我們的研究工作有兩項重要成果：首先，根據物理學的彈性體振動模型發現：主動脈硬化的定量分析訊息可由測量主動脈相對於心臟運動的延遲時間明確得知，而且可用目前臨床使用中的心臟超音波儀器直接進行此一測量。在對23 個樣品、每個樣品分析大約50至100 次心跳的初步研究中發現，此一延遲時間是確實存在的，而且延遲時間超過大約0.17秒時，樣品就可能具有動脈硬化的現象。其次，在比照過10 組樣品的數據後發現，上述之延遲時間確定可由體外的胸前超音波掃描（TTE）準確測得，而不需要採用侵入式的經食道超音波掃描（TEE），以免除受測者的不適，及避免副作用的風險，使得此一新方法更具有方便、普遍的優點。而且此一方法也可能由數據的分佈發覺心血管之其他病徵。未來仍需應用此一方法對較多樣品進行研究以進一步確定此診斷方法之可靠性。 Two important results were achieved in this research. Firstly, according to the physical model of elastic oscillation, we found that the qualitative analysis of aorta stiffness could be obtained by a measurement of the delay time of the aorta motion relative to the cardiac motion. This measurement could be carried out with theconventional echocardiography. A preliminary analysis based on 23 samples, with 50 to 100 heartbeats per sample, confirmed the existence of this delay time. Also, a delay time of greater than 0.17 sec might imply the symptom of aorta stiffness. Secondary, after a comparison of 10 samples, the aforementioned delay time could be measured with TaransThoracic Echo (TTE) instead of TransEsophadeal Echo (TEE), in which the later is invasive while the former is not. Therefore, the discomfort of the patient and the risk of invasive operation can be avoided, making this new method more convenient and more common to accomplish. This method could also clearly discern some abnormal cardiac performance. A large-scale study with this method should be conducted in the future.
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