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“魔法隱身與穿牆術”-全反射與光穿隧效應

自然課學過反射、折射和稜鏡色散,於是利用壓克力和不同液體來探討全反射和光穿隧現象,發現降低表面粗糙度能減少散射,以利觀察雷射光路徑;而紅光和紫光的折射角差值可作為色散的簡易指標。此外,液體溫度、濃度及相變化也會影響臨界角;結合不同臨界角可達成「魔法隱身」;結合不同全反射,則可應用於液體高度警示。 同時也探討全反射在介面形成的漸逝波(Ref.[1]),利用液體填入介質空氣縫來降低折射率落差,或是將空氣縫隙減小到幾微米以下,都能讓漸逝波穿越空氣縫來實現「魔法穿牆」,此現象稱作光穿隧(optical tunneling)效應(Ref.[1]),或受抑全反射(frustrated total internal reflection) (Ref.[2]),未來可應用在精密測量領域。

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高二學生對本土語文必修課程之滿意度分析­­—以臺灣某高中為例

政府在本年度首次把本土語文課程加入高中的必修學分中,然而這引起此校學生劇烈反彈。本研究以臺灣某校高二學生為研究對象,主要針對學生滿意的情況進行探究。研究者先透過文獻探討設計各因素,再將其製作為線上問卷,而後進行統計分析,包含敘述性統計、ANOVA分析、相關分析等方法。研究發現學生在日常中使用頻率、成績表現、溝通能力、個人效益(包含升學、社交圈、未來求職)、社會價值(包含文化多樣性、傳承文化、民主、尊重語言人權)、本土語能力的提升、老師的管教嚴苛程度、自主學習時間的減少等八項因素皆會對其滿意度造成影響。我們期待透過此研究促進制定政策者、教學者、學習者之間的討論,審視與調整目前政策實施的方法。

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臺灣北端PM 2.5來源分析與季節比對

本研究以具空間梯度的臺灣周邊離島測站實測數據及衛星氣膠光學深度時空變化及相關性推斷東亞境外氣膠對臺灣北端PM 2.5濃度的影響。我們選取鄰近中國的金門與馬祖、中等距離的馬公及臺灣北部(富貴角、基隆)、遠離大陸的日本離島(石垣、那霸)共七站,分析2015-2021年東北季風盛行冬春季與西南季風盛行夏季的資料。結果顯示各測站冬春季PM 2.5濃度均較夏季高2-3倍並由西向東下降,冬春季相關性均較夏季高;針對高濃度事件,氣膠光學深度顯現冬春季高PM 2.5傳輸和各站測值在時空上緊密連結,由西向東下降;冬春季當地汙染極低的馬公平均濃度與臺灣北端兩站數值一致但夏季顯著較低,顯示季節性境外汙染對馬公和富貴角、基隆影響程度的一致及重要性。以上結果均支持東亞境外氣膠傳輸為臺灣北端冬春季PM 2.5主要來源。

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桑白皮素透過抑制NUP62基因表現抑制GBM細胞遷移

本研究發現桑白皮素(Morusin)可抑制多形性膠質母細胞瘤(Glioblastoma, GBM)的細胞遷移作用,並透過觀察其細胞骨架的變化和NUP62基因表現量的變化,研究可能造成其抑制細胞遷移的機制。 從細胞遷移實驗(Transwell migration assay)觀察到Morusin能抑制GBM細胞的遷移能力,再對其細胞骨架的F-肌動蛋白(F-actin)染色,觀察GBM細胞骨架形態上差異。 接著透過次世代基因定序(NGS),找出受到Morusin影響的基因,並透過查詢文獻探討已被證實與細胞遷移相關的基因。我們發現了NUP62的基因表現量會受到Morusin抑制,且文獻中也提到了其在細胞遷移中的作用。最後透過RT-qPCR和Western Blot確認Morusin處理後的GBM細胞會降低其NUP62的基因表現量。

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拈拈有餘——單堆拈必勝策略探討

本文以單堆拈有關的問題出發,討論當給定首項為1的連續數列,接著再就未刪除、刪除不同長度連續或不連續的數列等條件,觀察結果並找出其必勝策略。在刪除特定數列時,發現必勝點的數量與大小與「刪除的數列的首項」和「刪除的數列的長度」有關,最後將其簡化成公式。

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In silico Screening of Forty Antiviral Phytochemicals as Inhibitors to the Envelope Protein of Dengue Virus Serotype 2 (DENV-2)

Infections by the Dengue virus (DENV) cause a disease amonghumansreferred to as Dengue fever, which causes thousands of fatalities globally. There is no existing treatment as of yet that successfully targets DENV. Among the factors thatdeterminetheentry of the virus and severity of the disease is the envelope(E) protein of DENV. This study aimed to examine forty antiviral phytochemicals enumeratedinpaststudiesaspossibleinhibitorstotheEprotein of DENV to provide candidates to aid in drug discovery against DENV. The phytochemicals were screened for their likelihood of inhibition of the E protein using AutoDock Suite and LigPlot+. Seven phytochemicals produced favorable binding affinities to the E protein, which are based on the interactions between the phytochemicals and amino acidsintheactivesiteoftheEprotein.Lipinski’s rule of 5 was then used to screen the seven phytochemicals for oral bioavailability. Glabridin has a binding affinity of -7.6 kcal/mol and was predicted to be orally bioavailable. This phytochemical interacts with amino acids in the E protein active site through hydrogen bonds to Asn355, andPhe337, as well as ten hydrophobic interactions. These interactions ensure that glabridin is able to specifically target and fit intotheactivesiteoftheEprotein, preventing its binding to the host cell and activating its viral proliferation. Glabridin is known to be found in the roots of licorice plants, providing anatural source for a possible cure for Dengue fever.

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甲殼下的清涼—黑水虻蛹殼的隔熱效果分析

在節能減碳的前提下,「隔熱」是綠建築中室內降溫的重要工法。本研究以仿生法及廢棄物再利用之核心理念進行研究發想,嘗試使用黑水虻蛹殼所萃取的甲殼素規劃隔熱實驗。由磁磚的隔熱效果分析中,將不同重量比例的黑水虻蛹殼甲殼素摻入三仙膠中,調製成隔熱塗料均勻塗抹在磁磚上方,並以鹵素燈模擬光照加熱。由重複實驗結果得知:1%萃取蛹殼甲殼素可以降低磁磚下方(背光面)溫度約5.56±0.51℃而3%降低8.29±0.22℃。由研究結果得知,含3%黑水虻蛹殼甲殼素之三仙膠塗料,能有效降低磁磚下方溫度高達6℃以上(0%降低1.71±0.16℃),未來具有發展為低價環保隔熱塗料的潛力,很值得進一步研究開發。

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SUSTUNI - SOFTWARE FOR SMART AND SUSTAINABLE DESIGN OF INDUSTRIAL ELECTRICAL CIRCUITS

The theme of this project is to develop software to facilitate and innovate the design of low-voltage industrial electrical circuits. The goal is to develop a program that makes projects more efficient in terms of time, accuracy, and sustainability, automating dimensions such as calculating conductor cross-sections, protections, single-line diagrams, and analyzing with AI at which points industrial electrical circuits can be more sustainable. The 2023 Electric Energy Yearbook of the Energy Research Company describes that electricity consumption increases 2% per year in Brazil, and industrial installations represent the largest part of the national electrical sector (36.2%). As stated in standard NBR 5410/2004, when developing an installation project, an electrical professional works with several processes, depending on several criteria and calculations to present a reliable electrical installation. Minimal errors in calculations can cause damage to equipment, conductors, and individuals present in the installation. Using software to model these circuits optimizes time and brings more confidence to the project. This work aims to differentiate itself in this field by filling in the gaps in existing solutions for the industry, providing support for Brazilian standards, automatically generating single-line diagrams and presenting suggestions for sustainability in the circuits. The program is developed in Python, based on NBR 5410/2004 and engineering works. The software developed allows the user to size different distribution boards, motors and circuits, calculating the cross-section of the conductors/electrical protections, a particular transformer, and generating a single-line diagram in CAD. The program also presents suggestions aimed at sustainability to reduce material/energy costs. Tests were carried out with electrical engineering companies and students in the technical area, where the software presented high precision and very positive feedback from the interviewees, and it can be said that the work achieved its objectives.

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DSUP: New Research On The Implementation Of Radioresistance In Cellular Systems

In radiation treatments and manned interplanetary space travel, radiation is one of the biggest problems. The radiotolerance of cancer cells makes it necessary to apply high doses to surrounding healthy tissues by subjecting the cells to heavy stress. With regard to space travel (which involves a minimum travel time of 6 months) (1,2) the danger concerns cosmic radiation which is capable of inducing genetic mutations that, in turn, can evolve into very serious pathologies, such as cancer, damage to dendrites consequently compromising synapses. The project is aimed at developing a technology that can address these issues and aims to make human DNA radioresistant. This study involves a nucleosome-binding protein called DSUP (Damage Suppressor Protein) unique to the tardigrade Ramazzottius Varieornatus and the subject of its radioresistance. It can theoretically safeguard genetic material damaged by radiation. *Internship theme at the Pino Torinese Astronomical Observatory and the DISIT-UPO Environmental Molecular Toxicology Laboratory. The study molecule: Numerous tests have been carried out through the "in silico" approach geared toward mathematical modeling of its protein structure and complex mechanisms of action simulated through artificial intelligence systems, followed by direct laboratory analysis involving biosynthesis of DSUP by genetically modified bacteria and related tests. Both approaches, applied synergistically, aim to make it accessible and useful for the protection of human health.

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LET 魚 GO—探討河岸墩式碼頭基樁設計,以減少死魚堆積問題

當地夏天的河岸碼頭常堆積了很多死魚,造成環境很大的惡臭問題。我們實地探勘和查考資料後,製造模型進行微型實驗,模擬了不同季節的風向、風速和浪的大小,以及墩式碼頭基樁不同的形狀對於死魚堆積的影響。 我們用 1/200的比例尺依照實境設計了模型河道,然後設計不同形狀的碼頭基樁模型。微型實驗中發現,矽膠小魚堆積與水流侵蝕和泥沙堆積有密切切關係,而碼頭基樁的截面形狀是「水滴流線型」或「雙尖流線型」,水流侵蝕效果最好,能有效減少65%的矽膠小魚堆積率。此外,採用被動式的雨水沖刷設計,把圓柱體後方的負壓區改成正壓區,也能有效減少22的矽膠小魚堆積率。我們的設計不僅符合環保,而且還能節省成本,能有效解決河岸碼頭死魚堆積的問題。

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柚子對環境中孑孓的影響

本研究主要探討柚子對孑孓的影響。我們將柚子分為成熟果皮、未成熟果皮、柚花、柚葉,其中果皮分為外果皮和中果皮,柚花則分為花瓣、雄蕊、雌蕊,並依據不同濃度加入水體之中,觀察孑孓呼吸管收縮頻率、存活率、扭動次數、閉氣時間的變化,同時也測量孑孓生活水域的pH 值和溶氧量。我們發現成熟柚子外果皮會降低死存活率以及增加閉氣時間。,柚花會降低存活率及閉氣時間,以雌蕊對孑孓的影響最顯著,而柚葉對孑孓並無顯著影響。經由實驗後我們建議拿來防治孑孓的濃度為0.45%的成熟外果皮溶液。

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「仙」境「桃」花源-蛋黃果的開發及應用

本研究選用蛋黃果(Pouteria campechiana)為原料開發成加工製品以增進蛋黃果之利用價值。添加不同比例蛋黃果於生鮮麵條,並分析相關影響。添加30%蛋黃果麵條色澤變化差異最大且抗氧化能力DPPH)及還原能力FRAP)皆最佳,但其彈性最差。蛋黃果麵條與原味麵條,在整體喜好上,無顯著性差異。結論30%蛋黃果麵條抗氧化分析結果最佳,但彈性最低影響口感,宜選用20%蛋黃果麵條在保有抗氧化活性下對口感之影響較少;選用熱風乾燥與真空乾燥在不同溫度下製作蛋黃果乾。80℃真空乾燥速率最快80℃熱風乾燥硬度與脆度最高。以80℃熱風乾燥及80℃真空乾燥之果乾較受消費者喜愛。結論未來可利用複合式乾燥方法,提升乾燥效率及產品品質。

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