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本研究旨在探討過去未曾探究過各種不同立體形狀泡泡的形成,並細微地觀察泡泡間互相吸附、堆積的結構下,造成泡泡形狀的改變,以及它們的夾角和作用力平衡的關係。 本研究藉由不同形狀的立體框架,做出了正四面、六面、八面體、十二面體、正五角柱的泡泡。深入剖析立體多邊形泡泡膜的形成及其物理現象是否受到各項變因(模型大小、框架材質、框架直徑、傾角)的影響,及以不同多邊形內部泡膜是生成時的條件與限制分別為何? 為了探討表面張力及最小面積的關係,並以正六面體作研究。最後以Excel和數學軟體 Geogebra進行分析,嚐試著找出泡膜結構中膜與膜夾角的特性、最小表面積和表面張力之間的相關性,透過數學論証方法協助提出實驗現象之解釋、應用與應用與展望。
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看到校園屋頂的太陽能板,只能朝著單一方向接收陽光,但太陽會依據時間而改變移動路徑。若太陽能板能隨著日照路徑移動,則能增加日照時間與發電效果。本次研究是利用雲端試算表計算太陽角度與方位,再利用物聯網開發板操控馬達與液壓機構,調整太陽能板裝置的角度與方位,以達到自動追日的效果。過程利用問題解決模式進行研究,經過蒐集資料與不斷測試修正,歷經五代的實驗裝置,已製作出太陽能板自動追日裝置,並可實際操作。不同於使用光敏電阻偵測光源而移動裝置,本次研究裝置是不受環境光源影響,可精確對準太陽位置。因時間和成本有限,目前只能以小型太陽板測試,期待日後能製作出大型太陽能板追蹤裝置並增加綠能發電的效率。
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白花蛇舌草免疫抗癌新機轉及活性物質分析
白花蛇舌草是中醫常使用的抗癌中藥,本研究主要探究白花蛇舌草治療大腸癌的可能效應、機轉及活性物質。本研究利用大腸癌動物實驗搭配次世代基因定序,期望發現白花蛇舌草的新穎免疫抗癌標靶,並利用氣相層析質譜儀搭配新穎免疫抗癌標靶分子對接,分析主要的活性物質。結果顯示,白花蛇舌草可以減少小鼠結直腸增生組織的數量及大小,將被影響的基因進行生物資訊程式分析,發現白花蛇舌草會干擾與免疫細胞趨化有關的基因群組以及與上皮細胞增生有關的白細胞介質IL-17訊息路徑,而且存在於白花蛇舌草的阿魏酸可以阻斷IL-17與IL-17受體的結合,減緩小鼠的大腸直腸癌。本研究將古老知識透過現代科學證實有用,呈現與發炎或與上皮細胞增生有關的細胞激素可以作為免疫抗癌標靶,也發現白花蛇舌草的免疫抗癌新機制,並由免疫抗癌新機轉成功求證白花蛇舌草的主要活性物質。
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Cross-lingual Information Retrieval
In this project, we evaluate the effectiveness of Random Shuffling in the Cross Lingual Information Retrieval (CLIR) process. We extended the monolingual Word2Vec model to a multilingual one via the random shuffling process. We then evaluate the cross-lingual word embeddings (CLE) in terms of retrieving parallel sentences, whereby the query sentence is in a source language and the parallel sentence is in some targeted language. Our experiments on three language pairs showed that models trained on a randomly shuffled dataset outperforms randomly initialized word embeddings substantially despite its simplicity. We also explored Smart Shuffling, a more sophisticated CLIR technique which makes use of word alignment and bilingual dictionaries to guide the shuffling process, making preliminary comparisons between the two. Due to the complexity of the implementation and unavailability of open source codes, we defer experimental comparisons to future work.
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癌症治療新利器-奈米氧化鐵藥物磁性複合微粒之應用
溫熱化學治療(Hyperthermic Intraperitoneal Chemotherapy, 簡稱HIPEC),為將化療藥物加熱後灌注到腹腔內殺死癌細胞,但溫熱化學治療只能在開刀時使用,治療次數有限。為達到多次的熱化療效果,本研究開發奈米氧化鐵藥物磁性複合微粒(Nano iron oxide magnetic drug complex particles, NIOMP),可利用開刀時包覆複合微粒於腹腔,術後用磁場加熱,加上微粒化療藥物釋放,達到多次溫熱化學治療。NIOMP以鐵氧化物奈米粒子為核心,海藻酸鈉為外殼體,利用電紡法將前其與氯化鈣交聯產生凝聚性微粒。數據顯示最佳製作條件為16 kv高電壓、距離4 cm、噴速5μm/s,可得直徑大小約為200~450 μm穩定性高微粒。藥物釋放實驗顯示,NIOMP於2~7小時藥物釋放速率較穩定。利用可變磁場之電磁效應加熱NIOMP中氧化鐵磁顆粒,可於30分鐘內快速升溫至43℃。細胞相容性測試結果得知,NIOMP對細胞無毒性。本研究改善HIPEC的治療限制,可多次針對腫瘤患部局部熱化學治療,未來將可改善病人存活率。
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The Population Structure of the Orange River mudfish (Labeo capensis) in Allemanskraal Dam and Its potential as a Fishery Species
The aim of this research was to investigate whether the ecology and biology of the Orange River mudfish Labeo capensis were suitable for the species to be used in fisheries. Three fleets of the gill nets were set, parallel to the shore. One fleet was lifted, and the fish were collected by hand. The two remaining fleets were lifted the next day. The seine net was pulled for 10 metres within the littoral zone. The net was then pulled towards the shore of the dam and the procedure was repeated four times. The four fyke nets were set parallel to the shore and were left for two nettings nights and then lifted. All fish caught were collected by hand and placed into buckets. The majority (82.93%) of the fish caught were within the 0-100 mm size class. The 101-200mm and 201-300mm size classes contain similar numbers of fish, while no fish were caught in the 301-400mm size class. The hypothesis was accepted. Allemanskraal Dam, as of the study period, has a very small juvenile fish population of L. capensis, as only 7 out of 41 fish individuals caught were within the 101- 300mm fork length size class. These results show that the population of L. capensis is not established as of yet, as the research did was right after their breeding season. Historical research has shown that sexually mature individuals of the L. capensis species tend to be a minimum of 300mm SL, 4-6 years after hatching. The population was largely young-of-the-year and may develop into an established population in 3-4 years (after sexual maturity). The L. capensis population in Allemanskraal Dam has the potential to be a fishery species if suitable conditions are maintained. Establishing this species’ potential will therefore allow economically viable fisheries to utilise them sustainably and to their full economic potential.
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EVALUATION OF THE SURFACE TENSIO, LARVICIDAL AND ANTIBACTERIAL ACTIVITY OF PLANT EXTRACTS FROM THE LEAF OF THE ARACA TO COMBAT THE PROLIFERATION OF THE Aedes aegypti MOSQUITO IN STILL WATER CONTAINERS
The Aedes aegypti mosquito is one of the main transmitters of viral diseases in countries close to the equator. This vector promotes a series of generalized endemics that are difficult to control and prevent in these regions. Furthermore, the presence of bacteria in the environment favors the proliferation of mosquito larvae, which increases the probability of Aedes aegypti reproductive success. The Araçzeiro (Psidium guineense Sw.) is a plant present throughout the Brazilian Atlantic Forest and has in its composition, especially in the leaves, several substances that can be used to solve problems. Thus, we sought to verify the activity of flavonoids and polyphenols in terms of their antibacterial potential and the performance of saponins in their larvicidal potential, as well as surfactant, in order to prevent the accommodation of the mosquito in the water at the time of egg deposition and larvae respiration. The saponins were extracted from the araçazeiro leaf using a hydroalcoholic solvent and the flavonoids/polyphenols using methanol, the latter being subsequently rotaevaporated to maintain the non-toxic nature of the extract. Through the aqueous extracts, the content of total saponins by UV-VIS spectrophotometry, surfactant activity, larvicidal activity and toxicity were determined. In relation to the ethanolic extracts, the content of polyphenols and total flavonoids by UV-VIS spectrophotometry and high performance liquid chromatography (HPLC), antibacterial activity and toxicity were determined. The results showed that the aqueous extract has a satisfactory amount of saponins, as well as a surfactant potential due to the formation of foam and larvicidal activity in the two highest concentrations of the extracts. Ethanol extracts showed phenolic acids, especially gallic and ellagic acid, and flavonoids, especially catechin and quercetin, and antibacterial activity in most of the worked concentrations. Both extracts (aqueous and ethanolic) showed a dominant nontoxic character, which favors their use without risk to the environment, having an alternative and sustainable potential for controlling the proliferation of the Aedes aegypti mosquito.
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「馬陸」三寶-探討小紅黑馬陸的棲地、動物行為與族群生態
台灣原生種小紅黑馬陸棲息在潮濕腐質土。齡數愈接近成蟲,棲息土壤的位置愈深。喜愛棲息在落葉層下的腐質土,呈叢生分布。成蟲有正趨地性、負趨光性。隨齡數增長,複眼避光程度漸增。成蟲對水的耐受度較幼體高。馬陸遇乾燥性粉末會迴避,對具刺激味道的植物較不會迴避。驚嚇時身體捲曲呈圓環狀或出現排泄行為。成蟲不會因土壤震動而從土壤中外出活動。成蟲發生期在夏初,喜愛食用腐爛的水果。步足數目=(體節數) X4-18。族群中雄性占19.8%,雌性占80.2%。夏末時交配最頻繁。眼為複眼,幼體五齡前,單眼數目的三角形底邊與齡數有規則關係。幼體期約一年,蛻皮八次後為成蟲。族群的生存曲線屬於平均死亡率型。蛻皮前體色變淡,呈螺旋狀蛻皮。
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菇的!GOOD!保養品─蕈類萃取液之研究
餐桌上美味的菜餚不乏菇類料理的出現,對於「菇」,我們常常與養生做聯想,因其富含營養物質,所以市面上許多保健食品都是以蕈類製成,但僅侷限於吃,較少擦在皮膚上的產品,因此我們想要探討蕈類萃取物拿來作為保養品的潛力。從研究中我們發現蕈類富含碳水化合物,也在萃取液中測得糖類,結果顯示蕈類萃取液可以提升肌膚含水度及肌膚彈性,藉此達到保濕的效果,這與糖類具有保水能力有關,且以玫瑰菇及柳松菇的萃取液效果最佳。但萃取液pH值並不適合長時間塗抹在人體肌膚上,所以如果要將萃取液作為化妝保養品,可以另外添加天然酸性的物質,我們也期許未來蕈類萃取液可以「廢材再利用」,萃取不會食用的下層蕈柄,將其運用在化妝保養品上。
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水中「晶」靈-探討硫酸銅結晶大小的變因
上自然課時,曾觀察到鹽的結晶,也曾看過使用過飽和溶液長出結晶的影片,特別是硫酸銅晶體型態明顯且吸睛,激起我們研究的興趣。從硫酸銅的溶解度曲線知道溫度愈高,硫酸銅溶解度愈大,配置過飽和硫酸銅溶液後,藉由溫度的變化,可以得到硫酸銅結晶。首先配置濃度33.3%硫酸銅水溶液,經過濾後倒入培養皿中,以取得型態良好的晶體,再將晶體取出作為晶核,綁上釣魚線,放入濃度33.3%過濾硫酸銅水溶液中,盛裝容器改為燒杯並於上方加蓋或用保鮮膜封住,以防異物掉入產生雜晶。隔天若發現底部出現結晶,將此溶液加熱溶解,或再補充同濃度的硫酸銅水溶液,等待溶液降溫後再將晶核放入,七天內即可得到5公分長的硫酸銅晶體,以水晶膠包覆後達到保存效果。
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群魔亂舞的水精靈──探討滴簇在熱水表面的物理現象
本研究探討滴簇的性質與行為,高溫穩定水溶液表面上會有一層水霧般的霧滴層,像是平貼飄浮在水面上,此水滴群為「滴簇」。本研究拍攝下熱水表面的滴簇,並使用ImageJ、Python分析滴簇粒徑等性質以建構物理模型。 藉雷射光凸顯滴簇,觀察滴簇的形成與消失過程。利用被雷射打亮的滴簇在水面的倒影,測量滴簇距水高度。滴簇由5~15μm厚蒸氣層撐起漂浮在水面上,水溫越高,蒸氣層越厚。華(繞射光像)半徑取決於水滴粒徑,本研究分析陽光經水面反射通過滴簇形成的華,測量滴簇粒徑10~20μm。由以上實驗推測:滴簇是高溫蒸氣層接觸低溫的室溫空氣凝結成,溫差愈大凝結量越多,粒徑、數量隨之上升。滴簇會因對流、氣流擾動集體離開水面,留下一道滴簇少的空隙,此現象為「絲狀剝離」。滴簇剛形成時粒徑小,吸收水氣後變大,因此絲狀剝離帶上少許滴簇皆是粒徑較小的滴簇。
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「扭」轉乾坤,「擺」挫不折-探討扭擺的各種性質
裝置被一條金屬線所繫住,以此線為軸,上端固定,垂直吊掛。當物體受外力被扭轉一角度θ時,金屬線因恢復力而產生來回扭擺的現象,且扭擺週期T受各種因素影響。經實驗後我們發現:1.金屬線的剛性係數越大,T越小。2.扭轉角度θ越大,T會些微增加,但不明顯。3.T與長度開根號成正比。4. T與質量開根號成正比。5.T與線徑粗細成反比。6.擺放方式-T⊥ > T//。7.所得公式 T=k×(√l×√m)/d,且k∝1/√G。 我們另外發現有「扭性疲乏」一事,實驗後發現金屬線的剛性係數越小,則扭性疲乏越明顯,且當金屬線重覆受到不同方向之扭轉時,疲乏的現象會比同方向來得明顯。我們希望未來還能找出「扭性疲乏臨界點」。
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