上皮細胞黏附分子(EpCAM)與上皮細胞間黏附、信息傳導、增殖與分化等功能有密切關係，已被證實會在多種上皮癌細胞中大量表達，被視為一種可行的臨床標記。透過細胞群落、細胞存活率、細胞轉移與侵入試驗，觀察到EpCAM能增強未分化性甲狀腺癌 (ATC)的細胞增殖、生長、轉移與侵入能力。 此外實驗發現 dabrafenib小分子抗癌藥物處理的ATC，其細胞增殖、生長、轉移與侵入能力均有下降的趨勢。藉由西方墨點法發現，磷酸化ERK蛋白的表現量隨dabrafenib濃度的上升而逐步下降，顯示dabrafenib具有抑制ATC細胞訊息傳遞路徑中ERK蛋白磷酸化的效果，進而影響ATC的生長。因此若能進一步了解EpCAM和dabrafenib在癌細胞中的作用機轉，EpCAM相關藥物與dabrafenib未來在臨床應用上，或許能為ATC患者提供另一種治療方式。

本研究探究日本藍泥蜂 (Chalybion japonicum punctatum)雌蜂築巢行為，從2023年7月至2024年6月，觀察與記錄人工巢18巢，自然巢78巢，共96巢。研究發現：巢位選擇部分，雌蜂築巢無樓層、方位及棲地材質偏好，人工巢位第1、2圈平均築巢率53.3%，具聚集性；借坑性築巢特性部分，巢洞1cm以下最多，巢室1間最多，巢室尺寸2.77cm最多，封口與洞口距離多為0cm；雌蜂獵捕蜘蛛育幼，獵物2科4種，每巢約 14-20隻；羽化後殘骸1節以下佔62.01%，幼蟲攝食方式為啃食；完成雌蜂築巢行為譜，雌蜂有競爭、築假巢等護幼行為；白門平均有0.864669mg/g氨氮值，尿酸濃度為比壁虎排遺低、氨濃度與壁虎排遺相當，約400~600uml/L;pH值平均6.11，弱酸性；水份平均281秒滲入白門，具透氣性；較其他蜂巢門滲入時間長，較具防水性。

Lower limb amputations affect about 28.9 million people worldwide, influencing normal human functions, we are developing a conscious brain mind-controlled Cybonthitic cyborg bionic-leg to provide a professional solution for this problem, which is classified as restricted knee movement, short-term solution, limited pressure bearing, unspecific analog reading of EMG; Because the output voltage measured in nano-volts, resulting in unspecific knee movement. The functionality of these modern gadgets is still limited due to a lack of neuromuscular control (i.e. For movement creation, control relies on human efferent neural signals to peripheral muscles). Electromyographic (EMG) or myoelectric signals are neuromuscular control signals that can be recorded from muscles for our engineering goals. We worked on a sophisticated prosthetic knee design with a 100-degree angle of motion. We also used a specific type of coiled spring to absorb abrupt or unexpected motion force. In addition, we amplified the EMG output from (Nano-Voltage) to (Milli-Voltage) using customized instrumentation amplifiers (operational amplifiers). We used a full-wave rectifier to convert AC to DC, as a consequence of these procedures, sine-wave output voltage measures in millivolts, and the spring constant indicates the most force for every 1cm. Von mises Stress analysis shows bearing as 3000N is the maximum load for the design. Detecting the edge of a stairwell using the first derivative. The benefit of a system that controls the prosthetic limb is activated by the patient’s own EMG impulses, rather than sensors linked to the body.

隨著越來越劇烈的天災，對農作物損害造成了許多危機。去了解植物如何對抗逆境，是刻不容緩的。田菁是台灣重要的綠肥作物，我們也常在濱海鄉村的農田看到其存在；綠豆是常用作物，在研究上與日常生活中都很常見，同樣身為豆科植物，兩者對於常見的鹽逆境的反應是否有差異呢？本研究透過比較田菁與綠豆兩種常見豆科植物，深入了解並比較其耐鹽機制。首先，在外表型上，田菁幼苗在鹽逆境下的發芽率、芽長、根長和鮮重皆有較好的生長情形。其次，鹽逆境下田菁的氣孔密度較低，進而可以減少水分蒸散。第三，在生化測試中，田菁在POD和CAT兩個酵素上，表現出更高的酵素活性。這些抗氧化酵素可以幫助植物在逆境下更容易生存。總之，田菁由於更高的抗氧化能力而具有更好的耐鹽性，並且將更多的能量用於生長更複雜的根結構。此外，我們發現田菁在根中出現中柱分離和更多的脯氨酸累積，以幫助它保持水分和遠離鹽害。上述所有機制使田菁在鹽逆境下具有更好的適應與生長。我們希望這項研究可以在未來應用於農業上，減少不可預測的環境災害造成的經濟損失。

本研究提出一款新型硫化氫偵測之螢光探針，我們選用BTIC作為探針螢光主結構並藉由修飾上疊氮達成偵測硫化氫之目的。帶入設計上，利用PPH3形成與粒線體的電位差使其將探針帶進粒線體，最終進行粒線體內硫化氫之偵測與顯影。 目前本實驗已合成出螢光探針基本結構與側鍊結構，並初步檢測探針對於硫化氫的偵測能力，確認其能夠與之反應並有顯著螢光變化。另外，目前已成功接上側鍊，待純化出目標產物後將進行進一步的性質檢測，包括選擇性、靈敏性、及持久性。 最後，我們預計將探針實際進行生物顯影，做多個結構顯影的比對，確認本研究之成效。此外，我們希望此款螢光探針除硫化氫偵測外，還能夠進行生物機制探討或疾病細胞篩選的應用。

Low-field (LF) MRI scanners have the power to revolutionize medical imaging by provid- 27 ing a portable and cheaper alternative to high-field MRI scanners. However, such scanners are usu- 28 ally significantly noisier and lower quality than their high-field counterparts. This prevents them 29 from appealing to global markets. The aim of this paper is to improve the SNR and overall image quality of low-field MRI scans (called super-resolution) to improve diagnostic capability and, as a result, make it more accessible. To address this issue, we propose a Nested U-Net neural network architecture super-resolution algorithm that outperforms previously suggested super-resolution deep learning methods with an average PSNR of 78.83 ± 0.01 and SSIM of 0.9551 ± 0.01. Our ANOVA paired t-test and Post-Hoc Tukey test demonstrate significance with a p-value < 0.0001 and no other network demonstrating significance higher than 0.1. We tested our network on artificial noisy downsampled synthetic data from 1500 T1 weighted MRI images through the dataset called the T1- mix. Four board-certified radiologists scored 25 images (100 image ratings total) on the Likert scale (1-5) assessing overall image quality, anatomical structure, and diagnostic confidence across our architecture and other published works (SR DenseNet, Generator Block, SRCNN, etc.). Our algo- rithm outperformed all other works with the highest MOS, 4.4 ± 0.3. We also introduce a new type of loss function called natural log mean squared error (NLMSE), outperforming MSE, MAE, and MSLE on this specific SR task. Additionally, we ran inference on actual Hyperfine scan images with successful qualitative results using a Generator RRDB block. In conclusion, we present a more ac- curate deep learning method for single image super-resolution applied to low-field MRI via a 45 Nested U-Net architecture.

本研究想了解利用馬祖天然的廢棄淡菜殼，回收再利用，將淡菜殼透過高溫鍛燒，研磨製成淡菜殼粉，淡菜殼中富含碳酸鈣，依不同比例，研發製作最佳比例的自熱包，並探討不同鍛燒溫度淡菜殼所製成的自熱包之溫度變化，及與市售自熱包的差異性。若能將這些廢棄的淡菜殼，變身為多元用途，不僅可解決廢殼堆棄所造成的環保問題，使淡菜殼的利用更趨多元化，同時也可提昇淡菜殼的附加價值。

首先以滴管、滴定管、水平微量滴定管等現有滴定裝置進行酸鹼滴定測試，滴定終點時呈現的色澤深淺並不一致，經實驗發現，造成滴定終點色澤深淺不同的主因，是現有滴定裝置產生液滴過大所致。接著針對液滴過大之缺點進行改良，利用螺旋擠壓原理搭配針頭為液滴出口，自製第一代滴定裝置；進而應用氣流吹落殘液，自製第二代滴定裝置。本研究改良型滴定裝置，具備螺旋擠壓液滴、氣流吹落殘液等兩大亮點，可使產生之液滴更微小。最後經實際測試，使用改良型滴定裝置所產生液滴更微小，可使滴定終點更接近當量點，所呈現的淡粉紅色深淺較一致。此全新改良型滴定裝置具備精準度高、操作簡易、成本低廉等優點，深具實用價值，未來有商品化之潛力。

The increased sensitivity of aquatic organisms to the effects of EMF has been proven by numerous experimental studies. It has been repeatedly noted that exposure to EMF of certain frequencies and intensities leads to disruption of physiological functions, orientation in time and space, changes in the behavior of organisms, suppression of motor activity. Other ranges of electromagnetic radiation, on the contrary, can cause the effects of increased regeneration, growth rate and survival. In connection with these trends, the purpose of our research is to analyze the effects of the influence of electromagnetic radiation of extremely high frequency on the development of the Xenopus laevis and the regeneration of newts and planarians

Given the high sensitivity of electronic instruments, electromagnetic field intensity measuring is now becoming an essential part of the industry. Current electric field intensity meters are unfit for individual use and focus mainly on electromagnetic radiation rather than the field itself. In ionic propulsion, the propulsion force is proportional to electric field intensity but the use of this property on measurement remains largely unexplored. Here, our team investigates ionic propulsion in electric fields generated by electro-static methods and then systematically varies the point of measurement inside the field, thereby altering the intensity of the field without focusing on electromagnetic radiation. By combining the Van de graaff generator with an adjustable ionic thrust propeller, we find that the propeller speed which is proportional to the electric field is directly determined by the electric field intensity. Furthermore, we applied stroboscopy to the system to measure RPM, and have achieved the direct interaction between field intensity and RPM, which could be a new meter for field intensity measurement.

為了回收二氧化碳，成為有價值的產物。本研究建立以化學吸收液捕捉二氧化碳，並生成碳酸鈣的流程。在吸收液吸收二氧化碳後的反應液中加入含鈣液，替換出碳酸鈣。以沉澱法、空氣柱法探討捕捉二氧化碳的化學吸收液特性，以變色法驗證吸收原理。以光阻法測量含鈣液的替換效果，並以吸收速率、吸收量、沉澱量、還原率，找出最佳吸收液。結果發現，以氫氧化鈉與二氧化碳產生酸鹼反應的方法固碳，再加入氫氧化鈣替換出碳酸鈣，並同時還原吸收液，循環利用，是二氧化碳捕捉再利用的好方法，不需要額外能量就能將二氧化碳轉換成碳酸鈣。最後研發捕碳成鈣循環裝置，包含二氧化碳吸收槽，替換沉澱槽、吸收液還原槽，展示了在生活中捕碳成鈣的應用潛力。