臺灣國際科展

Synthesis, Characterisation, and Temperature-sensitivity of Hydroxyl-Terminated Poly(N-isopropylamid

科展類別
臺灣國際科展
屆次
2003年
科別
生物化學
得獎情形
第一名
學校名稱
Raffles Junior College
指導老師
Wee Keng Yong
作者
Chong Yao Feng Victor
關鍵字
Synthesis, Characterisation

摘要或動機

Background:\r
Delivery of anticancer drugs in vivo can be achieved by using targetspecific\r
drug carriers of various types – e.g. microspheres and liposomes –\r
which can be applied intravenously, or subcutaneously via a hypodermal\r
patch, etc. as appropriate to the type of drug carrier employed. Recently,\r
interest has surged in the usage of amphiphilic polymeric micelles for this\r
purpose, as they prove superior to other drug carriers in many ways. They\r
have highly-hydrated hydrophilic shells, and hydrophobic cores wherein\r
hydrophobic anticancer drugs such as adriamycin can be encapsulated\r
during transport in the blood. Their main advantages include their\r
smallness of size – enabling them to elude capture by the\r
reticuloendothelial system (RES) – their stability in the bloodstream as\r
shown in their low critical micelle concentration (CMC) values, their\r
passive targeting of tumour sites via the enhanced permeability and\r
retention (EPR) effect, and their ability to integrate an active targeting\r
mechanism, e.g. antibody-antigen recognition, pH-sensitivity, etc.


「為配合國家發展委員會「推動ODF-CNS15251為政府為文件標準格式實施計畫」,以及 提供使用者有文書軟體選擇的權利,本館檔案下載部分文件將公布ODF開放文件格式, 免費開源軟體可至LibreOffice 下載安裝使用,或依貴慣用的軟體開啟文件。」

檔案名稱 檔案大小 格式
Synthesis, Characterisation, and Temperature-sensitivity of Hydroxyl-Terminated Poly(N-isopropylamid 156 KB Adobe Reader(Pdf)檔案