雌激素為一種環境賀爾蒙，若水生動物長期暴露於其中，即會導致其生理及行為異常。我們企圖從迪化汙水處理廠中純化出能降解雌激素之菌株，希冀了解其雌激素降解機制與生理特性。首先於菌液添加高濃度雌激素（1～2毫莫耳／升）培養以純化菌株，而後測定其16S核糖體核糖核酸序列確認純化出之菌株身分並設計引子，觀察此細菌之生長情形，並進行該菌株之生理測試，包含功能基因定序、代謝產物分析、脂肪酸組成分析、利用其它固醇為碳源之降解測定等。我們純化出一株新鞘氨醇桿菌屬（Novosphingobium）的變形菌，於雌激素濃度1毫莫耳／升的環境下能大量生長，確實能降解雌激素並生成代謝產物，具有與Sphingomonas sp. strain KC8相似之降解雌激素功能基因（oecC），且能降解其他固醇，包含雄烯二酮、膽酸、孕酮和睪酮，然而並不能降解乙炔雌二醇。該菌株具修復受汙染環境及製備雌激素相關藥品之應用潛力。

本作品首先證明了HiLo應用在散射光影像的可行性。目前看到有關HiLo的論文都只有提及收集螢光訊號，沒有看到有用在散射光訊號的收集上。本實驗透過架設自製原型機，證明HiLo的原理也能夠應用在散射光上，大幅提升HiLo光切片的深度與廣度。再者，本作品將自行撰寫之App結合雲端運算。再經過驗證後確認處理出來的影像是正確的影像。不僅加速影像處理流程，而且使用者只需攜帶手機便可立即看到處理出來的成果。接著，利用3D列表機自製具有光切片功能的手機顯微鏡實體。將原型機微小化並與日常生活常見的手機結合，讓使用者方便使用的同時也實現經濟便利性。最後，實現影像立體化，利用光切片的影像能使得原本平面的2D影像，可以呈現3D的立體化影像。

以往人類對抗癌症只能依靠手術、化療、電療等治標不治本的手段殺死癌細胞，不僅效率差且有強烈的副作用，而CAR-T免疫療法透過活化病人自身免疫細胞來專一性的治療癌症。 本研究旨在發展能治療實質固態瘤的CAR-T免疫療法，透過活化由人血中所分離出來的T細胞，使之能辨識在癌細胞中大量表現的上皮細胞黏附因子（EpCAM），並建立一套體外細胞毒殺測試的模型來測試CAR-T殺死腫瘤細胞的能力，以篩選出具有發展潛力CAR-T細胞。 本研究從外周血單個核細胞（PBMC）中分離T細胞，透過基因重組技術與lentivirus來改造T細胞，使T細胞表現CAR基因，再利用Dynabeads Human T-Activator CD3/CD28活化，並以大腸癌細胞株HCT116當作癌細胞目標，測試CAR-T是否有能力殺死腫瘤細胞，另外也以不表現EpCAM的A549肺癌細胞株、H460肺癌細胞株進行毒殺能力測試，結果顯示此CAR-T細胞有高度專一性，證明此CAR-T細胞具有潛力成為新一代的CAR-T免疫療法。

In today's world, medicine is very advanced, thanks to which many diseases that were previously considered incurable, are now treated almost all over the world. But, unfortunately, some diseases are still incurable and can only facilitate their course. One such disease is Raynaud's disease or Raynaud's syndrome. Statistics show that worldwide the percentage of patients with this disease is 3-4%. Raynaud's disease is a paroxysmal spasm of the arteries of the fingers of the hand, rarely the feet when cooling the extremities. As mentioned earlier, this disease is incurable. That is why the creation of a device that can help people overcome many inconveniences due to the inability to stay in the cold without gloves or the problem of discomfort in heated gloves is relevant. And one of the solutions to this problem is to create special heated gloves. This work is also relevant, because even existing treatments, such as medication and conservative, do not completely solve the problem of reducing the sensitivity of the hands when cooled or even the slightest moisture on the palms. Also, these methods are very expensive, so our device will be cheaper and more affordable than existing ones. When using our gloves together with the two already mentioned methods, the treatment will be more effective. Unfortunately, medical and conservative treatments will lead to complications over time, so we not only maintain sensitivity in the hands, but also prevent further amputation of the upper extremities and the emergence of human health problems associated with the effects of drugs on the whole body. Nowadays, people work hard to be able to live well, but it is difficult for people with Raynaud's phenomenon to do so, as the sensitivity of the upper extremities decreases during the exacerbation of the disease. It is important for us to maintain the sensitivity of the hands by normalizing the thermal balance of the hands, which leads to the elimination of spasms of the atria of the hand. The aim of the work is to create a simple and effective means to normalize and maintain the thermal balance of the upper extremities, in order to reduce the loss of sensitivity of the hands in patients, as well as reduce the likelihood of spasms of the arteries of the fingers. The subject of the study is the course of Raynaud's disease and the current treatments for it. The aim of the study is the creation of special gloves that can stop spasms of arteries and maintain blood flow in them by balancing the heat balance in the hand, and depriving patients of the disease during their wearing During the work the following tasks were set: - to theoretically investigate the peculiarities of Raynaud's disease; - to analyze the existing clothes on the market with heating; - to develop and improve its own design of heated gloves, which will be affordable and easy to use. - calculate the cost of gloves taking into account all factors

This research project focuses on developing a web-based multi-platform solution for augmenting prognostic strategies to diagnose breast cancer (BC), from a variety of different tests, including histology, mammography, cytopathology, and fine-needle aspiration cytology, all in an automated fashion. The respective application utilizes tensor-based data representations and deep learning architectural algorithms, to produce optimized models for the prediction of novel instances against each of these medical tests. This system has been designed in a way that all of its computation can be integrated seamlessly into a clinical setting, without posing any disruption to a clinician’s productivity or workflow, but rather an enhancement of their capabilities. This software can make the diagnostic process automated, standardized, faster, and even more accurate than current benchmarks achieved by both pathologists, and radiologists, which makes it invaluable from a clinical standpoint to make well-informed diagnostic decisions with nominal resources.

生活中發現線軸會因拉線角度的不同而收放自如，此現象激起了想探究的決心。我們初步發現線軸在不同變因下會有一個特定的臨界角θc而改變其滾動方向，因此本組選擇了拉力大小、線軸重量、線軸內外徑比值及不同接觸面性質(靜摩擦係數)作為實驗的四種變因，並設計了「線軸收放儀器」來進行實驗探討。為了精確測量臨界角，實驗時儀器中的粗調裝置是利用螺帽固定螺旋桿以大範圍調整定滑輪的升降高度，微調則利用指針帶動螺旋桿轉動角度來微調定滑輪的升降，將實驗過程攝影記錄，並再利用Tracker分析物體改變滾動方向時的臨界角。實驗顯示，影響線軸滾動方向的臨界角大小，和線軸之拉力大小、線軸重量及接觸面性質皆無關，只和線軸內外徑的比值有關，即cos⁡θc =r/R。

本設計利用了應變規(Strain Gauge)的原理去製作一台可以量測拔河時繩子兩端的施加力量值，本設計採用的原理是當應變規受力時其電阻值會因為不同的力量而產生不同的應變的變化。進一步地，本設計的準確性也進行了校正。透過拔河繩拉力所產生的應變造成電阻變化，來轉換成力量數值，而利用自已設計製造的夾具，放置在拔河繩上並固定在繩子的兩側，分析其應力應變和受力狀況來測出力量值。 本設計只用簡單的應變規、電子顯示器和電子零件，低成本、簡單構造的設計來達成本研究之目的，來解決拔河過程中比賽的兩隊平衡力之顯示，使拔河更增加樂趣，增加拔河的的趣味性、數值化。

在中地理論均質平面、均質人口密度的假設下，加入區域經濟學Hotelling模型(1929)分析降價與品質效益策略，得知當中地追求品質效益，所獲得的最大收益會大於使用降價策略的最大值。也就是說，追求品質效益的經營策略應是優於降價策略。 在台灣是所有便利商店龍頭的7-Eleven便是一個很好的例子。多數人都覺得7-Eleven的設點條件優於其他便利商店，但事實上真是如此嗎？ 以大安區為例，根據本研究所假定的三個問題皆為否，得知7-Eleven設點條件較不優於別人，卻比其他超商擁有更多消費者，便符合低級中地在品質效益模型的發展，表示提升品牌的品質，便能擴大可服務範圍。因此品質效益應是商店致力追求的目標。

英文句子簡化是一項單語言句子轉換的任務，其中一句複雜的句子會轉換為一句或多句的簡單句子。相較於過去研究學者著重於研究如何優化句子簡化的結果，如何將一句英文句子依閱讀程度簡化為不同簡單程度的簡化句是一項自然語言處理方面嶄新的研究領域。本研究首先訂定英文分級標準，整合歐洲(CEFR)與台灣(LTTC)母語非英語國家機構對英文的分級標準，將英文分為三種難易程度，並依此將Wekipedia及Newsela的簡化前-簡化後平行語料重新刪整為三種目標程度等級的平行語料庫。另一方面，運用已發展成熟的Seq2seq簡化模型，創造一個多解碼器模型，分別依據目標程度不同的訓練資料集訓練三種解碼器。在BLEU、SARI指標以及Coverage計算下，本研究結果相較於相關研究可展現出優異成果。

本研究旨在探討由法里數列生成的福特圓、以及與其有相似性，但是三維(或更高)的福特球的相關性質，我們分成三個部分來探討。一、首先我們驗證福特圓的衍生方式是否與法里數列相符合，並發想出另一種福特圓的衍生方法；二、以類似福特圓的方式，定義三維中的福特球、推導出以三顆球衍生第四顆球的公式、且限制其衍生的範圍，爾後由同一方向(以最新三顆球作衍生)、固定某一個球(固定某顆球，以最新兩顆球和固定球衍生)等方式衍生，並且利用空間中的索迪公式，對其半徑倒數與配合半徑倒數化繁後的x、y分子的遞迴關係式作探討；三、在高維度中，同樣定義出福特球(並非球體，只是敘述上方便的統稱)，利用索迪公式對同一方向衍生的半徑倒數數列的遞迴關係式來探討。