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Emotional Stress Relief Vest – Research on Heat Dissipation
Due to having Asperger's syndrome, I want to make a pressure vest suitable for hot and humid climates like Asia to help reduce the daily anxiety of children and adults with autism, ADHD, sensory disorders, etc. To solve this problem, I first tried using a porous material. But after seeing a pressure vest in person, I found it to be useless. Therefore, I came up with the idea of creating an active airflow cooling system between the body and the pressure vest. To experiment, I wanted to make pressure vests. However, I found that a high-frequency TPU welding machine is required. Thus, I made models of pressure vests using airbags, water-resistant nylon, and quick-drying fabric. I also made models, which came from sandwich fabric. Through this research, I discovered that the sandwich fabric design has the best passive heat dissipation, and the combination of the sandwich fabric and the active airflow cooling system has the best active heat dissipation.
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How do antihypertensive agents decrease the high mortality rate of sepsis and septic shock? (探討抗高血壓藥物如何降低敗血症的致死率)
過去已知敗血症患者使用β受體阻滯劑能有效改善心律、酸鹼參數、降低死亡率,在嚴重敗血症和敗血性休克的急性期,持續使用β受體阻滯劑可降低90天內的死亡率。然而,其中的分子機轉仍不明。我們先前利用健保資料庫進行大數據分析並以動物實驗驗證,發現β受體阻滯劑中的atenolol能顯著減少敗血症的致死率。此研究中,我們以LPS (脂多糖) 作為敗血症誘導劑,並利用西方墨點法及逆轉錄聚合酶鏈式反應等生物技術,來探討其中可能的保護機轉,結果發現atenolol可減緩肺部上皮細胞的EMT (上皮間質轉換)及先天免疫巨噬細胞的過度活化。因此,atenolol似乎能減緩LPS造成肺部的傷害,未來有望應用至臨床,以克服敗血症所造成的高死亡率。
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