The physiochemical properties of fullerenes have aroused wide interest, such as its ability to accept and lose electrons and relatively high reactivity that permit various modes of structural modifications. However, obstacles to further research include its complete lack of solubility in water and low processability.\r This project investigated the morphology and microstructure of a fullerene-grafted polymer as a potential candidate for better and novel systems for drug delivery. In this research, hydrophilic functionalities were introduced to the C60 fullerene by chemical modifications, through the attachment of poly(acrylic acid) (PAA) chain. The objective was to investigate the dynamics and the self-assembly properties of this polymer in aqueous solutions, and the knowledge gained would enhance the development of such system for potential applications in drug delivery and nanotechnology.

本研究首先利用NaOH 將PAN 薄膜改質形成PAA 水膠膜表面，進一步與異丙胺鍵結形成NIPAAm 結構，以做為藥物傳輸的載體。反應所得之PNIPAAm 薄膜其溫度轉換點為34 °C 其pH 敏感性介於pH 5 至10 之間，實驗進行進一步於34 °C將PNIPAAm 薄膜浸入共軛亞麻油酸(CLA)中，取出後置入4 oC 二次水中，最後測試經改質接枝後PAN 薄膜於膽固醇、三酸甘油酯的吸收效果，並以化學冷光儀分析改質接枝後PAN 薄膜其抗氧化效率。結果顯示改質接枝之PNIPAAm 薄膜於包埋CLA 其對於血液中膽固醇及三酸甘油酯有明顯的吸收效率，此外對血液中的自由基也有明顯較未改質之PAN 薄膜穩定的趨勢。A thin layer of poly(N-isopropyl acrylamide) (pNIPAAm) was synthesized in situ on the surface of hydrolyzed polyacrylonitrile (PAN) membrane. This thin layer exhibited both pH response due to the poly(acrylic acid) moiety and temperature response due to the pNIPAAm moiety. The swelling behavior of the membranes was evaluated under various temperatures and pH. The curve of the swelling ratio for the PAN-NIPAAm showed a lower critical solution temperature (LCST). Then conjugated linoleic acid (CLA) was loaded into the pNIPAAm layer. The effects of CLA on the blood coagulation and oxidative stress were evaluated using human blood. The level of reactive oxygen species (ROS) was measured by chemiluminescence (CL) method to evaluate the oxidative stress. Furthermore, the removal of bacterial endotoxin (lipopolysaccharide, LPS) by CLA-loaded PAN-NIPAAm was measured with ELISA. The results show that the LCST swelling curve was at 37°C. In addition, the swelling ratio increased by 71% when the pH increased from 5 to 10. The concentration of LPS can be reduced by CLA-loaded PAN-NIPAAm 2.1 and 1.2 5 times of that by unmodified PAN and PAN-NIPAAm membranes, respectively. In addition, the level of ROS against CLA-loaded PAN-NIPAAm was reduced significantly than that against unmodified PAN and PAN-NIPAAm. Therefore CLA-loaded PAN-NIPAAm membrane could offer protection for patients against oxidative stress and could also inhibit LPS for clinical applications

新興的 BlockChain（區塊鏈）技術具有去中心化及資料無法被竄改的特性，在需要資料透明的領域非常適用，尤其 Fintech（金融科技）方面因貨幣貴重的特性而特別有優勢。慈善募款常常有用款不透明與部分用途不被大眾認可的問題；因此本研究使用BlockChain技術之Ethereum（以太坊）平台，成功設計出一套Smart Contract（智能合約），主要功能針對募款組織的所有撥款，須經捐款者投票，通過後才可撥用，將監督的權利歸還給捐款者，使慈善捐款能夠公開透明且受監督。同時也研究網頁前後端程式語言，設計一套大眾能簡便進行操作之介面，期望真正將此募捐平台推廣至社會。

本文中我們探討一個有趣的數列。這個數列有一個非常特殊的性質：將數列相鄰兩項的前項當分子，後項當分母，所產生的分數數列，恰好會出現所有的正有理數。 這個特殊的性質表示，可以將正有理數按照這個方式作排序，這個排序將完全不同於常見的正有理數排序的方法。 (1). 在正有理數的排序的結構中，我們做出許多有關於此數列的定理。 (2). 用數學歸納法證明此分數數列涵蓋所有正有理數，且每一正有理數只出現過一次。 (3). 將數列分割後，利用試算表製成數列規則表，並整理出快速的方法將數列表達出來。 (4). 將an 數列排成“樹＂的模式，可更快速的把正有理數寫下來。 (5). 最後，設計出搜尋正有理數的演算法，解決在分數數列中第n個正有理數會是多少；以及正有理數會出現在數列中第幾項的問題。 Let’s discuss an interesting sequence. There is a very special quality in it. In this sequence, choose two numbers, which are close to each other, and suppose the first number as “member” while the second one as “denominator.” Then we can get a fraction sequence that includes all of the positive rational numbers! According to this special quality, we can arrange positive rational numbers by the following method. Then we can get a brand-new way of the arrangements. (1). We can find many theorems about this sequence according to this special arrangement of the positive rational numbers. (2). We can prove the rule that this fraction sequence includes all of the positive rational numbers by mathematical induction. Furthermore, every positive rational number appears only once. (3). After dividing this sequence into several parts, we can get a sequence rule list by using trial balance and find a faster method to express the sequence. (4). Arrange the an sequence by the tree model. By this way, we can get all of the positive rational numbers much faster. (5). Finally, we can develop the operation method to solve the questions that what position would one positive rational number be in the sequence and what is the first, second, third or nth positive rational number of the sequence.

In our experiment, the novel hydrothermal-galvanic couple method is used to produce nanostructured TiO2 thin film. Compared with the traditional hydrothermal method, whose process is conducted under high temperature and high pressure, the hydrothermal-galvanic couple method is a thermally and electrochemically driven process. The titanium atom is gradually oxidized on the surface driven by potential difference, and eventually become nanostructured TiO2. The advantages of the hydrothermal-galvanic couple method are numerous： they are simple, environment-friendly and energy-saving. Experimental parameters include time, concentration and types of solution. The hydrothermal method is used for comparison. By the cross-section and surface pictures of Field-emission scanning electron microscopy (FE-SEM), we can clearly observe that there is obvious change on the titanium surface, along with increased thickness and altered surface structure. The film of hydrothermal-galvanic couple method is thicker than that of hydrothermal method. Thickness increases with time and concentration as well. Both the hydrophile and decomposition of methylene blue examination indicate that the product on the surface contains photocatalyst-like feature.我們利用新穎水熱-化學電池法製備奈米級二氧化鈦薄膜。相較於一般傳統水熱法高溫高壓的製程，水熱-化學電池法結合了熱能與化學電能，讓鈦原子在電位差的驅動下於表面逐步氧化，最終形成奈米級二氧化鈦粒子，具備簡易、環保、省能的優點。實驗參數包括時間、濃度、溶液種類，並以水熱法作為對照組。由FE-SEM 橫截面圖及表面圖可清楚看到鈦的表面有明顯變化，膜厚增加、表面結構改變；以水熱-化學電池法所得的薄膜明顯較水熱法厚，而其厚度隨著濃度及時間的增加也有增加的趨勢，由試片親水性測試與亞甲基藍吸光度測試，皆顯示試片的表面產物具有類似光觸媒的性質。

NO.57-08 2018 OCT | 科學研習期刊目錄 本期專題 溫柔的力量：提升女性科學「實作」能力 溫柔的力量：提升女性科學「實作」能力 | 陳鴻宜教授、蘇萬生博士 跟女同學談科學是什麼 | 陳育霖教授 趣味科學實作課程的溫柔體驗 | 葛士瑋博士 自造你的科學實驗 | 賴雲立老師 女生愛科學 | 謝迺岳老師 如何提升高中女學生的科學學習興趣 | 于曉平教授 森棚教官的數學題 用三湊三 | 游森棚 科學讀書會 玩出創意5：50個魔法科學實作 | 白榮銓 教學現場 STEAM之小學科技教學活動設計與實施-以抖抖外星人為例 | 張玉山、李姿儀 總召集人的話 促進女性對科學(乃至STEM-科學、科技、工程與數學)的參與是因應全球挑戰(如環境污染、氣候變遷)的關鍵之一。例如，聯合國教科文組織於2017年出版的報告《破解密碼：婦女的STEM教育》(Cracking the code: Girls’ and women’s education in science, technology, engineering and mathematics (STEM))即旨在破解妨礙或促進婦女在STEM教育參與、成就和延續的因子，並指陳教育部門可以做些什麼，以促進婦女對STEM的興趣和參與。女性參與科學(或STEM)也是我國的重要教育課題之一，本期特別以「溫柔的力量提升女性科學『實作』能力」為專題，請臺灣師大物理系副教授陳鴻宜博士和科教館編輯蘇萬生博士擔任特約主編。 專題文章含專題導言共有六篇：「專題導言」〈溫柔的力量提升女性科學『實作』能力〉指出女性能否進入科學領域，最重要的因素之一或許在於是否有人及時鼓勵，並簡介其它五篇專題文章的來源。〈跟女同學談科學是什麼〉一文從「科學是什麼」和「科學存在的目的」談起，再以日常生活的實際物理實驗演示要求學生現場進行科學探究，立即與同組同學討論如何設計一套實驗方法來向他人證明自己的論點。〈趣味科學實作課程的溫柔體驗〉一文透過有趣、可動手參與及親身探究的DIY科學與實作體驗學習過程，讓女性在學習物理的過程中，展現出精巧的動手作能力、運用科技工具完成電路組裝，驗證物理知識，並體會物理之美與世界的連結。〈自造你的科學實驗〉一文分享利用容易取得或製作的平價器材自製光譜儀和數位溫度計的一些想法與設計。〈女生愛科學〉一文從兩性學科學的基本差異、合作分工、相互欣賞和趨利避害四個面向，分享其看法。〈如何提升高中女學生的科學學習興趣〉一文則先論述科學議題中的性別差異以及女性科學生涯的困境，再建議五種有助於提升女生科學學習興趣之方式與活動。 「森棚教官的數學題」刊登〈用三湊三〉一文，拋出以3的次方數(1, 3, 9, 27, 81…)用加法湊出3之倍數的問題，供讀者自主探索或發想科展題目。 十二年國教自然科學課綱期望強化學生的「科學探究能力」，但是究竟在科學實作中要如何玩出創意以及科學探究要如何融入科學實作？本期「科學讀書會」導讀《玩出創意5：50個魔法科學實作》一書，該書內含七大類共50項的實作科學實驗。各單元包含：操作過程、原理說明、叮嚀的話以及參考資料。 「教學現場」單元刊登〈STEAM之小學科技教學活動設計與實施-以抖抖外星人為例〉一文，分享一個國小STEAM教學活動--抖抖外星人，這樣的活動除了結合STEM + Arts的知識運用，也要培養學生動手實作的習慣。 總召編輯委員 - 李隆盛 關於本刊 出版單位：國立臺灣科學教育館 發行人：陳雪玉 總召集人：李隆盛 編輯委員：古建國/全中平/李文獻/李旺龍/李源順/李進寶/林沛練/林坤誼/許良榮/蔣中柱/胡秀芳/陳正改/陳竹亭/陳玫良/楊水平/游森棚/謝隆欽/張子超 策劃：曾聰邦 主編：錢康偉 本月專題特約主編：陳鴻宜/蘇萬生 編輯：吳郡怡 網頁設計編輯：施曉恬/陳璽君 投稿規範請來信詢問：article@mail.ntsec.gov.tw

(一)內錐孔傳統之量測方法： 利用兩直徑不同之鋼球置於錐孔內而測出兩球之中心距離，計算出半角(Sinθ/2)之值再求正切(Tanθ/2)函數乘以2即得： 兩球中心距 c=h-d1/2+d2/2=[2h-(d1-d2)]/2 兩球半徑差 a=d1/2-d2/2=(d1-d2)/2 Sinθ/2=a/c=[(d1-d2)/2]/{[2-(d1-d2)]/2}=(d1-d2)/[2h-(d1-d2)] (二)以上測量時須使用l.平板 2.鋼球 3.高度規 4.深度分厘卡等綜合如下。 1. 需較多之量具。 2. 測量手續繁多費時。 3. 須經計算。 且在工作進行中無怯量測須待工作完成時才能量測。

在「植物的秘密生命」這本書中提到植物在電場或磁場中會生長的更好,我最近正好學到了電磁場如何產生,以及一些產生電磁場的方法,所以想利用螺形管線圈來產生均勻的電磁場並用安培右手定則來控制磁場產生的方向來了解電磁場在高低室溫下對綠豆生長的影響. 在本實驗中我利用鐵碗纏繞線圈的方式並通入不同的電流大小來改變磁場的強度,所進行研究所得到的結果顯示（1）綠豆只有在適當的電流大小下所產生的電磁場才可以幫助加速綠豆的生長(2)栽培綠豆的環境所架設的電磁場越高,越能持續讓綠豆的生長加速（3）綠豆的加速生長並不需要整天都通電（4）綠豆在N極朝上的磁場中生長的速率較S極朝上的磁場中要快(5)在較低的室溫下,電磁場加速綠豆生長的效應較能顯現 It has been mentioned that the plants will grow faster in the electronic or magnetic field in the book of “the secret life of plants”, I learned about the knowledge and methods of how to produce the electromagnetic field just now, I use the screw wire to produce electromagnetic field and control the direction by the Amplifier’s rule to investigate the growing speed of green beans under electromagnetic field in those different temperature. In this experiment, I use the wire to screwed around the ironed bowl, and make different electric current to generate different strength of electromagnetic field, the results indicate that (1) The faster growing speed will only exist in some strength of electromagnetic field (2) The higher ironed bowls that full of screwed wire will result in the faster growing speed (3) It will not need electromagnetic field all days (4) The green beans will grow fast in those north magnetic pole than those in south magnetic pole (5)The effect of electromagnetic field to increase growing speed will be significant in higher room temperature

在這個研究當中，我們設計並製作完成一部手工機械車模型。實驗該車曲軸分別在 0.5、1、1.5、 2 、2.5、 3 公分，連桿在9、10、11、12、13 公分，後腳在 3、3.5、4、4.5、5 公分各種組合對速度及拉力所產生的影響。並用 GSP(The Geometer’s Sketchpad) 繪圖模擬來驗證其結果之可行性。在拉力部份，原始實驗（前後腳底加日式止滑墊）由於與底面積摩擦力不足，實驗數據無法忠實呈現拉力。於是我們決定在軌道上貼砂紙並用以下四種方式來做實驗(1)在四腳上各加一個電池 (2)在四腳上加電池，在後腳底貼上橢圓形橡膠軟墊 (3)四腳加電池，後腳做關節且加大腳底面積 (4)四腳加電池並鋸短四腳，且加大腳底面積。實驗數據顯示在曲軸、連桿、長度改變及後腳孔位置高低改變時，拉力會隨之增加或減少。本研究歸納出下列結論:曲軸越短，速度越慢，拉力越大。連桿越短，速度越快，拉力越小。後腳孔位置越高，速度越快，拉力越小。

本研究目的是探討大豆卵磷脂對於老化及學習記憶能力是否有改善之功能。以 24 隻 SAMP8 小白鼠，分為大豆卵磷脂組及對照組，飼養 8週。經由主動迴避試驗、單次被動迴避試驗，測其學習記憶能力；另測量其腦部丙二醛(MDA)之含量，評估其老化的程度。由實驗結果顯示，在主動迴避試驗中，大豆卵磷脂組被電擊次數有減少趨勢；在單次被動迴避試驗中，大豆卵磷脂組停留在明室的時間高於對照組。而在 MDA方面，大豆卵磷脂組腦中MDA含量低於對照組。由上結果推測大豆卵磷脂對於抗老化及學習記憶方面都有改善的功能。 The purpose of this research was to study the effects of soybean lecithin on improving the aging process and learning and memory abilities. The first part of the experiment is to raise 24 SAMP8 mice eight weeks, and divided them into group A and Group B. We tested them memory power by Active shuttle avoidance test and Single-trail passive avoidance test, and tested their degrees of the aging by the content of MDA. The result demonstrated that there was a decreasing tendency in times of being hitting in group A during Active shuttle avoidance test. The time which group A stayed in the bright room was higher than group B during Single-trail passive avoidance test, and the content of MDA in group A was apparently all less than group B in the experiment of MDA. So we can get the message that Soybean Lecithin has the improvement of ameliorating the speed of oxygenation and increasing memory power.

台灣西海岸的河川，常飽受嚴重的水污染，其中最嚴重者莫過於重金屬離子所造成的危害了。所以，本作品即探究：從了解【電解水的氧化還原反應】到設計【小型多重兩極分流電解槽】上，希望藉此設計能給相關單位參考，以為農田引水灌溉及養殖水域做把關的工作。最後並對長期以來校內涉及電解、電鍍…等含重金屬離子的實驗做徹底的減廢設計，以排出無污染性的廢水。;Rivers along the west coast of Taiwan have been seriously polluted for a long time, the most hazardous one of which has been caused by heavy metal ion. As such, this article aims at how to discharge a pollution-free wastewater by understanding first from the oxidation- reduction reaction of electrolytic water to design of a miniature multiple bipolarity divided-flow electrolyser. It is hoped that this design would provide related government regulatory agencies with adequate information so that they may be capable of doing a responsible pollution-prevention job in water irrigation for farming land and water for marine farming as well. Finally, the author may further add that this design has been through constant laboratory tests involving electrolysis and electroplating of heavy metal ion in the hope that a perfect design to eradicate wastewater can be produced so as to discharge pollution-free waste water.