcbpy, Ru(phen)₃, Ru(phen)₂(bpy), and Ru(phen)₂dcbpy were synthesized. These Ru complexes and N3 dye have been incorporated into the dye-sensitized solar cell system. The solar energy conversion of the ruthenium complexes were measured and converted to IPCE (incident photon-to-current conversion efficiency). There complexes were either chemically bonded or physically absorbed onto the nano-sized TiO₂ particles. The IPCE were utilized to compare the photon-to-current efficiency of these Ru complexes. Among the physical-absorbed dyes, Ru(phen)₂(bpy) has the highest IPCE. For chemical-absorbed dyes, the commercial N3 dye is still the best. Among the complexes synthesized in this research that are chemical-absorbed, Ru(phen)₂dcbpy has the highest IPCE The commercial N3 dye has the highest IPCE in the dye-sensitized TiO₂nanoparticle solar cell. We found that physically absorbed dye can convert photon to current. With better solar cell assembly, physically absorbed dye can have the same conversion efficiency as N3 dye.

In this research we derived heating effects on anti-oxidation by optical rotation analyses. A simple and accurate Polarimeter was devised with polar screens, laser, and photo resistor; the laser was used for light source, and the photo resistor for detection. Four kind of fruits, Hyloceeus polyrhizus, California plum, kiwi and tomato were experimented by heating them in boiling water and microwave oven. Their optical rotations versus time duration were calculated. Then we used ABTS/ the H2O2/HRP analysis system from Arnao's research to obtain the heating effects on anti-oxidation by calculating the vitamin C densities versus lag time. We found that there was a tendency of increased anti-oxidation at the beginning by heating, but decreased afterwards. Better oxidation was achieved by using microwave for Hyloceeus polyrhizus, by using boiling water for kiwi and tomato, and by using both methods for California plum. The same tendency was also found in the optical rotation analyses. Therefore we successfully developed a new method to measure the antioxidant activities by the optical rotation. We can also apply this method to simulate the fruit digestion process in the stomach, which let us understand further about anti-oxidation ( or optical rotation ) versus time. 本研究利用偏振片、雷射光為光源、光敏電阻為偵測器，組裝成一個簡易且精確的旋光度計。 我們利用此旋光度計對奇異果、火龍果、聖女蕃茄、加州李子四種水果以微波、水煮及油浴三種方式來處理，求出水果的旋光度與熱處理時間的關係。再藉由Arnao 研究的ABTS/ H2O2/HRP 分析系統，以不同濃度的維生素C與延遲時間畫圖作為標準曲線來測量總抗氧化活性，並比較熱處理後抗氧化活性的變化趨勢。 透過本研究可以了解不同熱處理方式對四種水果之抗氧化活性初期皆有增加的趨勢，但隨著時間增長則抗氧化活性降低。其中奇異果與聖女蕃茄用油浴，火龍果用微波處理，加州李子則是用任何熱處理方式均可得較佳的抗氧化活性，而熱處理後在旋光度測量上也有相同的趨勢。因為此兩種方法有一致的反應趨勢，所以證明我們成功地開發出一種可以利用旋光度來測定抗氧化的新方法。 最後，應用本方法進一步模擬水果在胃部裡的消化，讓我們更可以了解在整個消化的過程中抗氧化活性(旋光度)隨時間變化的情形。

秀麗隱桿線蟲(Caenorhabditis elegans)為在科學界備受矚目的模式生物，對於其生殖及發育過程已有諸多研究，然而對於其覓食及攝食行為的相關研究卻仍闕如；每一種生物都有其獨特的行為模式，而為了解線蟲發展出何種覓食與攝食的行為以適應自然的環境，因此著手進行研究。本研究歸納出線蟲的七種一般行為：前進、探頭、偏移、擺頭、後退、轉向及拐彎行為，並探討其意義。其中，前進及探頭行為為恆常出現。偏移與轉向行為與攝食有關，在有菌環境中出現，可避免其遠離食物來源，而連續的後退及轉向行為也構成特殊行為之樹枝狀行為，推測應為幫助線蟲的消化所出現的行為。擺頭與拐彎行為與覓食有關，在無菌環境中出現。後退行為雖在有無菌環境中皆出現，但由後退後行為的不同可以了解後退行為在兩種環境下具有不同意義。在有菌環境中，後退後通常伴隨轉向行為；在無菌環境中，後退後通常伴隨拐彎行為，為逃離不適環境且藉以覓食的行為。經過研究，發現線蟲的覓食機制為嗅覺，且對嗅覺有依賴性及專一性，在其他氣味存在的環境下會大大降低覓食的效率，但最後仍然能正確地找到食物來源。線蟲於覓食的過程中所出現的特殊行為之混亂行為，由實驗結果發現為是E. coli 所釋放至培養基的化學物質所造成，化學物質濃度越濃，線蟲所表現出的混亂行為就越明顯。推測此種現象發生的原因，應為E. coli 釋放化學物質以干擾線蟲，以避免本身受到捕食，然而，線蟲也演化出適應的能力，因此在發生混亂行為後仍然能抵達菌落，此種特殊的交互作用表現出線蟲與E. coli 間的共演化現象。Cenorhabditis elegans has long been a model organism used for developmental biology studies. However, researches about its foraging and feeding behaviors are still limited. Every organism has its unique behaviors, and this research was conducted in order to understand more on what kind of foraging and feeding behaviors were developed by C. elegans and how they helped C. elegans to adapt to the environment in which it lives. The research concluded with seven general behaviors of C. elegans : advancing, probing, slanting, swaying, backing, turning and bending, and the meanings of it. The advancing and probing behaviors are constant. The slanting and turning behaviors, which appear in presence of food, are feeding-associated behaviors, which help C. elegans avoid leaving the food source. Continuous backing and turning behaviors also make up the branching behavior, one of the special behaviors, which help C. elegans’ digestion. Swaying and bending behaviors, which appear in absence of food, are foraging-associated behaviors. Although backing behavior appear both in presence and absence of food, the difference in post-backing behaviors show that there are distinct meanings of backing behavior in each environment. In presence of food, turning after backing is usually observed; in absence of food, bending after backing is usually observed, which indicates the act of escaping from unsuitable environment and searching for food. Studies show that the foraging mechanism of C. elegans is by olfaction, and C. elegans is highly olfaction-dependent and specific: efficiency of foraging decreases significantly under environment with scents other than that of E. coli, but C. elegans is still able to locate the food. According the experiments, the chaos behavior, one of the special behaviors, appears during the foraging process of C. elegans, and is caused by chemicals released to the medium by E. coli. The density of the chemicals and the extent of chaos behavior is in direct proportion. The theory is E. coli secrets chemicals to disturb the worm to avoid being preyed upon. C. elegans, however, also evolved the ability to adapt to the chemical so that it can still reaches the food source even after chaos behavior appeared. This unique interaction is a manifestation of co-evolution between C. elegans and E. coli.

能源之獲得為當今半導體科技要突破所必須克服的課題，尤其須顧及到環保之要求。所以太陽能之研究及使用已經越趨重要之地位。本實驗用天然的染色子（葉綠素 A 及亞甲藍）當作觸媒劑加在自行研製的太陽電池薄膜： Cul /光敏物質/TiO? P-N型結構。光敏物質／ CuI/ Cu plate P-型結構。 光敏物質TiO?/ SnO?/glaaa N-型結構。不同層次薄膜分別是以溶膠凝膠法及化學沉積法將 TIO?及CuI長在玻璃甚板、鋼基板及 TIO?薄膜上。本實驗的太陽電池薄膜生長速率極其穩定 ( Cul : 0 . 25um/hr , TIO? :2um/hr) ，薄膜照光電壓 0 .01~0 .1V ，照光電流 0 . 030~0 . 050 mA/cm2。

高分子發光二極體乃是利用電子和電洞在發光工作層結合而形成激子，激子在形成後隨即以光的形式衰退，而發出光來。一般而言，高分子發光二極體是一種三明治的形式，電子注入層/發光工作層(高分子)/電動注入層，而通常我們會選擇加入電子傳遞層和電動傳遞層，來增加其發光效果。本研究係針對聚苯胺做為電洞傳遞層對發光二極體之影響，分別對有電洞傳遞曾和無電洞傳遞層之發光二極體作導電度測量、循環伏安法、電位-電流測量、亮度-電位測量。發光二極體中所須之高分子層，須利用旋轉塗佈機，將其均勻的披覆在載體上，由於本校並無此儀器，所以將離心機改造成簡易旋轉塗佈機，並觀察其披附之效果。另外，在封裝元件時，係因學校缺乏真空蒸鍍的儀器，所以將利用電鍍法把鋅鍍在ITO玻璃上，或將鋁片和ITO玻璃緊靠在一起，針對此二替代方法，本研究將探討其所製出原件成效。Polymer light emitting diode (PLED) utilizes the energy gap between the layer of electron and electric hole that emits the light due to the decay of solitron. PLED is always in the sandwich from, that means the conducting polymer is contained between metal as an cathode and indium tin oxide as an anode. It is used the addition of another electric transfer layer and electric hole transfer layer to improve the lighting efficiency of PLED. The purposes of this study are to discuss the effect of polyaniline as the electric hole transfer layer. The study methods are conductivity measure, the cyclic voltametry, the luminance-voltage curve. The simplified spin coating machine was designed to coat the polymer onto the ITO. The zinc was electroplated onto the graphite as an cathode.

通常使用隔熱材料可以降低熱量傳遞，而使用風扇、散熱片、熱導管等用來單向散熱。但如何在一個系統上同時滿足隔熱和雙向傳熱的需求呢？因此我研究設計了仿生智慧型熱控制系統，能隨環境改變而快速轉變成隔熱或轉變成雙向傳熱並控制熱傳遞的方向及大小，這可以應用在房屋、汽車、恆溫系統等。我先自製了自動傳熱量測系統，測試並找出好的隔熱和傳熱材料及構造。為了能快速控制熱的方向及大小，我又發展了第一代替換式、第二代熱柵式和第三代熱管式熱控制系統；經過多次實驗，利用低沸點有機溶劑和控制系統，我成功地完成仿生智慧型熱控制系統，讓熱隔絕或快速流進流出，比傳統的方法改進很多，也達到節約能源的目的。Insulation materials are usually used to reduce heat transfer rate, while fans, radiators and heat pipes are applied to increase heat transfer rate and bring heat away. But is it possible to have both functions of insulation and heat transfer together in a single system? This research is to design and develop an intelligent heat control system, with both function of insulation and function of transferring heat together. Besides, this system can control the direction and amount of heat transferred. Such a system can be applied in house walls, cars, thermostatic system, etc. I developed an automatic heat measurement system which was used to test the properties of heat transfer for different materials and structures. Three generations of intelligent bi-directional automatic heat control system were then developed to get fast heat transfer and function of heat control. They were phase 1 replacing-type system, phase 2 heat-grating system, and phase 3 heat-pipe system. After tens of experiments, I successfully control the amount and rate of heat transfer via low-boiling-point organic solutions and controller. The designed system is bi-directional, and is more innovative and efficient than conventional uni-directional heat control methods. Besides, this system also has huge contribution in reducing energy consumption.