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DIVE&CLEAN - Intervention Possible
The DIVE&CLEAN project is an educational and innovative initiative aimed at addressing a significant environmental challenge: marine pollution. With oceans covering over 70% of the Earth’s surface and providing a home to 50–80% of life on the planet, their health is critical. However, marine ecosystems are under threat due to plastic pollution, which impacts wildlife, coastal communities, and global biodiversity. This project centers around the idea of introducing underwater trash bins, especially in areas frequented by recreational divers. While most divers explore the seas without specific tools to collect trash, they could contribute significantly with the right infrastructure. The vision of DIVE&CLEAN is to inspire behavioral change, encourage collaboration, and promote actionable solutions to reduce ocean pollution. Using interactive robotics and storytelling, the project tells the story of divers rescuing animals entangled in plastic and collecting trash from the ocean floor using underwater bins. Through creative performances, it seeks to educate and motivate individuals, resorts, and authorities to adopt sustainable practices.
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天狗現形劑-研發分辨四型登革病毒之抗原快篩試劑
登革熱(Dengue Fever)俗稱天狗熱,由登革病毒(Dengue virus; DENV)透過埃及斑蚊(Aedes aegypti)和白線斑蚊(Aedes albopictus)傳播並於熱帶及溫帶地區肆虐。每年全球約有五千萬至一億人感染登革病毒,約有五十萬人因登革出血熱(Dengue Hemorrhagic Fever; DHF)而住院。登革熱主要流行於熱帶及亞熱帶地區,尤其是與台灣頻繁往來的東南亞國家,其中一型與二型在東南亞國家病例數較高。當不同血清型登革病毒交錯感染容易引發登革出血熱以及登革休克症候群(Dengue Shock Syndrome),對公共衛生構成重大挑戰。因此研發可快速辨識四型登革病毒之檢驗試劑將有助於提升臨床診斷與後續治療。本報告的研究結果有三項,(1)四型登革病毒NS1 (Nonstructural Protein 1)蛋白的表達與純化:利用分子生物技術成功構建載體並純化四型NS1蛋白,作為免疫原蛋白用於小鼠免疫;(2)單株抗體的篩選與親和性測試:經三次免疫後,利用小鼠脾臟細胞與骨髓瘤細胞進行融合,篩選並生產針對NS1蛋白的單株抗體(monoclonal antibody, mAb),並通過酵素結合免疫吸附法(Enzyme-linked immunosorbent assay, ELISA)驗證抗體的專一性及親和力;(3)快篩試劑的開發與性能測試:運用側向流體免疫層析法(lateral flow immunoassay)設計並組裝快篩試劑,先以重組蛋白進行初步測試,隨後將使用去活性病毒進行性能驗證,確保試劑的靈敏度與準確性。期望這些研究成果有助於台灣登革熱防疫且為臨床治療提供參考。
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Wibrazz is a wearable communication tool that allows the teacher, the therapist, the parent to communicate information to the child remotely using the device. Haptic (vibrationbased) feedback is becoming increasingly important in everyday life. A vibrating device that transmits information through clothing can help people with disabilities who have no or limited sensory use to live an integrated life in society without barriers.
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Analyzing Glucose Metabolism Connectivity in Huntington's Disease Using Dynamic Glucose-Enhanced MRI in zQ175 and R6/2 KI Mouse Models
亨丁頓舞蹈症為與認知功能障礙密切相關的神經退行性疾病。本研究首次應用動態葡萄糖強化磁振造影(DGE MRI)以了解葡萄糖代謝作為亨丁頓舞蹈症神經影像生物標記的可行性,以分析大腦中不同區域之間的代謝關係。 本研究對腦區間葡萄糖代謝關聯性進行分析,並針對訊號進行自動化分群,觀察特定訊號樣態之特徵。於zQ175 KI和R6/2 KI小鼠中不同的連接性變化模式中,發現紋狀體和齒狀回之間葡萄糖代謝連接性具顯著變化,與已知病理一致,顯示DGE MRI作為臨床生物標記之潛力,以利及時診斷和監測該疾病。 這項開創性的研究探索了使用DGE MRI作為亨丁頓舞蹈症影像標記可行性,並詳細分析腦區間葡萄糖代謝相關性,不僅進一步對該疾病之病理更加深入了解,同時提高早期診斷、疾病監測和精準醫療應用發展,說明可能有針對代謝紊亂的潛在治療策略。
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麥克納姆輪車直線 360 度全向控制與角度誤差之探討
近年來,作者觀察到餐飲業及飯店業引入自主移動機器人(AMR)提供服務,受到廣泛歡迎。不僅如此,隨著AI的風潮,愈來愈多產業引進機器人補足人力的空缺。就輪式機器人而言,麥克納姆輪具相對優異的機動性和運動靈活性,但傳統麥克納姆輪的行進模式只侷限45度倍數的方向。針對此限制,本研究分析傳統麥克納姆輪的合力方向,通過數學推導和實際控制方式的驗證,確認其18個方向移動的數學式,再利用ESP32-S單晶片的WIFI驅動控制系統,實現並驗證 合力分析結果 接著,進一步 建立 麥克納姆輪的全向 360 度直線移動的數學式, 並且用 PWM 脈波調變,實現全向控制。此外,分析地面材質對車子移動的影響,測試出麥克納姆輪適合的地面材質,針對誤差給出可能的校正方式以達更精密的控制。希望就本研究結果擴展未來的應用範圍及使用價值。
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自組裝DNA探針於GNP@PANI電極以檢測miRNA
在許多疾病,如癌症、心血管等疾病中,微核醣核酸 ( microRNA,簡稱miRNA) 的表現水平可作為診斷指標。現行檢測miRNA多使用RT-qPCR,然而此技術成本高、操作繁瑣且耗時。本研究自行設計可抓取目標miR-155的DNA分子探針,透過化學合成與修飾將此探針接合在奈米金-聚苯胺( GNP@PANI )電極上,組裝出具靈敏度與特異性的DNA分子電極。實驗結果顯示:此自組裝探針電極具有良好的線性檢量關係,偵測極限可達0.1 nM。在摻雜多種miRNA的樣品中,此電極仍具有極佳的專一性,回收率高達101.5 %。應用於含生物基質的尿液樣本,可不受背景干擾,其檢測差異僅約0.4 %。本研究採用電化學技術來檢測miRNA,不但成本低、操作簡便,且可依據目標分子進行客製化設計,為新一代檢測技術開創前景。
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含鐵、鎳之過渡金屬錯合物相變材料研究暨應用研析
量子運算發展日新月異,人類對上網溝通保密的需要與日俱增。市場已有量子資訊加解密所需的金鑰分配系統(QKD)搭配機密資料保險庫(Archive)。然實體金鑰因其安全性,不可或缺。本文探討以製備含鐵、鎳過渡金屬錯合物,利用含 X 光繞射儀等設備檢測、分析其結構與相變。並研析將該錯合物作為分子開關裝置,導入半導體製程,應用於研發上述金鑰之可行性。
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Application of Carbon Aerogels in Lithium-Air Batteries
One of the main challenges with today’s batteries is their relatively low volumetric and specific capacities. The highest specific capacity can be achieved with lithium-air batteries, which use metallic lithium as the anode and typically some form of porous carbon as the cathode. To enhance performance, aerogels—among the world’s lightest solid materials—are ideal candidates for cathodes. Resorcinol-formaldehyde (RF)-based carbon aerogels, for example, serve this purpose well. In my work, I utilized two types of carbon aerogels as cathode materials: one derived from pyrolyzed resorcinol-formaldehyde polymer and the other a graphene-oxide-modified version of this carbon gel. I integrated the carbon aerogels I had pyrolyzed into lithium-air batteries to improve the cell’s performance, energy density, and capacity compared to cells using activated carbon. In my research, I examined the pore structure and surface properties of these materials in aqueous media using NMR (nuclear magnetic resonance) relaxometry and cryoporometry, exploring their impact on battery efficiency. I found that the graphene-oxide-containing sample's pores filled with water in a layered manner, indicating a more hydrophilic surface, which suggests a denser arrangement of oxygen-containing functional groups compared to the unmodified carbon aerogel. The pore sizes were reduced after adding graphene oxide, resulting in an increased specific surface area for the sample. Incorporating the reduced graphene-oxide-containing carbon aerogel enabled the creation of a more efficient, higher-capacity battery than with the RF carbon aerogel. This improved performance is likely due to the aerogel’s higher oxygen content and altered morphology. The increased oxygen content provides more active sites for oxygen reduction, meaning that a greater specific power output can be obtained from the battery.
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二氧化碳捕捉術-銅鋅雙金屬奈米觸媒對二氧化碳還原反應效能及機制之研究(Carbon Dioxide Capture Technology: Study on the Efficiency and Mechanism of CO2 Reduction Reaction Using Copper-Zinc Bimetallic Nanocatalysts talyst)
本研究以電化學二氧化碳還原反應(CO2RR)技術將二氧化碳還原成高經濟能源燃料,使用水相合成法製備Cu/Zn銅鋅雙金屬奈米觸媒,改變金屬間的比例: Cu2Zn1、Cu1Zn1、Cu1Zn2以及通入N2/O2/H2 熱處理改變觸媒氧化態,而改變氧化態可以在化學性質、催化活性、電子結構等方面有重要影響使其催化出不同反應路徑,改變產物生產效率和選擇性。用能量散射光譜儀、X光繞射儀鑑定奈米觸媒間金屬比例和晶型;線性掃描伏安法和氣相層析儀探討二氧化碳還原法拉第效應和生產效能。結果發現Cu2Zn1-N2能產生最多的CH4,因改變氧化態使其效能高達53.03%; Cu1Zn2產生最多的CO,效能為44.99%,推論為鋅的比例較高所致。
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Exploring the Potential of Pachyrizus Erosus-Derived Calcium as an Affordable Nutritional Solution for Lactose Intolerance
An exploration of Pachyrhizus erosus as an option for plant-based milk in the 印尼n market for people with lactose intolerance. With its prevalence in tropical climates, Pachyrhizus erosus is an affordable crop in 印尼. Pachyrhizus erosus is a root vegetable containing a calcium content of 15.6 mg per cup (130g) in its unprocessed form, concentrated in its white flesh. Based on its affordability and calcium content, Pachyrhizus erosus can be transformed into a beverage product with nutritional qualities on par with existing plant-based milk, therefore being a solution for calcium sustenance that is more accessible due to its high capability to be locally grown in 印尼. However, this may be a partial case as Pachyrhizus erosus only thrives in regions with long warm seasons. In this research, three trials of Pachyrhizus erosus-based milk recipe have been conducted Trial 1 consists of a 1:1 ratio of Pachyrhizus erosus to water, Trial 2 consists of a 2:1 ratio of Pachyrhizus erosus to water, and Trial 3 consisting of a 10:10:1 ratio of Pachyrhizus erosus to water, and to a small amount of soybean. Based on the results of 14 organoleptic test respondents, it is concluded that the best ratio of ingredients is 10:10:1 (water: Pachyrhizus erosus: soybean) due to an overall preference of the third trial with this ratio, in terms of taste, aroma, color, and consistency. Pachyrhizus erosus is the dominant ingredient in developing alternate plant-based milk. However, findings from the most preferred trial in the organoleptic test suggest that implementing a minor amount of soybean would stabilize the milk-like consistency and flavor. Pachyrhizus erosus’ ability to retain calcium in its water content has been additionally proven in a calcium test using a reagent solution of ammonium oxalate, as even with the trials’ step of straining the liquid content of Pachyrhizus erosus that had been blended with added water, all three trials tested positive based on the high level of the precipitate. Other tests that tackle the quality of each trial include In Silico Testing, biuret protein test, alcohol test, COB test, and pH level testing.
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A Study on Hybrid Electromechanical Actuators
An actuator [7,22,28,29] is a motion control mechanism. Depending on the type of actuator, it can convert one type of energy (e.g. chemical, electromagnetic, thermal) into mechanical energy. The field that laid the foundations for the realization of actuators is the field of electromechanics, whose evolution was common with that of actuators. Thus, a periodization of the electromechanics paradigm includes 3 major stages [7,6,25,28,29]: I.1830-1950 Old electromechanics. It is the period when the development of electric cars is significant, which imposed the appearance of classical or primary electromechanical drives. It was a generous nineteenth century, dominated by the scientific results of the triumvirate: Michel Faraday (initiator of fundamental empirical experiments in the history of electricity; the law of induction, of the principle of electric motor, of the magnetic circuit, initiator of electro-chemistry), James Clerk Maxwell, (the genius theorist who put into mathematical form the equations of electric and magnetic fields, as well as the connection between them), and Werner Siemens (engineer and capitalist genius manager who managed to exploit and validate the relationship research-technology-economic development), triumvirate that can be disputed in the sense that other scientists also made outstanding contributions to the history of electricity: Edison, Ampere, Ohm (to name but a few who do not exhaust a significant list). Industrial production of electric machines also appeared and the first signs that will announce the emergence of electromechanical actuators as a basis for military applications. II.1950-1970, Traditional electromechanics, in which electrical power drives appear, a theoretical and experimental development on the emergence of new material and electromechanical principles. Much military research (such as missile control or ship and torpedo control) influences and produces the transfer of applications in ordinary life, including the actuator subfield. III. 1970-2020, Avant-garde electromechanics, representing according to Thomas Kuhn's theory, a paradigm forcing [30]. It is worth noting the contributions of the new scientific revolution. - Specific technologies of miniaturization, by material deposition. - Elastomeric polymeric materials with the help of which it was possible to make electrostrictive actuators, - Very special means of investigation, mainly the development of microscopy, - Gradient of applications in the field of medical engineering, with outstanding contributions both in investigation and microsurgery, applications of actuators in biological micropumps, etc. [25,27,28,29].
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數位物理實驗室:毫米波雷達系統之設計與應用
本研究旨在設計基於毫米波雷達的數位物理實驗系統,用於精確量化彈簧簡諧運動。傳統物理實驗易受肉眼觀察與手動測量的誤差影響,本系統利用24GHz毫米波雷達結合自製電路板,進行即時、無接觸的運動測量。透過設計電路板、撰寫韌體訊號轉換程式,並進行數位數據分析,成功開發了靈敏的毫米波雷達系統。我們利用彈簧簡諧運動實驗驗證了該系統,觀察不同質量砝碼對彈簧運動頻率的影響。實驗結果顯示,考慮彈簧質量後,測量數據與理論結果的均方根誤差從0.62Hz降低至0.35Hz,顯示出系統的高度精確性及穩定性。本研究成功解決了傳統實驗中的量測誤差問題,以毫米波雷達技術實現了精確觀測。開源設計有助於推廣至學校的物理實驗室,為學生提供先進的實驗工具與數據分析經驗。這展示了毫米波雷達在物理實驗中的應用潛力,並為未來教學實驗提供了高效、低成本的解決方案。
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