Inhibitory effects of the secondary metabolite of actinomycete were examined on cell cycle of the yeasts of S. pombe and S. cerevisiae. The secondary metabolite was obtained from cultivation of the actinomycete isolated from the soil of Owakudani in Hakone, Japan. The fifth fraction of the secondary metabolite by ODS column separation (HK-T5), which was soluble to pure methanol, was used in the present experiments. The HK-T5 brought about the delay of forming colonies of S. pombe for about 11 days compared to that cultivated without the HK-T5. The delay of the colony formation was longer for the S. pombe cultivated with more amount of the HK-T5. The cultivation with HK-T5 also brought about the extension of the lifespan of the S. pombe for more than 10 weeks in a liquidus medium. The cell life recovered the ordinary manner by removal of the HK-T5, meaning that the activities of the HK-T5 is reversible. These facts confirm the suppression of cell cycle, and the delay of cell growth by the HK-T5. These phenomena were similarly observed for S. cerevisiae. Comparison of the action of HK-T5 with hydroxyurea, which is an anticancer drug inhibiting the cell cycle at S phase, clarified that the inhibitory action of HK-T5 worked at the phase earlier than S phase. The combined effects of HK-T5 on the cell cycle were evaluated with triamcinolone acetonide (TA), or aspirin, the former of which is a drug synchronizing cancer cells in S phase, and the latter keeping human cells in G1/G0 phases. The combined use of HK-T5 with TA synchronized the cells at the phase slightly proceeding from G1 to S phase without toxicity. On the other hand, the combined use with aspirin made the inhibitory effect of HK-T5 inactive. Hence, the HK-T5 is attractive as a drug for the extension of cell lifespan, and anticancer therapy.

研究目的：脂肪肝的盛行率在全世界的現代化國家都在增加。病理醫師在評估脂肪肝的嚴重等級時，常缺乏參考意見以減少差異。許多地區也缺乏病理醫師。本研究旨在建立一個有效評估脂肪肝嚴重程度的病理組織學人工智慧模型。研究過程：本研究經由臺中榮民總醫院人體研究倫理審查委員會審核通過，篩選後取得病理資料庫中適合的肝臟組織切片，由兩位病理醫師獨立為肝組織中脂肪堆積的程度評分。再以病理醫師討論後的共識答案為分級標準，來訓練人工智慧模型。研究結果：在100個樣本的獨立測試中，人工智慧模型和病理專科醫師的評分，有71%完全相同、27%差異只有一個等級、2%差異2個等級、而沒有2個等級以上的差異。結論及應用：我們已初步建立一個可以評估脂肪肝嚴重程度的人工智慧模型。這模型可為將來人工智慧的臨床應用，建立一個良好的基礎。

This paper represents IOT Based Automatic Water Temperature Adjustor. IoT (Internet of Things) refers to the network of physical objects that are embedded with sensors, software, and other technologies for the purpose of connecting and exchanging data with other devices and systems over the internet. This system is for adjusting water temperature according to the possible surroundings such as home temperature, atmosphere temperature, etc. To solve problems like high water temperature while using, time-consuming waiting for water to heat and cool, high power consumption, and not satisfying water temperature this system offers the feature for automatically adjusting the temperature. Arduino, DHT11 (Temperature-Humidity Sensor), Bread Board, DS18B20 (Water Temperature Sensor), Jumper Wires, Resistor, I2C OLED, Water Heating Coil, Relay and LED are used for operating this system. The application of this system is very vast as it can be implemented in power plants, hospitals, mountain regions, local homes, and lodges. This system is time-saving, cost-efficient, easy to implement, provide automatic features, less power consumption, safety, and many more. Compared to other water geyser systems it has the feature of automatically detecting the environmental temperature and adjusting the temperature of the water accordingly. This system is still in its developing phase.

Max Gold's project, titled “Solving Mathematical and Chemical Equations using Python”, is a website comprising of 4 main programmes: one to find the smallest possible combination of two chemical compounds or elements; a self-made parsing function to convert a chemical equation into a matrix, then using Gaussian-Jordan elimination to find coefficients for an equation; a programme to parse a mathematical expression and use that parsed expression in algebraic division of an algebraic dividend of nth degree polynomial by a divisor of 1st degree polynomial; finally, a programme to solve binomial equations for the power s∈Q. This website was originally made so that Max Gold could improve his programming skills for GCSE computer science but expanded to incorporate his passion for chemistry and maths and thus allow others to use these programmes to help them with their problems as well. A problem with many conventional calculator websites is their lack of specificity – they tend to be able to compute some functions but not all. These programmes are tailored to GCSE and A level maths and chemistry, meaning this website provides an outlet to compute specific topics of problems.

Technology is erratic. We never know what could be the next big thing. Nowadays, IoT (the internet of things) has taken over the market. Every technology created nowadays is somehow related to IoT. You should manage to connect the IoT technology with a robust area of hospitality. Catering customers' needs during peak hours at any restaurant or cafe could get overwhelmed with hectic tasks such as taking orders, fetching water, and ordering meals. We created a raw model to accommodate the limitations of the human mind. The technology-based IoT (Internet of things) can come in handy during hectic sessions. A Robot waiter is built from scratch using materials like Arduino (2), Gear DC motor (2), L298N motor driver (1), Ultrasonic sensor (2), IR sensor (2), Servo motor (4) HC-05 Bluetooth module. Desired orders are sent on a wireless network through the menu bar to the kitchen. Then, the robots transfer the food from the kitchen to the customers. The floor will be all white, while there will be a strip of black line to connect every sitting and the kitchen. For instance, if table number three is to be served, we click the number three in the app, which renders an obstacle in table 3. The motor barricades the robot, and the ultrasonic sensors sense it, and it stops. If anyone picks the plate, the ultrasonic sensor senses it, the blockage is removed, and the robot paces in the designated path. People visited the place more often to experience such stimuli. Using the robots attracted more customers and made the work very quick.

Introduction: Using advanced technologies such as nanotechnology in the food and fishery industry, as one of the most important industrial sectors of countries, has received too much attention. Traditionally, fishing and hunting have been considered important sources of supplying food. The subject and methodology: The study aims to investigate nanotechnology for detecting fish hatching time. This is a review article that collects the information from databases such as Sid, civilica, and Google Scholar. In the end, 22 papers were studied for extracting and collecting the required information from the abovementioned scientific database. Finding: After examining the food, drug, and agricultural-related papers published from 2009 to 2020, it was concluded that small Nano-sensors, controlling & monitoring systems made from nanotechnology can be installed on fishing nets, fishing rods, and other fishing equipment. These devices (Nano-sensors and controlling & monitoring systems) will help fishes so that they don’t get caught. In this way, as a fish gets close to the fishing equipment, it will receive sound, smell, or heat-based alarm. Therefore, the fish will stay away from the fishing equipment. The result: according to the finding of this study, it can be concluded that excessive fishing in the hatching time will be avoided by the application of nanotechnology in the fishing equipment. As a result, the following advantages will be secured: 1- There are lots of opportunists who misuse fish during the hatching time. With the application of nanotechnology, they will be stopped. 2- Opportunists are ambushing in different time points to misuse fish. Also, the guards might be ignorant. With the application of nanotechnology, guards are no longer required. 3- This plant is cost-effective too.

球體在旋轉平台上的運動分三階段：進動階段、螺線振盪階段、打滑階段。進動階段、螺線振盪階段為兩個運動模式的疊加：迴旋半徑漸增的螺旋線運動、向平台中心靠近的平移運動。當迴旋半徑漸增至滑動摩擦力的上限值，球進入打滑階段並向外甩出平台。 研究紀錄球體質心運動參數，並以接觸點準靜態理論計算及滑動-滾動摩擦模型進行數值分析，找出各種變因與運動參數間的關係。 結果發現滾動階段中鋼球作迴旋運動的頻率f球和平台旋轉頻率f盤和有正比關係，且比例值和球標準化轉動慣量δ正相關。由滾動階段過渡到滑動階段的最大迴旋半徑Rmax和f球2成反比、和δ呈負相關、和滑動摩擦係數μk成正比。滾動摩擦使球向平台中心靠近，也使迴旋半徑漸增。平台傾斜或呈錐狀時，球體的運動會向水平方向偏移。

leidenfrost effect”是水滴能在熱表面產生蒸氣層並隨機跳動。我們便設想利用此特殊蒸氣層達到讓水滴往固定方向前進，甚至優化其加速結構。 我們設計 (角度θ=30°、45°、60°)×(高度h=1.0 mm、1.5 mm、2.0 mm)共9種具數學意義的微結構。測量微結構在(160°C -350°C)溫度下水滴的速度、生命週期，並獨創「珠光粉慢動作攝影」研究形變、熱流。 我們提出未有文獻紀錄的空腔體積、有效接觸面、水滴外部形變機制、內部熱流循環等機制。利用上述資訊建構運動模型，發現θ=60°、h=1.0 mm水滴有最快的速度。且發現高溫段(表面溫度≥300℃)，任何微結構，生命週期差距都極小。我們獨創性提出水滴在微結構下“leidenfrost effect”數學模型，理論值與數據吻合，成功解釋水滴的運動機制。

本研究主要探討塔粉綠尺蛾食草選擇與其葉內真菌之關係。觀察培養四種植物（烏臼、鵝掌柴、白匏子與島榕）葉內真菌，以真菌生長率、菌絲與孢子形態辨識真菌種類。當我們以烏臼葉內間座殼菌屬（Diaporthe sp.）真菌與不同植物放在一起時，幼蟲取食原為非食草的白匏子葉片，而島榕則有嘗試啃食之現象；此外，飼養過程中我們發現取食烏臼的塔粉綠尺蛾幼蟲糞便較其他種幼蟲易長出真菌，進行幼蟲糞便與消化道真菌培養後，皆有與葉內真菌相似的菌體形態。我們推測烏臼、葉內真菌與塔粉綠尺蛾間的交互作用關係之一可能為：烏臼透過葉內真菌誘使塔粉綠尺蛾雌蛾前往產卵，經幼蟲食用葉片後所排出之糞便以作為葉內真菌傳播的媒介。

This work is devoted to solving the problem of orientation in the space of visually impaired people. Working on the project, a new way of transmitting visual information through an acoustic channel was invented. In addition, was developed the device, which uses distance sensors to analyze the situation around a user. Thanks to the invented algorithm of transformation of the information about the position of the obstacle into the sound of a certain tone and intensity, this device allows the user to transmit subject-spatial information in real time. Currently, the device should use a facette locator made of 36 ultrasonic locators grouped in 12 sectors by the azimuth and 3 spatial cones by the angle. Data obtained in such a way is converted into its own note according to the following pattern : the angle of the place corresponds to octave, the azimuth corresponds to the note and the distance corresponds to the volume. The choice of the notes is not unambiguous. However, we used them for the reason that over the centuries, notes have had a felicitous way of layout on the frequency range and on the logarithmic scale. Therefore, the appearance of a new note in the total signal will not be muffled by a combination of other notes. Consequently, a blind person, moving around the room with the help of the tone and volume of the sound signals, will be able to assess the presence and location of all dangerous obstacles. After theoretical substantiation of the hypothesis and analysis of the available information, we started the production of prototypes of the devices that would implement the idea of transmitting information via the acoustic channel.

本作品研究星狀網路和完全網路，兩種不同結構的連結網路，使用點擴展運算結合成一個網路結構，並且在一定的容錯範圍內，保證存在漢米爾頓迴圈性質。漢米爾頓迴圈在連結網路的研究中相當重要，若存在此性質，則可以保證發送訊號時，能將訊號發送給連結網路上的每一個元件並接收，且不會重覆接收到訊號。我們使用圖形理論的方式，將星狀網路和完全網路，這兩種連結網路結構，分別抽象化成星狀圖和完全圖，網路中的元件抽象化為點，元件之間的連線，抽象化成邊。如果元件之間的連線故障，無法使用，則稱為壞邊。我們證明 n+1 維度星狀圖和 n 維度完全圖使用點擴展運算後，壞邊數量最多是 n-4 時，保證存在漢米爾頓迴圈。

方形盒盛透明液體，置放在冷源上方，液體發生熱擴散時，溫度由上往下逐漸下降，形成溫度梯度以及折射率梯度。雷射光照射和鉛直線成一定角度的玻棒透鏡，再穿過方形盒的透明液體時，在屏上形成斜直線，經一段時間的熱擴散後，變成曲線；曲線和斜直線的距離(h)，隨著時間(t)以及光線照射的位置(y)改變，作不同y的h-t圖可得知液體的熱擴散率狀況。 冷源的溫度0℃，分別用甘油和乙醇作待測液，得到的h-t圖，符合熱擴散推導出的h隨t改變的方程式；改用水當待測液，得到的h-t圖，就不符合熱擴散推導出的h隨t改變的方程式。改用-5℃的冷源，分別用水和氯化鈉水溶液作待測液，得到的h-t圖，不符合熱擴散推導出的h隨t改變的方程式。 用簡易的設備可以了解折射率梯度，溫度梯度，熱擴散率，以及液體的非線性熱擴散。