The process of gene targeting via Chimeraplasty is achieved by using a RNA-DNA oligonucleotide homologous to a gene of interest ,to introduce a single base pair or frameshift mutation in genomic DNA .The extensive use of chimeraplasty is currently limited by wide variation in its gene conversion rates(.01-40%) and its mechanism of action remains to be fully understood. For cell studies, chimeraplasty is an alternative strategy to homeologus recombination in generating gene knockout models.
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