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以卵黃細胞模擬紅血球在血管中之流動表現與潛在應用價值

本研究以塑膠水管、雞卵細胞搭配不同液體黏度,建置出七種生理情境,並藉由蒐集卵黃形變狀態、速率、側截面積,建構紅血球在血管中流動表現的模型,希望能達到預測生理情境的效果。研究的最後,我們使用Python撰寫程式,協助自動追蹤卵黃的最大瞬時速率與當下的側截面積。本研究發現卵黃會因流動速率的變化產生相對形變避免破裂;當模擬正常微血管時含有0.03%酒精,流動速率會提高;當模擬緊張型微血管時含有0.5%酒精,流動速率較接近正常微血管。另外,模擬微血管中的卵黃若在流動時受到阻力,比表面積會增加,但在小動脈模擬中卻相反;在模擬緊張型微血管時,隨著管內液體黏度上升,卵黃出現最大瞬時速率的位置離心臟越遠。

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攜帶型高效率氫能離子能雙輸出埠電力裝置 Dual-ports high hydrogen and ionic conversion efficient power generator

本研究以空氣為催化劑,降低KOH在水中解離成K+及OH- 的解離能,大幅提升KOH在水中解離的效率,配合以鋁板為電極,還原H2O及OH-,釋出氫氣H2。這還原反應過程同時輸出K+及H2為電力能源。利用解離出的K+組裝成鉀離子電池,同時以解離出的氫氣運作燃料電池,組成雙輸出埠電力裝置。本雙輸出埠電力裝置,可以分別利用KOH濃度及或空氣輸入量,來調控輸出功率。KOH濃度增加或空氣輸入量增加,均可提高兩輸出埠的功率。測試時採用KOH濃度為5M,輸出電壓達0.19 mV,電流達0.166 mA。採用摻雜0.3%鉍的鋁為電極板,提升輸出電壓達0.67 mV,電流達0.199 mA。在鉀離子電池2MKOH水溶液中串聯4組電極板,電壓提升至2.9 V,電流達5A,並能成功點亮LED燈及驅動市售燃料電池。再經電路板穩壓後,電壓從2.9 V提升至5 V,適合USB充電,顯示出其作為無碳排放電力能源。

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水中的奇妙力量探秘 沃辛頓射流

我們以實驗室及生活上容易取得的重物與乒乓球模擬網路上跳水彈射手中球體的沃辛頓射流實驗。結果發現以圓形的類天然海棉托住乒乓球丟入水中可成功產生射流,因此選擇此為托球的載體進行實驗。依據我們的實驗結果,至少需要15公分水深才能形成完整的射流彈射出乒乓球,原則上在下落軌跡完全垂直於水面時,落下高度越高,球體彈射高度越高,實際實驗水深15公分以上時,落下高度50公分彈射高度約可達47公分,但結果受限於托球的海綿在落下高度40公分後下落軌跡不穩定,若期望更高的射流強度需要尋找更穩定下落的載體。最後我們將實驗影片逐格分析計算,證實球體彈射過程是一個反覆受到重力及空氣阻力等因素影響降速,又受到下方射流水柱力量推擠而加速的過程,初步建立以乒乓球標示射流噴射過程運動模式的邏輯。

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Development of MBR, CO2 absorption ball

We invented the Midori which means green Bioreactor (MBR), beads of euglena and other microalgae fixed in calcium alginate that absorbs carbon dioxide (CO2). We examined the effect of 19 different solutions and two different organisms on MBR cultivation. Surprisingly, when the MBR was supplied with carbon dioxide or cultured with yeast, they became drastically darker green. Chromatography revealed this green color to be that of microalgae such as green algae or Euglena because chlorophyll a and chlorophyll b were detected. Under sunlight, MBR absorbed CO2 and the absorption rate was 1.5 L CO2/day/1L of MBR. Furthermore, when we put MBR in the water tank, they increased the amount of dissolved oxygen without polluting the environment. These results indicate that MBR can absorb CO2 by photosynthesizing without leaking out the inside microalgae.

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Trojan Horses in the Fight against Skin Cancer

In photodynamic therapy (PDT), reactive oxygen species are generated within the cytoplasm to destroy cancer cells selectively. Using porphyrinic structures (PS) as photosensitizers holds promise for targeting cancer cells. However, direct incorporation of the porphyrins into cancer cells remains elusive. Hence, Dr. Martina Vermathen’s research introduced specific membranous phospholipid nanocarriers for topical porphyrin applications. However, since a sufficiently high enough concentration of PS in cancer cells has not yet been achieved, this study aimed to improve skin uptake of the nanocarriers. Two approaches were examined: (1) comparing polar and nonpolar porphyrins and (2) assessing the effect of a penetration enhancer, DMSO, through a neat and diluted application. The polarity of the porphyrins was first quantified with a log P test. The nanocarriers were assembled by incorporating two different PS compounds, either the mono- or tetra-4-carboxy substituted phenyl porphyrin. They were then characterized by 1D and 2D-NMR analysis. The porphyrin permeation was tested by Franz diffusion tests on pig ear skin. For the second approach, DMSO was added in the Franz diffusion test, either directly applied on the skin (“neat“) or diluted in the nanocarriers (“diluted”). The log P test for the mono- and the tetra-carboxyphenyl porphyrin resulted in values of 4.5 and -1.1, respectively. The more polar tetra-carboxyphenyl porphyrin exhibited 2.8 times better skin uptake compared to the mono-carboxyphenyl porphyrin. The neat DMSO application increased uptake by a factor of 5.5. The diluted DMSO application worsened skin uptake slightly. Analytical techniques revealed differences in porphyrin encapsulation: The mono-carboxyphenyl porphyrins were encapsulated in the centre, whereas tetra-carboxyphenyl porphyrins were localised around the nanocarriers. Results indicated potential instability of the nanocarriers. The more polar tetra-substituted porphyrins showed superior skin diffusion than the mono-substituted derivative. The neat DMSO application facilitated enhanced skin uptake by inducing membrane destabilization and pore formation but may have limited applicability. Further research is suggested to explore porphyrinic PS with alternative polar substitution patterns and tailored penetration enhancers for lipid-based delivery systems. Overall, the study underscores the importance of molecular properties of the PS system and demonstrates the potential of penetration enhancers in optimizing PDT for skin cancer treatment.

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EIBraille: An Electromagnetic Field-Powered Braille Training Device with Development of Printed Circuits and Algorithms for Visually Impaired Individuals

Visual impairment ranks among the top three disabilities globally, with affected individuals projected to increase from 39 million in 2015 to 115 million by 2050. Despite this growing prevalence, over 95% of visually impaired individuals face difficulties in learning Braille (AFB, 2022). In Thailand, the issue is compounded by limited resources, with only 48 schools for the blind serving 6.5% of visually impaired children, alongside a shortage of trained teachers and prohibitively expensive Braille displays. To address these challenges, the EIBraille Box was developed as a cost-effective and accessible tool enabling visually impaired individuals to practice Braille independently. The device utilizes electromagnetic field generation based on Lenz's Law and electromagnetic induction, employing copper coils and varying currents to drive a Braille dot display mechanism controlled by a microcontroller. Results show the device achieves an average display rate of 30–120 milliseconds per cell and a Braille dot-changing frequency of 3–20 cycles per second. The production cost is reduced from 11,660 USD to 87 USD—over 130 times more affordable—while maintaining performance comparable to traditional mechanisms. Additionally, the device integrates with a web application aligned with the Ministry of Education's curriculum to enhance learning. The EIBraille Box is planned for deployment across 48 schools affiliated with the Northern School for the Blind. Plans include extending access to individuals unable to attend schools via alternative distribution channels. This project stores high capacity to achieve global reach by partnering with the World Blind Union, extending its services to rural areas and ensuring access for underprivileged communities. This effort seeks to promote literacy among the blind on a worldwide scale. This innovation strives to enhance equity for the visually impaired by enabling blind individuals to participate in inclusive educational environments alongside their peers. It aims to eradicate the challenges of illiteracy and ensure equitable access to quality education.

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上皮細胞黏附分子(EpCAM)與Dabrafenib對未分化性甲狀腺癌(ATC)進程機制之探討

上皮細胞黏附分子(EpCAM)與上皮細胞間黏附、信息傳導、增殖與分化等功能有密切關係,已被證實會在多種上皮癌細胞中大量表達,被視為一種可行的臨床標記。透過 細胞存活率、細胞群落、轉移與侵入試驗,觀察到EpCAM能增強未分化性甲狀腺癌(ATC)的細胞增殖、生長、轉移與侵入能力。 此外實驗發現dabrafenib小分子抗癌藥物處理的ATC,其細胞增殖、生長、轉移與侵入能力均有下降的趨勢,而細胞凋亡程度則有顯著的上升。此次研究藉由西方墨點法發現,磷酸化ERK蛋白的表現量隨dabrafenib濃度的上升而逐步下降,顯示dabrafenib能夠抑制ATC細胞訊息傳遞路徑中ERK蛋白的磷酸化,進而影響ATC的生長。若能深入了解EpCAM和dabrafenib在癌細胞中的作用機轉,EpCAM相關藥物與dabrafenib未來在臨床應用上,或許能為ATC患者提供另一種新的治療方式。

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水中的奇妙力量探秘 沃辛頓射流

我們以實驗室及生活上容易取得的重物與乒乓球模擬網路上跳水彈射手中球體的沃辛頓射流實驗。結果發現以圓形的類天然海棉托住乒乓球丟入水中可成功產生射流,因此選擇此為托球的載體進行實驗。依據我們的實驗結果,至少需要15公分水深才能形成完整的射流彈射出乒乓球,原則上在下落軌跡完全垂直於水面時,落下高度越高,球體彈射高度越高,實際實驗水深15公分以上時,落下高度50公分彈射高度約可達47公分,但結果受限於托球的海綿在落下高度40公分後下落軌跡不穩定,若期望更高的射流強度需要尋找更穩定下落的載體。最後我們將實驗影片逐格分析計算,證實球體彈射過程是一個反覆受到重力及空氣阻力等因素影響降速,又受到下方射流水柱力量推擠而加速的過程,初步建立以乒乓球標示射流噴射過程運動模式的邏輯。

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漫畫生成與預測

本研究探討了利用生成式人工智慧技術為漫畫創作帶來新可能性。在當今競爭激烈的漫畫產業中,創作者們需要不斷創新以吸引觀眾,而創作引人入勝的漫畫需要豐富的想像力和劇情結構。本研究希望能協助創作者製作草稿,並探索與AI當朋友的新型創作模式。在生成方面,提出了將漫畫劇情提取、劇情預測以及圖片生成三個步驟的生成流程,並使用了多種模型和技術,如 YOLO模型用於漫畫人臉檢測、文字生成模型用於劇情預測、LoRA技術用於模型微調等,為解決人物生成不連續的問題,我們也提出一種基於特徵提取與融合的解決辦法。本研究提供了一個全面的方案,旨在利用人工智慧技術幫助漫畫創作者創作出簡單的草稿。

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沙盒類遊戲式學習平台系統伺服器架設節能效率研究:以Minecraft為例

本研究以 Minecraft 為例,探討沙盒類遊戲式學習平台系統伺服器架設的節能效率,旨在透過動態調整伺服器數量降低總CPU使用率,提升伺服器的管理效能和能源使用效率。隨著線上遊戲的普及,伺服器的營運管理變得越來越複雜,如何在滿足玩家需求並同時降低能源消耗成為一個重要議題。本研究將分析伺服器資源使用狀況,特別是在玩家活動量高低波動的情境下,透過管理策略的調整,探討其對節能效率的影響。 研究透過實證數據的收集與回歸分析,建立一套可應用於 Minecraft 伺服器的節能動態調整系統,並探討動態調整的具體效率。研究結果發現隨著玩家人數增加,越接近系統負載上限,節能效果會越來越不明顯,以本次研究的伺服器來講玩家人數到達35人以後就無法再減少伺服器數量。

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利用體外測試方法探討生醫水凝膠與材料表面附著性質之關聯 Investigation of the relationship between biomedical hydrogels and surface adhesion properties using in vitro testing methods

醫療級水凝膠在注入人體後容易因運動行為而產生位移,因此需要體外測試方法來評估水凝膠的附著性,以製備適合不同部位使用的水凝膠。本研究設計兩種測試方法來模擬水凝膠在人體的斜角流動狀態和旋轉流動狀態的位移,藉此推斷水凝膠施打入體內後的變化。本研究採用兩種不同黏性的水凝膠和不同粗糙度表面如人工皮、陶瓷和金屬來模擬人體部位的接觸面,探討水凝膠的附著性質。斜角流動測試下,黏性高的水凝膠在陶瓷和金屬 30°、45°及90°的斜角下幾乎不會流動,黏性低的水凝膠則會隨著角度的增加而流速加快。陶瓷粗糙度最高,水凝膠在其表面上附著性質較強。旋轉流動測試下,高黏性的水凝膠在模擬跑步時都具穩定性,而低黏性則只適用於較穩定的步行狀況。體外測試方法能區分不同黏性水凝膠的附著性質,說明此方法可作為篩選適用的水凝膠的依據。

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The conspiracy mentality: its relationship with absurdity and ostracism

Conspiracy theories are generally perceived as irrational, absurd and as having a negative effect on our reputation. Yet some people do not see them as such. This may lead us to wonder why and how an individual would come to believe or support such statements. In this work, the primary goal is to obtain the level of absurdity of various conspiracy theories so that they can be used in experiments designed to test Williams' “Strategic Absurdity Hypothesis”. In addition, this study attempts to demonstrate the link between conspiracy mentality and feelings of ostracism. In this research, I analyzed a group of 47 participants recruited via social networks in May 2023. The survey collected their demographic information, their conspiracy mentality, their feeling of ostracism, their knowledge of conspiracy theories and their perception of absurdity toward them. The results were analyzed using correlations and linear regressions. The results show a negative correlation between conspiracy mentality and the perception of absurdity for most theories. In other words, the higher a participant's conspiracy mentality, the less absurd the theory is perceived to be. Therefore, hypothesis (I) is partially supported. On the other hand, hypothesis (II), which says that ostracism predicts conspiracy mentality, is not supported by the results. These results are in line with Williams' “Strategic Absurdity Hypothesis” and Sterelny's signaling theory, explaining that an individual, by expressing agreement with a conspiracy theory typically perceived as absurd, damages their reputation in the eyes of others to show that they belong to the group. However, for the theories relating to COVID-19 and climate change, the conspiracy mentality does not predict the vision of absurdity, suggesting that their currentness and media coverage influence whether they are used as signals. The literature does not fully agree with our results and still presents very divergent opinions regarding the links between feelings of ostracism and conspiracy mentality. Indeed, it remains difficult to determine whether conspiracy mentality influences ostracism or vice versa. In conclusion, this study provides new ideas for future research on the origins and impact of the conspiracy theories.

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