This research work is devoted to the stages of development and creation of a prototype of a laser 3D scanner model, programming of a controlling microcontroller, construction of 3D models of a scanned object. In the course of the work, the market of 3D scanners, which are used to build three-dimensional models of premises, was analyzed, the equipment necessary for the development and creation of the prototype was analyzed, as well as the software necessary for the operation of the prototype. The result of the work was the creation of a laser 3D scanner based on an Arduino microcontroller using a Lidar type sensor that scans and builds 3D models of objects. This working model of the 3D scanner demonstrates good capabilities and turned out to be easy to use.

Aspirin is one of the most used and well-known medicines world-wide. It can be synthesized by reacting acetic anhydride and salicylic acid in a warm temperature of around 60-80°C. This reaction is usually catalyzed by sulfuric or phosphoric acid. This paper will investigate alternative catalysts, safer and more environmentally friendly, as well as compare different synthesis methods with different heat mediums, one using a water bath and the other amicrowave. By doing so, the effects of the catalyst and the method of synthesis on the yield, purity and environmental consequence of crude aspirin synthesis will be deduced. The targeted utcome is to find the alternative method as more energy efficient, and to find a greener safer catalyst to sulfuric and phosphoric acid. Further background information, exploration, and explanation is in the appendix. The targeted outcome will be to find a viable alternative catalyst that is safer and more environmentally friendly, and to find that the microwave synthesis method consumes less energy.

本研究探討腔體受聲音震動導致開口噴出氣流的現象。實驗以揚聲器播放聲音，使固定於其上的剛體錐形瓶共振，揚聲器與腔體之間並無直接接觸。通過改變聲音頻率、腔體參數（包括體積、瓶口截面積、瓶頸長度），以及揚聲器震動振幅與腔體內外氣壓，研究噴流流速的變化。 研究發現腔體內氣壓振幅超過臨界值時，腔體開口處會噴出一連串渦流環，根據拍攝的影像確認連續的渦流環組成的噴流即為合成氣流(synthetic jet)。噴流流速在聲音頻率與腔體共振頻率相同時達到峰值，並隨聲音頻率偏離共振頻率而急速下降。流速峰值頻率符合修正後的亥姆霍茲公式，且瓶頸長度越長，共振時合成氣流峰值流速越低。本研究為聲能轉動能方面提供新的研究途徑，並有進階研究的可能性。

There have been numerous studies exploring the applications of graph theory in traffic management, often finding ways to reduce traffic congestion and make traveling more efficient. Such studies will be beneficial when applied to heavily congested areas such as España Boulevard, one of the busiest thoroughfares in Manila. This paper aimed tooptimize the road map of España Boulevard using graph theory. The current road map of España Boulevard was represented as a directed graphand subjected to the mutation method of edge removal, wherein an edge isremoved in each mutation based on a computed fitness function, F(G),which depicts better efficiency at lower values. Edges were removed until the graph got disconnected, which was tested using the Floyd-Warshall algorithm. The 28th mutation resulted in a minimum F(G) value of 144.4; this is a 50.18% decrease from the F(G) of the original graph, which is 290. After the 28th mutation, the removals resulted in an increase in the F(G). As a result, the final mutation resulted in an F(G) of 311.89, which characterized a less efficient graph. This study was able to apply graph theory concepts to optimize the España Boulevard road map using the mutation method, minimizing its F(G) by at most 50.18%. For future studies, the practicality of the alternate road map may be tested in simulations to examine its efficiency when other factors, such as traffic volume, are introduced.

The research project has an extremely relevant topic - the creation of an air quality monitoring system for general secondary education. In the context of the Covid 19 pandemic, proper air sanitation is a determining factor in counteracting the spread of coronavirus infection. Special requirements for the procedure of systematic ventilation of educational premises are set before teachers and technical staff of schools "Sanitary Regulations for General Secondary Education Institutions", which is mandatory for implementation in general secondary education institutions. Together with measures to counter the Covid 19 pandemic, the new health regulations somewhat neglect resource conservation and energy efficiency issues: ventilation during the heating season can lead to wasteful heat losses. Monitoring the quality of air purification is simply necessary if teachers and parents care about creating a safe educational environment for students at school. Requirements for air safety determine and regulate its characteristics such as temperature, humidity, the presence of dust particles of different sizes, the concentration of carbon dioxide (CO2), carbon monoxide (CO) and formaldehyde vapors. The level of hazardous substances such as formaldehyde, which can be released from building materials, carbon monoxide and carbon dioxide, should be closely monitored in accordance with the recommendations of sanitary regulations and hygiene requirements of health care facilities. With increased concentrations of carbon dioxide above normal, the human body will experience the negative effects of hypoxia: poor health, drowsiness, decreased cognitive processes, learning becomes less effective. Carbon monoxide is a poisonous substance that can damage the body, poison hemoglobin and cause constant hypoxia of all organs and systems, long stay indoors with it leads to death. Formaldehyde causes carcinogenic effects, and the excess concentration of dust particles worsens the condition of people with allergies and bronchial asthma, as well as dust promotes bacterial growth and the spread of viral particles, which is especially dangerous in a coronavirus pandemic. Our solution allows for a transparent permanent monitor of air quality in the school, makes this monitoring completely inclusive - because any user from among the participants in the educational process has access to up-to-date information about the air in the school and can make informed decisions about proper behavior Our system allows students to become more responsible, independent in terms of sanitary requirements and compliance. Therefore, the main idea of our project is extremely relevant today - to organize a digitalized system for monitoring the quality of air purification in the school, thus preventing inadequate ventilation with wasteful heat loss and reduced energy efficiency of the school building. The project has signs of sustainability - it is in line with the Sustainable Development Goals – 3 «Good health and well-being», 4 «Quality education», 5 «Gender equality», 11 «Sustainable cities and communities», 12 «Responsible consumption and production» and 13 «Climate action»

In our experiment, we used traditional Chinese medicine to dye on cheap wood, in addition to avoiding the impact of chemical paint on human body; After dyeing, the color and texture quality of the wood are improved, which makes cheap wood have higher price and improves the value of wood; At the same time, it can reduce the felling of slow growing precious wood, which has the functions of environmental protection, earth love and carbon saving. The test material was pretreated with hydrogen peroxide and surfactant, and the bleaching effect was obvious. After dyed with different Chinese medicinal, soak in strong acid and alkali solution for 15 minutes, which shows that strong acid and acid treatment is not allowed. On the other hand, after 15 minutes of immersion in detergent, the color difference value is less than 2, and the rubbing fastness is above grade 4. In the bacteriostasis experiment, no fungus grew in the first 3 days, and it did not grow in the 12th day. In the anti-termite experiment, the mortality rate on the fifth day was 65% for Lithospermum and 83.8% for Wolfberry, and the other groups had a good effect of total elimination. While plastic products have a great impact on the environment, wood that is dyed or modified with natural colored dye, its environmental value far exceeds the human visual perception.

The main goal of this paper was a creation of musical score for the composition from the 18th century Domine ad Ad juvandum in A minor and C major composed by Šimon Brixi. Another goal was finding as much information as possible related to this composition and summarize everything possible that was written previously. Separate parts were transcribed into one partiture. Nevertheless there were difficulties like mistakes in sheet music (corrected according to harmony of other voices), missing beats (replaced by identical parts of score), differences in period station. Hard times also bring on differences of period notation. The resulting musical scores can be directly used for music production, which is schemed for the next year. The second part was researching new or never-published information related to these compositions. Here I describe Š. Brixi´s life. I managed to read out the cause of Šimon Brixi death in a chronicle, which was not in the publication I found. Brixi died of tuberculosis like his son. Transcriptors, J.V.Flaška and J.J.Hoffman, are also mentioned. Lastly the information about sheet music itself and its historical context were described. Another discovery was an identification of watermark on sheet music paper. Assuming the sheet music is truly transcribed in 1742 the Kolinec paper mill watermark on the sheet music paper is the oldest evidence of its use. In this paper I summarized the historical context of the baroque era including social life, art and culture.I mentioned the most important events that were crucial for historical development in Bohemia and especially in the Klatovy region. This context can be useful for today’s musicians who want to understand the historical background and express the composition with full respect to the time of its creation.

The development of rapid and efficient synthetic approaches to the bioactive cyclic and polycyclic azaheterocycles is one of the most important challenges in organic synthesis. In this work effective and simple synthetic approaches to polysubstituted pyrrolidin-2-ones 2 and isoindolines 3 from donor-acceptor cyclopropanes 1, bearing the ester group as the one of acceptor substituents, and amines were developed. The γ- pyrrolidone based skeletons and isoindoline ring system is a constituent of many biologically active molecules, both natural and synthetic, and a key component of clinically relevant entities (Fig.1,2) [1,2]. The synthesis of pyrrolidin-2-ones 2 includes Lewis acid-catalyzed opening of the donor-acceptor cyclopropane with primary amines (anilines, benzylamines, etc.) to γ-amino esters, followed by in situ lactamization and dealkoxycarbonylation. The reaction has a broad scope of applicability; a variety of substituted anilines, benzylamines, and other primary amines as well as a wide diversity of donor-acceptor cyclopropanes bearing (hetero)aromatic or alkenyl donor groups and various acceptor substituents, can be involved in this transformation. In this process, donor-acceptor cyclopropanes react as 1,4-C,C-dielectrophiles, and amines as 1,1- dinucleophiles. The resulting di- and trisubstituted pyrrolidin-2-ones can be also used in subsequent chemistry to obtain various nitrogen-containing polycyclic compounds of interest to medicinal chemistry and pharmacology, such as benz[g]indolizidine derivatives. The synthesis of the substituted isoindolines 3 is based on the domino-reaction between donor-acceptor cyclopropanes, bearing in ortho-position of aromatic substituent a bromomethyl group, and different primary amines (e.g., anilines, benzylamines, cycloalkylamines) was developed. The reaction involves the generation of secondary amine followed by nucleophilic ring opening of cyclopropane with amino group. Moreover, this process provided a new practical method for the rapid synthesis of benzo[b]pyrrolizidinone 4 from readily available starting materials.

As part of the European project GEOTHERMICA - ERA NET and in order to assess the capacity of heat storage in Switzerland, the Centre d'Hydrogéologie et de Géothermie de l'Université de Neuchâtel (CHYN) is taking part in the HEATSTORE project, launched in 2018. The latter is expected to lead to commercial heat storage projects in the near future in Geneva and Bern, in fractured aquifers. The evaluation of the geological characteristics of these aquifers is essential to understand the thermal energy transport processes of fractured aquifers. For this, it is necessary to be able to measure the temperature distribution along boreholes. Thus, the study focuses on the evaluation of a distributed temperature system (DTS) and its optical fiber in order to determine its operation, limits and potential for use in geothermal energy. Laboratory and field tests have been carried out that the water temperature deviation measurements, with a scan time of 30 s, are reliable at less than 0.5°C at +/-5 m over 500 m of fiber. For absolute temperature values, however, a bath and a reference probe must be used to recalculate the absolute temperature to within 0.5°C. The acquired data are essential for a broader understanding of the locations of fractured and karstified aquifers at Concise, allowing the system to be used to better understand the potential for water storage at a depth of 45°C at 35 m.

癌症治癒方式成效有限，在iPSC中找出具有潛力的蛋白製成大腸直腸癌疫苗是本研究目的。 實驗先以C57BL/6小鼠之股骨及脛骨骨髓中造血幹細胞分化成為未活化的樹突細胞。放入安慰劑、CpG佐劑、CpG+MC38、CpG+iPSC等抗原物來進行免疫細胞活化測試，流式細胞儀分析結果驗證能否減緩小鼠大腸直腸癌的腫瘤生成。接著，利用質譜儀及大數據分析從iPSC中找出促使樹突細胞活化的抗原物蛋白成分，選出3個候選，透過西方墨點法確認其專一性。查詢候選蛋白TTW1、2、3在The Human Protein Atlas 網站對大腸直腸癌之表現數據。 結果 iPSC的抗原物促使樹突細胞的MHC1標記物活化，助於毒殺性 CD8+T細胞的產生進而透過免疫系統預防大腸直腸癌的產生。TTW1只有在iPSC細胞株表現出專一性，同時資料庫顯示TTW1在大腸直腸癌中具有高表現量。 目前未有文獻探討抗原疫苗的應用，團隊未來專注合成iPSC中TTW1蛋白，進一步開發成大腸直腸癌疫苗。

本研究是關於 nim 遊戲的兩種推廣（其中一種是一個稱為 the game of squayles 的遊戲的推廣），稱為 edge-removing game 和 star-removing game。此遊戲為兩人遊戲。在遊戲的一開始，有一個簡單圖 G。兩個玩家輪流刪除該圖的非空路徑或非空星子圖的邊。首先不能移動的一方輸掉遊戲。 在 edge-removing game 中，我成功計算出某些特殊圖的 Grundy numbers，並給出了一般 k 星的 Grundy numbers 上界。接著我定義了一種新的圖，稱為 nice graphs，並發現所有 nice graphs 都是 N-position。我由此給出了任意兩個非空圖的 join product 的解。至於圖的 Cartesian product，我給出了兩個滿足一定條件的非空圖的 Cartesian product 的解，並發現一個 fully nice graph 和任何至少有 2 個頂點的連通圖的 Cartesian product 也是 fully nice 的。使用這個性質，我給出了 r-dimensional grids 上的 edge-removing game 的解。 至於 star-removing game，我最大的突破是構思出對稱性這個概念。使用這個概念，我給出更一般化的結論，可以用來有效分析某些圖的 Cartesian product 上的的 star-removing game。使用這些結果，我給出了 r-dimensional grids 的解。

Improved methods of processing latex into rubber sheets will improve the incomes of small rubber producers. There are two ways in which latex can be processed into rubber sheets: fumigation and solar incubation. The fumigation method is expensive and produces pollution, but solar incubation can cause dark, sticky rubber sheets due to UV radiation, which reduces their value. A low-cost and environmentally-friendly solution to this problem was investigated here. A UV-protective roofing panel made using Nitrogen-doped Graphene Quantum Dots (NGQDs) was developed and tested. N-GQDs were made using the hydrothermal process for 2 and 4 hours (T2 and T4) and the solvothermal process for 4, 6, and 8 hours (TS4, TS6, and TS8). It was found that all types of N-GQDs absorbed light in the UV range, withT4 showing the greatest absorption. T4 had the greatest Fluorescent Intensity (FL) value, emitting blue light, while for the solvothermal method TS6 had the highest FL value, emitting red light. T4 and TS6 were chosen for further testing, and were applied to a clear roofing tile. After installing the roof on the chamber, the temperature inside was higher than outside. Then we measure the UV protection efficiency of the roof which was 93.27%. The average temperature was 45℃, which is the temperature for drying rubber sheets. Due to the roof’s capability to absorb UV radiation and heat the chamber, our N-GQDs roof has a great ability to produce higher-quality rubber sheets.