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「氫」雲直上-影響氫氣火箭飛行的各項因子探討-Discuss the Factors Affecting the Flight of the Hydrogen Rockets

本實驗主要在研究各項因子對氫氣火箭的影響,我們查了許多影片和資料,發現許多氫氣火箭實驗都沒有記錄各項因子的數據及比較,在歷屆科展的火箭實驗中,將氫氣作為燃料的作品也寥寥無幾,所以決定嘗試這個題目作為本實驗的研究主題。 我們的研究使用電解製造氫氣與氧氣,進行燃料、造型實驗,並用電腦計算出飛行高度,希望能找出最佳飛行高度因子。我們發現各種因子的飛升高度與質量、質心、燃料與造型有很大的關聯。 希望能藉由這些實驗讓人們更認識氫氣火箭,也能藉由氫氣火箭的飛行實驗讓大家更認識、更熟悉火箭之中的科學原理,讓大家對科學更有興趣。

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尋找木瓜病原菌的天然抑菌劑與抑菌機制

我們在潰爛的木瓜中純化出Lasiodiplodia theobromae與Neofusicoccum parvum兩種真菌,會使木瓜組織產生軟腐之現象,容易造成水果採收及運送時的大量損失。研究結果顯示,兩菌亦會感染其他植物,但部分具濃烈氣味的植物有較高的耐受性且薰衣草氣味可使該二菌種的菌絲與黑色素含量下降,藉以降低致病力。其中,薰衣草氣味中的芳樟醇是抑菌的關鍵成分。此外我們發現無光環境會誘導病原菌的黑色素累積並提升其致病力。綜上所述,未來在木瓜運送與保存上若能透過照光並配合薰蒸微量薰衣 草精油或芳樟醇氣味,應可有效降低病原菌感染機率,以此減少農損。

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Synthesis of Substituted Pyrrolidin-2-ones and Isoindolines from Donor-Acceptor Cyclopropanes and Anilines/Benzylamines

The development of rapid and efficient synthetic approaches to the bioactive cyclic and polycyclic azaheterocycles is one of the most important challenges in organic synthesis. In this work effective and simple synthetic approaches to polysubstituted pyrrolidin-2-ones 2 and isoindolines 3 from donor-acceptor cyclopropanes 1, bearing the ester group as the one of acceptor substituents, and amines were developed. The γ- pyrrolidone based skeletons and isoindoline ring system is a constituent of many biologically active molecules, both natural and synthetic, and a key component of clinically relevant entities (Fig.1,2) [1,2]. The synthesis of pyrrolidin-2-ones 2 includes Lewis acid-catalyzed opening of the donor-acceptor cyclopropane with primary amines (anilines, benzylamines, etc.) to γ-amino esters, followed by in situ lactamization and dealkoxycarbonylation. The reaction has a broad scope of applicability; a variety of substituted anilines, benzylamines, and other primary amines as well as a wide diversity of donor-acceptor cyclopropanes bearing (hetero)aromatic or alkenyl donor groups and various acceptor substituents, can be involved in this transformation. In this process, donor-acceptor cyclopropanes react as 1,4-C,C-dielectrophiles, and amines as 1,1- dinucleophiles. The resulting di- and trisubstituted pyrrolidin-2-ones can be also used in subsequent chemistry to obtain various nitrogen-containing polycyclic compounds of interest to medicinal chemistry and pharmacology, such as benz[g]indolizidine derivatives. The synthesis of the substituted isoindolines 3 is based on the domino-reaction between donor-acceptor cyclopropanes, bearing in ortho-position of aromatic substituent a bromomethyl group, and different primary amines (e.g., anilines, benzylamines, cycloalkylamines) was developed. The reaction involves the generation of secondary amine followed by nucleophilic ring opening of cyclopropane with amino group. Moreover, this process provided a new practical method for the rapid synthesis of benzo[b]pyrrolizidinone 4 from readily available starting materials.

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Bacteria with Headphones

I first found out about the Young Scientist competition last year, in 2021. I thought it was an interesting and challenging opportunity; something that could take students out of their comfort zone. I researched for some inspiration online and found a website with all the different types of project ideas. While reading about the experiments, I stumbled upon a project relating the music to bacterial growth. It sounded ridiculous at first, but I soon realized it was the right project for me. It intertwined music and biology- form of art I’ve been involved in since the age of 9, and one of my favorite subjects and a field I want to work in in the future.

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運用疾病軌跡搭配深度學習偵測胰臟癌風險

目的:在台灣,胰臟癌雖非癌症發生數最高,但85%為末期,五年存活率小於5%,有癌王之稱。如何早期偵測胰臟癌風險,一直是醫療上的重大議題。本研究運用時間矩陣搭配深度學習進行大量變數之胰臟癌風險偵測。 方法:健保資料庫收集國人疾病、用藥等結構化資料,可藉此反映每人健康狀態。將三年內診斷與藥物碼轉為時間矩陣,以卷積神經網路訓練,訓練組與測試組比例為9:1。 結果:共計案例組1095名及對照組10950名,訓練後測試組表現之AUROC(area under the receiver operating characteristiccurve)為0.937,六十歲以上及以下AUROC分別為0.846及0.897。 結論:結論:能將診斷、藥物、時間轉成矩陣,是以疾病軌跡預測胰臟癌風險,且能找到新特徵,未來搭配健康存摺,為低成本、快速、大量的胰臟癌數位快篩。

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Introduction of Omed-Omedan Tradition Through Augmented Reality-Based Card Games To Increase The Love of Local Culture

This research is motivated by the differences in the people's perceptions, mainly youth about the omed-omedan tradition. The difference is that many people think that the omed-omedan tradition violates the norms of decency and is also called the pornography tradition. The purpose of this study is to, 1) describe the mechanism of applying omed-omedan tradition recognition attitudes through augmented reality-based card games, 2) analyz the impact resulting from the application of omed-omedan tradition recognition attitudes through augmented reality-based card games, and 3) analyze about the feasibility of application resulting from the application of omed-omedan tradition recognition attitudes through augmented reality-based card games. This research is a type of R&D research conducted at Bali Mandara State High School from July 1-September 6, 2021. The subjects of this study were the teenagers of Kaja Sesetan Indigenous Village and the object of this study was the omed-omedan tradition through augmented reality-based card games. The data collection method used is the literature studies, questionnaires, interviews, and validation questionnaires. Data is processed based on qualitative descriptive approach and quantitative descriptive approach. The results showed that the mechanism of implementing the omed-omedan tradition originated from the download of assistive devices, namely android studios and applications from AR, the impact of augmented reality-based card games was seen as very helpful in the introduction of the omed-omedan tradition and was seen as able to help increase the love of local culture, besides that the media used was also very popular by players because it was seen as interesting and very helpful. Based on the feasibility tests that have been calculated, this game is considered very feasible to implement and researchers hope that the innovations that have been created can effectively provide understanding to help out the local community about omed-omedan tradition.

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利用 CRISPR/Cas 技術重建複雜的DNA 修復機制

本研究利用合成生物學技術開發的創新基因組篩檢平台PRISM(v2.0),採用合成轉錄因子(crispr-TF)辨認DNA但不進行剪切,透過修改CRISPR/Cas的PAM-interacting (PI) domain序列打破其辨認限制,由原本NGG序列變成可以結合NAG的序列,提升crispr-TF在高通量基因組的篩選能力,期待未來可以做出辨認NNN序列,以此技術初步成功建構Chk2/Rad53所參與的基因網絡,讓失去Chk2/Rad53功能的酵母菌能在DNA損傷的情況生存。Chk2/Rad53蛋白磷酸酶在DNA修復的訊息傳遞中調控龐大的基因網絡,其中潛在大量不同調控路徑聯結的組合性,過去的研究都無法有效地分析且重建完整的DNA修復機制。未來將進一步探討Chk2/Rad53調控的下游基因組,並以此新技術和研究應用於複雜腫瘤與老化疾病的預防及治療。

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Susanito, autonomous robot body temperature meter: support to reduce infections in rows

A variant of the coronavirus (2019-nCoV or COVID-19) was reported in Wuhan, China on December 31, 2019, spreading rapidly around the world. Owing to a plan to reactivate the economy, the Mexican government, requested to implement protective measures to enter establishments with confined spaces: wear a mask, provide alcohol-based hand rub and the measurement of body temperature, allowing problem when not have a fever; however, these measures cause long waiting lines, causing contagion risk. To support this problem, applied and experimental research was used, generating as a result, the creation of a robot that moves autonomously thanks to a line follower sensor. Dispenses alcohol-based hand rub and determines the temperature by means of an infrared sensor, checking that the distance is adequate, with an ultrasonic sensor, using a buzzer that emits a sound of half a second when it performs a normal detection, but, if it is equal to or greater os 38 ° C, emits a sound for 10 seconds asking the person to leave the line and go to a medical service, helping to reduce problems infections in lines

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Synthesize Sodium Sesquicarbonate and Increase Yield

In order to recycle disposable diapers, we investigated the conditions where sodium sesquicarbonate (Chemical formula Na2CO3・ NaHCO3・ 2H2O hereinafter called sesqui) precipitates selectively from sodium carbonate and the conditions for high yield. For the selective precipitation of sesqui, we defined the time required for the reaction solution to pass through the sesqui precipitation area in the Na2CO3-NaHCO3-H2O phase diagram (45°C) as Δ t. As a result, we revealed that Δt is involved in the selective precipitation of sesqui, and that we can synthesize sesqui without the expensive addition of L-Arginine as used in a previous research. Also, we proposed the “Stay method”, in which the supply of CO2 is stopped for 30 minutes to the lengthen the Δ t, and found that we could synthesize sesqui selectively even under conditions in which sodium bicarbonate is likely to be precipitated as well. Regarding the high yield of sesqui, the yield was greatly improved by the common ion effect of Na by adding NaOH to the reaction solution, sesqui synthesis by repeated reactions with CO2, and sesqui recovery by adding the anti-solvent ethanol, reaching a sesqui conversion rate of 95%. This means 109 g of sesqui can be synthesized from 100 g of Na2CO3. Moreover, we confirmed that these synthesized samples have almost the same detergency as commercial sesqui. We did a test calculation to reveal the usefulness of this research. First, if diaper recycling technology is put into practical use and all used diaper waste in Saijo City can be recycled, a reduction of 534 t/year of used diaper waste can be expected. This corresponds to a 2.3% reduction in Saijo City's waste output. From the ash that would ultimately remain after being recycled, we expect up to 35.3 t/year of synthesized sesqui using our experimental method. In addition, a CO2 reduction of 8.2 t/year is possible in the process, which is about equivalent to the volume of one gymnasium.

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Forming Polygons with Broken Pick-up Chocolate Bars and Spaghetti Noodles

”The broken pick-up sticks problem” is proposed by T. Kyle Petersen and Bridget Eileen Tenner in 2020. We solve the problem by considering the discrete version using random variables, and the limit behaviour of the discrete version gives us a combinatorial solution to the original problem. We also evaluate the probabilities of the triangles formed by the broken/pick-up sticks satisfying some specific geometric conditions with various techniques, including calculus and elementary number theory.

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Designing a LiDAR topographic navigation system: A novel approach to aid the visually impaired

The WHO reports 2.2 billion people internationally have a form of visual impairment, with Perkins School of Blind adding that 4 to 8 percent (8.8 - 17.6 million people) solely rely on a white cane for navigation. In an interview by Stephen Yin for NPR, visually impaired interviewees claimed that a white cane was ineffective as it failed to detect moving obstacles (ex. bikes), aerial obstacles (ex. falling objects), and it became physically demanding after a prolonged period. This problem can be solved with a headset that integrates LiDAR technology and haptic feedback to provide a real-time assessment of their environment. Theoretically, the device will determine how far an object is from the user and place it into one of three conditionals based on distance (0- 290mm, 310-500mm, 510-1200mm). As the user gets closer to the object, the haptic will vibrate more frequently. The device has 11 LIDAR sensors, beetle processors, and ERM motors so that when the LiDAR detects an object, the device will send a haptic signal in that area. It not only identifies the existence of an object but it tells the user its relative position with a latency period of approximately 2 milliseconds. When testing the device, a simulated walking environment was made. Ten obstacles were included: five below the waist (72”, 28”, 35” and 8.5” tall sticks) and five above the waist (paper suspended 6”, 10”, 48” and 28” from the ceiling). The white cane detected 4.1 obstacles, whereas the device detected 7.3 on average. The LiDAR navigation system is 178% more effective at detecting objects comparatively. Visually impaired individuals no longer must rely on the white cane; rather, using this device, they can detect small, moving, and aerial objects at a much faster, and more accurate speed.

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高斯光束照射橄欖油產生繞射的研究

高斯光束(Gaussian beam)穿過透明液體時,對液體局部加熱,使液體有溫度梯度,伴隨著產生折射率梯度。葉綠素-a(Chlorophyll-a)乙醇溶液對紫光的熱吸收率為乙醇的數百萬倍,橄欖油的葉綠素-a含量很高,利用高斯光束照射橄欖油時,橄欖油吸收的大量的熱量產生折射率梯度,以及產生熱透鏡(Thermal lens)和自調相(Self-phase modulation)現象。 以雷射光照射橄欖油,由於熱透鏡現象使光束擴張成大亮點(半徑R),由於自調相現象使光束在屏幕上產生繞射圖樣(繞射亮紋數目N)。圓柱筒裝橄欖油(液柱長度a),用不同功率的雷射照射橄欖油,探討吸收的熱量對R和N的影響。另外使光束先經凸透鏡聚光再照射低熱吸收率的色素水溶液做對照比較。

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