全國中小學科展

An In-Depth Patch-Clamp Study of HCN2 Channel (Year II): Discovery of Novel Biomarkers and Therapy for Ih Current Suppression in Autism Spectrum Disorders

科展類別

臺灣國際科展作品

屆次

2021年

科別

生物化學

得獎情形

一等獎

學校名稱

Maggie L Walker Governor's School for Government and International Studies

指導老師

Sharon B Snyder

作者

Perisa Satish Ashar

關鍵字

Ih current、sedation、Autism

摘要或動機

The main goal of this study was to address a variety of topics concerning the role of the Ih current in HCN channels of SHANK Wild-Type and Knock-Out Thalamus Neurons (as described further below). This research explored the cellular effects of sedation (like Dexmedetomidine) and laser light stimulations on the Ih current of neurons, as well as discovering novel biomarkers for detecting Autism Spectrum Disorder. This study also showed that methods (like utilizing laser therapy with and without various photosensitizers) have the potential in raising depressed Ih currents of SHANK Knock-Out neurons.

TISF2021-080020.pdf

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