In radiation treatments and manned interplanetary space travel, radiation is one of the biggest problems. The radiotolerance of cancer cells makes it necessary to apply high doses to surrounding healthy tissues by subjecting the cells to heavy stress. With regard to space travel (which involves a minimum travel time of 6 months) (1,2) the danger concerns cosmic radiation which is capable of inducing genetic mutations that, in turn, can evolve into very serious pathologies, such as cancer, damage to dendrites consequently compromising synapses. The project is aimed at developing a technology that can address these issues and aims to make human DNA radioresistant. This study involves a nucleosome-binding protein called DSUP (Damage Suppressor Protein) unique to the tardigrade Ramazzottius Varieornatus and the subject of its radioresistance. It can theoretically safeguard genetic material damaged by radiation. *Internship theme at the Pino Torinese Astronomical Observatory and the DISIT-UPO Environmental Molecular Toxicology Laboratory. The study molecule: Numerous tests have been carried out through the "in silico" approach geared toward mathematical modeling of its protein structure and complex mechanisms of action simulated through artificial intelligence systems, followed by direct laboratory analysis involving biosynthesis of DSUP by genetically modified bacteria and related tests. Both approaches, applied synergistically, aim to make it accessible and useful for the protection of human health.

本研究開發一種新穎孔洞性吸附材料：金屬有機骨架 (MOF)。MOF 在反應溶液中自組裝形成孔洞結構，透過物理吸附有效捕捉氣相乙酸分子。研發出綠色、快速可在常溫常壓下大量合成三種MOF（HKUST-1(Cu)、UTSA-280(Ca) 及 A520(Al)）方法。此外，為提升材料機械強度和應用價值，採用 PVA 聚合技術製備 MOF 複合物，使其造粒型化更易處理，提升商業和環境應用價值。吸附實驗結果顯示，HKUST-1(Cu) 粉末對乙酸移除率高達98%，而HKUST-1(Cu) PVA 複合物達93%，對比活性碳及其PVA複合物（移除率分別為85%和78%）表現更優異。MOF憑藉優異吸附性能和可大量生產低成本優勢，成為極具潛力有機無機氣體吸附劑，可為半導體產業提供一種維持高標準製程環境精密且簡便解決方案。

Recently,thefeedpricesforlivestockfarmshavebeencontinuouslyincreasing, while the prices of calves have been declining, leading to many livestock and dairy farms facing financial losses. If livestock farms are affected by diseases such as foot-and-mouth disease, they suffer significant losses. This is because reducedproductivityinlivestocknotonlyaffectstheirproductionbutalsoentails substantial costs for vaccines and treatments. Therefore, there is a need to explore how to effectively prevent diseases, focusing on common diseases in cattle such as subclinical mastitis and mastitis, and alleviate the burden on farms economically and environmentally. This study aims to investigate the production of bacterial growth-inhibiting straw bedding using substances such as illite and charcoal to contribute to disease prevention.

Formaldehyde is an air-borne, carcinogenic indoor pollutant. It may cause adverse effects on human health such as irritation of eyes and respiratory system. Shells of hermetia illucens, Black Soldier Flies (BSF) are leftovers when the insects mature from pupae to adults. BSF shells are rich in chitin which can be converted into chitosan by demineralisation and deacetylation. Chitosan and its ammonium salt (chitogel) can remove formaldehyde via condensation of water. In this investigation, the efficiency of removal of formaldehyde by different substrates were compared including shells of BSF before and after demineralization, deacetylation and action of vinegar; and common commercial products and Anti-Forma Chitogels made from shells of BSF and some crustaceans. Anti-Forma Chitogel of BSF was found to be effective in removing (91.2%) formaldehyde (1:20 by mass) among shells of BSF with different treatments and its efficiency was better than all commercial products tested. Concentration of formaldehyde in the container with deacetylated Anti-Forma Chitogel is 0.54 mg/m3. It removed 74.8% of formaldehyde compared to the control (2.14 mg/m3). Concentration of formaldehyde in the container with Anti-Forma Chitogel without deacetylation is 0.76 mg/m3 . It removed 64.5% of formaldehyde compared to the control (2.14 mg/m3). The Anti-forma Chitogel of BSF was found to be eco-friendly with high formaldehyde removal efficiency when placed in a drawer (removal of 54.8% of in 24 hours), the chamber of a newly renovated room (removal of 84.9% in 30 minutes reducing the conc. of formaldehyde from 0.53 mg/m3 to 0.08 mg/m3; cf. the safety limit of formaldehyde <0.125mg/m3) and drawers of a new wardrobe (removal of 83.7% at 20.2oC in 1 day reducing the conc. of formaldehyde from 0.49 mg/m3 to 0.08 mg/m3 & kept the conc. of drawers below 0.125mg/m3 most of the time over a month when temperature was below 21oC). Conc. of formaldehyde in air-tight boxes (5g of construction adhesive in 9.3 dm3) with air purifiers with and without Anti-forma Chitogel as filter before and after 3 hours was reduced by 44.5% (from 6.25mg/m3 to 3.47mg/m3 ) and 27.7% respectively showing that Anti-forma Chitogel as filter in air purifier outperformed that without by 160%. Besides, anti-forma Chitogel is antibacterial, so it would also kill bacteria when used in air purifiers. [1] proving that Anti-forma Chitogel is effective in removal of formaldehyde on the spot and can be applied to households. It can also help achieve Target 3.9 and 12.5 of the Sustainable Development Goals of the United Nations.

Agro-guard aims to revolutionize disease identification and community-based projects in the field of agriculture. Integrating Machine learning, Computer vision, clustering, and community-based technology, this project helped farmers to detect their plant disease with their solution and for early warning of plant disease which was spreading in their community which helped in crop management. The research project is divided into three parts.First,Integrating Machine learning to detect and classify plant disease with their solutions.Second,Integrating Density-Based Spatial Clustering of Applications with Noise (DBSCAN),to identify disease and analyze the pattern within agricultural regions.Third,Establishing notification system to notify real-time alerts to farmers about disease spreading in particular region.The research is crucial because it solve one of the crucial problem of our community which is untimely detection of disease.The finding of the research highlight the effectiveness of Agro-Guard framework in early disease detection and community detection.The machine learning models achieved high accuracy in identifying common plant disease and clustering results the pattern in diseases that were very important for notifying the community.The significance of these findings is that it can build powerful system which will overall grow the production of crops and plants due to timely update of the disease prevailing in the community.It contributes in sustainability production of crops and plants which ultimately ensure the good livelihood of farmer.

Due to widespread water shortages, there is an increasing need for innovative water conservation strategies, such as reusing greywater from laundry. The World Health Organization (WHO) recognizes greywater as suitable for plant irrigation, but commercial laundry detergents contain synthetic chemicals that can harm both the environment and plant health. Soap nuts, derived from the Sapindus mukorossi tree, offer a natural alternative. Their pericarp is rich in triterpenoid saponins, amphiphilic compounds, composed of hydrophilic sugar group and hydrophobic triterpenoid sapogenins. These saponins mimic the chemical structure of surfactants in detergents, allowing soap nuts to act as natural foaming and surface-active agents in water. As a result, soap nuts have long been used as a sustainable option for shampoo and laundry detergent in many Asian countries (Sochacki & Vogt, 2022). Greywater, an often overlooked resource, is generated from household activities like laundry, showers, and basins. Unlike blackwater, it contains lower levels of pathogens and bacteria. However, due to a lack of awareness, greywater is frequently mixed with blackwater and directed to the same sewage treatment systems (Greywater Systems: From Recycling to Filtration, n.d.). Greywater accounts for 50-80% of a household’s daily wastewater (Wong, 2011). Repurposing greywater offers a promising and sustainable solution to address water conservation challenges.

According to the 印尼n Association of Olefin Aromatic and Plastic Industries/INAPLAS, 2019 national plastic consumption still relies on plastic packaging at 65% and surprisingly, around 60% of plastic waste is absorbed by the food and beverage industry. The waste has been widely sought to be environmentally friendly, one of which is by developing biodegradable packaging. The purpose of this research is to make durian peel cellulose nanocomposites impregnated with TiO2 NPs, to form antibacterial properties against E. coli wild type and resistance. In this research, there are research methods consisting of nanocomposite synthesis, PSA test, FTIR, physical characteristics test and resistance test. The results analyzed that the nanocomposite nanocellulose-TiO2 NPs was successfully made using a 1:1 ratio and had a particle size of 458.7 nm based on the PSA test, which is classified as a nano size. The success of nanocomposite synthesis was proven by the results of FTIR analysis, which showed the formation of 698.65cm-1 and 1633.99cm-1 spectra, indicating the peak of TiO2 NPs and O-H functional groups on TiO2 NPs, as well as 1028.98cm-1 and 1158.42cm-1 showing C-O and C-O-C bonds in cellulose. The antibacterial test performed showed no significant activity in disc diffusion and well diffusion tests against E. coli wild type and resistance. This is potentially caused by inhomogeneous particle size variation. Physical characteristics test showed that the tensile strength test (0.075 > 0.0125 MPa) Durio Nano-Pack is superior to styrofoam, but the compressive strength test (0.125 > 0.875 MPa) shows the opposite. In this study, nanocomposite has a potential innovation that provides good mechanical properties and has a dual function mechanically as bio-based food packaging and chemically as antibacterial. Further research is needed to improve the particle size homogeneity of nanocomposites, modify the impregnation method, so that it has the potential to develop multifunctional materials that excel in various applications.

Problem • Rice is the primary cereal crop consumed by nearly half the population worldwide • By 2050, there will be a 50% increase in demand for rice • The world’s poor populations depend more on rice, both for income and consumption, than any other food. Rice is the single-largest source of employment and income for rural people • Worldwide, 51–82% of agricultural crop yield is lost annually due to abiotic stress due to climate change • Climate change causes extreme temperatures, erratic rainfall, dangerous droughts, and increased salinity from rising sea levels Solution • To adapt to abiotic stress, rice has intricate signaling pathways, particularly those mediated by the phytohormone abscisic acid (ABA), that cause an increase in stress tolerance • Clade A genes of the Protein Phosphatase 2C (PP2C) gene family are known to be negative regulators of the ABA signaling pathway. • “Deleting” these genes activates the ABA pathway and increases stress tolerance in rice without inducing stress CRISPR gene editing technology is the ideal solution Research Goal • While the role of PP2C genes in stress response is recognized, there is a gap in understanding the specific genes within this family that contribute significantly to stress signaling. Furthermore, there is a need for a detailed investigation into the effects of targeted CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing on rice stress response pathways.

The billiard table is a cuboid with integer side lengths. A point-wise ball moves with constant speed along segments making a 45◦ angle with the sides and bounces on these. We allow the ball to start from any of the 8 corners, resulting in a periodic trajectory known as a corner path. The geometry of the path depends on the artihmetic properties of the side lengths (for example if these are pairwise coprime). Points of contact between the ball and edges, known as edge points, are inves- tigated and their characteristics like distribution explicitly described. This generalizes a previous work by Perucca, Reguengo da Sousa and Tronto of University of Luxembourg.

Infections by the Dengue virus (DENV) cause a disease amonghumansreferred to as Dengue fever, which causes thousands of fatalities globally. There is no existing treatment as of yet that successfully targets DENV. Among the factors thatdeterminetheentry of the virus and severity of the disease is the envelope(E) protein of DENV. This study aimed to examine forty antiviral phytochemicals enumeratedinpaststudiesaspossibleinhibitorstotheEprotein of DENV to provide candidates to aid in drug discovery against DENV. The phytochemicals were screened for their likelihood of inhibition of the E protein using AutoDock Suite and LigPlot+. Seven phytochemicals produced favorable binding affinities to the E protein, which are based on the interactions between the phytochemicals and amino acidsintheactivesiteoftheEprotein.Lipinski’s rule of 5 was then used to screen the seven phytochemicals for oral bioavailability. Glabridin has a binding affinity of -7.6 kcal/mol and was predicted to be orally bioavailable. This phytochemical interacts with amino acids in the E protein active site through hydrogen bonds to Asn355, andPhe337, as well as ten hydrophobic interactions. These interactions ensure that glabridin is able to specifically target and fit intotheactivesiteoftheEprotein, preventing its binding to the host cell and activating its viral proliferation. Glabridin is known to be found in the roots of licorice plants, providing anatural source for a possible cure for Dengue fever.

When doing an experiment to produce colloidal ferric hydroxide, the bottom of the beaker used was colored in yellow-brown with thin film interference. This phenomenon is well-known, but the cause has not been clearly studied. As a result of the research, the coloration on the bottom of the beaker is caused by β-FeOOH forming a thin film which is chemically bonded with Si-OH on the glass surface. Also, the amount of β-FeOOH depends on the number of experiments, the area of the bottom of the beaker, and the concentration of FeCl3 aq. We found that it can be possible to determine the amount of β-FeOOH from the formula m=knsc and the adhesion constant was found to be 6.8✕10-3 (L/m2). In addition, from machine learning we predicted that the thin film thickness becomes thicker as it moves away from the center.

Certain specially structured ceramics, which can be used as biomaterials to replace bone, have recently started being utilized in the medical field. The aim of this study is to produce high-bioactivity silica from corn cob waste, a widely available organic material in nature, and combine it with calcium oxide (CaO) obtained by grinding organic mussel shell waste with high bioactivity. This combination is intended to synthesize dicalcium silicate (2CaO.SiO₂) to develop an alternative tissue scaffold with high bioactivity, capable of replacing bone, for existing titanium alloys. The goal is to incorporate this scaffold into PEEK (polyether ether ketone), a novel tissue scaffold material, at varying percentages to create a next-generation innovative bone substitute material. An additional objective is to demonstrate through biocompatibility tests that the produced ceramic-polymer biocomposite exhibits antibacterial activity against Staphylococcus aureus.