全國中小學科展

化學

透過超音波敏感性聚合物膠束達成藥物投遞減少根管治療癒後復發的應用

藥物釋放技術被普遍使用在臨床醫學以及人體攝影,本研究將合成具有超音波敏感之兩親性聚合物,水溶液中自組裝形成聚合物膠束,內部裝載藥物,經輸送到特定部位以超音波刺激,進行藥物釋放。在特定部位釋放的特性使藥物可以在特定區域釋放。 本實驗是因應牙醫進行根管治療時,消炎藥物容易被血清分解,因此,我們希望設計出適當的高分子藥物載體。當藥物到達牙根管時,利用聚焦式超音波(HIFU)進行刺激投放,載體分解後,藥物順利到達患部,進行治療。 經文獻蒐集,我們選定 PEG-b-PTHPMA (polyethylene glycol block 2- tetrahydropyranylmethacrylate)以及 PEG-b-PIBMA(polyethyleneglycol-block- iso- butyl methacrylate)作為載體包覆藥物之高分子材料,利用其具有雙親性高分子的特性,在水溶液中自組裝成高分子膠束。經透析純化後,透過 DLS 與 SEM鑑定此高分子膠束之粒徑大小。同時也以 NMR氫譜與 GPC鑑定該高分子純度與分子量分布。

以磁鄰近誘發非傳統超導

本研究以熱蒸鍍法製作 31 nm Sn 顆粒以及 15% Sn 被 Ni 取代的 38 nm Sn85Ni15 顆粒,探討奈米化及磁鄰近(magnetic proximity)共同引發的非傳統超導行為。分析 X 光繞射譜圖所得電子密度分布,顯示添加 Ni 引發部分內層電子轉移到鍵結區域。磁矩量測顯示 31 nm Sn 在300 K 仍具鐵磁性,而 38 nm Sn85Ni15 的磁矩是 31 nm Sn 的 3 倍之多,指出所添加的 Ni 確實提供較高磁分量,在 Sn 離子鄰近提供一區域磁場,誘發磁鄰近效應。38 nm Sn85Ni15 的超導溫度大幅提升到 7.75 K 為塊材 Sn 超導溫度 3.72K 的 2.1 倍,且外加磁場對弱化超導溫度的效率,在 200 Oe 出現大幅轉折,高於 200 Oe 對超導溫度幾乎沒有影響,出現拒磁及容磁兩種超導行為。這些行為可以用顆粒內層為 s-波(s-wave)超導耦合及外層為非 s 波(non-s-wave) 超導耦合來理解。

苧麻線微流體應用於工業廢水全範圍濃度量測

以台灣常見的植物”苧麻”所製之纖維線作為線微流體應用,開發出低成本、操作便利、量測信度高的工廠汙染物濃度判斷用模組。以線微流體進行了 鉛離子、銅離子、硫氰根、磷酸根,亞甲藍及剛果紅的濃度量測。這些經常於 工業製程上或是紡織業所產生的汙染源,透過線微流體分析,檢測濃度最高可 由 2.0g/L 到最低 0.4g/L,且獲得判定係數(R2)達 0.98 以上完整的檢量線,該模組可以進行相當準確的汙染源濃度檢測。此外,本研究也探討苧麻線微流體 在不同的待測物上所呈現的各種數值回歸。除了有線性回歸之外,亦發現也有 對數回歸。透過黏度的實驗,來探討微流體濃度與層析長度之間的關聯性,可 快速建立待測物檢測檢量線是否存在的方法。

開發組織蛋白酶B之抑制劑前驅藥物及其效能探究

在某些癌症或癌前病變時,存在於溶酶體的組織蛋白酶 B的表現量會增加,目前雖然已有Ac-LVK-CHO藥物可有效抑制組織蛋白酶 B,然而此藥物無法充分進入溶酶體,精準發揮藥效作用。本研究透過自行合成 Ac-LVK-CHO,且在其結構上進行化學修飾,製得前驅藥物以提升藥物效能。此研究自行設計合成方法與修飾基團,已成功在Ac-LVK-CHO 的胺基修飾上引導基團 morpholine,使其更易進入溶酶體,同時也在醛基修飾上光解性保護基團 2- nitrobenzyl alcohol,使此前驅藥物在溶酶體內可經調控發揮活性。實驗已驗證前驅藥物的光解性質,以HPLC 圖譜與質譜分析確認此藥物照光 30 秒可完全被釋放,且光解過程為一級反應。後續將統整前驅藥物富集於溶酶體的定量結果,完成此合成前驅藥物的全面性效能評估。

探討電漿沉積六甲基二矽氮烷與四氟化碳對材料疏水性與抗腐蝕性之影響

生醫材料的開發與應用,現今佔有極重要的地位,但以金屬製的生醫材料而言,仍有植入人體內,被體液腐蝕或氧化的問題。本研究希望藉由高分子薄膜沉積與基材表面處理兩種方式,使金屬醫材能夠抵抗腐蝕,以延長使用年限。 本研究比較以真空電漿系統分別沉積六甲基二矽氮烷 (HMDSZ) 薄膜與使用四氟化碳 (CF4) 處理基材後,對不鏽鋼基材表面之抗腐蝕性和疏水性的影響;並找出使基材表面具較佳抗腐蝕性的工作條件。實驗結果中發現:(1) 在單體壓力為 60mtorr、功率為 30W的電漿參數下,沉積 HMDSZ薄膜 30分鐘,具較佳抗腐蝕效果與疏水性;(2)在沉積後 21天內,HMDSZ薄膜置於室溫時間越長,其抗腐蝕效果越佳;(3)CF4表面處理可能造成蝕刻或沉積,實驗中尚未找到可增加疏水性與抗腐蝕性之參數。

青出於藍,勝於藍

本實驗利用不同的還原劑,分別為檸檬酸鈉、蘋果酸鈉及酒石酸鉀鈉與氯化鐵及赤血鹽反應時,利用日光燈及LED燈即可驅動藍晒反應進行,不需像傳統的藍晒反應需照紫外光才可使反應進行,達到安全、便宜且不受天氣限制的實驗改良。在改變不同還原劑種類,及還原劑與氯化鐵比例時,發現還原劑、氯化鐵和赤血鹽混合的順序、有無加熱、及照光的燈源種類會影響藍晒圖、反應速率及吸收度大小。

利用碳酸鉀作為觸媒對於甲醇解聚聚碳酸酯效能之探討

聚碳酸酯(PC)是一種具有多種用途的材料,廣泛應用在包裝、航空、製作容器等方面,但難以利用常見的方法如燃燒、掩埋等方式回收。 根據本研究結果,利用K2CO3作為異相觸媒,在60℃的溫度下,反應1小時後,成功地轉化出聚碳酸酯(PC)的單體雙酚A(BPA),PC的轉化率可達100%,BPA的產率可達 99.57%。提供了業界一個相較於其它傳統PC解聚法,得以在較低的溫度、較短的反應時間下,利用簡易裝置,即可使甲醇分解聚碳酸酯(PC)的效率高達100%之方法,且相較於傳統同相觸媒解聚法,異相觸媒K2CO3在反應後可以相當輕易的與產物分離並重複利用,因此本研究提供了一種高效率且對環境更友善且更符合綠色化學的聚碳酸酯(PC)回收方法。

利用水凝膠進行亞硝酸鹽的檢測

亞硝酸鹽與對胺基苯甲酸 (4-Aminobenzoicacid, PABA)反應生成重氮化合物,並與 N-(1- 萘基) 乙二胺二鹽酸鹽 (N-(1-Naphthyl)-1,2-ethanediamine dihydrochloride, NED) 進行偶聯反應,進一步生成紫色、褐色的化合物,使水凝膠的表面從無色轉變成化合物的顏色。隨著亞硝酸鹽濃度的改變,水凝膠成色的效果也會有所不同,這也導致了其表面灰階的變化。重氮化偶聯反應可用於亞硝酸鹽的比色測定,亦被證明可用於實際水樣本中的亞硝酸鹽檢測。

Development of a nano-filtration membrane using different linear aliphatic amines and linear cross-linkers for purification of expensive and precious organic solvents

Theseparation, purification, and recovery of precious organic solvents is a huge challenge for many industriesincludingpetroleumandpharmaceuticalcompanies,sincethesecompaniesusehugequantities of organic solvents [1-2]. Natural dissolvable nanofiltration(ON)has atremendous potential for supplantingafewenergy-concentratedcrudepurgingtechniques,similartorefiningandextraction[3-4- 5]. The importance of OSN is obvious from the fact that one cubic meter of methanol requires 1750 MJ of energy for distillation since the process of distillation is comprised of heating, evaporation, and condensation while OSN can purify the same volume of methanol by consuming 3 MJ of energy [6-7]. Additionally, OSN is a useful technology since it is simpler to use than conventional purification and separationmethods.Themembrane'sporestructure,whichinfluencesbothitsselectivityandpermeance, hasasignificantimpactonhowwellthemembranesperform[8-9].Ingeneral,thetrade-offbetweenflux andselectivityaffectsthemembrane'sperformance.Asaresult,themembranes'fluxandpermeabilityare affectedbythetailoringandtuningoftheirporestructure.Therefore,designinganefficientnanofiltration membranes with ideal porosity is highly desirable. Interfacial polymerization (IP) is highly versatile as it provides a freedom of selection of various monomersfortargetingaspecificapplicationsuchasnanofiltrationandreverseosmosisThepotentialfor organicsolventnanofiltration(ON)toreplacevariousenergy-intensivetraditionalpurificationtechniques, suchasdistillationandextraction,isenormous.[8-9].Despitethefactthatmanydifferentmonomershave been successfully used by utilizing IP to create thin film composite nanofiltration TFC-NF membranes, one of the main limitations of such membranes continues to be the poor selection of closely related comparable nanometer sized solutes. Many efforts are still being made to develop potential monomers with the perfect properties for creating membranes that operate excellently [10-11]. Another strategy is also getting more popular in which different porous additives are added to the TFC membrane either at thesupportleveloractivelayerlevel.Theseadditivesincludecarbonorganicframeworks(COFs),metal organic frameworks (MOFs), hyper-cross-linked porous polymers (HCPs), and natural polymers such as chitosan[12-13-14-15]. However,maintainingthecrystallinity ofsuch additives,particularlyMOFsthat lead to crystalline membranes, is extremely difficult while other additions suffer from aggregation and agglomeration that results in membrane flaws that impair the performance of the membranes [16]. Therefore,changingthechemistryofthereacting monomerduringIPcansignificantlyalterthestructure of the resultant active layers of the membranes. The current study was carried out by using linear aliphatic amines 4A-3P and 4A on a crosslinked PAN support. The study was carried out through interfacial polymerization between either 4A-3P and TPC or 4A and TPC on crosslinked PAN. In comparison to the previous studies where cyclic amines such as piperazine or aromatic amines such as meta-phenylenediamine (MPD) are used, we have used linear aliphatic amines 4A and 4A-3P crosslinked with organic phase containing terephthaloyl chloride (TPC) asacross-linker.TheIPreactionwascarriedoutbetweenamineandTPConacrosslinkedPANsupport. The fabricated membrane was extensively characterized by using scanning electron microscope (SEM), ATR-FTIR, water contact angle (WCA), energy dispersive X-ray (EDX) and elemental mapping . The fabricated membrane was used for OSN applications by using dead-end filtration setup.

Observation of volcanic gases with a simple alkaline filter paper method at Sakurajima Volcano in Kagoshima, Japan.

There are many active volcanoes in Kagoshima Prefecture, including Sakurajima Volcano. So, the volcanic disaster prevention is an urgent issue. Also, Hirabayashi of Tokyo Institute of Technology reported that the molar ratio of HCl/SO2 is large during periods of high HCl/SO2 and conversely small during periods of low HCl/SO2 , and that explosions increase one month after the molar ratio of HCl/SO2 increases during periods of no explosions. We decided to determine the composition ratio of volcanic gases (sulfur dioxide, hydrogen chloride, and hydrogen fluoride) emitted from Sakurajima crater in order to understand and predict volcanic activities. Th us, we established a simple collection method for volcanic gases using alkaline filter paper and a quantitative method using a self m ade absorbance photometer so that even high school students could perform the measurement at many points, and we discussed the data from various perspectives. Furthermore, since last year, we have found a correlation between the variation of Cl-/SO2 ratio and the number of eruptions at Sakurajima volcano. Also, a model for the behavior of volcanic gases was developed based on a comparison of the amount of volcanic ash and the number of eruptions.