本研究針對臺灣恆春半島海域所採集的棘皮動物海百合小卷海齒花Comanthus parvicirrus進行天然物化合物之成分研究，分離獲得三個角型萘並吡喃酮類型天然化合物，包括一個新化合物8-hydroxy-5,6,9,10-tetramethoxy-2-methyl-4H-benzo[h]chromen-4-one (1)以及兩個已知化合物comaparvin (2)與6-methoxycomaparvin-5-methyl ether (3)。上述化合物結構是由核磁共振儀、紅外線光譜儀、紫外光可見光譜儀、x-ray光譜儀和質譜儀等數據，以及比對相關化合物的文獻來分析確認。 化合物1-3進行體外抗發炎活性測試，並且探討化合物對脂多糖 (lipopolysaccharide, LPS) 誘發的小鼠巨噬細胞 (RAW264.7) 所產生的發炎性蛋白質一氧化氮合成酶 (iNOS) 以及第二型環氧化酶 (COX-2)。

The number of natural disasters has risen significantly in recent years, and with climate change there is no end in sight. Consequently, the demands on rescue forces around the world are increasing. For this reason, I asked myself what I can do to improve the work of rescue teams. Advances in artificial intelligence and drone technology enable new possibilities for problem solving. Based on the technological advances mentioned above, an autonomous Search and Rescue drone was developed as part of this project. The system assists rescue workers in searching for survivors of natural disasters or missing people. This paper also suggests a method for prioritizing survivors based on their vitality. The system was implemented using a commercial Parrot ANAFI drone and Python. The software was tested on a simulated drone. To simplify the development, the whole system was divided into the following subsystems: Navigation System, Search System and Mission Abort System. These subsystems were tested independently. The testing of solutions and new concepts were performed using smaller test programs on the simulated drone and finally on the physical drone. The Search and Rescue system was successfully developed. The person detection system can detect humans and distinguish them from the environment. Furthermore, based on the movements of a person, the system can distinguish whether the person is a rescuer or a victim. In addition, an area to be flown over can be defined. If something goes wrong during the mission, the mission can be aborted by the Mission Abort System. In the simulation, the predefined area can successfully be flown over. Unfortunately, controlling the physical drone does not work. It stops in the air after takeoff due to the firmware of the drone. It does not change the flight state of the drone, which results in all subsequent commands from the system being ignored. This paper shows that artificial intelligence and drone technologies can be combined to deliver better rescue services. The same system can be applied to other applications.

過去已知敗血症患者使用β受體阻滯劑能有效改善心律、酸鹼參數、降低死亡率，在嚴重敗血症和敗血性休克的急性期，持續使用β受體阻滯劑可降低90天內的死亡率。然而，其中的分子機轉仍不明。我們先前利用健保資料庫進行大數據分析並以動物實驗驗證，發現β受體阻滯劑中的atenolol能顯著減少敗血症的致死率。此研究中，我們以LPS (脂多糖) 作為敗血症誘導劑，並利用西方墨點法及逆轉錄聚合酶鏈式反應等生物技術，來探討其中可能的保護機轉，結果發現atenolol可減緩肺部上皮細胞的EMT (上皮間質轉換)及先天免疫巨噬細胞的過度活化。因此，atenolol似乎能減緩LPS造成肺部的傷害，未來有望應用至臨床，以克服敗血症所造成的高死亡率。

As the world has become concerned about the global waste crisis and global warming, there has been a surge of research within materials science to find materials that would replace plastic, such as bioplastics or biodegradable materials, in order to reduce environmental pollution. Plastics generates the microplastics that allowed them to become cross contamination enter the ocean through land, sea and river. Science research found (Lusher et al. (2017)) over 220 species of marine animals ingested microplastic, half of them are considered relevant for commercial purpose and increasing the risk of human consumption as it can induce immune response, oxidative stress, cytotoxicity, alter membrane integrity and cause differential expression of genes. Thailand is also experiencing such a challenge, as seen by the overabundance of plastic waste that might take centuries to decompose. For example, around 1680 million personal hygiene products such as diapers, sanitary napkins, and tampons are used each year. This study highlights the use of naturally accessible absorbent fibers from malva nut (Scaphium scaphigerum) (G. Don) Guib & Planch.), which is widely available and biodegradable in nature and has a low carbon footprint. This study also aimed to develop natural absorbent pads using compostable spun, external layers, and biodegradable glue. A prototype sanitary napkin with biodegradable absorbent pads was developed and evaluated for absorption ability, absorption rate, pH, and biodegradability. The absorbent material absorbed up to 19 times its weight in 2 minutes and 33 times its weight in 2 hours, which is enough for an average of 80-150 mL of menstrual blood. The prototype napkin deteriorated within 99 days, based on naked eye observation. Some signs of degradation and microorganisms growing on the prototype were also observed from scanning electron microscopic images. According to the findings, natural absorbent pads made from malva nut have the potential to be converted into sanitary napkins. Furthermore, it is proposed that the components, which include superabsorbent renewable materials, spinning compostable layer, external compostable layer and biodegradable glue, may be used in a variety of goods, including adult diaper pants, incontinence pads, and laboratory bench mats.

Inhibitory effects of the secondary metabolite of actinomycete were examined on cell cycle of the yeasts of S. pombe and S. cerevisiae. The secondary metabolite was obtained from cultivation of the actinomycete isolated from the soil of Owakudani in Hakone, Japan. The fifth fraction of the secondary metabolite by ODS column separation (HK-T5), which was soluble to pure methanol, was used in the present experiments. The HK-T5 brought about the delay of forming colonies of S. pombe for about 11 days compared to that cultivated without the HK-T5. The delay of the colony formation was longer for the S. pombe cultivated with more amount of the HK-T5. The cultivation with HK-T5 also brought about the extension of the lifespan of the S. pombe for more than 10 weeks in a liquidus medium. The cell life recovered the ordinary manner by removal of the HK-T5, meaning that the activities of the HK-T5 is reversible. These facts confirm the suppression of cell cycle, and the delay of cell growth by the HK-T5. These phenomena were similarly observed for S. cerevisiae. Comparison of the action of HK-T5 with hydroxyurea, which is an anticancer drug inhibiting the cell cycle at S phase, clarified that the inhibitory action of HK-T5 worked at the phase earlier than S phase. The combined effects of HK-T5 on the cell cycle were evaluated with triamcinolone acetonide (TA), or aspirin, the former of which is a drug synchronizing cancer cells in S phase, and the latter keeping human cells in G1/G0 phases. The combined use of HK-T5 with TA synchronized the cells at the phase slightly proceeding from G1 to S phase without toxicity. On the other hand, the combined use with aspirin made the inhibitory effect of HK-T5 inactive. Hence, the HK-T5 is attractive as a drug for the extension of cell lifespan, and anticancer therapy.

A variant of the coronavirus (2019-nCoV or COVID-19) was reported in Wuhan, China on December 31, 2019, spreading rapidly around the world. Owing to a plan to reactivate the economy, the Mexican government, requested to implement protective measures to enter establishments with confined spaces: wear a mask, provide alcohol-based hand rub and the measurement of body temperature, allowing problem when not have a fever; however, these measures cause long waiting lines, causing contagion risk. To support this problem, applied and experimental research was used, generating as a result, the creation of a robot that moves autonomously thanks to a line follower sensor. Dispenses alcohol-based hand rub and determines the temperature by means of an infrared sensor, checking that the distance is adequate, with an ultrasonic sensor, using a buzzer that emits a sound of half a second when it performs a normal detection, but, if it is equal to or greater os 38 ° C, emits a sound for 10 seconds asking the person to leave the line and go to a medical service, helping to reduce problems infections in lines

此研究旨在探討當腸道沙門氏菌感染人類腸道上皮細胞（HT-29）時半乳糖凝集素-4（galectin-4）所扮演的角色。我們用野生型（wild-type）以及半乳糖凝集素-4 剔除（galectin-4 knockout）的HT-29細胞進行沙門氏菌感染。我們首先經由CFU計數探討galectin-4對細胞內細菌量的影響，並檢測細胞釋出的LDH及IL-18和mature caspase-1的量，以此研究galectin-4是否會活化發炎體（inflammasome）。結果發現， wild type HT-29 cells相較galectin-4 knockout cells有較少的活細菌，釋出的LDH，IL-18也較少。但在經過wortmannin（一種自噬抑制劑）treatment後，wildtype HT-29 cells釋出較多的LDH，IL-18，並且也釋出了mature caspase-1。這些研究結果顯示galectin-4能夠降低細胞內活細菌的量，且能夠活化inflammasome。

A variant of the coronavirus (2019-nCoV or COVID-19) was reported in Wuhan, China on December 31, 2019, spreading rapidly around the world. Owing to a plan to reactivate the economy, the Mexican government, requested to implement protective measures to enter establishments with confined spaces: wear a mask, provide alcohol-based hand rub and the measurement of body temperature, allowing problem when not have a fever; however, these measures cause long waiting lines, causing contagion risk. To support this problem, applied and experimental research was used, generating as a result, the creation of a robot that moves autonomously thanks to a line follower sensor. Dispenses alcohol-based hand rub and determines the temperature by means of an infrared sensor, checking that the distance is adequate, with an ultrasonic sensor, using a buzzer that emits a sound of half a second when it performs a normal detection, but, if it is equal to or greater os 38 ° C, emits a sound for 10 seconds asking the person to leave the line and go to a medical service, helping to reduce problems infections in lines

本研究成功以不同化學方法自製磁性奈米粒子，並利用水熱法(Solvothermal)合成可見光光觸媒碘氧化鉍(Bi4O5I2)，再以不同比例複合出具磁性的光觸媒，藉由光降解結晶紫(Crystal Violet)染料實驗探討分解染料效率最佳之複合樣本，其最佳樣本為Bi4O5I2 -Fe3O4-90 %，反應速率常數達0.1118 h-1，並運用一系列儀器檢測其特性並探討其與光催化效率之關聯性。此外，針對觸媒在生活中的應用性探討，在生活不同水質、極端pH值或是高濃度之有機汙染物均仍保持良好的降解效率，並以Arduino開發板搭配各項組件模擬小型淨水場，以達到自動化降解有機汙染物。另外，利用自製紫外光照光裝置模擬捕捉CO2之光催化反應，並使用Arduino開發板之氣體偵測器確認生成化石燃料作為未來展望目標。

This research is motivated by the differences in the people's perceptions, mainly youth about the omed-omedan tradition. The difference is that many people think that the omed-omedan tradition violates the norms of decency and is also called the pornography tradition. The purpose of this study is to, 1) describe the mechanism of applying omed-omedan tradition recognition attitudes through augmented reality-based card games, 2) analyz the impact resulting from the application of omed-omedan tradition recognition attitudes through augmented reality-based card games, and 3) analyze about the feasibility of application resulting from the application of omed-omedan tradition recognition attitudes through augmented reality-based card games. This research is a type of R&D research conducted at Bali Mandara State High School from July 1-September 6, 2021. The subjects of this study were the teenagers of Kaja Sesetan Indigenous Village and the object of this study was the omed-omedan tradition through augmented reality-based card games. The data collection method used is the literature studies, questionnaires, interviews, and validation questionnaires. Data is processed based on qualitative descriptive approach and quantitative descriptive approach. The results showed that the mechanism of implementing the omed-omedan tradition originated from the download of assistive devices, namely android studios and applications from AR, the impact of augmented reality-based card games was seen as very helpful in the introduction of the omed-omedan tradition and was seen as able to help increase the love of local culture, besides that the media used was also very popular by players because it was seen as interesting and very helpful. Based on the feasibility tests that have been calculated, this game is considered very feasible to implement and researchers hope that the innovations that have been created can effectively provide understanding to help out the local community about omed-omedan tradition.

According to CNN Indonesia 2020, the demand for e-Commerce in Indonesia has nearly doubled during this pandemic. This surge in demand calls for a time-efficient method for warehouse order-picking. One approach to achieve that goal is by incorporating automation in their warehouse systems. Globally, the market of warehouse robotics is expected to reach 12.6 billion USD by 2027 (Data Bridge Market Research, 2020). In this research, the warehouse system studied would utilize AMR (Autonomous Mobile Robots) to lift and deliver movable shelf units to the packing station where workers are at. This research designed a heuristic algorithm called A.N.T.s (Algorithm for Navigating Traffic System) to conduct task assigning and pathfinding for AMR in the automated warehouse. The warehouse layout was drawn as a two-dimensional map in grids. When an order is placed, A.N.T.s would assign the task to a robot that would require the least amount of time to reach the target shelf. A.N.T.s then conducted pathfinding heuristically using Manhattan Distance. A.N.T.s would help the robot to navigate its way to the target shelf unit, lift the shelf and bring it to the designated packing station. A.N.T.s algorithm was tested in various warehouse layouts and with a varying number of AMRs. Comparison against the commonly used Djikstra’s algorithm was also conducted (Shaikh and Dhale, 2013). Results show that the proposed A.N.T.s algorithm could execute 100 orders in a 27x23 layout with five robots 9.96 times faster than Dijkstra with no collisions. The algorithm is also shown to be able to help assign tasks to robots and help them find short paths to navigate their ways to the shelf units and packing stations. A.N.T.s could navigate traffic to avoid deadlocks and collisions in the warehouse with the aid of lanes and directions.

As the world has become concerned about the global waste crisis and global warming, there has been a surge of research within materials science to find materials that would replace plastic, such as bioplastics or biodegradable materials, in order to reduce environmental pollution. Plastics generates the microplastics that allowed them to become cross contamination enter the ocean through land, sea and river. Science research found (Lusher et al. (2017)) over 220 species of marine animals ingested microplastic, half of them are considered relevant for commercial purpose and increasing the risk of human consumption as it can induce immune response, oxidative stress, cytotoxicity, alter membrane integrity and cause differential expression of genes. Thailand is also experiencing such a challenge, as seen by the overabundance of plastic waste that might take centuries to decompose. For example, around 1680 million personal hygiene products such as diapers, sanitary napkins, and tampons are used each year. This study highlights the use of naturally accessible absorbent fibers from malva nut (Scaphium scaphigerum) (G. Don) Guib & Planch.), which is widely available and biodegradable in nature and has a low carbon footprint. This study also aimed to develop natural absorbent pads using compostable spun, external layers, and biodegradable glue. A prototype sanitary napkin with biodegradable absorbent pads was developed and evaluated for absorption ability, absorption rate, pH, and biodegradability. The absorbent material absorbed up to 19 times its weight in 2 minutes and 33 times its weight in 2 hours, which is enough for an average of 80-150 mL of menstrual blood. The prototype napkin deteriorated within 99 days, based on naked eye observation. Some signs of degradation and microorganisms growing on the prototype were also observed from scanning electron microscopic images. According to the findings, natural absorbent pads made from malva nut have the potential to be converted into sanitary napkins. Furthermore, it is proposed that the components, which include superabsorbent renewable materials, spinning compostable layer, external compostable layer and biodegradable glue, may be used in a variety of goods, including adult diaper pants, incontinence pads, and laboratory bench mats.