2021年

近年來，再生醫療利用幹細胞幫助組織器官新生的方法已有長足進步，但仍然面臨許多的瓶頸。例如: 幹細胞注射進入人體以後，無法繼續分化生長成所需組織。最近，高能磁場的使用也是醫學界蓬勃發展的議題，我們試圖利用高能磁場誘導幹細胞的分化，希望可以增加幹細胞分化的效能，這是一創新的嘗試。我們比較新型高能磁場(RMS)與對照組於骨髓幹細胞(BMSCs)的分化效果，發現RMS 中叢集式刺激(iTBS)的SOX9和COL10的基因表現與免疫組織化學染色明顯優於15Hz RMS 與對照組。最佳的刺激設計為強度50%的iTBS連續施打五天。我們亦發現每回合900 pulses有優於每回合600 pulses的趨勢。此實驗證實iTBS能夠增加BMSCs在體外的軟骨分化表現，反映在基因表現層次到膠原蛋白合成的層次。未來，此方法將進一步使用於動物實驗，期望擴展到臨床上用於退化性關節炎的治療，對再生醫療發展有所幫助。

It is known that copper foil undergoes a color change in heating by oxide thin layer formation. Therefore, we focused on the color change by the oxidation of brass foil. Brass foil (Akaguchi (Cu87%Zn13% alloy) and Aoguchi (Cu85%Zn15% alloy)) also undergoes color change by oxidation, and it shows heating time and temperature dependence. Brass foil need longer heating time to appear color change than copper foil, and we can visually confirm that the brass has corrosion resistant. In addition, color change of brass foil depends on the percentage of copper in the brass, and Aoguchi shows rapidly color change in same heating condition. We show that brass has different physical properties than copper, even with a high percentage of copper in brass, and this was verified through comparison using diffusion length and RGB data in Aoguchi and Akaguchi. We demonstrate these colored brass foils are used as art materials, and our results expanded material using possibility of brass foil.

發炎反應與癌症具有密切的關係，而如何抗發炎是現今重要的研究主題。本研究主要探討雙黃酮類藥物CRYT對LPS誘發之發炎反應與免疫細胞遷移的影響。本研究首先以細胞試驗分析細胞激素與趨化因子的表現量觀察CRYT對發炎反應的影響。接著，利用反轉錄聚合酶連鎖反應 (RT-PCR) 和共軛焦顯微鏡觀察黏附分子與調控細胞骨架分子的表現量，以了解CRYT對免疫細胞遷移的影響。再來我們以西方墨點法分析免疫反應調控路徑之蛋白質表現量來研究CRYT的作用途徑。同時，透過程式模擬CRYT的標的蛋白，並用細胞轉染與雙冷光技術驗證模擬結果。本研究發現，CRYT會抑制TNF-、IL-1及IL-6三種促發炎因子與CXCL1、CCL3及CCL4三種趨化因子的表現量。另外，CRYT會抑制黏附分子LFA-1與VLA-4與調控細胞骨架分子Cdc42、PAK1、WASP、Rac1及LIMK1之mRNA表現量，以阻礙F-actin進行聚合作用。本研究也發現，CRYT能藉由抑制NF-B的表現量，進而影響巨噬細胞的發炎作用與細胞移動。在作用機制的方面，CRYT會結合在雌激素受體的配體結合位，並抑制雌激素受體的轉錄作用，而抑制發炎作用與細胞轉移。結論得知，CRYT不但可以抑制發炎反應，還能有效抑制免疫細胞的遷移。

This study considered the tensile and flexural characterization of new lighter and cheaper hybrid composite materials to replace the existing insert panel for the currently available bulletproof vest. The materials chosen included a natural fibre, i.e., kenaf fibre, chemically treated with sodium hydroxide solution, and, as a means of recycling, used x-ray films with a surface treatment. Using the traditional hand lay-up method, the materials were fabricated into seven layers of different configurations, which were then subjected to tensile and flexural tests. The findings showed that one of the configurations that consisted of both treated materials had a tensile strength of 396.9M Pa, which is quite strong, and a flexural modulus of 6.24G Pa, which makes it flexible enough to be made into wearable equipment. This configuration was then chosen to be the base design for the specimen subjected to impact test. The interfacial bond between the two distinct materials proved to be a major issue, even with the help of fibre treatment. Therefore, some improvements need to be made for the material to be comparable to existing materials performance-wise hence making this configuration suitable for ballistic application.

本研究主要考慮在盡量保留可讀性的情況下，找出將 Imperative Programming 程式碼對應的 Functional Programming 的程式碼並證明。 結果如下： 一、if statement 等價於由 ifte 函數所構成的程式碼，其中函數ifte定義在本文內 二、某些 for-loop statement 等價於由 foldl 函數所構成的程式碼 三、某些 for-loop statement 等價於由 map 函數所構成的程式碼

In today's world, medicine is very advanced, thanks to which many diseases that were previously considered incurable, are now treated almost all over the world. But, unfortunately, some diseases are still incurable and can only facilitate their course. One such disease is Raynaud's disease or Raynaud's syndrome. Statistics show that worldwide the percentage of patients with this disease is 3-4%. Raynaud's disease is a paroxysmal spasm of the arteries of the fingers of the hand, rarely the feet when cooling the extremities. As mentioned earlier, this disease is incurable. That is why the creation of a device that can help people overcome many inconveniences due to the inability to stay in the cold without gloves or the problem of discomfort in heated gloves is relevant. And one of the solutions to this problem is to create special heated gloves. This work is also relevant, because even existing treatments, such as medication and conservative, do not completely solve the problem of reducing the sensitivity of the hands when cooled or even the slightest moisture on the palms. Also, these methods are very expensive, so our device will be cheaper and more affordable than existing ones. When using our gloves together with the two already mentioned methods, the treatment will be more effective. Unfortunately, medical and conservative treatments will lead to complications over time, so we not only maintain sensitivity in the hands, but also prevent further amputation of the upper extremities and the emergence of human health problems associated with the effects of drugs on the whole body. Nowadays, people work hard to be able to live well, but it is difficult for people with Raynaud's phenomenon to do so, as the sensitivity of the upper extremities decreases during the exacerbation of the disease. It is important for us to maintain the sensitivity of the hands by normalizing the thermal balance of the hands, which leads to the elimination of spasms of the atria of the hand. The aim of the work is to create a simple and effective means to normalize and maintain the thermal balance of the upper extremities, in order to reduce the loss of sensitivity of the hands in patients, as well as reduce the likelihood of spasms of the arteries of the fingers. The subject of the study is the course of Raynaud's disease and the current treatments for it. The aim of the study is the creation of special gloves that can stop spasms of arteries and maintain blood flow in them by balancing the heat balance in the hand, and depriving patients of the disease during their wearing During the work the following tasks were set: - to theoretically investigate the peculiarities of Raynaud's disease; - to analyze the existing clothes on the market with heating; - to develop and improve its own design of heated gloves, which will be affordable and easy to use. - calculate the cost of gloves taking into account all factors

近年空氣品質已是居住環境與健康的指標，「細懸浮微粒」充斥在空氣中，造成過敏，增加肺癌的危險。本研究探討懸浮微粒在受到重力、空氣阻力與空氣浮力影響後，形成分層。並利用VPython軟體模擬不同大小的懸浮微粒(pm10、pm2.5與pm1.0)於空間中碰撞及受到空氣阻力產生能量衰減，藉此了解不同微粒之分層現象。再實作以居住樓層不同的垂直高度，設計組裝架設「懸浮微粒三維偵測器」及物聯網。以台灣中部地區，日益增加的空汙狀況下，模擬以台中火力發電廠為例，探討其風向、地理環境、以擴散模式理論模擬後，選定數棟建築物，監測每棟建築物地面上不同高度的空氣品質數值。最後監測數值自動上傳至物聯網雲端資料庫 ThingSpeak，並可於使用者端監測及取得測量數值；期許再利用機器學習及歷史累積的三維空氣品質資料，將來更優化預測空氣品質數值之成效。

矽元素因具有極高的理論電容和鋰攝取量(Li Uptake)而被認為是有潛力的鋰電池負極材料，然而該材料的特性使其在充放電時體積巨幅脹縮，造成結構碎裂，縮短了電池壽命。 本研究設計一套低耗能、低成本的製程，以現今台灣光伏產業大量難以回收之廢矽泥及鎂金屬為原料，將矽之粒徑縮小為奈米級以解決上述體積膨脹問題而成為極佳的鋰電池負極材料。 我們先將矽合成矽化鎂，再利用二氧化碳及氮氣的氧化還原反應製成多孔矽，隨後再利用創新的化學蝕刻法產出奈米矽。目前業界奈米矽的製備仍以高功率研磨為主，本研究首度使用銅離子、過氧化氫及氫氟酸作為蝕刻液，成功製造出平均粒徑100nm之負極材料。而過程中所使用的鎂粉可回收再使用，回收率高達94%，故幾乎無成本廢料排放，大幅降低當今鋰電池的生產成本，也落實防廢、再生、節能等綠色化學原則。

本研究以AI虛擬試衣系統(Virtual Try-on)為主題，透過深度學習技術，並結合幾何匹配模型，開發出試衣系統，可將使用者上傳的照片，模擬成穿著新衣的模樣。 首先，以深度學習模型將人物原始圖片取出骨架節點，並生成人體遮罩以及保留人物頭部，再結合以上三種資訊合成為高維特徵圖。接著將目標替換衣物生成出依照人體姿態扭曲後的衣物圖片。最後於Virtual Try-on模型中將人體高維特徵圖與扭曲衣物作為輸入，並經過深度學習網路合成出穿著目標衣物之人體圖像。本研究結果發現，人物站姿單純，且雙手緊貼身側，以及拍攝角度為正面、衣服款式為短袖、背景色彩對比度較高與衣服圖案單純的原始圖片，可得到較好的合成結果。

921地震震波對高11-15層大樓產生重大危害。本研究以模型模擬11層大樓建築物，頂樓設置水塔配合陽台天花板設置水撲滿的雙阻尼消能系統設計，探討不同震度震波在雙阻尼系統減震成效。模擬之設備利用3D列印機自製水撲滿、不同形式網狀隔間液體阻尼零件，自製地震模擬器以電流調整器控制怠速馬達，進行模擬不同震度下高樓產生擺動與震盪之狀態與特性。 實驗發現單一阻尼消能元件的減震阻尼效能較差，雙阻尼消能系統可提升39％至58％減震阻尼效能。其中雙阻尼消能系統若有網狀隔間，水波擾動震盪越明顯，阻尼效能提升 6％至14％。11層大樓於頂樓設置平行器壁網狀隔間正方形水塔，並配合在第9至11層樓處，設置隔間距離較短網狀隔間水撲滿，二者水位設定六分滿，此液體雙阻尼減震消能系統，可抑制模擬震度5至7級震波對大樓產生的順向波動共振與大樓結構體的自主扭轉共振。