臺灣國際科展

An In-Depth Patch-Clamp Study of HCN2 Channel (Year II): Discovery of Novel Biomarkers and Therapy for Ih Current Suppression in Autism Spectrum Disorders

科展類別
臺灣國際科展作品
屆次
2021年
科別
生物化學
得獎情形
一等獎
學校名稱
Maggie L Walker Governor's School for Government and International Studies
指導老師
Sharon B Snyder
作者
Perisa Satish Ashar
關鍵字
Ih current、sedation、Autism

摘要或動機

The main goal of this study was to address a variety of topics concerning the role of the Ih current in HCN channels of SHANK Wild-Type and Knock-Out Thalamus Neurons (as described further below). This research explored the cellular effects of sedation (like Dexmedetomidine) and laser light stimulations on the Ih current of neurons, as well as discovering novel biomarkers for detecting Autism Spectrum Disorder. This study also showed that methods (like utilizing laser therapy with and without various photosensitizers) have the potential in raising depressed Ih currents of SHANK Knock-Out neurons.


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檔案名稱 檔案大小 格式
TISF2021-080020.pdf 3 MB Adobe Reader(Pdf)檔案