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步步高昇~爬樓梯機器人大解密

創作爬樓梯機器人時,我們先進行校園樓梯實測,發現學校樓梯高度介於13~ 17.7 cm,材質也不一樣,小組決定以學校數量最多的樓梯尺寸為基準,進行實驗。查詢市面上爬樓梯機器人的構造,發現車子的電力、扭力要夠大,輪子形狀至少3個輻條以上,前後輪的車軸距離要在兩個階梯的斜邊頂點以上,接觸點的摩擦力要足夠,才能避免下滑。 因此,小組決定將爬樓梯機器人原型設計成車子的結構,讓輪子能與地面有較多的接觸點,上方也可以載物,讓實用性提高。結果發現最佳組合: 1.車身設計:山型車身、彎曲角度130度。 2.車輪大小:車輪直徑>樓梯高度1.5 cm以上。 3.車軸設計:輪距前寬後寬、軸距>樓梯斜邊長+前輪直徑。 4.載重位置:身體前上方,靠近馬達10 cm處。

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蒲公英萃取物之抗氧化評估與抗肺炎應用

自疫情爆發以來,各國都相繼研發新型冠狀病毒的藥物。蒲公英為一種傳統中草藥,具有抗氧化、抗發炎等生物活性。本研究以蒲公英為試驗植物。為了瞭解蒲公英的抗氧化及抗肺炎能力,我們使用磨粉後的蒲公英進行水和甲醇的過濾萃取物,將蒲公英水萃取物及甲醇萃取物分別進行試管清除DPPH自由基實驗、ABTS抗氧化實驗及總酚含量測定實驗,並進一步確定蒲公英萃取物的抗氧化能力。另外,我們還進行肺細胞發炎移動及遷移能力測試。最後發現甲醇萃取物的抗氧化效果比水萃取物佳。我們以脂多醣LPS誘導肺細胞發炎,運用顯微鏡觀察,發現甲醇萃取物有明顯抑制肺細胞發炎移動及遷移現象。經由以上實驗結果證明,蒲公英甲醇萃取物對抗氧化及抑制肺炎具有效果。

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多模式步態復健視覺提示系統與其提示參數自動最佳化

臺灣已進入高齡社會,步態復健對於亞健康及慢性病族群極為重要,以帕金森氏症患者為例,他們常行走困難且容易跌倒。提升跨步品質的視覺提示是非常有效的協助方式,但臨床多仰賴治療師在地上貼膠帶或擺物件,調整不易且只受限於特定場所,因此居家自行照顧困難。先前已有研究開發出輕便可攜的裝置,能調整視覺提示,但每位使用者對不同提示模式的反應不一。本研究提出創新方法解決治療師手動調整的問題。以低成本周邊所建置的系統已能即時無線的變換不同提示模式、調控其參數,和自動計算各步態參數。其使用MG90s伺服機調整投射角度、霍爾式旋轉角度計裝在輪子上測量位移、Wi-Fi無線接收及操控參數。已經完成自動化探索使用者能力,並作最佳化的視覺提示設定。讓使用者不必出門,居家使用時,皆有最佳的視覺提示設定,得以更短的時程達到更好的復健效果。

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結合物聯網與低功無損音樂傳輸的智慧書架音響

本專題設計一個音樂展示書架,結合射頻無線傳輸技術(RFid)感應在音樂CD上的射頻標籤,再透過低功耗藍芽傳輸技術(BLE)來傳輸資料給樹莓派媒體中心,透過資料庫程式去搜尋無損音樂庫中相對應的音樂,最後以高傳真數位類比轉換器(HiFi DAC)還原聲音的類比信號再傳輸至真空管擴大機。以既方便又無損害音質的方式來呈現大家所熟悉的藍芽音響。同時為了讓這項商品能夠應用在商業展示場合與藝術人文空間,我們讓播放音樂就如同向大家展示一張音樂CD一樣,只是將之放置在一個木質書架。且為了讓書架不需要插電或是充電,我們採用低功耗的藍芽傳輸並配合深眠模式,做出僅使用室內光源就能夠使用的智慧書架,更適合安置在一些不希望電線裸露出來的藝文空間。

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HOST TARGET PROTEINS OF SPIKE PROTEIN OF SARS-COV-2

Coronavirus Disease 2019 (COVID-19) is a newly emerged infectious disease caused by the new severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV-2). In less than one year, the virus has spread around the entire world, killing millions of people and disrupting travel and business worldwide. During infection, the virus uses its Spike protein to dock onto the Ace2 protein on the surface of its human host cell. Spike is 1273 amino acids long and only a short fragment of Spike (319-541) is sufficient to bind Ace2. We hypothesized that the remaining protein sequences of Spike might have functions for viral replication beyond the binding of Ace2. We have performed Split-Ubiquitin protein-protein interaction screens to isolate human proteins by their ability to bind to Spike, and we have identified Annexin2A2 and Cytochrome b as novel human protein interaction partners of Spike. Annexin2A2 is involved in both endocytosis and exocytosis, and the protein interaction with Spike might help the virus to enter and exit its host cell. The presence of the mitochondrial Cytochrome b protein inside the cytosol promotes apoptosis, and the protein interaction with Spike could speed up sapoptosis of the infected human cell. The Nub cDNA libraries that we have generated also allowed us to screen for synthetic peptides that interact with Spike. We have isolated two synthetic peptides, FL1a and FL7a, derived from the non-coding parts of human mRNAs by their ability to interact with Spike. We found that both FL1a and FL7a interact with the C-terminal half of the Spike protein. We also found that FL7a is able to block the Spike-Spike self-interaction at the C-terminal half of the Spike protein and we think that this could block the reassembly of the Spike protein in the host cell during viral reassembly. We hope that those synthetic peptides could be used as drugs due to their ability to block protein-protein interactions of Spike with human host proteins that are essential for viral replication.

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凡事「球」一個「圓」-環保洗衣球之研究

在日常生活中,人們常常為了便利大量使用塑膠製成的產品,如果事後處理不當,將會對地球造成極大的負擔。於是我們想利用海藻酸鈉與氯化鈣產生交聯作用形成的一層薄膜,包裹著洗衣精製成洗衣球,薄膜可取代一般市售洗衣精所使用的塑膠外包裝,並且找到了會影響晶球的幾個變因, 例如海藻酸鈉溶液之濃度為 2.5%時做出的球,膜厚度會最厚,並且比較了氯化鈣及硫酸鈣對晶球之影響,得到了由氯化鈣做出之球的效果會優於硫酸鈣,還有將球浸泡至不同濃度之電解質溶液中,得知了隨著電解質濃度愈高,膜的厚度就愈厚且浸泡時間愈長,膜的厚度也愈厚,最後還將晶球浸泡至 pH 值 1~13 之溶液中,得到了浸泡在 pH3 之溶液中,球的形狀最漂亮且膜也厚不易破。

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抽刀斷水水難流-水柱斷流的探討

這個研究想要探討水柱斷流的機制和影響因素,我們發現在斷流前,水柱會產生一節一節的現象,因此想探討節點的產生和水柱斷流是否有關係,根據之前的科展報告,一種說法是節的產生是因為表面張力;另一種則是節是水流因撞擊而產生的波。我們設計了實驗來分析水流量、節點、表面張力、黏性對水柱斷流的影響。

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嘉有「諸」叫聲-嘉義市諸羅樹蛙棲地與鳴叫行為調查研究

諸羅樹蛙(Zhangixalus arvalis)屬於樹蛙科(Rhacophoridae)為台灣特有種青蛙。研究者調查發現,在嘉義市頂庄里及新店里共有九處諸羅樹蛙的棲息地。在2020年3月至2021年4月間,於新店里農場進行的研究顯示:諸羅樹蛙共有五種叫聲,為整夜鳴叫的青蛙,在當日晚上7時至8時之間出現高峰,而過了翌日凌晨1時,鳴叫時間長度有再次上升的趨勢,凌晨3時之後才下降。相對濕度、水池水位高度、是否下雨以及氣溫都是影響諸羅樹蛙各種鳴叫聲次數的環境因子,其中水池水位高度越低,各種鳴叫聲出現的次數越高。未來從事諸羅樹蛙棲地調查時,建議使用晚上7時到9時的鳴叫高峰期進行棲地調查;在進行棲地改善時,水池水位高度為0~10公分最為合適。

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將廢矽泥製成奈米矽以及進一步應用於鋰離子電池負極材料之研究

矽元素因具有極高的理論電容和鋰攝取量(Li Uptake)而被認為是有潛力的鋰電池負極材料,然而該材料的特性使其在充放電時體積巨幅脹縮,造成結構碎裂,縮短了電池壽命。 本研究設計一套低耗能、低成本的製程,以現今台灣光伏產業大量難以回收之廢矽泥及鎂金屬為原料,將矽之粒徑縮小為奈米級以解決上述體積膨脹問題而成為極佳的鋰電池負極材料。 我們先將矽合成矽化鎂,再利用二氧化碳及氮氣的氧化還原反應製成多孔矽,隨後再利用創新的化學蝕刻法產出奈米矽。目前業界奈米矽的製備仍以高功率研磨為主,本研究首度使用銅離子、過氧化氫及氫氟酸作為蝕刻液,成功製造出平均粒徑100nm之負極材料。而過程中所使用的鎂粉可回收再使用,回收率高達94%,故幾乎無成本廢料排放,大幅降低當今鋰電池的生產成本,也落實防廢、再生、節能等綠色化學原則。

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Anti-bacterial Crab bio-bandages with Bio-dressings 2.0

Commercially available bandages such as hydrocolloid are neither biodegradable nor anti-bacterial. Chitin is known to be the second most naturally available polysaccharide which could be transformed to chitosan which is known to be anti-bacterial (Hasan, 2018) (Chao, 2019) and haemostatic (Okamoto, 2003) (Hu, 2018). Chitosan can be further converted to hydrogel which is bio-degradable and has good water absorbance. Anti-bacterial crab bio-bandages and crab bio-dressings should be bio-degradable as it took 42 days and a month for complete bio-degradation respectively, so they should be better than commercial bandages such as Nexcare Hydrocolloid as the disposal of anti-bacterial crab bio-bandages with bio-dressings would no longer pose burden to landfilling or threat to our environment. Anti-bacterial crab bio-bandages with bio-dressings are anti-bacterial with degree of deacetylation of DD% (measured using FTIR Spectrum II) 82.6% (due to the presence of chitosan) even without the application of other anti-bacterial agents and hence can provide complete protection of wounds from skin and soft tissues infections and haemostatic (due to the presence of chitosan). After testing and certification based on IS997:2004 and BS EN 13726-1, they should meet many requirements specified. Anti-bacterial crab bio-bandages should be eligible for marketing. Some results were as follows: 1.4 Anti-bacterial effect of crab hydrogels and roasted crab hydrogels Pure chitosan, crab chitosan, crab hydrogels and roasted crab hydrogels showed significant anti-bacterial effect. NO oral bacterial colonies were present in drinking water with crab hydrogels. Thus crab hydrogels could serve as effective anti-bacterial wound dressings. 1.6 Basing on IS997:2004 standard, the load per unit of area of anti-bacterial bio-bandages was 342g/m2 which met the minimum requirement of 36g/m2, the anti-bacterial bio-bandages had stronger tension strength (>20N both in dry and wet conditions) than commercial hydrocolloid. (2.7N dry 2.8N wet) which was comparable with that required (50-67N) and pH of about 7 which met the pH range of 4.5-8. 1.7 The FSA Free-Swell Absorbency of synthetic blood of crab hydrogel bio-dressings was 1.86g per 5cm x 5cm dressing which was much higher than that of commercial hydrocolloid (0.299g per 5cm x 5cm dressing) based on BS EN 13726-1.

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尿尿小童的煩惱~站立使用馬桶的尿液噴濺探究

本研究來自新聞報導:男生站立使用馬桶排尿會造成七千多滴尿滴噴濺,引發我們對此現象影響因素的好奇。研究設計以模擬真實排尿行為的噴水裝置,由紙張盛接噴濺液滴,測量噴濺液滴的重量。研究過程以不噴水的對照實驗模式,去除紙張自然吸收或蒸發水分的實驗誤差,接著針對尿液位置、水位高度、尿液流速、排尿高度、馬桶壁傾角、水面添加物等因素進行實驗,探討最少尿滴噴濺的站立排尿方式。研究結果發現選擇中央(水中)的尿液位置較佳,尿液流速無明顯影響,成人排尿高度較高會使噴濺量變大;而在水面添加一層泡泡或清潔慕斯,或將馬桶設計為垂直壁面,配合較低的水位高度,能讓尿滴噴濺大幅減少,可供衛浴業者設計馬桶參考。

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Development of an Audio Modulated Tesla Coil

Originally, the Tesla transformer was developed to transmit energy and messages wirelessly. But it did not prove itself for either of these applications, so today it is only used for research purposes. Over time, the Tesla transformer has evolved and improved. Today it is possible with Tesla transformers to generate powerful and highly precise controlled discharges. During operation, impressive high-voltage discharges occur at the transformer. A tesla transformer is basically a high voltage generator that achieves a voltage boost by using two magnetically coupled LC series resonant circuits of the same resonant frequency. The Dual Resonant Solid State Tesla Coil (DRSSTC) built in this work has a high power IGBT half bridge module to excite the primary resonant circuit at the resonant frequency. The IGBTs are driven in such a way that audible pressure waves, and therefore music, are generated by the electrical discharges at the high voltage electrode. Within the scope of this work were the following two questions: - How is a DRSSTC designed and built? The DRSSTC system realized in this work is about 80 cm high and reaches about one-meter-long discharges. The design, development, and construction of the transformer are documented in detail and extensively in this thesis. - How does one measure an electrical voltage of 200,000 V, which changes sign more than 100,000 times per second? Two approaches have been taken to measure the voltages. Derived from the energy balance of an ideal capacitor and an ideal coil, a secondary voltage of about 200 kV was calculated via secondary current measurement. The second approach uses a voltage measurement via an in-house developed measuring electrode and a calculated divider ratio between the measured voltage and the secondary voltage. A relatively unrealistic secondary voltage of about 750 kV was measured since the divider ratio depends on approximate values. Nevertheless, the measuring electrode can be used for investigations of the voltage curve, or the divider ratio can be calibrated via the secondary current measurement. The development of such a transformer laid the foundation for much further research and scientific analysis.

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