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俄羅斯

Study of regenerative and ontogenetic processes under the influence of EHF EMR.

The increased sensitivity of aquatic organisms to the effects of EMF has been proven by numerous experimental studies. It has been repeatedly noted that exposure to EMF of certain frequencies and intensities leads to disruption of physiological functions, orientation in time and space, changes in the behavior of organisms, suppression of motor activity. Other ranges of electromagnetic radiation, on the contrary, can cause the effects of increased regeneration, growth rate and survival. In connection with these trends, the purpose of our research is to analyze the effects of the influence of electromagnetic radiation of extremely high frequency on the development of the Xenopus laevis and the regeneration of newts and planarians

DECREASING CANSAT ANGULAR VELOCITY USING DEPLOYABLE FINS

CanSat (a can-size satellite) flight data revealed the occurrence of high spin angular velocities along the vertical axis of a CanSat during a parachute descent phase. A novel aerodynamic stabilization system of deployable fins was designed to decrease angular velocity. Deployable fins were attached to servomotors (rotary actuators) to provide control authority during the CanSat descent phase. Deployable fins positions were calculated based on an onboard gyroscope data using a PID (proportional-integral-derivative controller) regulator and a moving-average filter. After the assembly and the initial testing, the system was flight-proven by dropping it from a drone with and without enabling the stabilization system

Synthesis of fluconazole analogues with focusing on resistant strains Candida

Fungal infections, particularly those caused by resistant strains like Candida auris and Candida glabrata, pose a significant threat to global health. The widespread use of azole antifungals, such as fluconazole, has driven the emergence of multidrug-resistant strains, undermining the efficacy of existing treatments. These challenges necessitate the development of novel antifungal agents with enhanced activity and reduced resistance profiles. To address resistance mechanisms, we designed and synthesized hybrid molecules combining triazole and thiazolidine-2,4-dione (TZD) pharmacophores. This strategy leverages dual mechanisms of action: inhibiting fungal CYP51, a key enzyme in ergosterol biosynthesis, and disrupting fungal cell wall integrity. The structural versatility of hybrid molecules allows for targeted modifications to enhance antifungal potency, binding specificity, and pharmacokinetics. Using a stepwise synthetic approach, triazole-containing piperazine derivatives were first prepared and coupled with TZD-based carboxylic acids via optimized condensation reactions. The structures of the synthesized compounds were confirmed through advanced spectroscopic methods, including 1D/2D NMR and high-resolution mass spectrometry. The antifungal activity of these hybrids was evaluated in vitro against clinical and reference strains of Candida spp. and Aspergillus fumigatus. Among the synthesized compounds, 6a demonstrated notable activity against Candida parapsilosis (MIC 0.06 μg/mL), comparable to voriconazole. Compound 4b exhibited moderate activity against C. parapsilosis (MIC 1–2 μg/mL) and A. fumigatus (MIC 8 μg/mL). However, most compounds showed limited efficacy against highly resistant strains such as C. albicans 8R and C. krusei. This study highlights the potential of hybrid triazole-TZD molecules in overcoming resistance and improving antifungal efficacy. While promising, further optimization is required to broaden the spectrum of activity and enhance efficacy against multidrug-resistant pathogens. These findings contribute to the growing field of antifungal drug development, emphasizing hybrid approaches as a viable solution for combating fungal resistance.

Intellectual security system for industrial enterprises (ISS)

The economy around the world is changing rapidly, with new ways of industrial production being introduced all the time. This is due to the Fourth Industrial Revolution. The main objectives of Industry 4.0 [5] are digitalization and full automation of production processes, which increase productivity and worker safety.

NUMERICAL ANALYSIS OF A CANSAT PICOSATELLITE ENERGY CONSUMPTION

This paper describes a power-profile-based approach to CanSat picosatellite energy usage estimation. We measured the power profile of individual CanSat components on a test bench. The collected data was used to create a power consumption model for a simple flight control algorithm. The power consumption model was implemented in Python programming language and was used to simulate the CanSat flight. The simulation results were compared with the measured power profile of a fully integrated CanSat running the same flight control algorithm. The model showed an error of 2.2% and proved to be suitable for use in battery capacity optimization.

Non-invasive study of the electrical activity of the brain of various chordate animals

In clinical practice, EEG is used to diagnose a number of neurological diseases and to diagnose epilepsy. But at present, the question of the nature of EEG has not been completely resolved and is of great scientific interest. There have been no studies at all on the non-invasive study of the electrical activity of the brain of the shark superorder, which belongs to the class of cartilaginous fish. By studying the electrical activity of the brain of various gnathostomes, it is possible to obtain an answer to the question of the emergence of rhythms from the point of view of phylogenesis and evolution, and by comparing their EEG with the human EEG, one can identify similar patterns that help in the study of reactions to various influences. During the work, for the first time, EEG indicators of spotted cat sharks, ECG, heart rate and respiratory rate of cat sharks and toads were obtained. In the future, it is planned to assemble a smaller neuroheadset for non-invasive studies of the electrical activity of the brain of small animals (sharks, toads, monitor lizards). This data can be used for evolutionary and medical research. *No animals were harmed during or after the experiments.