The main goal of this paper was a creation of musical score for the composition from the 18th century Domine ad Ad juvandum in A minor and C major composed by Šimon Brixi. Another goal was finding as much information as possible related to this composition and summarize everything possible that was written previously. Separate parts were transcribed into one partiture. Nevertheless there were difficulties like mistakes in sheet music (corrected according to harmony of other voices), missing beats (replaced by identical parts of score), differences in period station. Hard times also bring on differences of period notation. The resulting musical scores can be directly used for music production, which is schemed for the next year. The second part was researching new or never-published information related to these compositions. Here I describe Š. Brixi´s life. I managed to read out the cause of Šimon Brixi death in a chronicle, which was not in the publication I found. Brixi died of tuberculosis like his son. Transcriptors, J.V.Flaška and J.J.Hoffman, are also mentioned. Lastly the information about sheet music itself and its historical context were described. Another discovery was an identification of watermark on sheet music paper. Assuming the sheet music is truly transcribed in 1742 the Kolinec paper mill watermark on the sheet music paper is the oldest evidence of its use. In this paper I summarized the historical context of the baroque era including social life, art and culture.I mentioned the most important events that were crucial for historical development in Bohemia and especially in the Klatovy region. This context can be useful for today’s musicians who want to understand the historical background and express the composition with full respect to the time of its creation.

我們發現市售濾水器的濾芯有陶土層和活性碳層，從文獻得知活性碳的過濾效果非常好，所以決定深入研究陶土層，開發自製陶濾芯。為了讓陶土能透水，陶藝老師建議可在陶土製作時加入麵粉，高溫素燒後麵粉會在陶土中留下孔隙，陶土就能透水。使用自製陶濾芯過濾檸檬酸水溶液、生態池水、公司田溪水及硫酸銅水溶液並與無過濾的對照組比較，發現自製陶濾芯對於過濾氯化物及磷酸鹽有不錯的效果，而且在較高濃度(10ppm)的銅離子溶液中也具有過濾效果。經過多次陶濾芯製作後，最佳製作方法為揉陶土時一起加入麵粉和鹽，鹽可以控制陶土水份含量及仰制微生物，此外陶濾芯製作成高圓柱狀及燒結溫度降至500度時，都可增加接觸面積和孔隙，大幅加快過濾速度。

Currently, no method can completely eliminate the human immunodeficiency virus (HIV) in an infected person. HIV employs an accessory protein called Nef that forms a complex with cellular AP-1, preventing detection of HIV-infected cells. Lovastatin has been recently identified to inhibit the formation of said Nef-AP-1 complex, but its effective concentration is remarked to be far higher than other Nef inhibitors. This study aims to develop a modified lovastatin molecule exhibiting higher binding affinity to the HIV-1 Nef protein than lovastatin in silico. Modified lovastatin molecules based on the interaction map of lovastatin with Nef were modeled, and flexible ligand-flexible receptor docking to the Nef binding site was performed using AutoDock Vina. Residues within the Nef binding site identified by Liu et al. (2019) to be crucial (Glu-63, Val-66, Phe-68, Asp-108, Leu-112, Tyr-115) were set as flexible. Fragment-based drug design was utilized to append molecular fragments to lovastatin in order to maximize its interactions with said crucial residues. From the fragment-based approach, molecule F4 ((1S,3S)‐8‐{2‐[(2R,4R)‐4‐chloro‐6‐oxooxan‐2‐yl]ethyl}‐3‐(hydroxymethyl)‐7‐methyl‐1,2,3,4‐tetrahydronaphthalen‐1‐yl 4‐aminobenzoate) exhibited a binding affinity of -9.0 kcal/mole, and its estimated IC50 ranges between 0.25-0.51 μM which is at least 7.5 times lower than the reported IC50 of lovastatin from literature. This study presents insights on the key modifications to improve lovastatin as an HIV-1 Nef inhibitor and pertinent information about the Nef binding site for future drug development studies.

本研究以鑽孔機操作情境做為機具操作安全智動化系統開端，進而跟上改善職業災害問題顯學，其內容包括建立操作情境、即時辨識、顯示警告與緊急處理。 操作情境包含休息、工作、發問與暈倒共四種情境模式，以坐姿、坐姿舉半手、坐姿舉手、站姿、站姿舉手與躺姿六種姿勢為表示，並依其情境來探討正常姿勢與異常姿勢。前端伺服器之OpenPose為人體姿勢偵測工具，並利用 幾何運算與自行開發程式來定義與勢辨識各類姿勢。當異常姿勢發生時，後端伺服器將即時接收前端伺服器之姿勢代碼與判斷顯示，進行控制硬體之警示裝置與切斷電源系統，所以此研究為多人即時機具操作安全之智動化系統，而後將以此研究基礎做為各類危險機具操作應用研究。

CRISPR/Cas9(Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR associated protein9)是合成生物學中重要技術，需引導RNA辨認特定的PAM序列-NGG引導合成轉錄因子啟動或抑制下游基因。然而這個特定的PAM序列卻會因此限制了crispr技術可篩選的基因位點，造成限制。因此我們研發出crisprTFv2，以NAG為例突破PNGG的限制，並透過定序得知更改後的PAM相互作用區序列為何，最後再挑選crisprTFv2可能辨認的其他PAM序列，未來再將此技術應用於探討參與DNA損傷修復的基因組合。

As the world has become concerned about the global waste crisis and global warming, there has been a surge of research within materials science to find materials that would replace plastic, such as bioplastics or biodegradable materials, in order to reduce environmental pollution. Plastics generates the microplastics that allowed them to become cross contamination enter the ocean through land, sea and river. Science research found (Lusher et al. (2017)) over 220 species of marine animals ingested microplastic, half of them are considered relevant for commercial purpose and increasing the risk of human consumption as it can induce immune response, oxidative stress, cytotoxicity, alter membrane integrity and cause differential expression of genes. Thailand is also experiencing such a challenge, as seen by the overabundance of plastic waste that might take centuries to decompose. For example, around 1680 million personal hygiene products such as diapers, sanitary napkins, and tampons are used each year. This study highlights the use of naturally accessible absorbent fibers from malva nut (Scaphium scaphigerum) (G. Don) Guib & Planch.), which is widely available and biodegradable in nature and has a low carbon footprint. This study also aimed to develop natural absorbent pads using compostable spun, external layers, and biodegradable glue. A prototype sanitary napkin with biodegradable absorbent pads was developed and evaluated for absorption ability, absorption rate, pH, and biodegradability. The absorbent material absorbed up to 19 times its weight in 2 minutes and 33 times its weight in 2 hours, which is enough for an average of 80-150 mL of menstrual blood. The prototype napkin deteriorated within 99 days, based on naked eye observation. Some signs of degradation and microorganisms growing on the prototype were also observed from scanning electron microscopic images. According to the findings, natural absorbent pads made from malva nut have the potential to be converted into sanitary napkins. Furthermore, it is proposed that the components, which include superabsorbent renewable materials, spinning compostable layer, external compostable layer and biodegradable glue, may be used in a variety of goods, including adult diaper pants, incontinence pads, and laboratory bench mats.

在數學上，六芒星是指由兩個正三角形顛倒疊在一起而成的圖形，且以交點為頂點形成正六邊形。本文先給定一三角形(此稱原三角形)，其三頂點與內心連線交內切圓之三點為切點，過此三切點作切線所形成的三角形(此稱共切圓三角形)，由原三角形與共切圓三角形所形成圖形稱為相切六芒星。 本研究主要探討相切六芒星中的原三角形、共切圓三角形及尖角三角形的幾何性質，首先利用尺規作圖建構相切六芒星時，推導出共切圓三角形的角度性質。進一步探討共切圓三角形的邊截線段恆等式及鏢形面積等性質，也探討尖角三角形中的所有內切圓半徑恆等式及相切六芒星中的共線(點)性質。最後將相切六芒星推廣至(非)相切 芒星，也推導出一些有趣的性質。

本研究目的是為了更了解海藻膠製成的膠膜於食品包裝的應用。我們將此膠膜命名為新型環保非塑性保鮮膜。實驗顯示，環保非塑性保鮮膜的成功取決於甘油和醋酸的關鍵比例成份。我們以適當比例的甘油，醋酸和海藻膠糊液，能夠控制薄膜的流動性和柔軟性。藉由透明度、穿刺強度、拉伸強度和伸長率的物理性能測試，我們的研究證明，新型保鮮膜具有初步商品化之水準。環保非塑性保鮮膜之水活性值遠小於0.6。在實際應用上，「自製新型保鮮膜」包裝功能特性、包裝視覺效果甚佳，並具備優良的冷藏保鮮效果，而且不用擔心因保鮮膜接觸油脂、蒸煮或微波加熱處理所衍生的食安問題。「自製新型保鮮膜」之水活性值遠小於0.6，因此，常溫下具有相當好的貯藏性。最後，經3週掩埋測試，證明「自製新型保鮮膜」之腐敗性甚佳，是一種對環境十分友善的環保材質。

竹筍為富含纖維及維生素的食材。在台灣竹筍收穫期集中，採收後容易失水老化，因此竹筍的加工保存就顯得十分重要。本研究針對水質、水溫、鹽濃度、陽光、形狀、糖濃度進行探討成功製作酸筍的條件。實驗結果發現水質以及水溫不是成功製作酸筍的條件；竹筍洗淨剝殼自然晾乾後絕對不能再碰水；鹽巴添加比例以１：100；溫度37℃最為適合，且切成絲狀竹筍為發酵製成健康酸筍的最佳條件。總結來說，製作酸筍的過程中添加鹽可以抑制壞菌生成，添加白糖可以幫助乳酸菌在發酵過程中成為強勢菌種，而整個過程必須在特定的環境溫度30度到40度區間才會發生，我們的實驗很好的複製乳酸菌生長適溫條件，並解釋其發酵條件與酸筍之間的連結。

目前正值疫情後時代食安及衛生與大眾的生活密不可分，日常所用之難以生物降解塑膠因環保及限塑法令應設法減量，故本研究冀望能實驗出市售保鮮膜之替代品。 研究使用醇沉澱法將回收之農業廢棄物過濾出果膠，再將果膠、海藻酸鈉、甘油、純水以比例1：1：4：100混合，可得不沾黏且易脫模之自製保鮮膜，再將其進行物理、化學性質、生物降解等測試，試驗其能於空氣中耐熱至少122 oC，會於85oC熱水中部份溶解；經黴菌生長測試13日發現其不會於空氣中生長黴菌；經拉力測試發現添加橘子保鮮膜拉力佳且優於PVC保鮮膜；經滲水實驗發現柚子果膠保鮮膜的滲水速度最慢；經掩埋測試三週後可完全降解，證明果膠保鮮膜可生物降解，對環境無害。

前人利用太陽在同一經度的南、北兩地點過中天時的仰角差與兩地距離，換算出地球的半徑。因測量儀器的精準度與日期、時間選擇的限制，測量方式有很大改良空間。本研究以測距輪、公路里程牌與Google© Map尺規工具，選擇同一經線上的南、北二測量點，量測出直線距離，再利用手機高精度陀螺儀，自製北極星仰角測量平台，搭載應用程式phyphox® APP，在測量點測量北極星的仰角，換算成地球半徑，量得最接近地球實際平均半徑的距離為6366.514507km，與實際值誤差約-0.0766%，準確度更勝前人研究，大幅縮短「利用天體仰角測量地球半徑」所需要的測量距離，且在任何一天，只要月相、天候允許，都可以進行測量。

石英音叉是一種高精密的壓電震盪器，本研究欲利用其高靈敏度(高品質係數)，探討其作為表面感測器之可行性。將音叉調整在最佳的驅動震盪狀態，並將待測物固定在三維旋轉台上，藉由調節輪控制待測物的移動方向，使其緩慢移動並與探針接觸。當音叉受到表面凸起之微擾時，其靈敏的性質將使其失去共振，可藉此得知待測物表面之起伏。在本研究中，我們得到的結論是以石英音叉作為表面感測器是可行的，此外，石英音叉探針黏著點、使用的黏著劑、探針的材質以及探測方法會對感測器靈敏度產生影響。